BRPI0516380A - derivados de triazolona, tetrazolona e imidazolona, composição compreendendo os mesmos, processo para sua preparação e uso - Google Patents
derivados de triazolona, tetrazolona e imidazolona, composição compreendendo os mesmos, processo para sua preparação e usoInfo
- Publication number
- BRPI0516380A BRPI0516380A BRPI0516380-3A BRPI0516380A BRPI0516380A BR PI0516380 A BRPI0516380 A BR PI0516380A BR PI0516380 A BRPI0516380 A BR PI0516380A BR PI0516380 A BRPI0516380 A BR PI0516380A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- tetrazolone
- preparation
- composition
- addiction
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
DERIVADOS DE TRIAZOLONA, TETRAZOLONA E IMIDAZOLONA, COMPOSIçãO COMPREENDENDO OS MESMOS, PROCESSO PARA SUA PREPARAçãO E USO. A presente invenção refere-se a derivados de triazolona, tetrazolona e imidazolona substituídos de acordo com a Fórmula geral (1) um sal de vício de base ou ácido farmaceuticamente aceitável dos mesmos, uma forma estereoquimicamente isomérica dos msmos, uma forma de Nóxido dos mesmos ou um sal de amónio quaternário dos mesmos, em que as variáveis estão definidas como na reivindicação 1, tendo a atividade de antagonismo de adrenoceptor <244>-~ 2c~ seletiva. Refere-se também a sua preparação, composições compreendendo-as e seu uso como um medicamento. Os compostos de acordo com a invenção são úteis para a prevenção e/ou tratamento de distúrbios do sistema nervoso central, transtornos de humor, distúrbios de ansiedade, distúrbios relacionados com estresse associados com depressão e/ou ansiedade, distúrbios cognitivos, distúrbios de personalidade, distúrbios esquizoafetivos, doença de Parkinson, demência do tipo Alzheimer, condições de dor crónica, doenças neurodegenerativas, distúrbios de vício, transtornos de humor e disfunção sexual.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04106817 | 2004-12-21 | ||
EP05104873 | 2005-06-03 | ||
PCT/EP2005/056951 WO2006067139A1 (en) | 2004-12-21 | 2005-12-20 | Triazolone, tetrazolone and imidazolone derivatives for use as alpha-2c adrenoreceptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0516380A true BRPI0516380A (pt) | 2008-09-02 |
Family
ID=36013649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0516380-3A BRPI0516380A (pt) | 2004-12-21 | 2005-12-20 | derivados de triazolona, tetrazolona e imidazolona, composição compreendendo os mesmos, processo para sua preparação e uso |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100029620A1 (pt) |
EP (1) | EP1831185A1 (pt) |
JP (1) | JP2008524312A (pt) |
KR (1) | KR20070090941A (pt) |
AR (1) | AR052342A1 (pt) |
AU (1) | AU2005318188A1 (pt) |
BR (1) | BRPI0516380A (pt) |
CA (1) | CA2588028A1 (pt) |
EA (1) | EA011514B1 (pt) |
IL (1) | IL184048A0 (pt) |
MX (1) | MX2007007472A (pt) |
NO (1) | NO20073760L (pt) |
PA (1) | PA8657301A1 (pt) |
TW (1) | TW200635906A (pt) |
WO (1) | WO2006067139A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2674237C (en) | 2006-12-28 | 2015-11-24 | Rigel Pharmaceuticals, Inc. | N-substituted-heterocycloalkyloxybenzamide compounds and methods of use |
EP2566853B1 (en) | 2010-05-05 | 2017-01-25 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
WO2012043791A1 (ja) * | 2010-10-01 | 2012-04-05 | 大正製薬株式会社 | 1,2,4-トリアゾロン誘導体 |
FR2976287B1 (fr) | 2011-06-09 | 2013-07-05 | Pf Medicament | Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique |
MY168930A (en) * | 2011-10-27 | 2019-01-09 | Taisho Pharmaceutical Co Ltd | Azole derivative |
EP2852589B1 (en) | 2012-05-22 | 2021-04-28 | Autifony Therapeutics Limited | Triazoles as kv3 inhibitors |
EP3008055B1 (en) * | 2013-06-11 | 2017-07-19 | F. Hoffmann-La Roche AG | Tetrazolone derivatives |
KR20160026897A (ko) * | 2013-06-27 | 2016-03-09 | 세다르스-신나이 메디칼 센터 | 신경퇴행성 질환의 예방 및 치료를 위한 아드레날린 수용체 길항제 |
US20190297887A1 (en) | 2016-07-12 | 2019-10-03 | Bayer Cropscience Aktiengesellschaft | Bicyclic compounds as pesticides |
CA3185336A1 (en) * | 2017-11-06 | 2019-05-09 | Acelot, Inc. | Small molecule drugs and related methods for treatment of diseases related to a.beta.42 oligomer formation |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3355457A (en) * | 1965-05-21 | 1967-11-28 | American Cyanamid Co | Substituted 2-imidazolinones |
DE2725148A1 (de) * | 1977-06-03 | 1978-12-14 | Hoechst Ag | 1-aryl-4-alkyl-1,2,4-triazol-5-one und verfahren zu ihrer herstellung |
PT741737E (pt) * | 1994-01-24 | 2000-04-28 | Janssen Pharmaceutica Nv | Antifungicos do tipo azole soluveis em agua |
JPH0899975A (ja) * | 1994-08-05 | 1996-04-16 | Nippon Bayeragrochem Kk | 5員複素環置換テトラゾリノン誘導体および除草剤 |
JPH09183770A (ja) * | 1995-10-31 | 1997-07-15 | Nippon Bayeragrochem Kk | 1−アジン−テトラゾリノン類及び除草剤 |
AU5519098A (en) * | 1996-12-13 | 1998-07-03 | E.I. Du Pont De Nemours And Company | Herbicidal heterocyclic amides |
WO1998051683A1 (en) * | 1997-05-15 | 1998-11-19 | E.I. Du Pont De Nemours And Company | Herbicidal tetrazolinones |
EP0957101A1 (en) * | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
WO2000010984A1 (fr) * | 1998-08-19 | 2000-03-02 | Hokko Chemical Industry Co., Ltd. | Derives de triazolinone et compositions herbicides |
JP3837242B2 (ja) * | 1998-08-25 | 2006-10-25 | 北興化学工業株式会社 | トリアゾリノン誘導体および除草剤 |
-
2005
- 2005-12-19 AR ARP050105336A patent/AR052342A1/es not_active Application Discontinuation
- 2005-12-20 WO PCT/EP2005/056951 patent/WO2006067139A1/en active Application Filing
- 2005-12-20 MX MX2007007472A patent/MX2007007472A/es unknown
- 2005-12-20 US US11/722,380 patent/US20100029620A1/en not_active Abandoned
- 2005-12-20 CA CA002588028A patent/CA2588028A1/en not_active Abandoned
- 2005-12-20 KR KR1020077014061A patent/KR20070090941A/ko not_active Application Discontinuation
- 2005-12-20 BR BRPI0516380-3A patent/BRPI0516380A/pt not_active IP Right Cessation
- 2005-12-20 AU AU2005318188A patent/AU2005318188A1/en not_active Abandoned
- 2005-12-20 EP EP05823472A patent/EP1831185A1/en not_active Withdrawn
- 2005-12-20 PA PA20058657301A patent/PA8657301A1/es unknown
- 2005-12-20 EA EA200701345A patent/EA011514B1/ru not_active IP Right Cessation
- 2005-12-20 JP JP2007547485A patent/JP2008524312A/ja active Pending
- 2005-12-21 TW TW094145703A patent/TW200635906A/zh unknown
-
2007
- 2007-06-19 IL IL184048A patent/IL184048A0/en unknown
- 2007-07-19 NO NO20073760A patent/NO20073760L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2006067139A1 (en) | 2006-06-29 |
CA2588028A1 (en) | 2006-06-29 |
MX2007007472A (es) | 2007-07-20 |
IL184048A0 (en) | 2007-10-31 |
PA8657301A1 (es) | 2007-01-17 |
JP2008524312A (ja) | 2008-07-10 |
TW200635906A (en) | 2006-10-16 |
EA011514B1 (ru) | 2009-04-28 |
NO20073760L (no) | 2007-07-19 |
AU2005318188A1 (en) | 2006-06-29 |
AR052342A1 (es) | 2007-03-14 |
EA200701345A1 (ru) | 2007-10-26 |
EP1831185A1 (en) | 2007-09-12 |
US20100029620A1 (en) | 2010-02-04 |
KR20070090941A (ko) | 2007-09-06 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |