HUP0301031A2 - Degradálható nukleinsavpróbák, és eljárások nukleinsavak kimutatására - Google Patents

Degradálható nukleinsavpróbák, és eljárások nukleinsavak kimutatására Download PDF

Info

Publication number
HUP0301031A2
HUP0301031A2 HU0301031A HUP0301031A HUP0301031A2 HU P0301031 A2 HUP0301031 A2 HU P0301031A2 HU 0301031 A HU0301031 A HU 0301031A HU P0301031 A HUP0301031 A HU P0301031A HU P0301031 A2 HUP0301031 A2 HU P0301031A2
Authority
HU
Hungary
Prior art keywords
probe
nucleic acid
region
probes
branch
Prior art date
Application number
HU0301031A
Other languages
English (en)
Hungarian (hu)
Inventor
David Albagli
Peter C. Cheng
Reuel Vanatta
Michael L. Wood
Original Assignee
Naxcor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naxcor filed Critical Naxcor
Publication of HUP0301031A2 publication Critical patent/HUP0301031A2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HU0301031A 2000-04-18 2001-04-18 Degradálható nukleinsavpróbák, és eljárások nukleinsavak kimutatására HUP0301031A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/551,305 US6573048B1 (en) 2000-04-18 2000-04-18 Degradable nucleic acid probes and nucleic acid detection methods
PCT/US2001/012701 WO2001079563A2 (en) 2000-04-18 2001-04-18 Degradable nucleic acid probes and nucleic acid detection methods

Publications (1)

Publication Number Publication Date
HUP0301031A2 true HUP0301031A2 (hu) 2003-07-28

Family

ID=24200719

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301031A HUP0301031A2 (hu) 2000-04-18 2001-04-18 Degradálható nukleinsavpróbák, és eljárások nukleinsavak kimutatására

Country Status (11)

Country Link
US (1) US6573048B1 (https=)
EP (1) EP1280938A2 (https=)
JP (1) JP2004501615A (https=)
KR (1) KR20030005289A (https=)
CN (1) CN1432069A (https=)
CA (1) CA2406096A1 (https=)
CZ (1) CZ20023749A3 (https=)
HU (1) HUP0301031A2 (https=)
MX (1) MXPA02010283A (https=)
PL (1) PL362928A1 (https=)
WO (1) WO2001079563A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002059137A1 (en) * 2000-11-03 2002-08-01 Isis Pharmaceuticals, Inc. Nuclease-based method for detecting and quantitating oligonucleotides
EP1513958B1 (en) 2002-06-14 2011-08-10 Gen-Probe Incorporated Compositions for detecting hepatitis b virus
US8575327B2 (en) * 2003-06-12 2013-11-05 Alnylam Pharmaceuticals, Inc. Conserved HBV and HCV sequences useful for gene silencing
EP2290071B1 (en) * 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
US20060078894A1 (en) * 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
CA2857881A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
JP4712814B2 (ja) * 2005-11-17 2011-06-29 独立行政法人科学技術振興機構 特定の塩基配列の標的核酸類を検出する方法、及び検出のための核酸類セット
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
EP2104734A2 (en) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-20 regulated genes and pathways as targets for therapeutic intervention
WO2008073915A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Micrornas differentially expressed in leukemia and uses thereof
CA2671270A1 (en) * 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
JP2010529966A (ja) * 2007-06-08 2010-09-02 アシュラジェン インコーポレイテッド 治療的介入の標的としてmiR−34によって調節される遺伝子および経路
US8361714B2 (en) * 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US20090186015A1 (en) * 2007-10-18 2009-07-23 Latham Gary J Micrornas differentially expressed in lung diseases and uses thereof
US8071562B2 (en) 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
WO2009126726A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
US8258111B2 (en) * 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
WO2010056577A1 (en) * 2008-11-17 2010-05-20 Magic Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
US9469868B2 (en) * 2008-11-17 2016-10-18 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
WO2012112563A2 (en) 2011-02-16 2012-08-23 Magic Technologies, Inc. Methods and compositions for the target-localized anchoring of detectable label
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
CN102703584B (zh) * 2012-04-20 2013-08-21 中国人民解放军第四军医大学 自组装聚合分支dna探针的制备方法
US9738925B2 (en) * 2013-03-15 2017-08-22 Lyle J. Arnold Methods for immobilizing target nucleic acids utilizing combinatorial capture probes
JP6210484B2 (ja) * 2013-06-25 2017-10-11 国立大学法人北陸先端科学技術大学院大学 鎖交換された二重鎖オリゴヌクレオチドの製造方法
GB201401885D0 (en) * 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
TWI710633B (zh) 2014-11-10 2020-11-21 美商阿尼拉製藥公司 B型肝炎病毒(HBV)iRNA組成物及其用途方法
GB2570412A (en) * 2016-08-31 2019-07-24 Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
US11324820B2 (en) 2017-04-18 2022-05-10 Alnylam Pharmaceuticals, Inc. Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
CA3106701A1 (en) 2018-08-13 2020-02-20 Alnylam Pharmaceuticals, Inc. Hepatitis b virus (hbv) dsrna agent compositions and methods of use thereof
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
CN110295235A (zh) * 2019-07-26 2019-10-01 合肥欧创基因生物科技有限公司 一种双标记探针及其在snp分型及肿瘤突变的应用
WO2021155063A1 (en) 2020-01-29 2021-08-05 Readcoor, Llc Compositions and methods for analyte detection
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4826967A (en) 1987-06-16 1989-05-02 Naxcor Psoralen-nucleoside adducts and method for their preparation
US5403711A (en) * 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
US6004826A (en) * 1988-07-20 1999-12-21 David Segev Repair-mediated process for amplifying and detecting nucleic acid sequences
US5082934A (en) 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
US5767259A (en) * 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
WO1994024120A1 (en) 1993-04-13 1994-10-27 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5616464A (en) 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
AU724506B2 (en) 1995-11-03 2000-09-21 Naxcor Double-stranded conformational polymorphism analysis
CN1285879A (zh) 1998-01-09 2001-02-28 美国3M公司 可特异性酶切断裂的多核苷酸底物和测试方法
WO1999042616A1 (en) 1998-02-20 1999-08-26 Dade Behring Inc. Methods for determining concentrations of nucleic acids
US6124099A (en) * 1998-06-22 2000-09-26 The University Of Vermont And State Agricultural College Method for placing a photo-cross-linking agent at specific internal sites within the sequence of synthetic strands of ribonucleic acids
US6303799B1 (en) 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents

Also Published As

Publication number Publication date
CN1432069A (zh) 2003-07-23
CA2406096A1 (en) 2001-10-25
US6573048B1 (en) 2003-06-03
EP1280938A2 (en) 2003-02-05
KR20030005289A (ko) 2003-01-17
MXPA02010283A (es) 2003-05-23
WO2001079563A2 (en) 2001-10-25
WO2001079563A3 (en) 2002-09-19
PL362928A1 (en) 2004-11-02
CZ20023749A3 (cs) 2003-04-16
JP2004501615A (ja) 2004-01-22

Similar Documents

Publication Publication Date Title
HUP0301031A2 (hu) Degradálható nukleinsavpróbák, és eljárások nukleinsavak kimutatására
US5681943A (en) Method for covalently linking adjacent oligonucleotides
JP2856804B2 (ja) 標識された相補的核酸プローブを開裂する触媒反応の補因子としての活性に基づく核酸配列検出のための触媒ハイブリッド形成系
EP2920320B1 (en) Rca reporter probes and their use in detecting nucleic acid molecules
CN101918596B (zh) 多重基因组获得和丢失分析
JP4510626B2 (ja) 脱塩基部位エンドヌクレアーゼアッセイ
JP2005502346A (ja) 核酸配列の非特異的ハイブリダイゼーションをブロックするための方法
WO2012016357A1 (en) Microarray-based assay integrated with particles for analyzing molecular interactions
WO2008002920A2 (en) Methods for generating target nucleic acid sequences
US20210269865A1 (en) Methods for Attaching Cellular Constituents to a Matrix
WO2007106802A2 (en) Method for linear amplification of bisulfite converted dna
JP2010521142A (ja) 遺伝子発現アッセイ
US6596489B2 (en) Methods and compositions for analyzing nucleotide sequence mismatches using RNase H
JP2005500051A (ja) 比率に基づくオリゴヌクレオチドプローブの選択
CN116194591A (zh) 序列转换反应
US20060240431A1 (en) Oligonucletide guided analysis of gene expression
US20150111774A1 (en) Method for Detecting Target Nucleic Acid
AU2001259096A1 (en) Degradable nucleic acid probes and nucleic acid detection methods