HUP9900964A2 - Proteáz inhibitorok és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents
Proteáz inhibitorok és a vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP9900964A2 HUP9900964A2 HU9900964A HUP9900964A HUP9900964A2 HU P9900964 A2 HUP9900964 A2 HU P9900964A2 HU 9900964 A HU9900964 A HU 9900964A HU P9900964 A HUP9900964 A HU P9900964A HU P9900964 A2 HUP9900964 A2 HU P9900964A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- general formula
- powder
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 3
- 201000004384 Alopecia Diseases 0.000 abstract 2
- -1 aroxyalkyl Chemical group 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000024963 hair loss Diseases 0.000 abstract 2
- 230000003676 hair loss Effects 0.000 abstract 2
- 229940122156 Cathepsin K inhibitor Drugs 0.000 abstract 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 229920000265 Polyparaphenylene Polymers 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003943 azolyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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Abstract
A találmány prőteáz, ezen belül katepszin K inhibitőr (I) általánősképletű vegyületekre (I) vőnatkőzik, amelyek képletében D jelentése vagy L G általánősképletű csőpőrt; és Q jelentése általánős képletű csőpőrt; amelyekben A jelentése -N(R')C(R8)C(O)-csőpőrt, B és G jelentése azőlil- vagy karbamőilcsőpőrt; L jelentésealkil-, aralkil-, heterőaril-alkil-, arőxi-alkil-, aminőcsőpőrt; M ésJ jelentése karbőnil- vagy szűlfőnilcsőpőrt; X, Y Z jelentése N, O, Svagy CR4-csőpőrt, és a tővábbi szűbsztitűensek jelentése a leírásbanmegadőtt. A találmány szerinti vegyületek és gyógyszerkészítményekkülönösen jól alkalmazhatók az őlyan betegségek kezelésére, amelyekbenjelentős szerepet játszanak cisztein prőteázők, különösen az excesszívcsőnt- és pőrcvesztéses betegségek, példáűl az ősteőpőrősis, aperiődőntitis és az arthritis kezelésére. ŕ
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US810895P | 1995-10-30 | 1995-10-30 | |
US747395P | 1995-11-22 | 1995-11-22 | |
US899295P | 1995-12-21 | 1995-12-21 | |
US1376496P | 1996-03-20 | 1996-03-20 | |
US1374896P | 1996-03-20 | 1996-03-20 | |
US1374796P | 1996-03-20 | 1996-03-20 | |
US1745596P | 1996-05-17 | 1996-05-17 | |
US1789296P | 1996-05-17 | 1996-05-17 | |
US2204796P | 1996-07-22 | 1996-07-22 | |
US2349496P | 1996-08-07 | 1996-08-07 |
Publications (2)
Publication Number | Publication Date |
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HUP9900964A2 true HUP9900964A2 (hu) | 1999-07-28 |
HUP9900964A3 HUP9900964A3 (en) | 2001-02-28 |
Family
ID=27580625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900964A HUP9900964A3 (en) | 1995-10-30 | 1996-10-30 | Protease inhibitors and pharmaceutical compositions containing these compounds |
Country Status (17)
Country | Link |
---|---|
US (5) | US5998470A (hu) |
EP (1) | EP0934291A1 (hu) |
JP (1) | JP2000500742A (hu) |
KR (1) | KR19990067184A (hu) |
CN (3) | CN1341593A (hu) |
AP (1) | AP9801222A0 (hu) |
AU (1) | AU1118097A (hu) |
BG (1) | BG102475A (hu) |
CZ (1) | CZ132798A3 (hu) |
EA (1) | EA199800353A1 (hu) |
HU (1) | HUP9900964A3 (hu) |
NO (4) | NO981938L (hu) |
OA (1) | OA10764A (hu) |
PL (1) | PL326508A1 (hu) |
SK (1) | SK56798A3 (hu) |
TR (1) | TR199800767T2 (hu) |
WO (1) | WO1997016433A1 (hu) |
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MA26631A1 (fr) * | 1998-05-21 | 2004-12-20 | Smithkline Beecham Corp | Composes a fonction bis-aminomethyl-carbonyle nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant |
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-
1996
- 1996-10-30 TR TR1998/00767T patent/TR199800767T2/xx unknown
- 1996-10-30 EP EP96941981A patent/EP0934291A1/en not_active Withdrawn
- 1996-10-30 AP APAP/P/1998/001222A patent/AP9801222A0/en unknown
- 1996-10-30 CZ CZ981327A patent/CZ132798A3/cs unknown
- 1996-10-30 HU HU9900964A patent/HUP9900964A3/hu not_active Application Discontinuation
- 1996-10-30 SK SK567-98A patent/SK56798A3/sk unknown
- 1996-10-30 WO PCT/US1996/018000 patent/WO1997016433A1/en not_active Application Discontinuation
- 1996-10-30 AU AU11180/97A patent/AU1118097A/en not_active Abandoned
- 1996-10-30 PL PL96326508A patent/PL326508A1/xx unknown
- 1996-10-30 EA EA199800353A patent/EA199800353A1/ru unknown
- 1996-10-30 JP JP9517638A patent/JP2000500742A/ja not_active Ceased
- 1996-10-30 KR KR1019980703135A patent/KR19990067184A/ko not_active Application Discontinuation
-
1998
- 1998-04-29 NO NO981938A patent/NO981938L/no unknown
- 1998-04-30 OA OA9800049A patent/OA10764A/en unknown
- 1998-05-21 BG BG102475A patent/BG102475A/xx unknown
-
1999
- 1999-04-13 US US09/290,958 patent/US5998470A/en not_active Expired - Fee Related
- 1999-06-11 US US09/330,451 patent/US6232342B1/en not_active Expired - Fee Related
- 1999-06-11 US US09/330,287 patent/US6057362A/en not_active Expired - Fee Related
-
2000
- 2000-04-19 US US09/552,616 patent/US6284777B1/en not_active Expired - Fee Related
- 2000-04-19 US US09/551,968 patent/US6331542B1/en not_active Expired - Fee Related
- 2000-12-29 NO NO20006716A patent/NO20006716D0/no not_active Application Discontinuation
- 2000-12-29 NO NO20006717A patent/NO20006717D0/no not_active Application Discontinuation
- 2000-12-29 NO NO20006718A patent/NO20006718D0/no not_active Application Discontinuation
-
2001
- 2001-02-20 CN CN01104789A patent/CN1341593A/zh active Pending
- 2001-02-20 CN CN01104788A patent/CN1341592A/zh active Pending
- 2001-02-20 CN CN01104787A patent/CN1341590A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
KR19990067184A (ko) | 1999-08-16 |
NO20006718L (no) | 1998-06-29 |
US6232342B1 (en) | 2001-05-15 |
AU1118097A (en) | 1997-05-22 |
EP0934291A4 (hu) | 1999-08-11 |
OA10764A (en) | 2002-12-11 |
WO1997016433A1 (en) | 1997-05-09 |
NO20006716D0 (no) | 2000-12-29 |
PL326508A1 (en) | 1998-09-28 |
NO20006716L (no) | 1998-06-29 |
AP9801222A0 (en) | 1998-06-30 |
NO20006717L (no) | 1998-06-29 |
EP0934291A1 (en) | 1999-08-11 |
SK56798A3 (en) | 1998-12-02 |
EA199800353A1 (ru) | 1998-12-24 |
NO981938D0 (no) | 1998-04-29 |
CN1341593A (zh) | 2002-03-27 |
CZ132798A3 (cs) | 1999-02-17 |
NO20006718D0 (no) | 2000-12-29 |
HUP9900964A3 (en) | 2001-02-28 |
US6284777B1 (en) | 2001-09-04 |
BG102475A (en) | 1999-04-30 |
US5998470A (en) | 1999-12-07 |
MX9803548A (es) | 1998-09-30 |
NO981938L (no) | 1998-06-29 |
US6331542B1 (en) | 2001-12-18 |
JP2000500742A (ja) | 2000-01-25 |
NO20006717D0 (no) | 2000-12-29 |
TR199800767T2 (xx) | 1998-07-21 |
CN1341592A (zh) | 2002-03-27 |
CN1341590A (zh) | 2002-03-27 |
US6057362A (en) | 2000-05-02 |
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