HUP9701137A2 - Eljárás gyógyszeripari közbenső termék előállítására - Google Patents
Eljárás gyógyszeripari közbenső termék előállításáraInfo
- Publication number
- HUP9701137A2 HUP9701137A2 HU9701137A HUP9701137A HUP9701137A2 HU P9701137 A2 HUP9701137 A2 HU P9701137A2 HU 9701137 A HU9701137 A HU 9701137A HU P9701137 A HUP9701137 A HU P9701137A HU P9701137 A2 HUP9701137 A2 HU P9701137A2
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- solvent
- intermedier
- dichlorophenyl
- dihydro
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- KJCVRFUGPWSIIH-UHFFFAOYSA-N 1-naphthol Chemical compound C1=CC=C2C(O)=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 abstract 1
- JGMBHJNMQVKDMW-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-3,4-dihydro-2h-naphthalen-1-one Chemical compound C1=C(Cl)C(Cl)=CC=C1C1C2=CC=CC=C2C(=O)CC1 JGMBHJNMQVKDMW-UHFFFAOYSA-N 0.000 abstract 1
- 238000005727 Friedel-Crafts reaction Methods 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229940117389 dichlorobenzene Drugs 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány tárgya eljárás nagytisztaságú (I) képletű 4-(3,4-diklór-fenil)-3,4-dihidrő-1(2H)-naftalin-1-őn előállítására, ő-diklór-benzőlés alfa-naftől őldószeres közegben Friedel-Crafts katalizátőr-jelenlétében történő reakciója útján őly módőn a nyers reakciótermékettetszés szerinti sőrrendben legalább egyszer pőlárős őldószerből éslegalább egyszer apőlárős őldószerből vagy azt tartalmazóőldószerelegyből kristályősítják és ilymódőn a (II) képletű 4-(2,3-diklór-fenil)3,4-dihidrő-1(2H)-naftalin-1-őn melléktermék mennyiségét1% alá csökkentik. Az (I) képletű vegyület ismert gyógyszeripariközbenső termék. A találmány szerinti eljárás előnye, hőgy az (I) képletű vegyületetrendkívül tiszta főrmában teszi hőzzáférhetővé. ŕ
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9701137A HU218599B (hu) | 1996-10-09 | 1997-07-02 | Eljárás 4-(3,4-diklór-fenil)-3,4-dihidro-1-(2H)-naftalin-1-on előállítására |
PCT/HU1997/000058 WO1998015516A1 (en) | 1996-10-09 | 1997-10-08 | Process for the preparation of a pharmaceutical intermediate |
SK341-99A SK284671B6 (sk) | 1996-10-09 | 1997-10-08 | Spôsob prípravy vysoko čistého 4-(3,4-dichlórfenyl)-3,4-dihydro- 1(2H)-naftalén-1-ónu |
CZ19991207A CZ295766B6 (cs) | 1996-10-09 | 1997-10-08 | Způsob přípravy farmaceutického meziproduktu |
AU48788/97A AU4878897A (en) | 1996-10-09 | 1997-10-08 | Process for the preparation of a pharmaceutical intermediate |
RO99-00294A RO120194B1 (ro) | 1996-10-09 | 1997-10-08 | Procedeu pentru prepararea 4-(3,4-diclorfenil)-3,4-dihidro-1(2h)-naftalen-1-onei de puritate înaltă |
PL332779A PL192111B1 (pl) | 1996-10-09 | 1997-10-08 | Sposób otrzymywania wysokiej czystości 4-(3,4-dwuchloro-fenylo)-3,4-dwuwodoro-1(2H)-naftalen-1-onu |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9602762A HUP9602762A2 (en) | 1996-10-09 | 1996-10-09 | Process for producing naphtalene derivatives |
HU9701137A HU218599B (hu) | 1996-10-09 | 1997-07-02 | Eljárás 4-(3,4-diklór-fenil)-3,4-dihidro-1-(2H)-naftalin-1-on előállítására |
Publications (4)
Publication Number | Publication Date |
---|---|
HU9701137D0 HU9701137D0 (en) | 1997-08-28 |
HUP9701137A2 true HUP9701137A2 (hu) | 1999-04-28 |
HUP9701137A3 HUP9701137A3 (en) | 1999-05-28 |
HU218599B HU218599B (hu) | 2000-10-28 |
Family
ID=89995311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9701137A HU218599B (hu) | 1996-10-09 | 1997-07-02 | Eljárás 4-(3,4-diklór-fenil)-3,4-dihidro-1-(2H)-naftalin-1-on előállítására |
Country Status (7)
Country | Link |
---|---|
AU (1) | AU4878897A (hu) |
CZ (1) | CZ295766B6 (hu) |
HU (1) | HU218599B (hu) |
PL (1) | PL192111B1 (hu) |
RO (1) | RO120194B1 (hu) |
SK (1) | SK284671B6 (hu) |
WO (1) | WO1998015516A1 (hu) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1250522C (zh) * | 1999-11-16 | 2006-04-12 | 西巴特殊化学品控股有限公司 | 制备酮亚胺的方法 |
IN187170B (hu) | 2000-01-04 | 2002-02-23 | Sun Pharmaceutical Ind Ltd | |
CN116041160A (zh) * | 2021-10-28 | 2023-05-02 | 上虞京新药业有限公司 | 一种将异舍曲酮转化为舍曲酮的方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2632633B1 (fr) * | 1988-06-08 | 1991-04-05 | Delalande Sa | Procede de preparation de 4-aryl-1-tetralones |
-
1997
- 1997-07-02 HU HU9701137A patent/HU218599B/hu not_active IP Right Cessation
- 1997-10-08 SK SK341-99A patent/SK284671B6/sk unknown
- 1997-10-08 CZ CZ19991207A patent/CZ295766B6/cs not_active IP Right Cessation
- 1997-10-08 AU AU48788/97A patent/AU4878897A/en not_active Abandoned
- 1997-10-08 RO RO99-00294A patent/RO120194B1/ro unknown
- 1997-10-08 PL PL332779A patent/PL192111B1/pl not_active IP Right Cessation
- 1997-10-08 WO PCT/HU1997/000058 patent/WO1998015516A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
PL332779A1 (en) | 1999-10-11 |
WO1998015516A1 (en) | 1998-04-16 |
CZ295766B6 (cs) | 2005-10-12 |
HUP9701137A3 (en) | 1999-05-28 |
HU218599B (hu) | 2000-10-28 |
AU4878897A (en) | 1998-05-05 |
RO120194B1 (ro) | 2005-10-28 |
PL192111B1 (pl) | 2006-08-31 |
CZ120799A3 (cs) | 1999-09-15 |
SK284671B6 (sk) | 2005-08-04 |
HU9701137D0 (en) | 1997-08-28 |
SK34199A3 (en) | 2000-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC9A | Change of name, address |
Owner name: EGIS GYOGYSZERGYAR NYRT., HU Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU |
|
MM4A | Lapse of definitive patent protection due to non-payment of fees |