EA199800019A1 - Способ повышения плотности кальциевых каналов - Google Patents

Способ повышения плотности кальциевых каналов

Info

Publication number
EA199800019A1
EA199800019A1 EA199800019A EA199800019A EA199800019A1 EA 199800019 A1 EA199800019 A1 EA 199800019A1 EA 199800019 A EA199800019 A EA 199800019A EA 199800019 A EA199800019 A EA 199800019A EA 199800019 A1 EA199800019 A1 EA 199800019A1
Authority
EA
Eurasian Patent Office
Prior art keywords
density
increasing
calcium channels
alkyl
phenyl
Prior art date
Application number
EA199800019A
Other languages
English (en)
Other versions
EA000873B1 (ru
Inventor
Нэнси Л. Баулинг
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199800019A1 publication Critical patent/EA199800019A1/ru
Publication of EA000873B1 publication Critical patent/EA000873B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/56—Preparation of melamine
    • C07D251/58—Preparation of melamine from cyanamide, dicyanamide or calcium cyanamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

Abstract

Способ повышения плотности кальциевых каналов в ткани сосудов и сердца без изменений инотропного или прессорного ответа, который включает введение теплокровному животному, которое в этом нуждается, фармацевтически эффективного количества соединения формулы (I)в котором Rи Rнезависимо представляет водород, C-C-алкил, -CO(C-C-алкил), -CHAr или -CO-Ar, где Ar представляет фенил или замещенный фенил; Rвыбирают из группы, состоящей из пирролидино, гексаметиленимино и пиперидино; или его фармацевтически приемлемой соли.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800019A 1995-06-07 1996-06-04 Способ повышения плотности кальциевых каналов EA000873B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/485,317 US5532254A (en) 1995-06-07 1995-06-07 Modulation of calcium channels using benzothiophenes
PCT/US1996/009161 WO1996039833A1 (en) 1995-06-07 1996-06-04 Modulation of calcium channels

Publications (2)

Publication Number Publication Date
EA199800019A1 true EA199800019A1 (ru) 1998-06-25
EA000873B1 EA000873B1 (ru) 2000-06-26

Family

ID=23927688

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800019A EA000873B1 (ru) 1995-06-07 1996-06-04 Способ повышения плотности кальциевых каналов

Country Status (19)

Country Link
US (1) US5532254A (ru)
EP (1) EP0873051B1 (ru)
JP (1) JPH11506787A (ru)
KR (1) KR19990022365A (ru)
CN (1) CN1094758C (ru)
AT (1) ATE272315T1 (ru)
AU (1) AU692400B2 (ru)
CA (1) CA2222739A1 (ru)
CZ (1) CZ288547B6 (ru)
DE (1) DE69633070D1 (ru)
EA (1) EA000873B1 (ru)
HU (1) HUP9900860A3 (ru)
IL (1) IL122282A (ru)
NO (1) NO975738D0 (ru)
NZ (1) NZ310177A (ru)
PL (1) PL323930A1 (ru)
RO (1) RO117892B1 (ru)
UA (1) UA42837C2 (ru)
WO (1) WO1996039833A1 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840747A (en) * 1995-06-07 1998-11-24 Eli Lilly And Company Calcium channel antagonists
US5846983A (en) † 1996-02-09 1998-12-08 Mayo Foundation For Medical Education And Research Colonic delivery of nicotine to treat inflammatory bowel disease
US6458811B1 (en) * 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
PT910369E (pt) 1996-03-26 2010-06-04 Lilly Co Eli Benzotiofenos, formulações que os contêm, e métodos
AU7170898A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Antithrombotic agents
WO1998049161A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company Antithrombotic agents
CA2288224A1 (en) 1997-04-30 1998-11-05 Mary George Johnson Antithrombotic agents
WO1998049160A1 (en) 1997-04-30 1998-11-05 Eli Lilly And Company Antithrombotic agents
US5760030A (en) * 1997-06-30 1998-06-02 Eli Lilly And Company Benzothiophene compounds and methods of use
US6284756B1 (en) 1998-04-30 2001-09-04 Eli Lilly And Company Antithrombotic agents
EP0997460B1 (en) * 1998-10-28 2002-12-11 Eli Lilly And Company Benzothiophene compounds as antithrombotic agents and intermediates
EP1533295A1 (en) * 2003-11-24 2005-05-25 Newron Pharmaceuticals S.p.A. Cyclopentyl Derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
CN1058390C (zh) * 1993-10-15 2000-11-15 伊莱利利公司 苯并噻吩类化合物的用途
US6562862B1 (en) * 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y

Also Published As

Publication number Publication date
NZ310177A (en) 2000-06-23
HUP9900860A2 (hu) 1999-09-28
RO117892B1 (ro) 2002-09-30
NO975738L (no) 1997-12-05
EP0873051A1 (en) 1998-10-28
ATE272315T1 (de) 2004-08-15
DE69633070D1 (de) 2004-09-09
AU692400B2 (en) 1998-06-04
CZ288547B6 (cs) 2001-07-11
IL122282A (en) 2001-08-08
WO1996039833A1 (en) 1996-12-19
EA000873B1 (ru) 2000-06-26
NO975738D0 (no) 1997-12-05
UA42837C2 (ru) 2001-11-15
CA2222739A1 (en) 1996-12-19
KR19990022365A (ko) 1999-03-25
CN1094758C (zh) 2002-11-27
US5532254A (en) 1996-07-02
CN1192121A (zh) 1998-09-02
JPH11506787A (ja) 1999-06-15
CZ388097A3 (cs) 1998-06-17
IL122282A0 (en) 1998-04-05
EP0873051A4 (en) 1999-01-07
EP0873051B1 (en) 2004-08-04
HUP9900860A3 (en) 1999-11-29
PL323930A1 (en) 1998-04-27
AU6091896A (en) 1996-12-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU