HUP0302892A2 - (Aminoalkenilbenzoil) benzofuránok vagy- benzotiofének, előállításukra alkalmas eljárás és a vegyületeket tartalmazó készítmények - Google Patents

(Aminoalkenilbenzoil) benzofuránok vagy- benzotiofének, előállításukra alkalmas eljárás és a vegyületeket tartalmazó készítmények

Info

Publication number
HUP0302892A2
HUP0302892A2 HU0302892A HUP0302892A HUP0302892A2 HU P0302892 A2 HUP0302892 A2 HU P0302892A2 HU 0302892 A HU0302892 A HU 0302892A HU P0302892 A HUP0302892 A HU P0302892A HU P0302892 A2 HUP0302892 A2 HU P0302892A2
Authority
HU
Hungary
Prior art keywords
group
hydrogen atom
same
benzofuran
aminoalkenylbenzoyl
Prior art date
Application number
HU0302892A
Other languages
English (en)
Inventor
Jean-Louis Assens
Claude Bernhart
Frédérique Cabanel-Haudricourt
Victor Dos Santos
Patrick Gautier
Dino Nisato
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HUP0302892A2 publication Critical patent/HUP0302892A2/hu
Publication of HUP0302892A3 publication Critical patent/HUP0302892A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Abstract

A találmány (1) általános képletű benzofurán- vagybenzotiofénszármazékokra és gyógyászatilag elfogadható sóikra és avegyületeket tartalmazó készítményekre vonatkozik, a képletben C Cjelentése -CH=CH- csoport vagy -C=C- csoport, A jelentésealkiléncsoport vagy alkeniléncsoport, T jelentése hidrogénatom vagyalkilcsoport, R jelentése: ciano-, hidroximetil-, formil- vagytetrazolilcsoport, észtercsoport, karboxilcsoport,alkálifémkarboxilátcsoport, adott esetben helyettesített amidcsoport,adott esetben helyettesített aminoalkoxikarbonilcsoport, R1 jelentésehidrogénatom, alkilcsoport, cikloalkilcsoport vagy fenilcsoport, R2 ésR3 jelentése hidrogénatom, alkilcsoport vagy cikloalkilcsoport, vagyR2 és R3 együtt alkiléncsoportot alkot, W, W' és Z jelentése olyan,hogy - amikor W és W' azonos, és jelentése CH csoport, Z jelentése -O-vagy -S-, - amikor W jelentése CH csoport és W' jelentése C-R8általános képletű csoport, Z jelentése -CH=C(R9)- általános képletűcsoport, R8 és R9 jelentése hidrogénatom, halogénatom, alkilcsoportvagy alkoxicsoport, X jelentése -O- vagy -S-. Ó
HU0302892A 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same HUP0302892A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0010835A FR2813307B1 (fr) 2000-08-23 2000-08-23 Aminoalkenylbenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
PCT/FR2001/002656 WO2002016338A1 (fr) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Publications (2)

Publication Number Publication Date
HUP0302892A2 true HUP0302892A2 (hu) 2003-12-29
HUP0302892A3 HUP0302892A3 (en) 2005-02-28

Family

ID=8853675

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302892A HUP0302892A3 (en) 2000-08-23 2001-08-23 Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same

Country Status (25)

Country Link
US (1) US6946483B2 (hu)
EP (1) EP1315708B1 (hu)
JP (1) JP4918209B2 (hu)
KR (1) KR20030023768A (hu)
CN (1) CN1471519A (hu)
AT (1) ATE273293T1 (hu)
AU (1) AU2001284154A1 (hu)
BG (1) BG107553A (hu)
BR (1) BR0113350A (hu)
CA (1) CA2415846A1 (hu)
CZ (1) CZ2003520A3 (hu)
DE (1) DE60104866T2 (hu)
EA (1) EA200300063A1 (hu)
FR (1) FR2813307B1 (hu)
HU (1) HUP0302892A3 (hu)
IL (1) IL153637A0 (hu)
IS (1) IS6676A (hu)
MA (1) MA26944A1 (hu)
MX (1) MXPA03001592A (hu)
NO (1) NO20030801L (hu)
OA (1) OA12358A (hu)
PL (1) PL362123A1 (hu)
SK (1) SK2112003A3 (hu)
WO (1) WO2002016338A1 (hu)
ZA (1) ZA200300746B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI641593B (zh) 2009-01-16 2018-11-21 美商艾克塞里克斯公司 包含ｎ-（４-｛〔６，７-雙（甲氧基）喹啉-４-基〕氧基｝苯基）-ｎ’-（４-氟苯基）環丙烷-１，１-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
CN107935972B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(异丙胺基)丙氧基]苯并呋喃类衍生物及其应用
CN107857748B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用
CN107827849B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 6-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
US4831054A (en) * 1988-04-18 1989-05-16 Taro Pharmaceuticals, Ltd. 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
AT391316B (de) * 1988-09-15 1990-09-25 Ebewe Arzneimittel Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
US5622974A (en) * 1995-03-10 1997-04-22 Eli Lilly And Company α-substituted-3-benzyl-benzofurans
CA2220991A1 (en) * 1995-06-26 1997-01-16 Eli Lilly And Company Benzothiophene compounds
US5827876A (en) * 1996-04-09 1998-10-27 American Home Products Corporation Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo b!-thiophenes
WO1999054325A1 (fr) * 1998-04-17 1999-10-28 Senga Pharmaceutical Laboratory Inc. Derives 1-heteroindene et compositions medicinales a base de tels derives

Also Published As

Publication number Publication date
KR20030023768A (ko) 2003-03-19
WO2002016338A1 (fr) 2002-02-28
EP1315708A1 (fr) 2003-06-04
DE60104866T2 (de) 2005-10-20
MXPA03001592A (es) 2003-09-10
NO20030801L (no) 2003-04-23
WO2002016338A8 (fr) 2002-05-10
BR0113350A (pt) 2003-07-08
OA12358A (fr) 2006-05-16
PL362123A1 (en) 2004-10-18
US6946483B2 (en) 2005-09-20
EA200300063A1 (ru) 2003-08-28
IL153637A0 (en) 2003-07-06
DE60104866D1 (de) 2004-09-16
HUP0302892A3 (en) 2005-02-28
NO20030801D0 (no) 2003-02-20
EP1315708B1 (fr) 2004-08-11
IS6676A (is) 2003-01-13
JP2004506726A (ja) 2004-03-04
JP4918209B2 (ja) 2012-04-18
MA26944A1 (fr) 2004-12-20
FR2813307A1 (fr) 2002-03-01
CZ2003520A3 (cs) 2003-05-14
ATE273293T1 (de) 2004-08-15
AU2001284154A1 (en) 2002-03-04
CN1471519A (zh) 2004-01-28
SK2112003A3 (en) 2003-08-05
CA2415846A1 (fr) 2002-02-28
FR2813307B1 (fr) 2002-11-08
BG107553A (en) 2004-01-30
ZA200300746B (en) 2004-02-10
US20030187060A1 (en) 2003-10-02

Similar Documents

Publication Publication Date Title
IL115335A0 (en) Naphthyl compounds intermediates processes compositions and methods
EP0845985A4 (en) NON-STEROIDIAN SULFATASE INHIBITOR COMPOUNDS AND METHODS OF USE
DE69316068D1 (de) 1-[2-(Arylsulfonylamino)-1-oxoethyl]piperidin-Derivate, ihre Herstellung und therapeutische Verwendung
HUP0401235A2 (hu) 5-HT6 receptor affinitással rendelkező arilszulfonil-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
HUP0302961A2 (hu) (Aminoalkoxibenzoil) benzofuránok vagy benzotiofének, eljárás ilyen vegyületek előállítására és ilyen vegyületeket tartalmazó készítmények
IT1230859B (it) 2 alchinilfenoli sostituiti ad azione anti infiammatoria, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
MX9800800A (es) Compuestos, intermedios de naftilo y dihidronaftilo, composiciones y metodos.
HUP0302892A2 (hu) (Aminoalkenilbenzoil) benzofuránok vagy- benzotiofének, előállításukra alkalmas eljárás és a vegyületeket tartalmazó készítmények
ES486824A1 (es) Procedimiento para la preparacion de nuevos derivados de 4- (naftilmetil) piperidinas
YU52498A (sh) UPOTREBA 2-ARILBENZO (b) TIOFENA ZA DOBIJANJE LEKA
ES2172376A1 (es) Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
NO20006350L (no) Derivater av 3-(2-okso-[1,3']bipyrrolidinyl-3-ylidenmetyl)- cephemer
MEP38508A (en) Benzofuran derivatives, their preparation and use
AU625238B2 (en) Anti-psychotic piperidylbenzimidazole compounds
KR960007566A (ko) 신규한 퀴놀릴아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도
UA72934C2 (uk) Феніл- і піридилтетрагідропіридини, що інгібують фактор некрозу пухлин, спосіб їх одержання та фармацевтична композиція
DE69402703T2 (de) 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
ES8105981A1 (es) Procedimiento para la preparacion de derivados de 4-(nafta- leniloxi)piperidina
DK1189908T3 (da) Indolcarbazolalkaloider fra en marin strålesvamp
SE8405332L (sv) 2h-azeto (2,1-a)-isokinolinderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande dem
RS49886B (sr) Benzotiofenska jedinjenja, intermedijari, kompozicije i metode
NO892761L (no) Fremgangsmaate for fremstilling av inhibitorer for 3-keto-hmg-coa-reduktase.