HUP9900816A2 - Piperidin-karbonsav-származékok alkalmazása rotamáz enzim inhibitor hatású gyógyszerkészítmények előállítására - Google Patents
Piperidin-karbonsav-származékok alkalmazása rotamáz enzim inhibitor hatású gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP9900816A2 HUP9900816A2 HU9900816A HUP9900816A HUP9900816A2 HU P9900816 A2 HUP9900816 A2 HU P9900816A2 HU 9900816 A HU9900816 A HU 9900816A HU P9900816 A HUP9900816 A HU P9900816A HU P9900816 A2 HUP9900816 A2 HU P9900816A2
- Authority
- HU
- Hungary
- Prior art keywords
- acid derivatives
- inhibitors
- carboxylic acid
- pharmaceutical compositions
- enzyme activity
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- DNUTZBZXLPWRJG-UHFFFAOYSA-N 1-Piperidine carboxylic acid Chemical class OC(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-N 0.000 title 1
- 101710103508 FK506-binding protein Proteins 0.000 title 1
- 101710104425 FK506-binding protein 2 Proteins 0.000 title 1
- 101710104423 FK506-binding protein 3 Proteins 0.000 title 1
- 101710104333 FK506-binding protein 4 Proteins 0.000 title 1
- 101710104342 FK506-binding protein 5 Proteins 0.000 title 1
- 101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 title 1
- 101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710114693 Outer membrane protein MIP Proteins 0.000 title 1
- 101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 title 1
- 101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 title 1
- 101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 title 1
- 101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 title 1
- 101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 title 1
- 101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 title 1
- 101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 title 1
- 101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 title 1
- 101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 title 1
- 101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 title 1
- 101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 title 1
- 101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 title 1
- 101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 title 1
- 102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 title 1
- 101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 title 1
- 101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 title 1
- 101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 title 1
- 101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 title 1
- 101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 title 1
- 101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 title 1
- 101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000000521 Immunophilins Human genes 0.000 abstract 2
- 108010016648 Immunophilins Proteins 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 102000004195 Isomerases Human genes 0.000 abstract 1
- 108090000769 Isomerases Proteins 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány tárgya neűrőtrópiás hatású, tővábbá FKBP-típűsúimműnőfilinek iránt affinitást műtató pipekőlsav-származékőkalkalmazása gyógyszerkészítmények előállítására. A találmány szerintipipekőlsav-származékők imműnőfilin prőteinekkel kapcsőlatősenzimaktivitás inhibitőrők, különösen a peptidil-prőpil-izőmeráz vagy-rőtamáz enzimeket gátőlják, ezáltal stiműlálják vagy elősegítik azidegek növekedését vagy regenerálódását. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/474,072 US5798355A (en) | 1995-06-07 | 1995-06-07 | Inhibitors of rotamase enzyme activity |
US08/653,905 US5696135A (en) | 1995-06-07 | 1996-05-28 | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9900816A2 true HUP9900816A2 (hu) | 1999-07-28 |
HUP9900816A3 HUP9900816A3 (en) | 2000-02-28 |
Family
ID=27044341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900816A HUP9900816A3 (en) | 1995-06-07 | 1996-06-05 | Use of piperidine carboxylic acid derivatives for producing pharmaceutical compositions as inhibitors of rotamase enzyme activity |
Country Status (28)
Country | Link |
---|---|
US (5) | US5696135A (hu) |
EP (1) | EP0777478B1 (hu) |
AU (1) | AU710423B2 (hu) |
BG (1) | BG102072A (hu) |
BR (1) | BR9608485A (hu) |
CA (1) | CA2206824C (hu) |
CH (1) | CH689541A5 (hu) |
CZ (1) | CZ232997A3 (hu) |
DE (1) | DE19680255T1 (hu) |
DK (1) | DK125696A (hu) |
EA (1) | EA001379B1 (hu) |
EE (1) | EE9700331A (hu) |
ES (3) | ES2138518B1 (hu) |
FI (1) | FI964137A (hu) |
GB (1) | GB2305605B (hu) |
HK (1) | HK1013254A1 (hu) |
HU (1) | HUP9900816A3 (hu) |
LU (1) | LU88834A1 (hu) |
LV (1) | LV11986B (hu) |
MX (1) | MX9707552A (hu) |
NO (1) | NO974290L (hu) |
NZ (1) | NZ310767A (hu) |
PL (1) | PL323381A1 (hu) |
SE (1) | SE9604097L (hu) |
SI (1) | SI9620089A (hu) |
SK (1) | SK161097A3 (hu) |
TW (1) | TW523410B (hu) |
WO (1) | WO1996040140A1 (hu) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
GB2332673A (en) * | 1995-06-07 | 1999-06-30 | Guilford Pharm Inc | Small molecule inhibitors of rotamase enzyme activity |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US6509477B1 (en) | 1998-11-12 | 2003-01-21 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme activity |
US7056935B2 (en) * | 1995-06-07 | 2006-06-06 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US6291510B1 (en) | 1995-06-07 | 2001-09-18 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US5794887A (en) | 1995-11-17 | 1998-08-18 | Komerath; Narayanan M. | Stagnation point vortex controller |
US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US5780484A (en) * | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
US5840736A (en) * | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
US5935989A (en) | 1996-12-31 | 1999-08-10 | Gpi Nil Holdings Inc. | N-linked ureas and carbamates of heterocyclic thioesters |
JP2002515050A (ja) | 1996-12-31 | 2002-05-21 | ジーピーアイ エヌアイエル ホールディングス インコーポレイテッド | ヘテロ環式チオエステルのn−結合尿素およびカルバメート |
US5874449A (en) * | 1996-12-31 | 1999-02-23 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of heterocyclic thioesters |
US5721256A (en) * | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
US5846979A (en) * | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
US6852496B1 (en) | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
US6268384B1 (en) | 1997-08-29 | 2001-07-31 | Vertex Pharmaceuticals Incorporated | Compounds possessing neuronal activity |
US5968921A (en) * | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
US6121280A (en) * | 1998-03-24 | 2000-09-19 | Pfizer Inc. | Azabicyclic rotomase inhibitors |
CA2333997A1 (en) | 1998-06-02 | 1999-12-09 | Bristol-Myers Squibb Company | Neurotrophic difluoroamide agents |
AU1708099A (en) | 1998-06-03 | 1999-12-20 | Amgen, Inc. | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
HUP0200637A3 (en) | 1998-07-17 | 2003-05-28 | Agouron Pharmaceuticals Inc La | Compounds, compositions, and their use for stimulating neuronal growth and elongation |
GB9815880D0 (en) | 1998-07-21 | 1998-09-16 | Pfizer Ltd | Heterocycles |
US7338976B1 (en) * | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6376517B1 (en) * | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
WO2000009108A2 (en) * | 1998-08-14 | 2000-02-24 | Gpi Nil Holdings, Inc. | Compositions and uses for vision and memory disorders |
US6335348B1 (en) * | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US7265150B1 (en) * | 1998-08-14 | 2007-09-04 | Gpi Nil Holdings Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
AU3221300A (en) * | 1999-02-03 | 2000-08-25 | Schering Aktiengesellschaft | Carboxylic acid derivatives, process for their preparation and their use as rotamase enzyme activity inhibitors |
US6284779B1 (en) | 1999-02-03 | 2001-09-04 | Schering Aktiiengesellschaft | Heteroaromatic compounds |
WO2001002363A2 (en) | 1999-07-06 | 2001-01-11 | Vertex Pharmaceuticals Incorporated | N-substituted glycine derivatives |
WO2001004090A2 (en) * | 1999-07-09 | 2001-01-18 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods |
US6734211B1 (en) | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
MXPA02000330A (es) | 1999-07-09 | 2004-05-21 | Johnson & Johnson | Pirrolidinas y piperidinas neurotroficas y composiciones y metodos relacionados. |
WO2001004091A1 (en) | 1999-07-09 | 2001-01-18 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods |
AU6913700A (en) * | 1999-08-18 | 2001-03-13 | Schering Aktiengesellschaft | Piperidine and pyrrolidine derivatives displaying neuronal activity |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
JP2003508512A (ja) | 1999-09-08 | 2003-03-04 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | 非ペプチド性サイクロフィリン結合化合物とその用途 |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
ATE335524T1 (de) * | 1999-11-12 | 2006-09-15 | Alcon Inc | Verwendung von neurophilin liganden zur behandlung von augenerkrankungen |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
DOP2000000107A (es) | 1999-12-01 | 2002-09-16 | Agouron Pharmaceutical Inc | Compuestos, composiciones y metodos para estimular el crecimiento y alongamiento de las neuronas |
US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
CA2393466C (en) | 1999-12-21 | 2010-01-19 | Gpi Nil Holdings, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
WO2002059080A2 (en) | 2001-01-25 | 2002-08-01 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
US7041283B1 (en) | 2001-02-16 | 2006-05-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants |
US6593362B2 (en) | 2001-05-21 | 2003-07-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
CA2449019A1 (en) * | 2001-05-29 | 2002-12-05 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
ATE421525T1 (de) * | 2001-08-20 | 2009-02-15 | Max Planck Gesellschaft | Katalyse der cis-trans isomerisierung von sekundären-amid peptidverbindungen |
CN1173960C (zh) | 2001-12-06 | 2004-11-03 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代六元氮杂环类化合物及其作为神经调节剂的用途 |
US20030176455A1 (en) * | 2002-03-13 | 2003-09-18 | Wyeth | Method of inhibiting cell death |
EP1402888A1 (en) * | 2002-09-18 | 2004-03-31 | Jerini AG | The use of substituted carbocyclic compounds as rotamases inhibitors |
EP1552834B1 (en) * | 2002-10-15 | 2007-05-02 | Astellas Pharma Inc. | N-acetyl-l-pipecolic acid as neurotrophic factor production promoter |
US7033612B2 (en) * | 2003-01-03 | 2006-04-25 | Kang David S | Composition and method for treating age-related disorders |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
EP1682132A1 (en) | 2003-09-18 | 2006-07-26 | Macusight, Inc. | Transscleral delivery |
BRPI0508084A (pt) * | 2004-03-02 | 2007-07-17 | Wyeth Corp | método para o tratamento de um distúrbio neurológico, e, uso de meridamicina ou um sal do mesmo |
CA2556622A1 (en) * | 2004-03-02 | 2005-09-15 | Wyeth | Macrolides and methods for producing same |
CA2567043A1 (en) * | 2004-06-03 | 2005-12-22 | Wyeth | Biosynthetic gene cluster for the production of a complex polyketide |
US7777042B2 (en) * | 2004-06-29 | 2010-08-17 | Aventis Pharmaceuticals Inc. | N-sulfonylpipecolic acid derivative FKBP binding composition and pharmaceutical use thereof |
ATE546430T1 (de) * | 2004-06-29 | 2012-03-15 | Aventis Pharma Inc | Fkbp bindende zusammensetzung und deren pharmazeutische verwendung |
US20060189551A1 (en) * | 2004-10-04 | 2006-08-24 | Duke University | Combination therapies for fungal pathogens |
ES2380779T3 (es) * | 2004-12-20 | 2012-05-18 | Wyeth Llc | Análogos de rapamicina y usos de los mismos en el tratamiento de trastornos neurológicos, proliferativos e inflamatorios |
MX2007007409A (es) * | 2004-12-20 | 2007-07-12 | Wyeth Corp | Derivados de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos. |
US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
AU2006213673A1 (en) | 2005-02-09 | 2006-08-17 | Santen Pharmaceutical Co., Ltd. | Formulations for ocular treatment |
KR20080018874A (ko) * | 2005-04-27 | 2008-02-28 | 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. | 인간 질병과 관련된 돌연변이 단백질의 분해 촉진을 위한물질 및 방법 |
WO2006125324A1 (en) * | 2005-05-27 | 2006-11-30 | Queen's University At Kingston | Treatment of protein folding disorders |
CA2635797C (en) | 2006-02-09 | 2015-03-31 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
JP5506378B2 (ja) | 2006-03-23 | 2014-05-28 | 参天製薬株式会社 | 血管透過性に関連する疾患または病気のための製剤および方法 |
CA2709566A1 (en) * | 2007-12-17 | 2009-06-25 | Gliamed, Inc. | Stem-like cells and method for reprogramming adult mammalian somatic cells |
DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
US20100317711A1 (en) * | 2008-12-17 | 2010-12-16 | Gliamed, Inc. | Stem-like cells and method for reprogramming adult mammalian somatic cells |
EP2705856A1 (en) | 2012-09-07 | 2014-03-12 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. | Compounds for the treatment of neurodegenerative disorders |
US9121859B2 (en) * | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
EP3087101B1 (en) * | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
RU2751660C2 (ru) | 2014-07-21 | 2021-07-15 | Новартис Аг | Лечение злокачественного новообразования с использованием гуманизированного химерного антигенного рецептора против всма |
CA2961636A1 (en) | 2014-09-17 | 2016-03-24 | Boris ENGELS | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
WO2017136717A1 (en) | 2016-02-04 | 2017-08-10 | The Johns Hopkins University | Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof |
US11066416B2 (en) | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
AU2017213630B2 (en) | 2016-02-04 | 2022-05-12 | The Johns Hopkins University | Rapaglutins, novel inhibitors of GLUT and use thereof |
JP6891183B2 (ja) * | 2016-02-04 | 2021-06-18 | ザ・ジョンズ・ホプキンス・ユニバーシティ | ラパフシン・ライブラリの合成と組成物 |
CA3100724A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof |
CN114533708A (zh) * | 2022-03-23 | 2022-05-27 | 四川大学 | Boropinol-B在制备治疗脑卒中药物中的应用 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4578474A (en) * | 1980-06-23 | 1986-03-25 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4390695A (en) * | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4310461A (en) * | 1980-06-23 | 1982-01-12 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4531964A (en) * | 1982-09-13 | 1985-07-30 | Nippon Kayaku Kabushiki Kaisha | Heterocyclic compound and a herbicidal composition containing said compound |
US4593102A (en) * | 1984-04-10 | 1986-06-03 | A. H. Robins Company, Inc. | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position |
US5242932A (en) * | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
US5504197A (en) * | 1990-06-20 | 1996-04-02 | The Salk Institute For Biological Studies | DNA encoding neurotrophic growth factors |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
AU8727491A (en) * | 1990-08-29 | 1992-03-30 | Vertex Pharmaceuticals Incorporated | Modified di- and tripeptidyl immunosuppressive compounds |
AU1677092A (en) * | 1991-03-20 | 1992-10-21 | Vertex Pharmaceuticals Incorporated | Tetrahydroxyalkane derivatives as inhibitors of hiv aspartyl protease |
US5321009A (en) * | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
WO1992019745A1 (en) * | 1991-05-08 | 1992-11-12 | Vertex Pharmaceuticals Incorporated | Rfkbp: a novel prolyl isomerase and rapamycin/fk506 binding protein |
EP0584223B1 (en) * | 1991-05-09 | 1999-08-11 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
US5620971A (en) * | 1991-05-09 | 1997-04-15 | Vertex Pharmaceuticals Incorporated | Biologically active acylated amino acid derivatives |
MX9202466A (es) * | 1991-05-24 | 1994-06-30 | Vertex Pharma | Compuestos inmunosupresores novedosos. |
WO1993007269A1 (en) * | 1991-10-11 | 1993-04-15 | Vertex Pharmaceuticals Incorporated | ISOLATION OF AN Mr 52,000 FK506 BINDING PROTEIN AND MOLECULAR CLONING OF A CORRESPONDING HUMAN cDNA |
CA2091194A1 (en) * | 1992-04-08 | 1993-10-09 | Richard D. Connell | 2-oxo-ethyl derivatives as immunosuppressants |
AU4388893A (en) * | 1992-05-20 | 1993-12-13 | Vertex Pharmaceuticals Incorporated | Method of detecting tissue-specific FK506 binding protein messenger RNAs and uses thereof |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
WO1994013629A1 (en) * | 1992-12-11 | 1994-06-23 | Vertex Pharmaceuticals Incorporated | Mannitol derivatives and their use as inhibitors of aspartyl protease |
DE4302860A1 (de) * | 1993-01-22 | 1994-08-04 | Chemie Linz Deutschland | N-Cyclische und N,N'dicyclische Harnstoffe |
US5385918A (en) * | 1993-02-09 | 1995-01-31 | Miles Inc. | Aminomethylene-peptides as immunosuppressants |
US5846981A (en) * | 1993-05-28 | 1998-12-08 | Gpi Nil Holdings Inc. | Inhibitors of rotamase enzyme activity |
US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
GB2279006A (en) * | 1993-06-03 | 1994-12-21 | Fujisawa Pharmaceutical Co | Treatment of amyotrophic lateral sclerosis |
CA2183653A1 (en) * | 1994-03-07 | 1995-09-14 | Roger Dennis Tung | Sulphonamide derivatives as aspartyl protease inhibitors |
US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
US5898029A (en) * | 1994-04-12 | 1999-04-27 | The John Hopkins University | Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US6057119A (en) * | 1994-06-17 | 2000-05-02 | Vertex Pharmaceuticals, Incorporated | Crystal structure and mutants of interleukin-1β converting enzyme |
US5488816A (en) * | 1994-07-21 | 1996-02-06 | Boehringer Mannheim Corporation | Method and apparatus for manufacturing a coagulation assay device in a continuous manner |
IL115685A (en) * | 1994-11-16 | 2000-08-31 | Vertex Pharma | Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
US5543423A (en) * | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
US5726184A (en) * | 1995-05-19 | 1998-03-10 | Vertex Pharmaceuticals Incorporated | Tetralin compounds with improved MDR activity |
SI9500173B (sl) | 1995-05-19 | 2002-02-28 | Lek, | Trofazna farmacevtska oblika s konstantnim in kontroliranim sproščanjem amorfne učinkovine za enkrat dnevno aplikacijo |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
-
1996
- 1996-05-28 US US08/653,905 patent/US5696135A/en not_active Expired - Fee Related
- 1996-06-05 WO PCT/US1996/009561 patent/WO1996040140A1/en not_active IP Right Cessation
- 1996-06-05 LU LU88834A patent/LU88834A1/de unknown
- 1996-06-05 NZ NZ310767A patent/NZ310767A/xx unknown
- 1996-06-05 SI SI9620089A patent/SI9620089A/sl not_active IP Right Cessation
- 1996-06-05 CZ CZ972329A patent/CZ232997A3/cs unknown
- 1996-06-05 CA CA002206824A patent/CA2206824C/en not_active Expired - Fee Related
- 1996-06-05 AU AU61622/96A patent/AU710423B2/en not_active Ceased
- 1996-06-05 EA EA199700360A patent/EA001379B1/ru not_active IP Right Cessation
- 1996-06-05 ES ES009650031A patent/ES2138518B1/es not_active Expired - Fee Related
- 1996-06-05 ES ES200050035A patent/ES2166740B1/es not_active Expired - Lifetime
- 1996-06-05 DE DE19680255T patent/DE19680255T1/de not_active Withdrawn
- 1996-06-05 BR BR9608485A patent/BR9608485A/pt not_active Application Discontinuation
- 1996-06-05 CH CH02789/96A patent/CH689541A5/de not_active IP Right Cessation
- 1996-06-05 PL PL96323381A patent/PL323381A1/xx unknown
- 1996-06-05 GB GB9624258A patent/GB2305605B/en not_active Expired - Fee Related
- 1996-06-05 EP EP96919227A patent/EP0777478B1/en not_active Expired - Lifetime
- 1996-06-05 EE EE9700331A patent/EE9700331A/xx unknown
- 1996-06-05 SK SK1610-97A patent/SK161097A3/sk unknown
- 1996-06-05 HU HU9900816A patent/HUP9900816A3/hu unknown
- 1996-10-15 FI FI964137A patent/FI964137A/fi unknown
- 1996-10-24 TW TW085113075A patent/TW523410B/zh not_active IP Right Cessation
- 1996-11-08 SE SE9604097A patent/SE9604097L/xx not_active Application Discontinuation
- 1996-11-08 DK DK125696A patent/DK125696A/da not_active Application Discontinuation
-
1997
- 1997-01-23 US US08/787,162 patent/US5843960A/en not_active Expired - Fee Related
- 1997-09-17 NO NO974290A patent/NO974290L/no not_active Application Discontinuation
- 1997-09-30 MX MX9707552A patent/MX9707552A/es not_active IP Right Cessation
- 1997-11-27 BG BG102072A patent/BG102072A/xx unknown
-
1998
- 1998-02-02 LV LVP-97-244A patent/LV11986B/en unknown
- 1998-06-05 ES ES200150041A patent/ES2194596B1/es not_active Expired - Fee Related
- 1998-07-10 US US09/113,330 patent/US6022878A/en not_active Expired - Fee Related
- 1998-12-22 HK HK98114579A patent/HK1013254A1/xx not_active IP Right Cessation
-
1999
- 1999-11-05 US US09/435,323 patent/US6500843B2/en not_active Expired - Fee Related
-
2002
- 2002-08-27 US US10/228,312 patent/US20030114365A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP9900816A2 (hu) | Piperidin-karbonsav-származékok alkalmazása rotamáz enzim inhibitor hatású gyógyszerkészítmények előállítására | |
FI942423A (fi) | Sakkariinijohdannisia proteolyyttisen entsyymin inhibiittoreina | |
HUP9901752A2 (hu) | Rotamáz enzim hatását gátló piperidin-karbonsav-származékok alkalmazása neurológiai aktivitás kezelésére alkalmas gyógyszerkészítmény előállítására | |
ES2131457A1 (es) | Pequeños inhibidores de moleculas de la actividad de enzimas de rotamasa. | |
AU2829292A (en) | Saccharin derivative proteolytic enzyme inhibitors | |
HUP0002974A2 (hu) | Szulfonamidokkal N-szubsztituált heterociklusos tioészter-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények | |
TR200001644T2 (tr) | Rotamaz enzim aktivtesinin küçük molekülle inhibitörleri | |
NZ507720A (en) | Effecting neuronal activity with heterocyclic thioesters and ketones | |
AU4384397A (en) | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants | |
MXPA02005510A (es) | Compuestos, composiciones y metodos para estimular el crecimiento y alargamiento neuronal. | |
DE69728869D1 (de) | Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien | |
MY132553A (en) | Methods of making hiv-protease inhibitors and intermediates for making hiv-protease inhibitors | |
BR0210060A (pt) | Ligandos de fkbp de heterobiciclos | |
RO112643B1 (ro) | Procedeu de preparare a aminoacidului-d sau a derivaţilor aminoacidului-d | |
WO1998009951A3 (en) | Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors |