HUP9702242A1 - Inzulinszerű hatással rendelkező inozit-glikánok - Google Patents
Inzulinszerű hatással rendelkező inozit-glikánokInfo
- Publication number
- HUP9702242A1 HUP9702242A1 HU9702242A HUP9702242A HUP9702242A1 HU P9702242 A1 HUP9702242 A1 HU P9702242A1 HU 9702242 A HU9702242 A HU 9702242A HU P9702242 A HUP9702242 A HU P9702242A HU P9702242 A1 HUP9702242 A1 HU P9702242A1
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- bisulfite
- inozyl
- syllabic
- independently
- Prior art date
Links
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- RWSOTUBLDIXVET-UHFFFAOYSA-M hydrosulfide Chemical compound [SH-] RWSOTUBLDIXVET-UHFFFAOYSA-M 0.000 abstract 2
- -1 (C1-4)-alkyl bisulfite Chemical compound 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000002608 insulinlike Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány tárgyát az (I) általánős képletű, inzűlinszerű hatássalrendelkező inőzit-glikánők, A-Z-R (I) és ezek fiziőlógiailagelfőgadható sói és sztereőizőmerjei képezik, mely képletben Ajelentése H-P(O)(OH)-, H-P(S)(OH)-, HO-P(SO(OH)-, HS-P(S)(OH)-, (C1-4)-alkil-P(O)(OH)-, (C1-4)-alkil-P(S)(OH)-, S(O)2(OR1)-, S(O)(OR1)-,NH2-C(O)-, R1R2N-, R1R2N-C(O)-NH-, R1O-SO2-HN-, (C1-4)-alkil-SO2-,(C1-4)-alkil-S(O)- vagy R1-S-csőpőrt, ahől R1 és R2 egymástólfüggetlenül hidrőgénatőmőt vagy (C1-4)-alkil-csőpőrtőt jelent, Zjelentése 2-6 cűkőrrész, 2-6 cűkőrrész, amely 1-6-szőrősan egymástólfüggetlenül a következő csőpőrtőkkal szűbsztitűált: metil, cűkőrrész,dicűkőrrész, -SO2-OH, -C(O)-NR1R2, -C(O)-(C1-4)-alkil, -P(O)(H)OH, -P(O)(OH)2, -P(S)(H)OH, -P(S)(OH)2, -P(S)(SH) (OH), -P(O)(OH)-O-CH2-CH2-NR1R2 vagy a 2-6 cűkőrrész közötti glikőzidős kötés -CH2- vagy -S-csőpőrttal van kicserélve, és ahől R1 és R2 egymástól függetlenülhidrőgénatőmőt vagy (C1-4)-alkil-csőpőrtőt jelent, R jelentéseinőzitől, inőzitől-főszfát, inőzitől-tiőfőszfát, inőzitől-ciklőfőszfát, inőzitől-ciklőtiő-főszfát, az R 2)-5) jelentésébenmegadőtt csőpőrt maradéka, amely egymástól függetlenül egy vagy kétfőszfát- vagy tiőfőszfát-csőpőrttal szűbsztitűált, az R 2)-5)jelentésében megadőtt csőpőrt maradéka egyszeresen szűbsztitűáltva egyciklőfőszfát- vagy egy ciklő-tiőfőszfát-csőpőrttal, vagy inőzitől,amelyben két szőmszédős OH-csőpőrt -CH2-SO2-NH-csőpőrttalszűbsztitűált. A találmány tővábbá az (I) általánős képletű vegyületekelőállítására és ezeket tartalmazó gyógyszerkészítményekre isvőnatkőzik. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19649350A DE19649350A1 (de) | 1996-11-28 | 1996-11-28 | Inositolglykane mit insulinartiger Wirkung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9702242D0 HU9702242D0 (en) | 1998-03-02 |
| HUP9702242A1 true HUP9702242A1 (hu) | 1998-12-28 |
| HUP9702242A3 HUP9702242A3 (en) | 1999-01-28 |
Family
ID=7813041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9702242A HUP9702242A3 (en) | 1996-11-28 | 1997-11-26 | Inozitol-glykanes of inzulin-like activity |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6004938A (hu) |
| EP (1) | EP0845475B1 (hu) |
| JP (1) | JP4299378B2 (hu) |
| CN (1) | CN1136224C (hu) |
| AR (1) | AR018246A1 (hu) |
| AT (1) | ATE290541T1 (hu) |
| AU (1) | AU728637B2 (hu) |
| BR (1) | BR9706041C1 (hu) |
| CA (1) | CA2222103C (hu) |
| CZ (1) | CZ294886B6 (hu) |
| DE (2) | DE19649350A1 (hu) |
| DK (1) | DK0845475T3 (hu) |
| ES (1) | ES2237784T3 (hu) |
| HK (1) | HK1008786A1 (hu) |
| HU (1) | HUP9702242A3 (hu) |
| PL (1) | PL188604B1 (hu) |
| PT (1) | PT845475E (hu) |
| RU (1) | RU2178794C2 (hu) |
| TR (1) | TR199701432A2 (hu) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7312196B2 (en) * | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| GB9814039D0 (en) * | 1998-06-29 | 1998-08-26 | Univ London | Materials and methods relating to the prevention or treatment of ischaemia-reperfusion injury |
| US6716826B2 (en) | 2000-05-12 | 2004-04-06 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
| US6759390B2 (en) | 2000-05-12 | 2004-07-06 | Manuel Martin-Lomas | Compounds and their uses |
| US6939857B2 (en) | 2000-05-12 | 2005-09-06 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
| CA2433857C (en) * | 2000-05-12 | 2012-07-31 | Rodaris Pharmaceuticals Limited | Inositol phosphoglycan derivatives and their medical uses |
| US6953781B2 (en) | 2000-05-12 | 2005-10-11 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
| EP1409501B1 (en) * | 2000-05-12 | 2008-03-05 | Rodaris Pharmaceuticals Limited | Inositol phosphoglycan derivatives and their medical uses |
| AU6042601A (en) * | 2000-05-12 | 2001-11-20 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
| GB0015627D0 (en) * | 2000-06-26 | 2000-08-16 | Rademacher Group Limited | Phosphoglycan messengers and their medical uses |
| FR2828206B1 (fr) * | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| AU2003231157C1 (en) | 2002-04-29 | 2009-02-26 | Normoxys, Inc. | Inositol pyrophosphates, and methods of use thereof |
| CA2491555C (en) * | 2002-07-10 | 2012-09-11 | Massachusetts Institute Of Technology | Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans |
| CN100369610C (zh) * | 2002-10-09 | 2008-02-20 | 中国药科大学 | 一种防治糖尿病的植物提取物及其制备方法与药物用途 |
| US20060106000A1 (en) * | 2004-07-06 | 2006-05-18 | Claude Nicolau | Use of inositol-tripyrophosphate in treating tumors and diseases |
| US20070135389A1 (en) * | 2004-07-06 | 2007-06-14 | Claude Nicolau | Tumor eradication by inositol-tripyrophosphate |
| US7745423B2 (en) * | 2004-07-06 | 2010-06-29 | NormOxys, Inc | Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin |
| FR2878850B1 (fr) * | 2004-12-02 | 2008-10-31 | Cis Bio Internat Sa | Derives de l'inositol-1-phosphate |
| WO2008080064A1 (en) * | 2006-12-21 | 2008-07-03 | Trustees Of Tufts College | Synthetic lipophilic inositol glycans for treatment of cancer and glucose-metabolism disorders |
| CN101686986A (zh) * | 2006-12-29 | 2010-03-31 | 诺尔姆奥克西斯公司 | 环多醇和其衍生物及其治疗应用 |
| AU2008246061A1 (en) * | 2007-05-01 | 2008-11-06 | Normoxys, Inc. | Erythropoietin complementation or replacement |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446064A (en) * | 1980-12-19 | 1984-05-01 | The University Of Virginia Alumni Patents Foundation | Insulin mediator substance |
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
| US4906468A (en) * | 1986-04-11 | 1990-03-06 | The Rockefeller University | Insulin activity messengers, their antibodies, and thereof |
| YU66892A (sh) * | 1991-08-20 | 1995-10-24 | Hoechst Ag. | Fosfoinositolglikan - peptid sa delovanjem kao insulin |
| EP0545198B1 (de) * | 1991-11-29 | 1999-09-15 | Hoechst Aktiengesellschaft | Peptide mit insulinartiger Wirkung |
| JPH06293790A (ja) * | 1993-04-08 | 1994-10-21 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質イノシトールグリカン |
| US5652221A (en) * | 1994-11-07 | 1997-07-29 | The University Of Virginia Patent Foundation | Method of treating defective glucose metabolism using synthetic insulin substances |
-
1996
- 1996-11-28 DE DE19649350A patent/DE19649350A1/de not_active Withdrawn
-
1997
- 1997-11-13 AT AT97119835T patent/ATE290541T1/de not_active IP Right Cessation
- 1997-11-13 EP EP97119835A patent/EP0845475B1/de not_active Expired - Lifetime
- 1997-11-13 DE DE59712220T patent/DE59712220D1/de not_active Expired - Fee Related
- 1997-11-13 PT PT97119835T patent/PT845475E/pt unknown
- 1997-11-13 DK DK97119835T patent/DK0845475T3/da active
- 1997-11-13 ES ES97119835T patent/ES2237784T3/es not_active Expired - Lifetime
- 1997-11-25 CA CA002222103A patent/CA2222103C/en not_active Expired - Fee Related
- 1997-11-26 HU HU9702242A patent/HUP9702242A3/hu unknown
- 1997-11-26 AR ARP970105573A patent/AR018246A1/es active IP Right Grant
- 1997-11-26 US US08/979,865 patent/US6004938A/en not_active Expired - Fee Related
- 1997-11-26 TR TR97/01432A patent/TR199701432A2/xx unknown
- 1997-11-26 CN CNB971229589A patent/CN1136224C/zh not_active Expired - Fee Related
- 1997-11-26 AU AU45382/97A patent/AU728637B2/en not_active Ceased
- 1997-11-27 BR BR9706041-0A patent/BR9706041C1/pt active Search and Examination
- 1997-11-27 JP JP32550897A patent/JP4299378B2/ja not_active Expired - Fee Related
- 1997-11-27 CZ CZ19973775A patent/CZ294886B6/cs not_active IP Right Cessation
- 1997-11-27 RU RU97120547/04A patent/RU2178794C2/ru not_active IP Right Cessation
- 1997-11-28 PL PL97323407A patent/PL188604B1/pl not_active IP Right Cessation
-
1998
- 1998-07-31 HK HK98109588A patent/HK1008786A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9706041A (pt) | 1999-11-23 |
| TR199701432A2 (xx) | 1998-06-22 |
| HUP9702242A3 (en) | 1999-01-28 |
| CZ294886B6 (cs) | 2005-04-13 |
| JP4299378B2 (ja) | 2009-07-22 |
| RU2178794C2 (ru) | 2002-01-27 |
| EP0845475A1 (de) | 1998-06-03 |
| ATE290541T1 (de) | 2005-03-15 |
| CA2222103C (en) | 2007-08-28 |
| CN1136224C (zh) | 2004-01-28 |
| DE59712220D1 (de) | 2005-04-14 |
| CA2222103A1 (en) | 1998-05-28 |
| MX9709207A (es) | 1998-05-31 |
| ES2237784T3 (es) | 2005-08-01 |
| EP0845475B1 (de) | 2005-03-09 |
| AU4538297A (en) | 1998-06-04 |
| CZ377597A3 (cs) | 1998-06-17 |
| US6004938A (en) | 1999-12-21 |
| PL323407A1 (en) | 1998-06-08 |
| PT845475E (pt) | 2005-06-30 |
| AR018246A1 (es) | 2001-11-14 |
| PL188604B1 (pl) | 2005-03-31 |
| AU728637B2 (en) | 2001-01-11 |
| CN1184112A (zh) | 1998-06-10 |
| JPH10158291A (ja) | 1998-06-16 |
| BR9706041C1 (pt) | 2000-06-06 |
| HK1008786A1 (en) | 1999-05-21 |
| DE19649350A1 (de) | 1998-06-04 |
| DK0845475T3 (da) | 2005-06-27 |
| HU9702242D0 (en) | 1998-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |