HUP9900360A2 - Eljárás norbenzomorfánszármazékok előállítására - Google Patents

Eljárás norbenzomorfánszármazékok előállítására

Info

Publication number
HUP9900360A2
HUP9900360A2 HU9900360A HUP9900360A HUP9900360A2 HU P9900360 A2 HUP9900360 A2 HU P9900360A2 HU 9900360 A HU9900360 A HU 9900360A HU P9900360 A HUP9900360 A HU P9900360A HU P9900360 A2 HUP9900360 A2 HU P9900360A2
Authority
HU
Hungary
Prior art keywords
alkyl
atom
amino
powder
trimethyl
Prior art date
Application number
HU9900360A
Other languages
English (en)
Inventor
Hanfried Baltes
Matthias Grauert
Herbert Merz
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of HUP9900360A2 publication Critical patent/HUP9900360A2/hu
Publication of HUP9900360A3 publication Critical patent/HUP9900360A3/hu
Publication of HU222038B1 publication Critical patent/HU222038B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya eljárás nőrbenzőmőrfánszármazékők előállítására,amelyek közpőnti intermedierek a gyógyászatilag hatásős, (1) általánősképletű benzőmőrfánszármazékők, különösen az (-)-(1R,5S,2"R)-3-hidrőxi-2-(2-metőxi-prőpil)-5,9,9-trimetil-6,7-benzőmőrfán vagy az(-)-(2R,6S,2R)-3-(2-metőxi-prőpil)-6,11,11-trimetil-1,2,3,4,5,6-hexa-hidrő-2,6-metanő-benző őxacin-9-ől előállításában. Az (1) képletben R1jelentése hidrőgén- vagy halőgénatőm, alkil-, hidrőxi- vagyalkőxicsőpőrt, egy őxigénatőmőn keresztül kapcsőlódó benzőilcsőpőrtvagy egy alkilcsőpőrtőt hőrdőzó alkil-karbőxil-csőpőrt -, ahől azalkilrész adőtt esetben egy vagy több halőgénatőmmal szűbsztitűáltlehet -, tővábbá nitrő-, cianő-, aminő-, (1-8 szénatőmős alkil)-aminő-, di(1-8 szénatőmős alkil)-aminőcsőpőrt, (1-8 szénatőmős alkil)-acil-aminő-csőpőrt. Az (1) általánős képletű vegyületekidegdegenerációs megbetegedések kezelésére alkalmazhatóak. ŕ
HU9900360A 1995-08-03 1996-08-02 Eljárás norbenzomorfánszármazékok előállítására HU222038B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19528472A DE19528472A1 (de) 1995-08-03 1995-08-03 Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
PCT/EP1996/003401 WO1997006146A1 (de) 1995-08-03 1996-08-02 Neues verfahren zur herstellung von norbenzomorphan einer zwischenstufe bei herstellung von pharmazeutisch wertvollen benzomorphanderivaten, insbesondere von (-)-(1r,5s,2'r)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomorphan

Publications (3)

Publication Number Publication Date
HUP9900360A2 true HUP9900360A2 (hu) 1999-06-28
HUP9900360A3 HUP9900360A3 (en) 1999-11-29
HU222038B1 HU222038B1 (hu) 2003-03-28

Family

ID=7768562

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900360A HU222038B1 (hu) 1995-08-03 1996-08-02 Eljárás norbenzomorfánszármazékok előállítására

Country Status (31)

Country Link
US (3) US5945535A (hu)
EP (1) EP0842153B1 (hu)
JP (1) JP3887756B2 (hu)
KR (1) KR100399669B1 (hu)
CN (1) CN1125053C (hu)
AR (1) AR003167A1 (hu)
AT (1) ATE201672T1 (hu)
AU (1) AU703700B2 (hu)
BR (1) BR9609959A (hu)
CA (1) CA2228511C (hu)
CO (1) CO4750808A1 (hu)
CZ (1) CZ292589B6 (hu)
DE (2) DE19528472A1 (hu)
DK (1) DK0842153T3 (hu)
ES (1) ES2157004T3 (hu)
GR (1) GR3036417T3 (hu)
HK (2) HK1010537A1 (hu)
HU (1) HU222038B1 (hu)
IL (1) IL118992A (hu)
MX (1) MX9800357A (hu)
NO (1) NO308247B1 (hu)
NZ (1) NZ316463A (hu)
PL (1) PL185218B1 (hu)
PT (1) PT842153E (hu)
RU (1) RU2167868C2 (hu)
SI (1) SI0842153T1 (hu)
TR (1) TR199800164T1 (hu)
TW (1) TW350847B (hu)
UA (1) UA64699C2 (hu)
WO (1) WO1997006146A1 (hu)
ZA (1) ZA966588B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19822822A1 (de) * 1998-05-20 1999-11-25 Boehringer Ingelheim Pharma Verbessertes Verfahren zur Herstellung von pharmazeutisch wertvollen Norbenzomorphanderivaten
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
DE10029851A1 (de) * 2000-06-16 2001-12-20 Boehringer Ingelheim Pharma Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
US6495694B2 (en) 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
DE10130020A1 (de) * 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
KR20040039732A (ko) * 2002-11-04 2004-05-12 주식회사 동진쎄미켐 캠포릴이 결합된 펜던트 기를 가지는 화학적으로 증폭된고분자와 그 제조방법, 및 이를 포함하는 레지스트 조성물
CN104829662B (zh) * 2015-03-30 2017-11-07 石药集团欧意药业有限公司 一种阿奇霉素有关物质的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
US4012392A (en) * 1969-06-04 1977-03-15 Acf Chemiefarma N.V. 2-Benzyl-4-piperidones useful as intermediates in the production of 6,7-benzomorphan derivatives
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
NL7907800A (nl) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
DK0842153T3 (da) 2001-08-06
NO308247B1 (no) 2000-08-21
HK1015362A1 (en) 1999-10-15
TW350847B (en) 1999-01-21
PL185218B1 (pl) 2003-04-30
CN1190959A (zh) 1998-08-19
CA2228511C (en) 2007-11-06
WO1997006146A1 (de) 1997-02-20
JPH11511135A (ja) 1999-09-28
BR9609959A (pt) 1999-02-02
KR19990036091A (ko) 1999-05-25
IL118992A0 (en) 1996-11-14
CZ31598A3 (cs) 1998-07-15
HK1010537A1 (en) 1999-06-25
PL324859A1 (en) 1998-06-22
PT842153E (pt) 2001-09-28
ATE201672T1 (de) 2001-06-15
AR003167A1 (es) 1998-07-08
US6140502A (en) 2000-10-31
EP0842153B1 (de) 2001-05-30
MX9800357A (es) 1998-07-31
HU222038B1 (hu) 2003-03-28
ZA966588B (en) 1997-02-03
EP0842153A1 (de) 1998-05-20
CN1125053C (zh) 2003-10-22
DE59607007D1 (de) 2001-07-05
AU703700B2 (en) 1999-04-01
AU6870296A (en) 1997-03-05
GR3036417T3 (en) 2001-11-30
CO4750808A1 (es) 1999-03-31
DE19528472A1 (de) 1997-02-06
UA64699C2 (en) 2004-03-15
IL118992A (en) 2000-06-01
NO980449L (no) 1998-02-02
CA2228511A1 (en) 1997-02-20
NZ316463A (en) 1999-07-29
HUP9900360A3 (en) 1999-11-29
RU2167868C2 (ru) 2001-05-27
US5945535A (en) 1999-08-31
US6054604A (en) 2000-04-25
NO980449D0 (no) 1998-02-02
KR100399669B1 (ko) 2004-03-24
ES2157004T3 (es) 2001-08-01
JP3887756B2 (ja) 2007-02-28
TR199800164T1 (xx) 1998-04-21
SI0842153T1 (en) 2001-10-31
CZ292589B6 (cs) 2003-10-15

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20030127

MM4A Lapse of definitive patent protection due to non-payment of fees