HUP1600483A2 - - Google Patents

Info

Publication number
HUP1600483A2
HUP1600483A2 HUP1600483A HUP1600483A2 HU P1600483 A2 HUP1600483 A2 HU P1600483A2 HU P1600483 A HUP1600483 A HU P1600483A HU P1600483 A2 HUP1600483 A2 HU P1600483A2
Authority
HU
Hungary
Application number
Other languages
Hungarian (hu)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9893121&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP1600483(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of HUP1600483A2 publication Critical patent/HUP1600483A2/hu
Publication of HU230669B1 publication Critical patent/HU230669B1/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6875Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compression Of Band Width Or Redundancy In Fax (AREA)
HUP1600483A 2000-06-06 2001-06-05 Humán tumor nekrózis faktor alfa specifikus antitest molekulák és alkalmazásuk HU230669B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0013810.7A GB0013810D0 (en) 2000-06-06 2000-06-06 Biological products
PCT/GB2001/002477 WO2001094585A1 (en) 2000-06-06 2001-06-05 Antibody molecules having specificity for human tumor necrosis factor alpha, and use thereof

Publications (2)

Publication Number Publication Date
HUP1600483A2 true HUP1600483A2 (en:Method) 2002-10-28
HU230669B1 HU230669B1 (hu) 2017-07-28

Family

ID=9893121

Family Applications (4)

Application Number Title Priority Date Filing Date
HUP1600483A HU230669B1 (hu) 2000-06-06 2001-06-05 Humán tumor nekrózis faktor alfa specifikus antitest molekulák és alkalmazásuk
HU1600016A HU230553B1 (hu) 2000-06-06 2001-06-05 Humán tumor nekrózis faktor alfa specifikus antitest molekulák és alkalmazásuk
HU0202346A HU230561B1 (hu) 2000-06-06 2001-06-05 Humán tumor nekrózis faktor-alfa specifikus antitest molekulák és alkalmazásuk
HUS1700013C HUS1700013I1 (hu) 2000-06-06 2017-04-06 Humán tumor nekrózis faktor-alfa specifikus antitest molekulák és alkalmazásuk

Family Applications After (3)

Application Number Title Priority Date Filing Date
HU1600016A HU230553B1 (hu) 2000-06-06 2001-06-05 Humán tumor nekrózis faktor alfa specifikus antitest molekulák és alkalmazásuk
HU0202346A HU230561B1 (hu) 2000-06-06 2001-06-05 Humán tumor nekrózis faktor-alfa specifikus antitest molekulák és alkalmazásuk
HUS1700013C HUS1700013I1 (hu) 2000-06-06 2017-04-06 Humán tumor nekrózis faktor-alfa specifikus antitest molekulák és alkalmazásuk

Country Status (42)

Country Link
US (4) US7012135B2 (en:Method)
EP (4) EP2230308B1 (en:Method)
JP (3) JP4064812B2 (en:Method)
KR (1) KR20020047097A (en:Method)
CN (1) CN1289671C (en:Method)
AP (1) AP2092A (en:Method)
AR (1) AR033978A1 (en:Method)
AT (1) ATE451460T1 (en:Method)
AU (1) AU783756B2 (en:Method)
BE (1) BE2010C019I2 (en:Method)
BG (1) BG66072B1 (en:Method)
BR (2) BR0106682A (en:Method)
CA (2) CA2380298C (en:Method)
CY (6) CY1109889T1 (en:Method)
CZ (1) CZ300737B6 (en:Method)
DE (3) DE122010000027I1 (en:Method)
DK (4) DK3059314T3 (en:Method)
EC (1) ECSP024210A (en:Method)
ES (5) ES2403217T3 (en:Method)
FR (1) FR10C0015I2 (en:Method)
GB (2) GB0013810D0 (en:Method)
HU (4) HU230669B1 (en:Method)
IL (3) IL147992A0 (en:Method)
IS (2) IS2808B (en:Method)
LT (1) LT2308975T (en:Method)
LU (1) LU91674I2 (en:Method)
MX (1) MXPA01013440A (en:Method)
MY (1) MY136603A (en:Method)
NL (1) NL300982I9 (en:Method)
NO (4) NO334808B1 (en:Method)
NZ (1) NZ516596A (en:Method)
OA (1) OA12282A (en:Method)
PE (1) PE20020292A1 (en:Method)
PL (2) PL218516B1 (en:Method)
PT (4) PT2308975T (en:Method)
RU (1) RU2303604C2 (en:Method)
SI (3) SI2230308T1 (en:Method)
SK (1) SK288343B6 (en:Method)
TR (1) TR201900227T4 (en:Method)
TW (2) TWI316088B (en:Method)
WO (1) WO2001094585A1 (en:Method)
ZA (1) ZA200200097B (en:Method)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
GB0129105D0 (en) * 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
WO2003080674A1 (en) * 2002-03-20 2003-10-02 Pharmacia Corporation Antibody disulfide isomers, use thereof, and methods of analyzing same
US20040009172A1 (en) * 2002-04-26 2004-01-15 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
HUE030806T2 (hu) * 2002-05-02 2017-05-29 Wyeth Holdings Llc Calicheamicin származék-hordozó konjugátumok
WO2003099226A2 (en) * 2002-05-28 2003-12-04 Celltech R & D Limited Antibody peg positional isomers, compositions comprising same, and use thereof
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
TWI430810B (zh) * 2002-07-19 2014-03-21 Abbott Lab S A TNFα相關病症之治療
WO2004019860A2 (en) * 2002-08-28 2004-03-11 Pharmacia Corporation Formulations of modified antibodies and methods of making the same
WO2004019861A2 (en) * 2002-08-28 2004-03-11 Pharmacia Corporation Stable ph optimized formulation of a modified antibody
US20040105858A1 (en) * 2002-08-29 2004-06-03 Kim Joanne Young Hee Kwak Diagnosis and treatment of infertility
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
EP1558640B1 (en) 2002-10-29 2011-04-13 Anaphore, Inc. Trimeric binding proteins for trimeric cytokines
ATE472556T1 (de) 2002-12-02 2010-07-15 Amgen Fremont Inc Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
US7101978B2 (en) 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
US7575893B2 (en) * 2003-01-23 2009-08-18 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
GB0303337D0 (en) * 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
EP1597299A2 (en) * 2003-02-19 2005-11-23 Pharmacia Corporation Carbonate esters of polyethylene glycol activated by means of oxalate esters
WO2004098578A2 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517
JP5087274B2 (ja) * 2003-06-30 2012-12-05 ドマンティス リミテッド ポリペプチド
WO2005014649A2 (en) * 2003-08-08 2005-02-17 Pharmacia Corporation Method for the preparation of molecules having antibody activity
DE602004004796T2 (de) * 2003-08-13 2007-12-06 Sandoz Ag Expressionsvektoren, transformierte wirtszellen und fermentationsverfahren zur herstellung rekombinanter polypeptide
US20060173167A1 (en) * 2003-08-13 2006-08-03 Gunter Stempfer Process for the purification of recombinant polypeptides
GB0319601D0 (en) * 2003-08-20 2003-09-24 Sandoz Ag Production process
KR100570422B1 (ko) * 2003-10-16 2006-04-11 한미약품 주식회사 대장균 분비서열을 이용하여 항체 단편을 분비·생산하는 발현벡터 및 이를 이용하여 항체 단편을 대량 생산하는 방법
CN100393748C (zh) * 2003-11-06 2008-06-11 上海中信国健药业有限公司 全人源肿瘤坏死因子抗体,其制备方法以及药物组合物
KR100772800B1 (ko) * 2003-11-17 2007-11-01 주식회사유한양행 인간 종양괴사인자 α를 인식하는 단일클론항체의가변영역 및 이를 코딩하는 유전자
US7435799B2 (en) 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
CN100427504C (zh) * 2004-06-02 2008-10-22 北京天广实生物技术有限公司 TNFα高亲和力嵌合抗体及其用途
JP2008504356A (ja) * 2004-06-30 2008-02-14 ドマンティス リミテッド 炎症性疾患を治療するための組成物及び方法
GB0425972D0 (en) * 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
US8022040B2 (en) * 2004-11-29 2011-09-20 The Regents Of The University Of California Hydroxyapatite-binding peptides for bone growth and inhibition
WO2006071091A1 (en) * 2004-12-29 2006-07-06 Yuhan Corporation Humanized antibody specific for tumor necrosis factor-alpha
NZ627177A (en) * 2005-05-16 2016-02-26 Abbvie Biotechnology Ltd Use of tnf inhibitor for treatment of erosive polyarthritis
AU2006254333B2 (en) * 2005-06-01 2011-02-17 Amgen Research (Munich) Gmbh Anti-IL2 antibodies
DK2390267T3 (da) * 2005-06-07 2013-08-26 Esbatech A Novartis Co Llc Stabile og opløselige antistoffer, der hæmmer TNF(alfa)
GB0520169D0 (en) * 2005-10-04 2005-11-09 Celltech R&D Ltd Biological products
WO2007117685A2 (en) 2006-04-07 2007-10-18 Nektar Therapeutics Al, Corporation Conjugates of an anti-tnf-alpha antibody
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
EP2666472A3 (en) * 2006-04-10 2014-04-02 Abbott Biotechnology Ltd Uses and compositions for treatment of psoriatic arthritis
EP2010214A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
AU2007269714A1 (en) 2006-07-03 2008-01-10 Charles David Adair Composition for modulating the expression of cell adhesion molecules
EP1914242A1 (en) * 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
AU2008223091B2 (en) * 2007-03-02 2014-04-24 Farnam Companies, Inc. Sustained release pellets comprising wax-like material
WO2008153997A1 (en) * 2007-06-07 2008-12-18 Brookwood Pharmaceuticals, Inc. Reduced-mass, long-acting dosage forms
WO2008154543A2 (en) 2007-06-11 2008-12-18 Abbott Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis
EP2185188B1 (en) * 2007-08-22 2014-08-06 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
BRPI0907485A2 (pt) * 2008-02-05 2015-08-04 Delenex Therapeutics Ag Polipeptídeos de ligação a antígeno contra degeneração de cartilagem
WO2009135861A2 (en) * 2008-05-07 2009-11-12 Novo Nordisk A/S Humanized antibodies against human interferon-alpha
PT3444274T (pt) 2008-06-25 2021-03-17 Novartis Ag Anticorpos que inibem tnf estáveis e solúveis
HUE032894T2 (hu) 2008-06-25 2017-11-28 Esbatech Alcon Biomed Res Unit VEGF-gátló, stabilis és oldható antitestek
ES2890405T3 (es) 2008-06-25 2022-01-19 Novartis Ag Humanización de anticuerpos de conejo usando un armazón de anticuerpo universal
EP2752428B8 (en) 2008-06-25 2020-02-26 Novartis Ag Humanization of rabbit antibodies using a universal antibody framework
CN101684156B (zh) * 2008-09-27 2011-12-28 苏州工业园区晨健抗体组药物开发有限公司 人TNFα单克隆抗体、其PEG化纳米颗粒及其应用
US20110165063A1 (en) * 2009-01-29 2011-07-07 Abbott Laboratories Il-1 binding proteins
AU2010208637A1 (en) * 2009-01-29 2011-08-04 Abbvie Inc. IL-1 binding proteins
DK2451839T3 (da) 2009-07-10 2020-07-13 Ablynx Nv Fremgangsmåde til produktion af variable domæner
US9109216B2 (en) 2009-09-24 2015-08-18 Ucb Pharma, S.A. Bacterial host strain
SG10201407757XA (en) 2009-10-23 2015-01-29 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201001791D0 (en) 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
WO2011109662A1 (en) 2010-03-04 2011-09-09 Vet Therapeutics, Inc. Monoclonal antibodies directed to cd52
US9616120B2 (en) 2010-03-04 2017-04-11 Vet Therapeutics, Inc. Monoclonal antibodies directed to CD20
EP2555797A4 (en) 2010-04-07 2014-02-12 Abbvie Inc TNF-ALPHA-BINDING PROTEINS
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
GB201012784D0 (en) * 2010-07-29 2010-09-15 Ucb Pharma Sa Method
TWI538918B (zh) 2010-10-20 2016-06-21 財團法人工業技術研究院 人源化之單株抗體、其核苷酸序列與其用途
AR083495A1 (es) 2010-10-22 2013-02-27 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles
EP2714912B1 (en) 2011-06-01 2018-05-02 Intrexon Actobiotics NV Polycistronic expression system for bacteria
EP2546267A1 (en) 2011-07-13 2013-01-16 UCB Pharma S.A. Bacterial host strain expressing recombinant DsbC
HUE035674T2 (en) 2011-07-13 2018-05-28 Ucb Biopharma Sprl Bacterial host strain expressing recombinant dsbc
US9347036B2 (en) 2011-09-23 2016-05-24 Intrexon Actobiotics Nv Modified gram positive bacteria and uses thereof
DK2758512T3 (en) 2011-09-23 2018-07-23 Intrexon Actobiotics Nv MODIFIED GRAM POSITIVE BACTERIES AND APPLICATIONS THEREOF
WO2013087914A1 (en) 2011-12-16 2013-06-20 Synthon Biopharmaceuticals B.V. EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
JP6352264B2 (ja) 2012-08-13 2018-07-04 ジェネンテック, インコーポレイテッド 抗jagged抗体および使用方法
JP2017518737A (ja) 2014-04-21 2017-07-13 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. SYK標的治療薬のための抗pSYK抗体分子及びその使用
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
CA2964463C (en) 2014-10-22 2024-02-13 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
BR112017013398B1 (pt) 2014-12-22 2023-12-05 Ucb Biopharma Sprl Método de fabricar anticorpo ou fragmento de ligação ao antígeno do mesmo
US11091559B2 (en) 2015-08-27 2021-08-17 Celldex Therapeutics, Inc. Anti-ALK antibodies and methods for use thereof
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
US10905727B2 (en) 2016-01-14 2021-02-02 Intrexon Actobiotics N.V. Compositions and methods for the treatment of type 1 diabetes
RU2680011C2 (ru) * 2016-04-29 2019-02-14 Закрытое Акционерное Общество "Биокад" Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы
BR112018074922B1 (pt) * 2016-06-02 2022-10-25 Abbvie Inc Compostos agonistas de receptores de glucocorticoides, composição farmacêutica compreendendo ditos compostos e uso terapêutico dos mesmos
US20200087390A1 (en) 2016-12-21 2020-03-19 Amgen Inc. Anti-tnf alpha antibody formulations
EP3658192B1 (en) 2017-12-01 2021-04-28 AbbVie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
SG11202107995SA (en) 2019-01-31 2021-08-30 Numab Therapeutics AG Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof
KR102323342B1 (ko) * 2019-04-26 2021-11-08 주식회사 와이바이오로직스 IL-17A 및 TNF-α에 특이적으로 결합하는 이중표적 항체
CN111909268B (zh) * 2019-05-07 2022-04-19 北京天成新脉生物技术有限公司 低免疫原性低ADCC/CDC功能抗TNF-α人源化单克隆抗体TCX060及其应用
TW202237639A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 鳥苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法
TW202237638A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 烏苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法
JP2024506200A (ja) 2021-02-15 2024-02-09 武田薬品工業株式会社 細胞治療用組成物及びtgf-bシグナル伝達を調節する方法
JP2024531480A (ja) 2021-08-26 2024-08-29 デュアリティ バイオロジクス(スーチョウ)カンパニー,リミティド ステロイド化合物及びそのコンジュゲート
SE545694C2 (en) * 2021-09-24 2023-12-05 Xbrane Biopharma Ab Dna construct comprising nucleotide sequences encoding amino acid sequences of certolizumab and pelb signal peptides
SE545714C2 (en) * 2021-09-24 2023-12-19 Xbrane Biopharma Ab Dna contructs for producing a pelb signal peptide
CA3232722A1 (en) 2021-09-24 2023-03-30 Kiavash MIRZADEH Dna constructs and host cells for expressing recombinant protein
WO2023154799A1 (en) 2022-02-14 2023-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination immunotherapy for treating cancer
IL319526A (en) 2022-09-30 2025-05-01 Extend Biosciences Inc Long-acting parathyroid hormone
WO2024180518A1 (en) * 2023-03-01 2024-09-06 Lupin Limited Process for manufacturing antibody fragment protein
WO2025049345A1 (en) 2023-08-25 2025-03-06 Proteologix Us Inc. Anti-il-13 multispecific antibody constructs and uses thereof
WO2025099576A1 (en) 2023-11-06 2025-05-15 Momenta Pharmaceuticals, Inc. Compositions and methods for treating rheumatoid arthritis

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DK336987D0 (da) 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
US5030570A (en) 1988-06-30 1991-07-09 The Eunice Kennedy Shriver Center For Mental Retardation DNA encoding and method of expressing human monoamine oxidase type A
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
PT92900A (pt) * 1989-01-24 1990-07-31 Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9109645D0 (en) 1991-05-03 1991-06-26 Celltech Ltd Recombinant antibodies
US5919452A (en) 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
ES2138662T3 (es) * 1993-06-03 2000-01-16 Therapeutic Antibodies Inc Produccion de fragmentos de anticuerpos.
NO309690B1 (no) 1995-01-23 2001-03-12 Western Atlas Int Inc Detonasjonsanordning av type eksploderende brotråd for bruk med et perforeringsverktöy i en brönn
EP0871641A4 (en) 1995-04-20 2001-09-26 Kennedy Inst Of Rheumatology MULTIPLE ADMINISTRATION OF ANTI-TNF ANTIBODIES
NZ536216A (en) 1996-02-09 2006-08-31 Abbott Biotech Ltd Use of an isolated antibody D2E7 for the treatment of a disorder in which TNF(alpha) activity is detrimental
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
GB9625640D0 (en) * 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
US6350860B1 (en) * 1997-08-18 2002-02-26 Innogenetics N.V. Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
GB9720054D0 (en) * 1997-09-19 1997-11-19 Celltech Therapeutics Ltd Biological products
ES2307865T3 (es) 1998-03-12 2008-12-01 Nektar Therapeutics Al, Corporation Metodo para preparar conjugados polimericos.
GB9812545D0 (en) * 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products

Also Published As

Publication number Publication date
CY1118220T1 (el) 2017-06-28
DE60140738D1 (de) 2010-01-21
PT1287140E (pt) 2010-03-08
ECSP024210A (es) 2002-05-23
EP1287140A1 (en) 2003-03-05
DK3059314T3 (en) 2019-02-18
GB0128386D0 (en) 2002-01-16
GB2366800B (en) 2005-01-19
HUS1700013I1 (hu) 2017-08-28
CN1289671C (zh) 2006-12-13
IL147992A (en) 2009-06-15
ATE451460T1 (de) 2009-12-15
TR201900227T4 (tr) 2019-02-21
NO2014026I1 (no) 2014-10-23
BRPI0106682B1 (pt) 2020-10-13
CY2019018I1 (el) 2020-05-29
SK3152002A3 (en) 2002-07-02
PL399351A1 (pl) 2012-12-17
BE2010C019I2 (en:Method) 2020-08-20
NO20160694A1 (no) 2002-04-08
CY1121173T1 (el) 2020-05-29
CN1383450A (zh) 2002-12-04
EP2230308A1 (en) 2010-09-22
JP2003535591A (ja) 2003-12-02
OA12282A (en) 2006-05-11
RU2303604C2 (ru) 2007-07-27
WO2001094585A1 (en) 2001-12-13
ES2337763T3 (es) 2010-04-29
US20030026805A1 (en) 2003-02-06
TWI353358B (en) 2011-12-01
MXPA01013440A (es) 2003-09-04
CA2707766A1 (en) 2001-12-13
AP2002002690A0 (en) 2002-12-31
EP2308975A1 (en) 2011-04-13
JP2007105043A (ja) 2007-04-26
SI2230308T1 (sl) 2013-06-28
FR10C0015I2 (fr) 2011-12-30
CY2019018I2 (el) 2020-05-29
SI1287140T1 (sl) 2010-04-30
HUP0202346A3 (en) 2004-11-29
PL218516B1 (pl) 2014-12-31
ES2230975A1 (es) 2005-05-01
AU783756B2 (en) 2005-12-01
HUP1600016A2 (en) 2002-10-28
BR0106682A (pt) 2002-05-14
BG66072B1 (bg) 2011-01-31
NZ516596A (en) 2004-07-30
DE10192353T1 (de) 2003-05-22
AP2092A (en) 2010-02-28
LU91674I2 (fr) 2010-05-31
CY2010011I2 (el) 2012-01-25
PT2308975T (pt) 2016-11-14
US20020151682A1 (en) 2002-10-17
AR033978A1 (es) 2004-01-21
HU230561B1 (hu) 2016-12-28
FR10C0015I1 (en:Method) 2010-04-16
EP2230308B1 (en) 2013-01-23
CA2380298C (en) 2010-09-28
US7012135B2 (en) 2006-03-14
CY1114143T1 (el) 2016-07-27
TW200817430A (en) 2008-04-16
NO341218B1 (no) 2017-09-11
US7402662B2 (en) 2008-07-22
BRPI0106682B8 (pt) 2021-05-25
NO339282B1 (no) 2016-11-21
CZ2002837A3 (cs) 2002-05-15
NO334808B1 (no) 2014-06-02
DK2308975T3 (da) 2016-10-31
CZ300737B6 (cs) 2009-07-29
IS3016B (is) 2019-10-15
US20060233800A1 (en) 2006-10-19
HU230553B1 (hu) 2016-11-28
GB2366800A (en) 2002-03-20
HU230669B1 (hu) 2017-07-28
CA2380298A1 (en) 2001-12-13
LU91674I9 (en:Method) 2019-01-03
CA2707766C (en) 2013-05-21
AU6051101A (en) 2001-12-17
SK288343B6 (sk) 2016-04-01
DK2230308T3 (da) 2013-05-06
ES2707714T3 (es) 2019-04-04
IS2808B (is) 2012-09-15
ES2403217T3 (es) 2013-05-16
HK1051385A1 (en) 2003-08-01
JP4064812B2 (ja) 2008-03-19
DK1287140T3 (da) 2010-04-19
CY1109889T1 (el) 2012-01-25
US7186820B2 (en) 2007-03-06
PE20020292A1 (es) 2002-05-08
IL147992A0 (en) 2002-09-12
NO2014026I2 (no) 2018-02-14
IL195085A0 (en) 2009-08-03
PT2230308E (pt) 2013-05-03
MY136603A (en) 2008-10-31
NL300982I1 (en:Method) 2019-05-01
CY2010011I1 (el) 2012-01-25
EP1287140B1 (en) 2009-12-09
KR20020047097A (ko) 2002-06-21
JP4476989B2 (ja) 2010-06-09
ZA200200097B (en) 2003-01-06
PT3059314T (pt) 2019-02-01
NO20020554L (no) 2002-04-08
DE122010000027I1 (de) 2010-08-12
NL300982I9 (nl) 2019-05-06
LT2308975T (lt) 2016-11-10
EP2308975B1 (en) 2016-08-10
NO20020554D0 (no) 2002-02-04
PL212738B1 (pl) 2012-11-30
NO20131316L (no) 2002-04-08
PL353960A1 (en) 2003-12-15
IS6217A (is) 2002-01-03
HK1148776A1 (en) 2011-09-16
JP2009171966A (ja) 2009-08-06
ES2600080T3 (es) 2017-02-07
US7977464B2 (en) 2011-07-12
JP5185143B2 (ja) 2013-04-17
EP3059314B1 (en) 2018-10-24
EP3059314A1 (en) 2016-08-24
SI2308975T1 (sl) 2016-11-30
TWI316088B (en) 2009-10-21
BG106278A (bg) 2002-12-29
US20080269465A1 (en) 2008-10-30
HUP0202346A2 (en) 2002-10-28
GB0013810D0 (en) 2000-07-26
ES2230975B2 (es) 2007-04-16

Similar Documents

Publication Publication Date Title
BE2012C026I2 (en:Method)
BE2011C032I2 (en:Method)
BE2009C057I2 (en:Method)
LU91674I9 (en:Method)
BE2010C040I2 (en:Method)
CH694022C1 (en:Method)
BR122012015772A2 (en:Method)
CN3135930S (en:Method)
CN3139578S (en:Method)
AU2001294354A8 (en:Method)
AU2000280319A8 (en:Method)
BY4905C1 (en:Method)
BY6855C1 (en:Method)
BY7030C1 (en:Method)
AU2000278563A8 (en:Method)
CL2001002979A1 (en:Method)
CN3133795S (en:Method)
CN3135469S (en:Method)
CN3135513S (en:Method)
CN3135563S (en:Method)
CN3135640S (en:Method)
CN3135921S (en:Method)
AU2000274567A8 (en:Method)
CN3136619S (en:Method)
CN3136721S (en:Method)