HUP0202625A2 - Antibody dye conjugates for binding to target structures of angiogenesis in order to intraoperatively depict tumor peripheries - Google Patents

Antibody dye conjugates for binding to target structures of angiogenesis in order to intraoperatively depict tumor peripheries

Info

Publication number
HUP0202625A2
HUP0202625A2 HU0202625A HUP0202625A HUP0202625A2 HU P0202625 A2 HUP0202625 A2 HU P0202625A2 HU 0202625 A HU0202625 A HU 0202625A HU P0202625 A HUP0202625 A HU P0202625A HU P0202625 A2 HUP0202625 A2 HU P0202625A2
Authority
HU
Hungary
Prior art keywords
binding
dye conjugates
angiogenesis
intraoperatively
order
Prior art date
Application number
HU0202625A
Other languages
English (en)
Inventor
Dinkelborg
Licha
Schirner
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7924318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0202625(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of HUP0202625A2 publication Critical patent/HUP0202625A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0039—Coumarin dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány olyan antitest-színezék-konjugátumokra vonatkozik, amelyekalkalmasak újonnan képződött véredények struktúráihoz kötődni, és ezekalkalmazására patológiás angingenezis operáció alatti (intraoperatív)megjelenítéséhez. A találmány szerinti antitest-színezék-konjugátumokés ezeket tartalmazó gyógyszerkészítmények felhasználhatók tumorokkörvonalainak operáció alatti meghatározására és ezáltal a tumorokpontosabb eltávolítására. Ó
HU0202625A 1999-09-24 2000-08-19 Antibody dye conjugates for binding to target structures of angiogenesis in order to intraoperatively depict tumor peripheries HUP0202625A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19947559A DE19947559A1 (de) 1999-09-24 1999-09-24 Antikörper-Farbstoffkonjugate gegen Zielstrukturen der Angiogenese zur intraoperativen Tumorranddarstellung
PCT/EP2000/008121 WO2001023005A1 (de) 1999-09-24 2000-08-19 Antikörper-farbstoffkonjugate gegen zielstrukturen der angiogenese zur intraoperativen tumorranddarstellung

Publications (1)

Publication Number Publication Date
HUP0202625A2 true HUP0202625A2 (en) 2002-12-28

Family

ID=7924318

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202625A HUP0202625A2 (en) 1999-09-24 2000-08-19 Antibody dye conjugates for binding to target structures of angiogenesis in order to intraoperatively depict tumor peripheries

Country Status (23)

Country Link
EP (2) EP1214099A1 (hu)
JP (1) JP2003510294A (hu)
KR (2) KR100832937B1 (hu)
CN (1) CN1269530C (hu)
AU (1) AU779026B2 (hu)
BG (1) BG65682B1 (hu)
BR (1) BR0014192A (hu)
CA (1) CA2385593A1 (hu)
CZ (1) CZ2002991A3 (hu)
DE (1) DE19947559A1 (hu)
EE (1) EE05176B1 (hu)
HK (1) HK1050491A1 (hu)
HU (1) HUP0202625A2 (hu)
IL (2) IL148405A0 (hu)
MX (1) MXPA02002639A (hu)
NO (1) NO20021441L (hu)
NZ (1) NZ517944A (hu)
RO (1) RO121598B1 (hu)
RU (1) RU2002109237A (hu)
SK (1) SK3972002A3 (hu)
WO (1) WO2001023005A1 (hu)
YU (1) YU20702A (hu)
ZA (1) ZA200203225B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003524018A (ja) 2000-02-24 2003-08-12 アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
AT413487B (de) * 2002-08-12 2006-03-15 Igeneon Krebs Immuntherapie Verwendung von antikörpern gegen ein tumor-assoziiertes antigen
NO20034351D0 (no) * 2003-09-29 2003-09-29 Amersham Health As Optisk avbilding av endometrose
ATE374367T1 (de) * 2004-07-22 2007-10-15 Bayer Schering Pharma Ag Verwendung von cyanin-farbstoffen zur diagnose von krankheiten, welche mit angiogenese assoziert sind
EP1679082A1 (en) * 2005-01-07 2006-07-12 Schering AG Use of cyanine dyes for the diagnosis of proliferative diseases
US20120041305A1 (en) * 2009-04-21 2012-02-16 The University Of Utah Research Foundation Light-emitting dye for intraoperative imaging or sentinel lymph node biopsy
WO2018026965A1 (en) * 2016-08-02 2018-02-08 Isi Life Sciences, Inc. Compositions and methods for detecting cancer cells in a tissue sample

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341223A (en) * 1981-02-04 1982-07-27 Lutz Lauralee A Fluoresceable composition and method of determining fluid flow
WO1996001653A1 (en) * 1994-07-11 1996-01-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
TWI259837B (en) * 1998-05-11 2006-08-11 Eidgenossische Tech Hochscule Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis

Also Published As

Publication number Publication date
KR20070087232A (ko) 2007-08-27
HK1050491A1 (en) 2003-06-27
NO20021441D0 (no) 2002-03-22
WO2001023005A1 (de) 2001-04-05
DE19947559A1 (de) 2001-04-19
CN1269530C (zh) 2006-08-16
CA2385593A1 (en) 2001-04-05
NO20021441L (no) 2002-05-15
PL354027A1 (en) 2003-12-15
EE05176B1 (et) 2009-06-15
EE200200152A (et) 2003-04-15
RU2002109237A (ru) 2003-11-27
KR100832937B1 (ko) 2008-05-27
EP1532988A3 (de) 2008-09-17
EP1532988A2 (de) 2005-05-25
BG106528A (bg) 2002-12-29
BR0014192A (pt) 2002-05-21
BG65682B1 (bg) 2009-06-30
IL148405A (en) 2009-06-15
IL148405A0 (en) 2002-09-12
CN1376074A (zh) 2002-10-23
YU20702A (sh) 2005-06-10
MXPA02002639A (es) 2002-07-30
ZA200203225B (en) 2003-07-23
CZ2002991A3 (cs) 2002-06-12
AU779026B2 (en) 2005-01-06
JP2003510294A (ja) 2003-03-18
RO121598B1 (ro) 2007-12-28
SK3972002A3 (en) 2002-09-10
AU6702600A (en) 2001-04-30
NZ517944A (en) 2004-06-25
KR20020039349A (ko) 2002-05-25
EP1214099A1 (de) 2002-06-19

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees