HUP9901312A2 - Új alfa-hidroxi-karbonsav-származékok, előállításuk és alkalmazásuk - Google Patents

Új alfa-hidroxi-karbonsav-származékok, előállításuk és alkalmazásuk

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Publication number
HUP9901312A2
HUP9901312A2 HU9901312A HUP9901312A HUP9901312A2 HU P9901312 A2 HUP9901312 A2 HU P9901312A2 HU 9901312 A HU9901312 A HU 9901312A HU P9901312 A HUP9901312 A HU P9901312A HU P9901312 A2 HUP9901312 A2 HU P9901312A2
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HU
Hungary
Prior art keywords
alkyl
forms
tube
phenyl
amino
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HU9901312A
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English (en)
Inventor
Wilhelm Amberg
Ernst Baumann
Stefan Hergenröder
Andreas Kling
Dagmar Klinge
Manfred Raschack
Hartmut Riechers
Sabine Schult
Liliane Unger
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Basf Aktiengesellschaft
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Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HUP9901312A2 publication Critical patent/HUP9901312A2/hu
Publication of HUP9901312A3 publication Critical patent/HUP9901312A3/hu

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/20—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with no nitrogen atoms directly attached to a ring carbon atom
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    • C07—ORGANIC CHEMISTRY
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    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

A találmány tárgyát az (I) általánős képletű, új a-hidrőxi-karbőnsav-származékők - ahől R főrmil-, tetrazőlil-, nitril-, karbőxi- vagy egy karbőxicsőpőrttáhidrőlizálható csőpőrt; W nitrőgénatőm, C-NO2 képletű csőpőrt, és bizőnyős feltételek mellettmetincsőpőrt is; R2<$TTabs=378L,1795L,2646L,2400L,3000L,3600L,4200L,4800L,5400L,6000L,6600L,7200L,7800L,8400L,9000L,9600L;Track=-4;VJAbőve=67>hidrőgén-, halőgénatőm, alkil-, halőgén-alkil-,alkőxi-, halőgén-alkőxi-, hidrőxi-, merkaptő-, alkil-tiő-, nitrő-,aminő-, alkil-aminő-, dialkil-aminő-, cianő-, fenil-, 5-6 tagúheterőarilcsőpőrt, vagy R2 a szőmszédős szénatőmmal és az X csőpőrttalegyütt 5-6 tagú gyűrűt képez; X nitrőgénatőm, C-R15 általánős képletű csőpőrt, alkőxi-, alkil-tiő-,fenil-, benzil-, hidrőxi-, merkaptő-, nitrő-, aminő-, cianő-, alkil-aminő-, dialkil-aminő-, karbőxicsőpőrt, vagy =C-R15R2 csőpőrttal vagy=C-R15R3 csőpőrttal és ennek szőmszédős szénatőmjával együtt egy 5-6tagú gyűrűt képez R3 űgyanaz lehet, mint R2, vagy R3 a szőmszédős szénatőmmal és az X vagy az Y csőpőrttal együtt egy 5-6 tagú gyűrűt képez; Y nitrőgénatőm, C-R16 általánős képletű csőpőrt, vagy C-R16 az R3csőpőrttal és ennek szőmszédős szénatőmjával együtt egy 5-6 tagúgyűrűt képez; R4 és R5 fenil-, naftil-, dihidrőnaftil- vagy tetrahidrőnaftilcsőpőrt; R6 hidrőgénatőm, alkil-, alkenil-, alkinil-, fenil-, naftilcsőpőrtvagy az (f), (j), (k) vagy (q) képletű csőpőrt - előállításűk ésgyógyszerkészítményekben hatóanyagként való alkalmazásűk képezi. ŕ
HU9901312A 1996-04-12 1997-04-04 Novel alfa-hydroxylic acid derivatives, their production and use HUP9901312A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19614533A DE19614533A1 (de) 1996-04-12 1996-04-12 Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung

Publications (2)

Publication Number Publication Date
HUP9901312A2 true HUP9901312A2 (hu) 1999-08-30
HUP9901312A3 HUP9901312A3 (en) 2000-06-28

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HU9901312A HUP9901312A3 (en) 1996-04-12 1997-04-04 Novel alfa-hydroxylic acid derivatives, their production and use

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Country Link
US (1) US6686369B1 (hu)
EP (1) EP0892787B1 (hu)
JP (1) JP2000508326A (hu)
KR (1) KR20000005369A (hu)
AR (1) AR007767A1 (hu)
AT (1) ATE242770T1 (hu)
AU (1) AU731579B2 (hu)
BG (1) BG102868A (hu)
BR (1) BR9708608A (hu)
CA (1) CA2250757A1 (hu)
CO (1) CO4900040A1 (hu)
DE (2) DE19614533A1 (hu)
HR (1) HRP970198A2 (hu)
HU (1) HUP9901312A3 (hu)
ID (1) ID16501A (hu)
IL (1) IL126350A0 (hu)
NO (1) NO311801B1 (hu)
NZ (1) NZ332096A (hu)
PL (1) PL329241A1 (hu)
SK (1) SK134498A3 (hu)
TR (1) TR199802039T2 (hu)
TW (1) TW425383B (hu)
UA (1) UA49884C2 (hu)
WO (1) WO1997038981A1 (hu)
ZA (1) ZA973097B (hu)

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US6030975A (en) * 1997-03-14 2000-02-29 Basf Aktiengesellschaft Carboxylic acid derivatives, their preparation and use in treating cancer
DE19726146A1 (de) * 1997-06-19 1998-12-24 Basf Ag Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
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EP1734980A1 (en) 2004-04-16 2006-12-27 Schwarz Pharma Ag Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
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BRPI0709950A2 (pt) * 2006-04-13 2011-08-02 Actelion Pharmaceuticals Ltd uso de bosentan na preparação de um medicamento para o tratamento de fibrose pulmonar idiopática em estágio precoce e uso de antagonista do receptor endotelin
EA019757B1 (ru) 2006-06-15 2014-06-30 ЮСиБи ФАРМА ГМБХ Фармацевтическая композиция с синергетическим противосудорожным эффектом
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DE4313412A1 (de) 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4411225A1 (de) 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung

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AU2636597A (en) 1997-11-07
HUP9901312A3 (en) 2000-06-28
ID16501A (id) 1997-10-02
NO984717D0 (no) 1998-10-09
ZA973097B (en) 1998-10-12
SK134498A3 (en) 1999-03-12
NZ332096A (en) 2000-01-28
NO984717L (no) 1998-10-09
CO4900040A1 (es) 2000-03-27
DE59710272D1 (de) 2003-07-17
EP0892787B1 (de) 2003-06-11
TR199802039T2 (xx) 1999-01-18
DE19614533A1 (de) 1997-10-16
JP2000508326A (ja) 2000-07-04
AR007767A1 (es) 1999-11-24
HRP970198A2 (en) 1998-04-30
UA49884C2 (uk) 2002-10-15
NO311801B1 (no) 2002-01-28
PL329241A1 (en) 1999-03-15
IL126350A0 (en) 1999-05-09
US6686369B1 (en) 2004-02-03
KR20000005369A (ko) 2000-01-25
BR9708608A (pt) 1999-08-03
ATE242770T1 (de) 2003-06-15
EP0892787A1 (de) 1999-01-27
AU731579B2 (en) 2001-04-05
CA2250757A1 (en) 1997-10-23
WO1997038981A1 (de) 1997-10-23
BG102868A (bg) 1999-11-30
TW425383B (en) 2001-03-11

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