HUP9901093A2 - Eljárás benzotiofénszármazékok felhasználása melanóma gátlására alkalmas gyógyszerkészítmények előállítására - Google Patents

Eljárás benzotiofénszármazékok felhasználása melanóma gátlására alkalmas gyógyszerkészítmények előállítására

Info

Publication number
HUP9901093A2
HUP9901093A2 HU9901093A HUP9901093A HUP9901093A2 HU P9901093 A2 HUP9901093 A2 HU P9901093A2 HU 9901093 A HU9901093 A HU 9901093A HU P9901093 A HUP9901093 A HU P9901093A HU P9901093 A2 HUP9901093 A2 HU P9901093A2
Authority
HU
Hungary
Prior art keywords
production
pipe powder
melanoma
inhibiting melanoma
general formula
Prior art date
Application number
HU9901093A
Other languages
English (en)
Inventor
Robert A. Swift
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9901093A2 publication Critical patent/HUP9901093A2/hu
Publication of HUP9901093A3 publication Critical patent/HUP9901093A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány eljárás melanóma gátlására, alkalmas gyógyszerelőállítására, mely az (I) általánős képletű -, ahől R1 és R3jelentése egymástól függetlenül hidrőgénatőm, -CH3, -C(=O) -(1-6szénatőmős alkil) vagy -C(=O)-Ar képletű, illetve általánős képletűcsőpőrt, melyen belül Ar jelentése adőtt esetben helyettesítettfenilcsőpőrt; R2 jelentése pirrőlidinből származó csőpőrt, hexametil-imidő- vagy piperidinőcsőpőrt - vegyületnek, gyógyászati szempőntbólalkalmazható sójának vagy szőlvátjának hatásős mennyiségét tartalmazzaönmagában vagy egy vagy több melanómát gátló hatóanyag kíséretében.(I) ŕ
HU9901093A 1995-06-06 1996-06-06 Use of benzotiophene derivatives for production of pharmaceuticals inhibiting melanoma HUP9901093A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/466,673 US5843974A (en) 1995-06-06 1995-06-06 Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se

Publications (2)

Publication Number Publication Date
HUP9901093A2 true HUP9901093A2 (hu) 1999-10-28
HUP9901093A3 HUP9901093A3 (en) 2000-02-28

Family

ID=23852667

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901093A HUP9901093A3 (en) 1995-06-06 1996-06-06 Use of benzotiophene derivatives for production of pharmaceuticals inhibiting melanoma

Country Status (16)

Country Link
US (1) US5843974A (hu)
EP (1) EP0747053A3 (hu)
JP (1) JPH11507371A (hu)
KR (1) KR19990022364A (hu)
CN (1) CN1192141A (hu)
AU (1) AU702716B2 (hu)
CA (1) CA2223157A1 (hu)
CZ (1) CZ383197A3 (hu)
EA (1) EA000680B1 (hu)
HU (1) HUP9901093A3 (hu)
IL (1) IL118574A0 (hu)
MX (1) MX9709466A (hu)
NO (1) NO975580D0 (hu)
PL (1) PL323924A1 (hu)
WO (1) WO1996039135A1 (hu)
ZA (1) ZA964682B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048847A (en) * 1997-09-30 2000-04-11 Dabur Research Foundation Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this
US6228850B1 (en) * 1997-09-30 2001-05-08 Dabur Research Foundation Antiangiogenic activity of betulinic acid and its derivatives
US6670345B1 (en) 1997-09-30 2003-12-30 Dabur Research Foundation Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
ES2246234T3 (es) 1999-05-04 2006-02-16 Strakan International Limited Glicosidos de androgenos y actividad androgenica de los mismos.
WO2005084712A2 (en) * 2004-02-27 2005-09-15 Antisense Pharma Gmbh Use of an oligonucleotide or its active derivative for the preparation of a pharmaceutical composition for inhibiting the formation of metastases in cancer treatment
EP1744788A4 (en) * 2004-03-19 2010-08-18 Penn State Res Found COMBINATIVE METHODS AND COMPOSITIONS FOR TREATING MELANOMA
CN110037999B (zh) 2012-08-13 2023-01-13 洛克菲勒大学 治疗和诊断黑素瘤
CA2939120A1 (en) 2014-01-10 2015-07-16 Rgenix, Inc. Lxr agonists and uses thereof
US9758786B2 (en) 2016-02-09 2017-09-12 Autotelic, Llc Compositions and methods for treating pancreatic cancer
WO2019104062A1 (en) 2017-11-21 2019-05-31 Rgenix, Inc. Polymorphs and uses thereof
AU2020401286A1 (en) 2019-12-13 2022-06-23 Inspirna, Inc. Metal salts and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
US5075321A (en) * 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
ATE220323T1 (de) * 1993-10-15 2002-07-15 Lilly Co Eli Methode zur behandlung von resistenten neoplasmen
US5457113A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
UA32427C2 (uk) * 1993-10-15 2000-12-15 Елі Ліллі Енд Компані Застосування бензотіофенів або їх фармацевтично прийнятних солей або сольватів для інгібування ангіогенезу і/або ангіогенних захворювань
US5476862A (en) * 1993-12-21 1995-12-19 Eli Lilly And Company Methods of increasing thrombomodulin expression
US5622975A (en) * 1995-06-01 1997-04-22 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell migration
US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
US5780497A (en) * 1996-04-19 1998-07-14 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents

Also Published As

Publication number Publication date
IL118574A0 (en) 1996-10-16
CA2223157A1 (en) 1996-12-12
MX9709466A (es) 1998-02-28
EP0747053A3 (en) 1997-01-29
EA000680B1 (ru) 2000-02-28
EP0747053A2 (en) 1996-12-11
HUP9901093A3 (en) 2000-02-28
WO1996039135A1 (en) 1996-12-12
CZ383197A3 (cs) 1998-07-15
EA199800015A1 (ru) 1998-06-25
JPH11507371A (ja) 1999-06-29
NO975580L (no) 1997-12-03
PL323924A1 (en) 1998-04-27
AU702716B2 (en) 1999-03-04
NO975580D0 (no) 1997-12-03
KR19990022364A (ko) 1999-03-25
CN1192141A (zh) 1998-09-02
US5843974A (en) 1998-12-01
AU6109096A (en) 1996-12-24
ZA964682B (en) 1997-12-05

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