BR112015004511A8 - Derivados de pirazol carboxamida como moduladores de taar para uso no tratamento de diversas desordens, tais como depressão, diabetes e doença de parkinson - Google Patents

Derivados de pirazol carboxamida como moduladores de taar para uso no tratamento de diversas desordens, tais como depressão, diabetes e doença de parkinson

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Publication number
BR112015004511A8
BR112015004511A8 BR112015004511A BR112015004511A BR112015004511A8 BR 112015004511 A8 BR112015004511 A8 BR 112015004511A8 BR 112015004511 A BR112015004511 A BR 112015004511A BR 112015004511 A BR112015004511 A BR 112015004511A BR 112015004511 A8 BR112015004511 A8 BR 112015004511A8
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BR
Brazil
Prior art keywords
various disorders
treatment
carboxamide derivatives
parkinson
diabetes
Prior art date
Application number
BR112015004511A
Other languages
English (en)
Other versions
BR112015004511A2 (pt
BR112015004511B1 (pt
Inventor
Guido Galley
Philippe Pflieger
Roger Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015004511A2 publication Critical patent/BR112015004511A2/pt
Publication of BR112015004511A8 publication Critical patent/BR112015004511A8/pt
Publication of BR112015004511B1 publication Critical patent/BR112015004511B1/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)

Abstract

derivados de pirazol carboxamida como moduladores de taar para uso no tratamento de diversas desordens, tais como depressão, diabetes e doença de parkinson. a presente invenção refere-se a compostos da fórmula n h o nh z n n r 3 r 2 r 1 i em que r1 ; r2 ; r3 ; e z são definidos ao longo do presente pedido; ou a um seu sal de adição ácido farmaceuticamente adequado. a invenção inclui todas as misturas racêmicas, todos seus isômeros óticos e/ou enantiômeros correspondentes, todas as formas tautoméricas dos compostos da fórmula i. verificou-se agora que os compostos da fórmula i têm uma boa afinidade aos receptores associados à amina em traços (taars), especialmente para taar1. a presente invenção também descreve o uso dos derivados de pirazol carboxamida na preparação de medicamentos para o tratamento terapêutico e/ou profilático de diversas desordens.
BR112015004511-1A 2012-09-14 2013-09-11 Derivados de pirazol carboxamida como moduladores de taar para uso no tratamento de diversas desordens, tais como depressão, diabetes e doença de parkinson BR112015004511B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12184360.1 2012-09-14
EP12184360 2012-09-14
PCT/EP2013/068769 WO2014041007A1 (en) 2012-09-14 2013-09-11 Pyrazole carboxamide derivatives as taar modulators for use in the treatment of several disorders, such as depression, diabetes and parkinson's disease

Publications (3)

Publication Number Publication Date
BR112015004511A2 BR112015004511A2 (pt) 2017-07-04
BR112015004511A8 true BR112015004511A8 (pt) 2021-11-03
BR112015004511B1 BR112015004511B1 (pt) 2022-08-02

Family

ID=47044779

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015004511-1A BR112015004511B1 (pt) 2012-09-14 2013-09-11 Derivados de pirazol carboxamida como moduladores de taar para uso no tratamento de diversas desordens, tais como depressão, diabetes e doença de parkinson

Country Status (35)

Country Link
US (1) US9487501B2 (pt)
EP (1) EP2895477B1 (pt)
JP (2) JP2015531782A (pt)
KR (1) KR101706486B1 (pt)
CN (2) CN104619700A (pt)
AR (1) AR092537A1 (pt)
AU (1) AU2013314388B2 (pt)
BR (1) BR112015004511B1 (pt)
CA (1) CA2882821C (pt)
CL (1) CL2015000580A1 (pt)
CR (1) CR20150087A (pt)
DK (1) DK2895477T3 (pt)
EA (1) EA026062B1 (pt)
ES (1) ES2654653T3 (pt)
HK (2) HK1206720A1 (pt)
HR (1) HRP20171981T1 (pt)
HU (1) HUE037689T2 (pt)
IL (1) IL237332B (pt)
LT (1) LT2895477T (pt)
MA (1) MA37944B2 (pt)
MX (1) MX363362B (pt)
MY (1) MY178667A (pt)
NO (1) NO2895477T3 (pt)
NZ (1) NZ705154A (pt)
PE (1) PE20150735A1 (pt)
PH (1) PH12015500489B1 (pt)
PL (1) PL2895477T3 (pt)
PT (1) PT2895477T (pt)
RS (1) RS56747B1 (pt)
SG (1) SG11201501958QA (pt)
SI (1) SI2895477T1 (pt)
TW (1) TWI610926B (pt)
UA (1) UA113776C2 (pt)
WO (1) WO2014041007A1 (pt)
ZA (1) ZA201501126B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106715395B (zh) * 2014-07-30 2020-05-12 豪夫迈·罗氏有限公司 作为taar调节剂的6-氨基-5,6,7,8-四氢萘-2-基或3-氨基色满-7-基衍生物
RU2731095C2 (ru) 2016-03-17 2020-08-28 Ф. Хоффманн-Ля Рош Аг Производное 5-этил-4-метил-пиразол-3-карбоксамида, обладающее активностью агониста taar
MX2019007030A (es) * 2016-12-15 2020-01-15 Univ California Composiciones y metodos para el tratamiento del cancer.
EP3953356B1 (en) 2019-04-09 2023-07-26 F. Hoffmann-La Roche AG Hexahydro-1h-pyrazino[1,2-a]pyrazine compounds for the treatment of autoimmune disease
CN117120427A (zh) * 2021-06-18 2023-11-24 上海拓界生物医药科技有限公司 一种malt1抑制剂及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425211D0 (en) 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
US6841684B2 (en) 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
RU2460725C2 (ru) 2007-02-15 2012-09-10 Ф. Хоффманн-Ля Рош Аг Новые 2-аминооксазолины в качестве лигандов taar1
US9452980B2 (en) * 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
TW201236685A (en) * 2010-11-11 2012-09-16 Daiichi Sankyo Co Ltd New pyrazole amide derivatives
US9073911B2 (en) * 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) * 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives

Also Published As

Publication number Publication date
IL237332A0 (en) 2015-04-30
EP2895477B1 (en) 2017-11-01
JP6529998B2 (ja) 2019-06-12
KR20150054947A (ko) 2015-05-20
BR112015004511A2 (pt) 2017-07-04
US9487501B2 (en) 2016-11-08
UA113776C2 (xx) 2017-03-10
NZ705154A (en) 2018-03-23
PH12015500489A1 (en) 2015-04-20
PH12015500489B1 (en) 2015-04-20
MX2015002900A (es) 2015-06-03
ES2654653T3 (es) 2018-02-14
EP2895477A1 (en) 2015-07-22
HK1252981A1 (zh) 2019-06-06
WO2014041007A1 (en) 2014-03-20
PT2895477T (pt) 2017-12-29
PL2895477T3 (pl) 2018-03-30
ZA201501126B (en) 2016-01-27
AU2013314388B2 (en) 2016-07-14
SG11201501958QA (en) 2015-04-29
HRP20171981T1 (hr) 2018-02-09
IL237332B (en) 2018-07-31
HK1206720A1 (en) 2016-01-15
MA37944A1 (fr) 2016-04-29
TW201425308A (zh) 2014-07-01
MX363362B (es) 2019-03-21
DK2895477T3 (en) 2018-01-15
KR101706486B1 (ko) 2017-02-13
CN107903251A (zh) 2018-04-13
RS56747B1 (sr) 2018-03-30
CL2015000580A1 (es) 2015-07-10
JP2015531782A (ja) 2015-11-05
SI2895477T1 (en) 2018-02-28
HUE037689T2 (hu) 2018-09-28
CR20150087A (es) 2015-04-06
TWI610926B (zh) 2018-01-11
MY178667A (en) 2020-10-20
NO2895477T3 (pt) 2018-03-31
LT2895477T (lt) 2018-01-25
EA026062B1 (ru) 2017-02-28
AR092537A1 (es) 2015-04-22
AU2013314388A1 (en) 2015-03-05
CA2882821A1 (en) 2014-03-20
CA2882821C (en) 2018-05-22
CN104619700A (zh) 2015-05-13
EA201590454A1 (ru) 2015-09-30
PE20150735A1 (es) 2015-05-17
JP2017122103A (ja) 2017-07-13
MA37944B2 (fr) 2017-10-31
BR112015004511B1 (pt) 2022-08-02
US20150218131A1 (en) 2015-08-06

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B11Z Dismissal: petition dismissal - article 216, par 2 of industrial property law

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B12F Other appeals [chapter 12.6 patent gazette]
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