HUP9900609A2 - Cefditoren pivoxilt tartalmazó, orálisan beadható antibakteriális kompozíció - Google Patents
Cefditoren pivoxilt tartalmazó, orálisan beadható antibakteriális kompozícióInfo
- Publication number
- HUP9900609A2 HUP9900609A2 HU9900609A HUP9900609A HUP9900609A2 HU P9900609 A2 HUP9900609 A2 HU P9900609A2 HU 9900609 A HU9900609 A HU 9900609A HU P9900609 A HUP9900609 A HU P9900609A HU P9900609 A2 HUP9900609 A2 HU P9900609A2
- Authority
- HU
- Hungary
- Prior art keywords
- stone
- water
- cefditoren pivoxil
- oral administration
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 239000004575 stone Substances 0.000 abstract 6
- 229960002142 cefditoren pivoxil Drugs 0.000 abstract 5
- AFZFFLVORLEPPO-UVYJNCLZSA-N cefditoren pivoxil Chemical compound S([C@@H]1[C@@H](C(N1C=1C(=O)OCOC(=O)C(C)(C)C)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1\C=C/C=1SC=NC=1C AFZFFLVORLEPPO-UVYJNCLZSA-N 0.000 abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical class NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 2
- 235000019658 bitter taste Nutrition 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Abstract
A találmány őrális beadásra alkalmas új, antibakteriális kőmpőzícióravőnatkőzik, amely cefditőren pivőxil és egy vízőldható kazeinsókeverékét tartalmazza. A kőmpőzícióból, amelyben gyengébb a cefditőrenpivőxil keserű íze, a cefditőren pivőxil vízben könnyebben őldódik ki,és nagyőbb százalékős kiőldódás érhető el a cefditőren pivőxil vízzelvaló kiőldásakőr. A kőmpőzíció őrális beadásakőr a cefditőrenkőmpőnensnagymértékben felszívódik az emésztőcsatőrnában. A kőmpőzícióban acefditőren pivőxil - kazeinsó tömegarány előnyösen 1 : 0,1 és 1 : 4közötti. A találmány másődik váltőzata szerint az előbbi kőmpőzíciótővábbi összetevőként egy vízőldható pőlifőszfőrsavas sót tartalmaz.Ezáltal a cefditőrenpivőxil-kőmpőnens nagymértékű vízőldhatósága akkőris megmarad, ha a kőmpőzíciót szélsőséges körülmények között tárőlják. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26584795 | 1995-10-13 | ||
PCT/JP1996/002967 WO1997013516A1 (fr) | 1995-10-13 | 1996-10-14 | Composition antibacterienne administree par voie orale |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9900609A2 true HUP9900609A2 (hu) | 1999-07-28 |
HUP9900609A3 HUP9900609A3 (en) | 2001-04-28 |
HU224922B1 HU224922B1 (en) | 2006-04-28 |
Family
ID=17422903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900609A HU224922B1 (en) | 1995-10-13 | 1996-10-14 | Antibacterial composition of cefditoren pivoxil for oral administration |
Country Status (16)
Country | Link |
---|---|
US (1) | US5958915A (hu) |
EP (1) | EP0862915B1 (hu) |
KR (1) | KR100311576B1 (hu) |
CN (1) | CN1102046C (hu) |
AR (1) | AR004014A1 (hu) |
AT (1) | ATE214930T1 (hu) |
BR (1) | BR9610836A (hu) |
CA (1) | CA2234426C (hu) |
DE (1) | DE69620220T2 (hu) |
ES (1) | ES2174109T3 (hu) |
HK (1) | HK1016477A1 (hu) |
HU (1) | HU224922B1 (hu) |
MX (1) | MX9802849A (hu) |
PT (1) | PT862915E (hu) |
TW (1) | TW458778B (hu) |
WO (1) | WO1997013516A1 (hu) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1051978E (pt) * | 1998-01-07 | 2012-11-20 | Meiji Seika Pharma Co Ltd | Composições de cefalosporina amorfa cristalograficamente estável e processo para a sua produção |
US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
CA2348871C (en) * | 1998-11-02 | 2009-04-14 | John G. Devane | Multiparticulate modified release composition |
WO2002041887A1 (fr) * | 2000-11-21 | 2002-05-30 | Kyorin Pharmaceutical Co., Ltd. | Preparations seches de sirop |
US7125565B2 (en) | 2000-12-01 | 2006-10-24 | Kyowa Hakko Kogyo Co., Ltd. | Composition improved in the solubility or oral absorbability |
US20030060451A1 (en) * | 2001-05-29 | 2003-03-27 | Rajneesh Taneja | Enhancement of oral bioavailability of non-emulsified formulations of prodrug esters with lecithin |
EP1401402B1 (en) | 2001-05-29 | 2016-09-07 | Takeda Pharmaceuticals U.S.A., Inc. | Enhancement of oral bioavailability of non-emulsified formulation of cefditoren pivoxil with lecithin |
TW200306868A (en) * | 2002-05-22 | 2003-12-01 | Shionogi & Co | Composition of hardly soluble medicine with improved solubility |
AUPS303202A0 (en) * | 2002-06-20 | 2002-07-11 | Pacific Biolink Pty Limited | Protein based oral lubricant |
KR101019769B1 (ko) | 2002-10-02 | 2011-03-04 | 메이지 세이카 가부시키가이샤 | 경구 흡수성이 개선된 항균성 약제학적 조성물 |
ATE539738T1 (de) * | 2003-10-08 | 2012-01-15 | Meiji Seika Pharma Co Ltd | Nichtkristalline antibakterielle zusammensetzung mit cefditoren-pivoxil |
JP2005162696A (ja) * | 2003-12-04 | 2005-06-23 | Nichiko Pharmaceutical Co Ltd | 溶出性に優れたセフジトレンピボキシル製剤 |
EP2401997B1 (en) | 2004-11-16 | 2016-08-24 | 3M Innovative Properties Company | Dental compositions with calcium phosphorus releasing glass |
CN101098673B (zh) | 2004-11-16 | 2012-02-29 | 3M创新有限公司 | 包括磷酸盐的牙科填料和组合物 |
EP1811944B1 (en) | 2004-11-16 | 2010-09-08 | 3M Innovative Properties Company | Compositions including a caseinate treated dental filler |
CN101115459B (zh) | 2004-11-16 | 2012-03-21 | 3M创新有限公司 | 包括含磷表面处理的牙科填料 |
EP1954253A4 (en) | 2005-06-08 | 2011-07-27 | Elan Pharma Int Ltd | NANOTEILIC AND CONTROLLED RELEASED COMPOSITIONS WITH CEFDITORS |
US20080069879A1 (en) * | 2006-05-02 | 2008-03-20 | Ravishekhar Bhiwgade | Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof |
US8790707B2 (en) | 2008-12-11 | 2014-07-29 | 3M Innovative Properties Company | Surface-treated calcium phosphate particles suitable for oral care and dental compositions |
TR201000688A2 (tr) | 2010-01-29 | 2011-08-22 | B�Lg�� Mahmut | Aktif madde olarak sefaklor ve klavulanik asit içeren efervesan formülasyonlar. |
US20130143857A1 (en) * | 2010-07-23 | 2013-06-06 | Lupin Limited | Pharmaceutical compositions of cefditoren pivoxil |
WO2016114727A1 (en) | 2015-01-16 | 2016-07-21 | Öğün Yusuf Toktamiş | Cefditoren pivoxil compositions with improved stability and production methods thereof |
CN105663058A (zh) * | 2016-02-01 | 2016-06-15 | 济南康和医药科技有限公司 | 一种头孢妥仑匹酯纳米粒药物制剂及制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5936609A (ja) * | 1982-08-26 | 1984-02-28 | Nitto Electric Ind Co Ltd | 粘着性貼付製剤 |
JPS59184122A (ja) * | 1983-03-31 | 1984-10-19 | Nitto Electric Ind Co Ltd | アクリル系膏体 |
JPS60102168A (ja) * | 1983-11-08 | 1985-06-06 | Tsukishima Shokuhin Kogyo Kk | エイコサペンタエン酸強化乳化物及び食品の製造方法 |
IE58487B1 (en) * | 1984-09-07 | 1993-09-22 | Kaisha Maiji Seika | New cephalosporin compounds and the production thereof |
JPH0678234B2 (ja) * | 1988-04-19 | 1994-10-05 | 明治製菓株式会社 | 経口投与用抗菌組成物 |
JPH0635394B2 (ja) * | 1989-02-28 | 1994-05-11 | 雪印乳業株式会社 | 薬物の溶解性および吸収性の改善方法 |
JPH0717866A (ja) * | 1993-06-16 | 1995-01-20 | Meiji Seika Kaisha Ltd | 医薬組成物 |
JPH0840907A (ja) * | 1994-08-03 | 1996-02-13 | Meiji Seika Kaisha Ltd | セファロスポリン注射剤 |
-
1996
- 1996-10-11 AR ARP960104719A patent/AR004014A1/es active IP Right Grant
- 1996-10-14 US US09/051,318 patent/US5958915A/en not_active Expired - Lifetime
- 1996-10-14 DE DE69620220T patent/DE69620220T2/de not_active Expired - Fee Related
- 1996-10-14 WO PCT/JP1996/002967 patent/WO1997013516A1/ja active IP Right Grant
- 1996-10-14 HU HU9900609A patent/HU224922B1/hu unknown
- 1996-10-14 CA CA002234426A patent/CA2234426C/en not_active Expired - Lifetime
- 1996-10-14 BR BR9610836A patent/BR9610836A/pt not_active IP Right Cessation
- 1996-10-14 CN CN96198295A patent/CN1102046C/zh not_active Expired - Lifetime
- 1996-10-14 PT PT96933635T patent/PT862915E/pt unknown
- 1996-10-14 EP EP96933635A patent/EP0862915B1/en not_active Expired - Lifetime
- 1996-10-14 AT AT96933635T patent/ATE214930T1/de not_active IP Right Cessation
- 1996-10-14 KR KR1019980702618A patent/KR100311576B1/ko active IP Right Grant
- 1996-10-14 ES ES96933635T patent/ES2174109T3/es not_active Expired - Lifetime
- 1996-10-22 TW TW085112901A patent/TW458778B/zh not_active IP Right Cessation
-
1998
- 1998-04-13 MX MX9802849A patent/MX9802849A/es unknown
-
1999
- 1999-04-10 HK HK99101467A patent/HK1016477A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100311576B1 (ko) | 2001-12-28 |
DE69620220D1 (de) | 2002-05-02 |
BR9610836A (pt) | 1999-07-13 |
CA2234426C (en) | 2003-07-08 |
CN1102046C (zh) | 2003-02-26 |
PT862915E (pt) | 2002-09-30 |
EP0862915A1 (en) | 1998-09-09 |
AR004014A1 (es) | 1998-09-30 |
EP0862915B1 (en) | 2002-03-27 |
MX9802849A (es) | 1998-11-30 |
CA2234426A1 (en) | 1997-04-17 |
HUP9900609A3 (en) | 2001-04-28 |
ATE214930T1 (de) | 2002-04-15 |
US5958915A (en) | 1999-09-28 |
ES2174109T3 (es) | 2002-11-01 |
DE69620220T2 (de) | 2002-11-28 |
HU224922B1 (en) | 2006-04-28 |
CN1202110A (zh) | 1998-12-16 |
EP0862915A4 (en) | 1998-11-11 |
TW458778B (en) | 2001-10-11 |
HK1016477A1 (en) | 1999-11-05 |
WO1997013516A1 (fr) | 1997-04-17 |
KR19990064137A (ko) | 1999-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB9A | Succession in title |
Owner name: MEIJI SEIKA PHARMA CO., LTD., JP Free format text: FORMER OWNER(S): MEIJI SEIKA KAISHA, LTD., JP |