EA201590454A1 - Производные пиразолкарбоксамида в качестве модуляторов рецепторов следовых аминов (taar) для применения при лечении различных расстройств, таких как депрессия, диабет и болезнь паркинсона - Google Patents
Производные пиразолкарбоксамида в качестве модуляторов рецепторов следовых аминов (taar) для применения при лечении различных расстройств, таких как депрессия, диабет и болезнь паркинсонаInfo
- Publication number
- EA201590454A1 EA201590454A1 EA201590454A EA201590454A EA201590454A1 EA 201590454 A1 EA201590454 A1 EA 201590454A1 EA 201590454 A EA201590454 A EA 201590454A EA 201590454 A EA201590454 A EA 201590454A EA 201590454 A1 EA201590454 A1 EA 201590454A1
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- disorders
- disease
- diabetes
- taar
- compounds
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A61P3/04—Anorexiants; Antiobesity agents
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- A61P3/06—Antihyperlipidemics
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Изобретение относится к соединениям формулыили к их фармацевтически приемлемым солям присоединения кислоты, где R, R, Rи Z представляют собой такие, как раскрыто в описании изобретения. В настоящее время обнаружено, что соединения формулы I обладают высоким сродством к рецепторам, ассоциированным со следовыми аминами (TAAR; от англ. "trace amine associated receptors"), в частности к TAAR1. Эти соединения можно применять для лечения депрессии, тревожных расстройств, биполярного расстройства, синдрома дефицита внимания и гиперактивности (СДВГ), расстройств, обусловленных стрессом, психотических расстройств, таких как шизофрения, неврологических расстройств, таких как болезнь Паркинсона, нейродегенеративных расстройств, таких как болезнь Альцгеймера, эпилепсии, мигрени, гипертензии, злоупотребления веществами и метаболических расстройств, таких как нарушения питания, диабет, осложнения диабета, ожирение, дислипидемия, нарушений поглощения энергии и ассимиляции, расстройств и дисфункции гомеостаза температуры тела, расстройств сна и циркадного ритма и сердечно-сосудистых расстройств.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12184360 | 2012-09-14 | ||
| PCT/EP2013/068769 WO2014041007A1 (en) | 2012-09-14 | 2013-09-11 | Pyrazole carboxamide derivatives as taar modulators for use in the treatment of several disorders, such as depression, diabetes and parkinson's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201590454A1 true EA201590454A1 (ru) | 2015-09-30 |
| EA026062B1 EA026062B1 (ru) | 2017-02-28 |
Family
ID=47044779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590454A EA026062B1 (ru) | 2012-09-14 | 2013-09-11 | Производные пиразолкарбоксамида в качестве модуляторов рецепторов следовых аминов (taar) для применения при лечении различных расстройств, таких как депрессия, диабет и болезнь паркинсона |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US9487501B2 (ru) |
| EP (1) | EP2895477B1 (ru) |
| JP (2) | JP2015531782A (ru) |
| KR (1) | KR101706486B1 (ru) |
| CN (2) | CN107903251A (ru) |
| AR (1) | AR092537A1 (ru) |
| AU (1) | AU2013314388B2 (ru) |
| BR (1) | BR112015004511B1 (ru) |
| CA (1) | CA2882821C (ru) |
| CL (1) | CL2015000580A1 (ru) |
| CR (1) | CR20150087A (ru) |
| DK (1) | DK2895477T3 (ru) |
| EA (1) | EA026062B1 (ru) |
| ES (1) | ES2654653T3 (ru) |
| HK (2) | HK1252981A1 (ru) |
| HR (1) | HRP20171981T1 (ru) |
| HU (1) | HUE037689T2 (ru) |
| IL (1) | IL237332B (ru) |
| LT (1) | LT2895477T (ru) |
| MA (1) | MA37944B2 (ru) |
| MX (1) | MX363362B (ru) |
| MY (1) | MY178667A (ru) |
| NO (1) | NO2895477T3 (ru) |
| NZ (1) | NZ705154A (ru) |
| PE (1) | PE20150735A1 (ru) |
| PH (1) | PH12015500489B1 (ru) |
| PL (1) | PL2895477T3 (ru) |
| PT (1) | PT2895477T (ru) |
| RS (1) | RS56747B1 (ru) |
| SG (1) | SG11201501958QA (ru) |
| SI (1) | SI2895477T1 (ru) |
| TW (1) | TWI610926B (ru) |
| UA (1) | UA113776C2 (ru) |
| WO (1) | WO2014041007A1 (ru) |
| ZA (1) | ZA201501126B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2731095C2 (ru) * | 2016-03-17 | 2020-08-28 | Ф. Хоффманн-Ля Рош Аг | Производное 5-этил-4-метил-пиразол-3-карбоксамида, обладающее активностью агониста taar |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016016162A1 (en) * | 2014-07-30 | 2016-02-04 | F. Hoffmann-La Roche Ag | 6-amino-5,6,7,8-tetrahydronaphthalen-2-yl or 3-aminochroman-7-yl derivatives as taar modulators |
| RU2019121922A (ru) * | 2016-12-15 | 2021-01-18 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Композиции и способы лечения рака |
| KR20210149163A (ko) | 2019-04-09 | 2021-12-08 | 에프. 호프만-라 로슈 아게 | 자가면역 질환의 치료를 위한 헥사하이드로-1H-피라지노[1,2-a]피라진 화합물 |
| WO2022262855A1 (zh) * | 2021-06-18 | 2022-12-22 | 上海拓界生物医药科技有限公司 | 一种malt1抑制剂及其制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425211D0 (en) | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
| GB9520150D0 (en) | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
| US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| KR101335845B1 (ko) | 2007-02-15 | 2013-12-02 | 에프. 호프만-라 로슈 아게 | Ｔａａｒ1 리간드로서의 2-아미노옥사졸린 |
| US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| WO2012063896A1 (ja) * | 2010-11-11 | 2012-05-18 | 第一三共株式会社 | 新規ピラゾールアミド誘導体 |
| US9073911B2 (en) * | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
| US9029370B2 (en) * | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
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2013
- 2013-09-11 HU HUE13759754A patent/HUE037689T2/hu unknown
- 2013-09-11 UA UAA201503288A patent/UA113776C2/uk unknown
- 2013-09-11 ES ES13759754.8T patent/ES2654653T3/es active Active
- 2013-09-11 WO PCT/EP2013/068769 patent/WO2014041007A1/en active Application Filing
- 2013-09-11 EP EP13759754.8A patent/EP2895477B1/en active Active
- 2013-09-11 SG SG11201501958QA patent/SG11201501958QA/en unknown
- 2013-09-11 BR BR112015004511-1A patent/BR112015004511B1/pt active IP Right Grant
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- 2013-09-11 KR KR1020157009118A patent/KR101706486B1/ko active IP Right Grant
- 2013-09-11 AU AU2013314388A patent/AU2013314388B2/en active Active
- 2013-09-11 EA EA201590454A patent/EA026062B1/ru not_active IP Right Cessation
- 2013-09-11 CN CN201711272710.XA patent/CN107903251A/zh active Pending
- 2013-09-11 NZ NZ705154A patent/NZ705154A/en unknown
- 2013-09-11 MX MX2015002900A patent/MX363362B/es unknown
- 2013-09-11 NO NO13759754A patent/NO2895477T3/no unknown
- 2013-09-11 PL PL13759754T patent/PL2895477T3/pl unknown
- 2013-09-11 RS RS20171358A patent/RS56747B1/sr unknown
- 2013-09-11 CN CN201380047584.1A patent/CN104619700A/zh active Pending
- 2013-09-11 DK DK13759754.8T patent/DK2895477T3/en active
- 2013-09-11 MY MYPI2015000641A patent/MY178667A/en unknown
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- 2013-09-11 PE PE2015000364A patent/PE20150735A1/es active IP Right Grant
- 2013-09-11 CA CA2882821A patent/CA2882821C/en active Active
- 2013-09-11 SI SI201330900T patent/SI2895477T1/en unknown
- 2013-09-11 PT PT137597548T patent/PT2895477T/pt unknown
- 2013-09-12 AR ARP130103258A patent/AR092537A1/es not_active Application Discontinuation
- 2013-09-13 TW TW102133263A patent/TWI610926B/zh active
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- 2015-02-19 IL IL237332A patent/IL237332B/en active IP Right Grant
- 2015-02-20 CR CR20150087A patent/CR20150087A/es unknown
- 2015-03-06 PH PH12015500489A patent/PH12015500489B1/en unknown
- 2015-03-09 CL CL2015000580A patent/CL2015000580A1/es unknown
- 2015-03-13 US US14/656,853 patent/US9487501B2/en active Active
- 2015-07-27 HK HK18112341.1A patent/HK1252981A1/zh unknown
- 2015-07-27 HK HK15107153.1A patent/HK1206720A1/xx unknown
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- 2017-02-22 JP JP2017031116A patent/JP6529998B2/ja active Active
- 2017-12-19 HR HRP20171981TT patent/HRP20171981T1/hr unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2731095C2 (ru) * | 2016-03-17 | 2020-08-28 | Ф. Хоффманн-Ля Рош Аг | Производное 5-этил-4-метил-пиразол-3-карбоксамида, обладающее активностью агониста taar |
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