FR2413383A1 - Derives de type 5,6-dihydro-prostacycline, leurs procedes de preparation et leurs applications therapeutiques - Google Patents

Derives de type 5,6-dihydro-prostacycline, leurs procedes de preparation et leurs applications therapeutiques

Info

Publication number
FR2413383A1
FR2413383A1 FR7836902A FR7836902A FR2413383A1 FR 2413383 A1 FR2413383 A1 FR 2413383A1 FR 7836902 A FR7836902 A FR 7836902A FR 7836902 A FR7836902 A FR 7836902A FR 2413383 A1 FR2413383 A1 FR 2413383A1
Authority
FR
France
Prior art keywords
derivatives
methods
prostacycline
dihydro
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7836902A
Other languages
English (en)
Other versions
FR2413383B1 (fr
Inventor
Carmelo Gandolfi
Franco Fausteni
Alessendro Andreoni
Carlo Passarotti
Angelo Framagalli
Robert Ceserani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlo Erba SpA filed Critical Carlo Erba SpA
Publication of FR2413383A1 publication Critical patent/FR2413383A1/fr
Application granted granted Critical
Publication of FR2413383B1 publication Critical patent/FR2413383B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

LES COMPOSES DE L'INVENTION SONT DES COMPOSES DE FORMULE: (CF DESSIN DANS BOPI) (CF DESSIN DANS BOPI) OU LES SYMBOLES SONT DEFINIS, AINSI QUE LEURS LACTONES, LEURS SELS ET LEURS DIVERS ISOMERES SEPARES OU EN MELANGE; DES PROCEDES DE PREPARATION DE CES COMPOSES SONT EGALEMENT DECRITS. LES DERIVES DE L'INVENTION SONT NOTAMMENT UTILES COMME MEDICAMENTS A USAGE HUMAIN ET VETERINAIRE AYANT DE FACON AVANTAGEUSE LES APPLICATIONS DES PROSTAGLANDINES NATURELLES.
FR7836902A 1977-12-30 1978-12-29 Derives de type 5,6-dihydro-prostacycline, leurs procedes de preparation et leurs applications therapeutiques Granted FR2413383A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT31423/77A IT1089247B (it) 1977-12-30 1977-12-30 5-6-di idro-prostaciclina derivati

Publications (2)

Publication Number Publication Date
FR2413383A1 true FR2413383A1 (fr) 1979-07-27
FR2413383B1 FR2413383B1 (fr) 1982-04-09

Family

ID=11233616

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7836902A Granted FR2413383A1 (fr) 1977-12-30 1978-12-29 Derives de type 5,6-dihydro-prostacycline, leurs procedes de preparation et leurs applications therapeutiques

Country Status (10)

Country Link
JP (1) JPS54103863A (fr)
BE (1) BE873129A (fr)
DE (1) DE2853849A1 (fr)
FR (1) FR2413383A1 (fr)
GB (1) GB2012762A (fr)
HU (1) HU182021B (fr)
IT (1) IT1089247B (fr)
NL (1) NL7812132A (fr)
SE (1) SE7813428L (fr)
ZA (1) ZA786963B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410653A1 (fr) * 1977-12-05 1979-06-29 Upjohn Co Nouveaux analogues de prostacycline et medicament les contenant
FR2490641A1 (fr) * 1980-09-22 1982-03-26 Hoffmann La Roche Nouvelles prostacyclines utiles comme medicaments et leur procede de preparation

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3035713A1 (de) * 1980-09-22 1982-04-29 F. Hoffmann-La Roche & Co. AG, 4002 Basel Prostacycline
EP0059307A1 (fr) 1981-02-26 1982-09-08 Grünenthal GmbH Préparation de composés 2-oxabicyclo(3,3.0)-octane et leurs dérivés

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2376134A1 (fr) * 1976-12-30 1978-07-28 Upjohn Co Derives de 6-oxo-prostaglandines, leur procede de preparation et medicaments en contenant
US4126744A (en) * 1977-12-05 1978-11-21 The Upjohn Company 4-Oxo-PGI1 compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2376134A1 (fr) * 1976-12-30 1978-07-28 Upjohn Co Derives de 6-oxo-prostaglandines, leur procede de preparation et medicaments en contenant
US4126744A (en) * 1977-12-05 1978-11-21 The Upjohn Company 4-Oxo-PGI1 compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410653A1 (fr) * 1977-12-05 1979-06-29 Upjohn Co Nouveaux analogues de prostacycline et medicament les contenant
FR2490641A1 (fr) * 1980-09-22 1982-03-26 Hoffmann La Roche Nouvelles prostacyclines utiles comme medicaments et leur procede de preparation

Also Published As

Publication number Publication date
ZA786963B (en) 1979-11-28
SE7813428L (sv) 1979-07-01
NL7812132A (nl) 1979-07-03
JPS54103863A (en) 1979-08-15
BE873129A (fr) 1979-04-17
GB2012762A (en) 1979-08-01
DE2853849A1 (de) 1979-10-18
HU182021B (en) 1983-12-28
IT1089247B (it) 1985-06-18
FR2413383B1 (fr) 1982-04-09

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Legal Events

Date Code Title Description
CD Change of name or company name
ST Notification of lapse