AR003167A1 - Nuevo procedimiento para la preparacion de norbenzomorfanos. - Google Patents

Nuevo procedimiento para la preparacion de norbenzomorfanos.

Info

Publication number
AR003167A1
AR003167A1 ARP960103851A AR10385196A AR003167A1 AR 003167 A1 AR003167 A1 AR 003167A1 AR P960103851 A ARP960103851 A AR P960103851A AR 10385196 A AR10385196 A AR 10385196A AR 003167 A1 AR003167 A1 AR 003167A1
Authority
AR
Argentina
Prior art keywords
preparation
benzomorphan
trimethyl
norbenzomorphans
new procedure
Prior art date
Application number
ARP960103851A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of AR003167A1 publication Critical patent/AR003167A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El presente invento se refiere a un nuevo procedimiento para la preparación de norbenzomorfanos de fórmula general (I), en donde R1 tiene lesignificado indicado en la reivindicación 1,procedimiento caracterizado por las etapas a) a j)que se describen en la reivindicación 1. El invento tambiénse refiere, en particular, a la preparación de (-)-(1R,5S,2R)-3-hidroxi-2- (2-metoxipropil)-5,9,9-trimetil-6,7-benzomorfano o[(-)-(2R,6S,2R)-3-(2-metoxi-propil)-6,11,11-trimetil-1,2,3,4,-5,6- hexahidro-2,6-metano-benzo[alfa]oxacin -9-ol)(BIII 277). Frente a otras estrategias de síntesis ya conocidas, elprocedimiento del invento presenta la ventaja de que evita laformación de regioisómeros al constituirse el entramado fundamental d el benzomorfano y,además, permite obtener con mayores rendimientos el estereoisómero farmacológicamente más activo. Estos derivados de benzomorfano sonsustanciasactivas muy prometedoras para el tratamiento de enfermedades neurodegenerat ivas y de isquemias cerebrales de diversa génesis.
ARP960103851A 1995-08-03 1996-08-01 Nuevo procedimiento para la preparacion de norbenzomorfanos. AR003167A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19528472A DE19528472A1 (de) 1995-08-03 1995-08-03 Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Publications (1)

Publication Number Publication Date
AR003167A1 true AR003167A1 (es) 1998-07-08

Family

ID=7768562

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103851A AR003167A1 (es) 1995-08-03 1996-08-01 Nuevo procedimiento para la preparacion de norbenzomorfanos.

Country Status (31)

Country Link
US (3) US5945535A (es)
EP (1) EP0842153B1 (es)
JP (1) JP3887756B2 (es)
KR (1) KR100399669B1 (es)
CN (1) CN1125053C (es)
AR (1) AR003167A1 (es)
AT (1) ATE201672T1 (es)
AU (1) AU703700B2 (es)
BR (1) BR9609959A (es)
CA (1) CA2228511C (es)
CO (1) CO4750808A1 (es)
CZ (1) CZ292589B6 (es)
DE (2) DE19528472A1 (es)
DK (1) DK0842153T3 (es)
ES (1) ES2157004T3 (es)
GR (1) GR3036417T3 (es)
HK (2) HK1010537A1 (es)
HU (1) HU222038B1 (es)
IL (1) IL118992A (es)
MX (1) MX9800357A (es)
NO (1) NO308247B1 (es)
NZ (1) NZ316463A (es)
PL (1) PL185218B1 (es)
PT (1) PT842153E (es)
RU (1) RU2167868C2 (es)
SI (1) SI0842153T1 (es)
TR (1) TR199800164T1 (es)
TW (1) TW350847B (es)
UA (1) UA64699C2 (es)
WO (1) WO1997006146A1 (es)
ZA (1) ZA966588B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19822822A1 (de) * 1998-05-20 1999-11-25 Boehringer Ingelheim Pharma Verbessertes Verfahren zur Herstellung von pharmazeutisch wertvollen Norbenzomorphanderivaten
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
DE10029851A1 (de) * 2000-06-16 2001-12-20 Boehringer Ingelheim Pharma Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
US6495694B2 (en) 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
DE10130020A1 (de) * 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
KR20040039732A (ko) * 2002-11-04 2004-05-12 주식회사 동진쎄미켐 캠포릴이 결합된 펜던트 기를 가지는 화학적으로 증폭된고분자와 그 제조방법, 및 이를 포함하는 레지스트 조성물
CN104829662B (zh) * 2015-03-30 2017-11-07 石药集团欧意药业有限公司 一种阿奇霉素有关物质的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012392A (en) * 1969-06-04 1977-03-15 Acf Chemiefarma N.V. 2-Benzyl-4-piperidones useful as intermediates in the production of 6,7-benzomorphan derivatives
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
NL7907800A (nl) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
US6140502A (en) 2000-10-31
IL118992A (en) 2000-06-01
TW350847B (en) 1999-01-21
HUP9900360A3 (en) 1999-11-29
NO980449D0 (no) 1998-02-02
ATE201672T1 (de) 2001-06-15
SI0842153T1 (en) 2001-10-31
HU222038B1 (hu) 2003-03-28
HK1010537A1 (en) 1999-06-25
DE59607007D1 (de) 2001-07-05
AU6870296A (en) 1997-03-05
PL324859A1 (en) 1998-06-22
EP0842153A1 (de) 1998-05-20
RU2167868C2 (ru) 2001-05-27
TR199800164T1 (xx) 1998-04-21
CZ292589B6 (cs) 2003-10-15
AU703700B2 (en) 1999-04-01
UA64699C2 (en) 2004-03-15
PT842153E (pt) 2001-09-28
PL185218B1 (pl) 2003-04-30
NZ316463A (en) 1999-07-29
JPH11511135A (ja) 1999-09-28
GR3036417T3 (en) 2001-11-30
KR19990036091A (ko) 1999-05-25
IL118992A0 (en) 1996-11-14
US6054604A (en) 2000-04-25
CN1125053C (zh) 2003-10-22
CA2228511A1 (en) 1997-02-20
JP3887756B2 (ja) 2007-02-28
CN1190959A (zh) 1998-08-19
US5945535A (en) 1999-08-31
BR9609959A (pt) 1999-02-02
NO980449L (no) 1998-02-02
KR100399669B1 (ko) 2004-03-24
WO1997006146A1 (de) 1997-02-20
ZA966588B (en) 1997-02-03
DK0842153T3 (da) 2001-08-06
EP0842153B1 (de) 2001-05-30
CA2228511C (en) 2007-11-06
HK1015362A1 (en) 1999-10-15
HUP9900360A2 (hu) 1999-06-28
CZ31598A3 (cs) 1998-07-15
CO4750808A1 (es) 1999-03-31
DE19528472A1 (de) 1997-02-06
MX9800357A (es) 1998-07-31
ES2157004T3 (es) 2001-08-01
NO308247B1 (no) 2000-08-21

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