GB2012762A - 5,6-dihydro prostacyclin derivatives - Google Patents

5,6-dihydro prostacyclin derivatives

Info

Publication number
GB2012762A
GB2012762A GB7848599A GB7848599A GB2012762A GB 2012762 A GB2012762 A GB 2012762A GB 7848599 A GB7848599 A GB 7848599A GB 7848599 A GB7848599 A GB 7848599A GB 2012762 A GB2012762 A GB 2012762A
Authority
GB
United Kingdom
Prior art keywords
group
hydrogen
image
compounds
c6alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7848599A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of GB2012762A publication Critical patent/GB2012762A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

Compounds (I> <IMAGE> where R is a carboxyl group or a derivative thereof, D is C2-C18-alkylene chain; one of R1 and R2 a radical Z (which is hydrogen, deuterium, tritium, C1-C12 alkyl, C2-C4alkenyl, C2-C4alkynyl or phenyl) or a -X-C1-C6-alkyl group where X is -O- or -S-, and the other is hydrogen, deuterium, tritium, halogen, hydroxy, -X-C1-C6alkyl, with X as defined above, or a R7-COO- or R7-SO2-O- group in which R7 is C1-C6alkyl, C6-C10aryl or C7-C12arylalkyl, R1, R2 and the carbon atom to which they are bound form a <IMAGE> group, with X as defined above, a <IMAGE> group in which R8 is hydrogen, C1-C8alkyl or aryl, or a <IMAGE> group in which X1 and X2, whether the same or different, are oxygen or sulfur and A1 is C2-C18alkylene, unsubstituted or substituted with halogen; R3 is hydrogen or C1-C6alkyl; and q, R4, Y, R5, R6, E and G are various groups and the symbol ----- is a single or double bond with various provisos; and the corresponding lactones of compounds wherein R is COOH and one of R1 and R2 is hydroxy; and the usual salts and isomers thereof. These compounds are substitutes for natural prostaglandins with various advantages thereover in terms of slower metabolization and more selective therapeutic action. They are prepared by introducing the chain containing R, D, R1, R2, and R3 in place of a hydroxy group initially occupying the chain attachment point. A process is disclosed for preparing compounds (I) where one of R1 and R2 is a radical Z and the other is hydrogen deuterium or tritium by reducing the corresponding compound where R1 and/or R2 is other than Z. <IMAGE>
GB7848599A 1977-12-30 1978-12-14 5,6-dihydro prostacyclin derivatives Withdrawn GB2012762A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT31423/77A IT1089247B (en) 1977-12-30 1977-12-30 5-6-DI HYDRO-PROSTACYCLINE DERIVATIVES

Publications (1)

Publication Number Publication Date
GB2012762A true GB2012762A (en) 1979-08-01

Family

ID=11233616

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7848599A Withdrawn GB2012762A (en) 1977-12-30 1978-12-14 5,6-dihydro prostacyclin derivatives

Country Status (10)

Country Link
JP (1) JPS54103863A (en)
BE (1) BE873129A (en)
DE (1) DE2853849A1 (en)
FR (1) FR2413383A1 (en)
GB (1) GB2012762A (en)
HU (1) HU182021B (en)
IT (1) IT1089247B (en)
NL (1) NL7812132A (en)
SE (1) SE7813428L (en)
ZA (1) ZA786963B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430497A (en) 1981-02-26 1984-02-07 Gruenenthal Gmbh Process for the preparation of 2-oxa-bicyclo [3.3.0] octane derivatives and products produced thereby

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126744A (en) * 1977-12-05 1978-11-21 The Upjohn Company 4-Oxo-PGI1 compounds
FR2490641A1 (en) * 1980-09-22 1982-03-26 Hoffmann La Roche 6,9-Epoxy 15-hydroxy prost-13-enoic and prostanoic acid derivs. - are antisecretories, bronchodilators, blood platelet aggregation inhibitors, antiulcer and antihypertensive cpds.
DE3035713A1 (en) * 1980-09-22 1982-04-29 F. Hoffmann-La Roche & Co. AG, 4002 Basel 6,9-Epoxy 15-hydroxy prost-13-enoic and prostanoic acid derivs. - are antisecretories, bronchodilators, blood platelet aggregation inhibitors, antiulcer and antihypertensive cpds.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues
US4126744A (en) * 1977-12-05 1978-11-21 The Upjohn Company 4-Oxo-PGI1 compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430497A (en) 1981-02-26 1984-02-07 Gruenenthal Gmbh Process for the preparation of 2-oxa-bicyclo [3.3.0] octane derivatives and products produced thereby

Also Published As

Publication number Publication date
JPS54103863A (en) 1979-08-15
SE7813428L (en) 1979-07-01
HU182021B (en) 1983-12-28
IT1089247B (en) 1985-06-18
DE2853849A1 (en) 1979-10-18
ZA786963B (en) 1979-11-28
NL7812132A (en) 1979-07-03
FR2413383B1 (en) 1982-04-09
BE873129A (en) 1979-04-17
FR2413383A1 (en) 1979-07-27

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)