CA2233173A1 - Dopamine and serotonin transporter ligands and imaging agents - Google Patents
Dopamine and serotonin transporter ligands and imaging agentsInfo
- Publication number
- CA2233173A1 CA2233173A1 CA002233173A CA2233173A CA2233173A1 CA 2233173 A1 CA2233173 A1 CA 2233173A1 CA 002233173 A CA002233173 A CA 002233173A CA 2233173 A CA2233173 A CA 2233173A CA 2233173 A1 CA2233173 A1 CA 2233173A1
- Authority
- CA
- Canada
- Prior art keywords
- imaging agents
- dopamine
- compounds
- serotonin transporter
- receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract 4
- 239000012216 imaging agent Substances 0.000 title abstract 3
- 229960003638 dopamine Drugs 0.000 title abstract 2
- 102000006441 Dopamine Plasma Membrane Transport Proteins Human genes 0.000 title 1
- 108010044266 Dopamine Plasma Membrane Transport Proteins Proteins 0.000 title 1
- 102000019208 Serotonin Plasma Membrane Transport Proteins Human genes 0.000 title 1
- 108010012996 Serotonin Plasma Membrane Transport Proteins Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052702 rhenium Inorganic materials 0.000 abstract 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052713 technetium Inorganic materials 0.000 abstract 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 abstract 1
- XLRPYZSEQKXZAA-OCAPTIKFSA-N tropane Chemical compound C1CC[C@H]2CC[C@@H]1N2C XLRPYZSEQKXZAA-OCAPTIKFSA-N 0.000 abstract 1
- 229930004006 tropane Natural products 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
This invention presents a series of novel tropane-based derivatives complexed with either technetium or rhenium having the formula (See formula I) with X, Z, N, and Q being specifically defined herein.
These compounds are specific for central nervous system receptors, in particular, dopamine or serotonin receptors. The compounds of the invention have utility, inter alia, as imaging agents for CNS receptors. Methods of using these novel compounds as imaging agents are presented, as are intermediates and methods for making these novel compounds.
These compounds are specific for central nervous system receptors, in particular, dopamine or serotonin receptors. The compounds of the invention have utility, inter alia, as imaging agents for CNS receptors. Methods of using these novel compounds as imaging agents are presented, as are intermediates and methods for making these novel compounds.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54532795A | 1995-10-19 | 1995-10-19 | |
| US08/545,327 | 1995-10-19 | ||
| US08/649,782 US6241963B1 (en) | 1995-10-19 | 1996-05-17 | Dopamine and serotonin transporter ligands and imaging agents |
| US08/649,782 | 1996-05-17 | ||
| PCT/US1996/016908 WO1997014445A1 (en) | 1995-10-19 | 1996-10-21 | Dopamine and serotonin transporter ligands and imaging agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2233173A1 true CA2233173A1 (en) | 1997-04-24 |
| CA2233173C CA2233173C (en) | 2006-04-04 |
Family
ID=36143343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002233173A Expired - Fee Related CA2233173C (en) | 1995-10-19 | 1996-10-21 | Dopamine and serotonin transporter ligands and imaging agents |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2233173C (en) |
-
1996
- 1996-10-21 CA CA002233173A patent/CA2233173C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2233173C (en) | 2006-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT929319E (en) | DOPAMINE AND SEROTONIN TRANSPORTER LIGANDS AND IMAGE AGENTS | |
| NZ330023A (en) | Fused pyrrolecarboxanilides and their use as a GABA brain receptor ligands | |
| CA2128955A1 (en) | Tricyclic benzazepine vasopressin antagonists | |
| GB2317615B (en) | Antifungal agent compound therefor process for producing the same | |
| CA2103861A1 (en) | Novel 7-(substituted)-8-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracyclines | |
| BR1100273A (en) | Compound | |
| AU3548993A (en) | Novel alkylenediammonium diclavulanate derivatives, a process for the preparation thereof as well as the use thereof | |
| GB2243150B (en) | Method for synthesizing diamond by combustion | |
| YU1302A (en) | Aminothiazole derivatives and their use as crf receptor ligands | |
| AU4312396A (en) | Five-membered heteroaromatic compounds as dopamine receptor subtype ligands | |
| HUP9900968A3 (en) | Herbicidal substituted 3-aryl-pyrazoles, compositions containing them, method for their use and process for preparing the compounds | |
| IL113780A0 (en) | Glucopyranoside benzothiophenes | |
| HUT69738A (en) | Substituted pyridylsalicylaldehyde-and salicyklicacid derivatives, process for their preparation und their use as herbicide | |
| CA2233173A1 (en) | Dopamine and serotonin transporter ligands and imaging agents | |
| ZA961748B (en) | Novel process for preparing 2,3-dihydro-benzofuranol derivatives | |
| FI960332A (en) | Process for preparing substituted 4,6-diamino-5-cyano-pyrimidines | |
| UA35556C2 (en) | process for the preparation of hydrocortisone AND INTERMEDIATE compounds in the synthesis of hydrocortisone | |
| ZA912278B (en) | Compounds affecting serotonin receptors | |
| AU4420296A (en) | Aminomethyl aryl compounds; dopamine receptor subtype selective ligands | |
| EP0755916A3 (en) | Process for the preparation of amine compound | |
| DE69611148T2 (en) | Pyrrolo (4,3,2-de) quinoline derivative | |
| DE69711506T2 (en) | Methylsulfomycin 1, process for its preparation and use | |
| HU9500962D0 (en) | Process for the preparation of substituted, nitrogen containing heterocyclic compounds | |
| CA2367410A1 (en) | Novel process for the preparation of 1-phenyl-2-(2-piridyl)ethanamine | |
| FI946172A0 (en) | A novel radiolabeled compound, a mixture containing the compound and a process for their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |