ATE147756T1 - Neue oral wirksame elastase-inhibitoren - Google Patents

Neue oral wirksame elastase-inhibitoren

Info

Publication number
ATE147756T1
ATE147756T1 AT92114411T AT92114411T ATE147756T1 AT E147756 T1 ATE147756 T1 AT E147756T1 AT 92114411 T AT92114411 T AT 92114411T AT 92114411 T AT92114411 T AT 92114411T AT E147756 T1 ATE147756 T1 AT E147756T1
Authority
AT
Austria
Prior art keywords
elastase inhibitors
new oral
oral elastase
morpholinourea
pentafluoroethyl
Prior art date
Application number
AT92114411T
Other languages
English (en)
Inventor
Norton P Peet
Michael R Angelastro
Joseph P Burkhart
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE147756T1 publication Critical patent/ATE147756T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
AT92114411T 1991-08-22 1992-08-24 Neue oral wirksame elastase-inhibitoren ATE147756T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74860791A 1991-08-22 1991-08-22

Publications (1)

Publication Number Publication Date
ATE147756T1 true ATE147756T1 (de) 1997-02-15

Family

ID=25010166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92114411T ATE147756T1 (de) 1991-08-22 1992-08-24 Neue oral wirksame elastase-inhibitoren

Country Status (16)

Country Link
EP (1) EP0529568B1 (de)
JP (1) JP3311392B2 (de)
KR (1) KR100242046B1 (de)
AT (1) ATE147756T1 (de)
AU (1) AU655831B2 (de)
CA (1) CA2076307C (de)
DE (1) DE69216713T2 (de)
DK (1) DK0529568T3 (de)
ES (1) ES2099186T3 (de)
FI (1) FI923787A7 (de)
GR (1) GR3022915T3 (de)
HU (1) HU208703B (de)
IL (1) IL102858A (de)
NO (1) NO308999B1 (de)
NZ (1) NZ243998A (de)
ZA (1) ZA926185B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
EP0656902B1 (de) * 1992-07-29 1997-12-17 Merrell Pharmaceuticals Inc. Peptide als lungensurfactant und therapeutisch wirksame mischungen
EP0652894B1 (de) * 1992-07-31 1997-09-03 Merrell Pharmaceuticals Inc. Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien
US5977074A (en) * 1993-10-01 1999-11-02 Merrell Pharmaceuticals, Inc. Inhibitors of β-amyloid protein production
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
ES2199247T3 (es) * 1994-03-11 2004-02-16 Pharmacopeia Drug Discovery, Inc. Derivados de sulfonamida y su uso.
HU221311B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Perfluoroalkyl tripeptides inhibitors of elastase, pharmaceutical compositions comprising thereof and their use
AU696292B2 (en) * 1994-06-02 1998-09-03 Merrell Pharmaceuticals Inc. Acylated enol derivatives as prodrugs of elastase inhibitors
CN1149877A (zh) * 1994-06-02 1997-05-14 赫彻斯特马里恩鲁斯公司 新型弹性蛋白酶抑制剂
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US20020119985A1 (en) 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US5691368A (en) * 1995-01-11 1997-11-25 Hoechst Marion Roussel, Inc. Substituted oxazolidine calpain and/or cathepsin B inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
KR100343553B1 (ko) * 1995-03-23 2002-10-31 에스케이케미칼주식회사 열가소성폴리에테르에스테르블록공중합체조성물
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
IL139761A0 (en) * 1998-05-20 2002-02-10 Expression Genetics Inc A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier
EP1089752A4 (de) 1998-06-03 2002-01-02 Cortech Inc Alpha-keto oxadiazole als serinprotease inhibitoren
EP2834216A1 (de) 2012-04-04 2015-02-11 Catylix Inc. Selektive androgenrezeptormodulatoren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0318318A1 (de) * 1987-11-27 1989-05-31 Sensititre Limited Urintestverfahren und Testsatz
HUT62312A (en) * 1990-03-05 1993-04-28 Cephalon Inc Process for producing chymotrypsin-like proteases and their inhibitors
KR920701200A (ko) * 1990-03-30 1992-08-11 미즈노 시게루 신규의 4h-3,1-벤조옥사진-4-온 유도체

Also Published As

Publication number Publication date
NO923280L (no) 1993-02-23
HUT62014A (en) 1993-03-29
IL102858A0 (en) 1993-01-31
JPH05213991A (ja) 1993-08-24
ES2099186T3 (es) 1997-05-16
KR930004280A (ko) 1993-03-22
NO923280D0 (no) 1992-08-21
FI923787A0 (fi) 1992-08-21
JP3311392B2 (ja) 2002-08-05
EP0529568B1 (de) 1997-01-15
DK0529568T3 (da) 1997-02-03
GR3022915T3 (en) 1997-06-30
AU2106592A (en) 1993-02-25
AU655831B2 (en) 1995-01-12
DE69216713T2 (de) 1997-05-28
CA2076307C (en) 2003-01-07
ZA926185B (en) 1993-03-01
DE69216713D1 (de) 1997-02-27
EP0529568A1 (de) 1993-03-03
NZ243998A (en) 1994-11-25
IL102858A (en) 1998-12-27
HU208703B (en) 1993-12-28
CA2076307A1 (en) 1993-02-23
KR100242046B1 (ko) 2000-03-02
FI923787A7 (fi) 1993-02-23
NO308999B1 (no) 2000-11-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee