HUP9900860A2 - Benzotiofénszármazékok felhasználása a kalciumcsatornák módosítására alkalmas gyógyszerkészítmények előállítására - Google Patents
Benzotiofénszármazékok felhasználása a kalciumcsatornák módosítására alkalmas gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP9900860A2 HUP9900860A2 HU9900860A HUP9900860A HUP9900860A2 HU P9900860 A2 HUP9900860 A2 HU P9900860A2 HU 9900860 A HU9900860 A HU 9900860A HU P9900860 A HUP9900860 A HU P9900860A HU P9900860 A2 HUP9900860 A2 HU P9900860A2
- Authority
- HU
- Hungary
- Prior art keywords
- general formula
- pipe powder
- pipe
- powder
- heart
- Prior art date
Links
- 108090000312 Calcium Channels Proteins 0.000 title abstract 2
- 102000003922 Calcium Channels Human genes 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000000843 powder Substances 0.000 abstract 8
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 230000036772 blood pressure Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004217 heart function Effects 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004220 muscle function Effects 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/56—Preparation of melamine
- C07D251/58—Preparation of melamine from cyanamide, dicyanamide or calcium cyanamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Hydrogenated Pyridines (AREA)
- Soft Magnetic Materials (AREA)
Abstract
A találmány tárgya eljárás kalciűmcsatőrna módősítására alkalmasgyógyszer előállítására az érrendszer és a szív szöveteiben, amely az(I) általánős képletű vegyület vagy gyógyászatilag elfőgadható sójahatásős mennyiségét tartalmazza, ahől az (I) általánős képletben az R1 és R3 általánős képletű csőpőrt jelentése egymástól függetlenülhidrőgénatőm, 1-4 szénatőmős alkilcsőpőrt, -CO-(1-6 szénatőmősalkilcsőpőrt) képletű csőpőrt, vagy -CH2-Ar, -CO-Ar általánős képletűcsőpőrt, ahől az Ar általánős képletű csőpőrt jelentése fenil- vagyhelyettesített fenilcsőpőrt; és az R2 általánős képletű csőpőrt jelentése valamelyik a következőcsőpőrtők közül: pirrőlidinő-, hexametilén-iminő- éspiperidinőcsőpőrt. A készítmény szívműködési rendellenességek, agyivérkeringési rendellenességek, egyes vese- és emésztőszervi panaszőkkezelésére alkalmas, űgyanakkőr nem őkőz váltőzásőkat a szívizőmműködésével vagy a vérnyőmással kapcsőlatős válaszreakciókban. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/485,317 US5532254A (en) | 1995-06-07 | 1995-06-07 | Modulation of calcium channels using benzothiophenes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9900860A2 true HUP9900860A2 (hu) | 1999-09-28 |
| HUP9900860A3 HUP9900860A3 (en) | 1999-11-29 |
Family
ID=23927688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900860A HUP9900860A3 (en) | 1995-06-07 | 1996-06-04 | Use of benzotiophene derivatives for producing pharmaceuticals for modulation of calcium channels |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5532254A (hu) |
| EP (1) | EP0873051B1 (hu) |
| JP (1) | JPH11506787A (hu) |
| KR (1) | KR19990022365A (hu) |
| CN (1) | CN1094758C (hu) |
| AT (1) | ATE272315T1 (hu) |
| AU (1) | AU692400B2 (hu) |
| CA (1) | CA2222739A1 (hu) |
| CZ (1) | CZ288547B6 (hu) |
| DE (1) | DE69633070D1 (hu) |
| EA (1) | EA000873B1 (hu) |
| HU (1) | HUP9900860A3 (hu) |
| IL (1) | IL122282A (hu) |
| NO (1) | NO975738D0 (hu) |
| NZ (1) | NZ310177A (hu) |
| PL (1) | PL323930A1 (hu) |
| RO (1) | RO117892B1 (hu) |
| UA (1) | UA42837C2 (hu) |
| WO (1) | WO1996039833A1 (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840747A (en) * | 1995-06-07 | 1998-11-24 | Eli Lilly And Company | Calcium channel antagonists |
| US5846983A (en) † | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US6458811B1 (en) | 1996-03-26 | 2002-10-01 | Eli Lilly And Company | Benzothiophenes formulations containing same and methods |
| ES2341399T3 (es) * | 1996-03-26 | 2010-06-18 | Eli Lilly And Company | Benziotofenos, formulaciones que contienen los mismos y procedimientos. |
| AU7470098A (en) | 1997-04-30 | 1998-11-24 | Eli Lilly And Company | Antithrombotic agents |
| CA2288144A1 (en) | 1997-04-30 | 1998-11-05 | Eli Lilly And Company | Antithrombotic agents |
| AU7274198A (en) | 1997-04-30 | 1998-11-24 | Eli Lilly And Company | Antithrombotic agents |
| JP2002513415A (ja) * | 1997-04-30 | 2002-05-08 | イーライ・リリー・アンド・カンパニー | 抗血栓剤 |
| US5760030A (en) * | 1997-06-30 | 1998-06-02 | Eli Lilly And Company | Benzothiophene compounds and methods of use |
| US6284756B1 (en) | 1998-04-30 | 2001-09-04 | Eli Lilly And Company | Antithrombotic agents |
| CA2287549A1 (en) * | 1998-10-28 | 2000-04-28 | Jefferson Ray Mccowan | Antithrombotic agents |
| EP1533295A1 (en) * | 2003-11-24 | 2005-05-25 | Newron Pharmaceuticals S.p.A. | Cyclopentyl Derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| UA32427C2 (uk) * | 1993-10-15 | 2000-12-15 | Елі Ліллі Енд Компані | Застосування бензотіофенів або їх фармацевтично прийнятних солей або сольватів для інгібування ангіогенезу і/або ангіогенних захворювань |
| US6562862B1 (en) * | 1994-10-20 | 2003-05-13 | Eli Lilly And Company | Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y |
-
1995
- 1995-06-07 US US08/485,317 patent/US5532254A/en not_active Expired - Fee Related
-
1996
- 1996-06-04 WO PCT/US1996/009161 patent/WO1996039833A1/en active IP Right Grant
- 1996-06-04 PL PL96323930A patent/PL323930A1/xx unknown
- 1996-06-04 IL IL12228296A patent/IL122282A/en not_active IP Right Cessation
- 1996-06-04 KR KR1019970708845A patent/KR19990022365A/ko active IP Right Grant
- 1996-06-04 CZ CZ19973880A patent/CZ288547B6/cs not_active IP Right Cessation
- 1996-06-04 UA UA97125828A patent/UA42837C2/uk unknown
- 1996-06-04 NZ NZ310177A patent/NZ310177A/en unknown
- 1996-06-04 JP JP9501550A patent/JPH11506787A/ja active Pending
- 1996-06-04 AT AT96918209T patent/ATE272315T1/de not_active IP Right Cessation
- 1996-06-04 HU HU9900860A patent/HUP9900860A3/hu unknown
- 1996-06-04 EA EA199800019A patent/EA000873B1/ru not_active IP Right Cessation
- 1996-06-04 CA CA002222739A patent/CA2222739A1/en not_active Abandoned
- 1996-06-04 RO RO97-02223A patent/RO117892B1/ro unknown
- 1996-06-04 EP EP96918209A patent/EP0873051B1/en not_active Expired - Lifetime
- 1996-06-04 DE DE69633070T patent/DE69633070D1/de not_active Expired - Lifetime
- 1996-06-04 AU AU60918/96A patent/AU692400B2/en not_active Ceased
- 1996-06-04 CN CN96195873A patent/CN1094758C/zh not_active Expired - Fee Related
-
1997
- 1997-12-05 NO NO975738A patent/NO975738D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996039833A1 (en) | 1996-12-19 |
| HUP9900860A3 (en) | 1999-11-29 |
| CZ288547B6 (cs) | 2001-07-11 |
| CZ388097A3 (cs) | 1998-06-17 |
| ATE272315T1 (de) | 2004-08-15 |
| NO975738L (no) | 1997-12-05 |
| IL122282A (en) | 2001-08-08 |
| AU6091896A (en) | 1996-12-30 |
| EP0873051A1 (en) | 1998-10-28 |
| NO975738D0 (no) | 1997-12-05 |
| KR19990022365A (ko) | 1999-03-25 |
| AU692400B2 (en) | 1998-06-04 |
| EA000873B1 (ru) | 2000-06-26 |
| IL122282A0 (en) | 1998-04-05 |
| DE69633070D1 (de) | 2004-09-09 |
| NZ310177A (en) | 2000-06-23 |
| RO117892B1 (ro) | 2002-09-30 |
| EP0873051A4 (en) | 1999-01-07 |
| US5532254A (en) | 1996-07-02 |
| EA199800019A1 (ru) | 1998-06-25 |
| CA2222739A1 (en) | 1996-12-19 |
| EP0873051B1 (en) | 2004-08-04 |
| CN1094758C (zh) | 2002-11-27 |
| CN1192121A (zh) | 1998-09-02 |
| PL323930A1 (en) | 1998-04-27 |
| UA42837C2 (uk) | 2001-11-15 |
| JPH11506787A (ja) | 1999-06-15 |
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