HUP0200308A3 - Quinolinecarboxamides as antiviral agents, pharmaceutical compositions containing them and their use - Google Patents
Quinolinecarboxamides as antiviral agents, pharmaceutical compositions containing them and their useInfo
- Publication number
- HUP0200308A3 HUP0200308A3 HU0200308A HUP0200308A HUP0200308A3 HU P0200308 A3 HUP0200308 A3 HU P0200308A3 HU 0200308 A HU0200308 A HU 0200308A HU P0200308 A HUP0200308 A HU P0200308A HU P0200308 A3 HUP0200308 A3 HU P0200308A3
- Authority
- HU
- Hungary
- Prior art keywords
- quinolinecarboxamides
- pharmaceutical compositions
- compositions containing
- antiviral agents
- antiviral
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- ZEXKKIXCRDTKBF-UHFFFAOYSA-N quinoline-2-carboxamide Chemical class C1=CC=CC2=NC(C(=O)N)=CC=C21 ZEXKKIXCRDTKBF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11530199P | 1999-01-08 | 1999-01-08 | |
US14061099P | 1999-06-23 | 1999-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0200308A2 HUP0200308A2 (en) | 2002-06-29 |
HUP0200308A3 true HUP0200308A3 (en) | 2003-03-28 |
Family
ID=26813058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0200308A HUP0200308A3 (en) | 1999-01-08 | 1999-12-22 | Quinolinecarboxamides as antiviral agents, pharmaceutical compositions containing them and their use |
Country Status (19)
Country | Link |
---|---|
US (1) | US6248739B1 (hu) |
EP (1) | EP1140850A1 (hu) |
JP (1) | JP2002534416A (hu) |
KR (1) | KR20010101421A (hu) |
CN (1) | CN1161336C (hu) |
AU (1) | AU760207B2 (hu) |
BR (1) | BR9916772A (hu) |
CA (1) | CA2353636A1 (hu) |
CZ (1) | CZ20012454A3 (hu) |
EA (1) | EA003945B1 (hu) |
HK (1) | HK1041699A1 (hu) |
HU (1) | HUP0200308A3 (hu) |
ID (1) | ID29550A (hu) |
IL (1) | IL144171A0 (hu) |
NO (1) | NO20013383L (hu) |
NZ (1) | NZ512824A (hu) |
SK (1) | SK8302001A3 (hu) |
TR (1) | TR200101906T2 (hu) |
WO (1) | WO2000040561A1 (hu) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA72611C2 (uk) * | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
US6525049B2 (en) | 2000-07-05 | 2003-02-25 | Pharmacia & Upjohn Company | Pyrroloquinolones as antiviral agents |
US6624159B2 (en) | 2000-07-12 | 2003-09-23 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6673793B2 (en) | 2000-07-12 | 2004-01-06 | Pharmacia & Upjohn Co. | Oxazinoquinolones useful for the treatment of viral infections |
WO2002004462A1 (en) * | 2000-07-12 | 2002-01-17 | Pharmacia & Upjohn Company | Oxazinoquinolones useful for the treatment of viral infections |
US6562822B2 (en) | 2000-07-12 | 2003-05-13 | Pharmacia & Upjohn Company | Heterocyle carboxamides as antiviral agents |
US6682892B2 (en) | 2000-07-13 | 2004-01-27 | Pharmacia & Upjohn Company | Method for treating herpes viruses |
FR2817257B1 (fr) | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
US6544990B2 (en) | 2001-03-01 | 2003-04-08 | Pharmacia & Upjohn Company | Substituted quinolinecarboxamides as antiviral agents |
US7425559B2 (en) | 2001-07-13 | 2008-09-16 | Btg International Limited | Medicine containing pyrimidine derivative |
WO2003020728A1 (en) | 2001-08-30 | 2003-03-13 | Pharmacia & Upjohn Company | 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS |
JP4164028B2 (ja) | 2001-10-12 | 2008-10-08 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アルキンマトリックスメタロプロテイナーゼ阻害剤 |
US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
JP3787295B2 (ja) * | 2001-10-23 | 2006-06-21 | ローム株式会社 | 半導体装置 |
US20030207877A1 (en) * | 2001-12-20 | 2003-11-06 | Strohbach Joseph Walter | Pyridoquinoxaline antivirals |
AR038117A1 (es) | 2002-01-14 | 2004-12-29 | Upjohn Co | Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida |
AR038294A1 (es) | 2002-01-14 | 2005-01-12 | Upjohn Co | Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales |
AR038118A1 (es) | 2002-01-14 | 2004-12-29 | Upjohn Co | Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales |
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
JP4532263B2 (ja) * | 2002-05-14 | 2010-08-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 置換されたキノロンカルボン酸、その誘導体、作用の部位、およびその使用 |
US6800625B2 (en) | 2002-06-19 | 2004-10-05 | Janssen Pharmaceutica N.V. | Substituted 2,4-dihydro-pyrrolo[3,4-b]quinolin-9-one derivatives useful as phosphodiesterase inhibitors |
AU2003262947A1 (en) * | 2002-08-30 | 2004-03-19 | Pharmacia And Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
AU2003262910A1 (en) * | 2002-08-30 | 2004-03-19 | Pharmacia And Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
WO2004019933A1 (en) * | 2002-08-30 | 2004-03-11 | Pharmacia & Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
US20040116464A1 (en) * | 2002-09-04 | 2004-06-17 | Schnute Mark E. | Aryl-ethanolamine derivatives as antiviral agents |
WO2004022567A1 (en) * | 2002-09-04 | 2004-03-18 | Pharmacia & Upjohn Company Llc | Heteroaryl-ethanolamine derivatives as antiviral agents |
SI1564210T1 (sl) | 2002-11-20 | 2010-01-29 | Japan Tobacco Inc | 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze |
CN100406007C (zh) | 2002-12-20 | 2008-07-30 | 安姆根有限公司 | 哮喘和过敏性炎症调节剂 |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
CN100471842C (zh) * | 2003-07-24 | 2009-03-25 | 安斯泰来制药有限公司 | 喹诺酮衍生物或其盐 |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
EP1758581A1 (en) | 2004-05-21 | 2007-03-07 | Japan Tobacco, Inc. | Combinations comprising a 4-isoquinolone derivative and anti-hiv agents |
EP1758866A1 (en) | 2004-06-18 | 2007-03-07 | Wyeth | Processes for preparing 6-alkyl-5-arylsulfonyl- dihydrophenanthridines |
HUE032540T2 (hu) | 2004-06-24 | 2017-09-28 | Vertex Pharma | ATP-kötõ kazetta transzporterek modulátorai |
DE102004035203A1 (de) | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituierte Chinolone |
TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
AU2006277682A1 (en) * | 2005-04-21 | 2007-02-15 | Targanta Therapeutics Inc. | Phosphonated fluoroquinolones, antibacterial analogs thereof, and methods for the prevention and treatment of bone and joint infections |
DE102005030524A1 (de) | 2005-06-30 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone II |
US20070032522A1 (en) * | 2005-07-01 | 2007-02-08 | Kumar Dange V | Antiviral agents |
PL1993360T3 (pl) | 2005-12-28 | 2017-08-31 | Vertex Pharmaceuticals Incorporated | Stałe postacie n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4- dihydro-4-oksochinolino-3-karboksyamidu |
DE102006005861A1 (de) * | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
EA017861B9 (ru) | 2006-03-06 | 2014-05-30 | Джапан Тобакко Инк. | Способ получения 4-оксохинолинового соединения |
CN101437801B (zh) | 2006-03-06 | 2013-02-06 | 日本烟草产业株式会社 | 制备4-氧代喹啉化合物的方法 |
US8247442B2 (en) * | 2006-03-29 | 2012-08-21 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use |
TW200815353A (en) * | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
WO2007118854A1 (en) * | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and the use thereof |
WO2008124118A1 (en) * | 2007-04-09 | 2008-10-16 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use therof |
US8765736B2 (en) * | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
ES2471919T3 (es) | 2007-12-19 | 2014-06-27 | Amgen, Inc | Derivados de ácido fenilac�tico como moduladores de inflamación |
EP2786760B1 (en) * | 2008-09-03 | 2019-01-16 | NBC Meshtec, Inc. | Antiviral agent |
WO2010108162A1 (en) | 2009-03-20 | 2010-09-23 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
SI2408749T1 (sl) | 2009-03-20 | 2018-10-30 | Vertex Pharmaceuticals Incorporated | Modulatorji regulatorja transmembranske prevodnosti pri cistični fibrozi |
WO2011004389A2 (en) | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | An improved process for the preparation of elvitegravir |
US20130224293A1 (en) | 2012-02-27 | 2013-08-29 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
US9303015B2 (en) | 2012-10-16 | 2016-04-05 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORγt |
SI2909192T1 (sl) | 2012-10-16 | 2017-08-31 | Janssen Pharmaceutica Nv | Metilensko vezani kinolinilni modulatorji za ROR-gama-t |
US9309222B2 (en) | 2012-10-16 | 2016-04-12 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
WO2014070976A1 (en) * | 2012-11-03 | 2014-05-08 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
KR101564337B1 (ko) | 2012-12-10 | 2015-10-30 | 주식회사 이큐스앤자루 | 디하이드로퀴놀린 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 인플루엔자 a형 바이러스에 의한 질환의 예방 또는 치료용 약학적 조성물 |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
AU2014334616A1 (en) * | 2013-10-15 | 2016-04-28 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORyt |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
JP6423423B2 (ja) | 2013-10-15 | 2018-11-14 | ヤンセン ファーマシューティカ エヌ.ベー. | Rorγtのアルキル結合キノリニルモジュレーター |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
JP6746569B2 (ja) | 2014-10-07 | 2020-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶 |
US10723708B2 (en) * | 2014-11-10 | 2020-07-28 | Evrys Bio, Llc | Anti-HCMV compositions and methods |
CN108892639B (zh) * | 2018-08-13 | 2021-05-14 | 云南民族大学 | 一种高效环保制备喹诺酮类化合物的方法 |
AU2019339777B2 (en) | 2018-09-12 | 2022-09-01 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
US11667613B2 (en) | 2019-09-26 | 2023-06-06 | Novartis Ag | Antiviral pyrazolopyridinone compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1034124A (en) * | 1973-05-11 | 1978-07-04 | Ciba-Geigy Ag | Process for the manufacture of new quinolines |
JPH02124871A (ja) | 1988-07-27 | 1990-05-14 | Dainippon Pharmaceut Co Ltd | 1位が置換された複素環式カルボン酸アミド誘導体 |
US4959363A (en) * | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
US5175151A (en) * | 1990-09-07 | 1992-12-29 | Schering Corporation | Antiviral compounds and antihypertensive compounds |
EP0841929B1 (en) | 1995-08-02 | 2003-05-07 | Darwin Discovery Limited | Quinolones and their therapeutic use |
CA2225555A1 (en) * | 1995-08-02 | 1997-02-13 | Chiroscience Limited | Quinolones and their therapeutic use |
CA2262786A1 (en) | 1996-09-10 | 1998-03-19 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
HUP0101999A3 (en) * | 1997-12-22 | 2003-06-30 | Upjohn Co | 4-hydroxyquinoline-3-carboxamides and hydrazides use of them and pharmaceutical compositions containing them |
-
1999
- 1999-12-17 US US09/466,712 patent/US6248739B1/en not_active Expired - Fee Related
- 1999-12-22 KR KR1020017008629A patent/KR20010101421A/ko not_active Application Discontinuation
- 1999-12-22 IL IL14417199A patent/IL144171A0/xx unknown
- 1999-12-22 TR TR2001/01906T patent/TR200101906T2/xx unknown
- 1999-12-22 EA EA200100757A patent/EA003945B1/ru not_active IP Right Cessation
- 1999-12-22 CA CA002353636A patent/CA2353636A1/en not_active Abandoned
- 1999-12-22 CZ CZ20012454A patent/CZ20012454A3/cs unknown
- 1999-12-22 JP JP2000592270A patent/JP2002534416A/ja active Pending
- 1999-12-22 SK SK830-2001A patent/SK8302001A3/sk unknown
- 1999-12-22 HU HU0200308A patent/HUP0200308A3/hu unknown
- 1999-12-22 BR BR9916772-7A patent/BR9916772A/pt not_active IP Right Cessation
- 1999-12-22 AU AU23486/00A patent/AU760207B2/en not_active Ceased
- 1999-12-22 WO PCT/US1999/027960 patent/WO2000040561A1/en not_active Application Discontinuation
- 1999-12-22 NZ NZ512824A patent/NZ512824A/en unknown
- 1999-12-22 EP EP99967145A patent/EP1140850A1/en not_active Ceased
- 1999-12-22 ID IDW00200101386A patent/ID29550A/id unknown
- 1999-12-22 CN CNB99815458XA patent/CN1161336C/zh not_active Expired - Fee Related
-
2001
- 2001-07-06 NO NO20013383A patent/NO20013383L/no not_active Application Discontinuation
-
2002
- 2002-05-04 HK HK02103396.2A patent/HK1041699A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU760207B2 (en) | 2003-05-08 |
AU2348600A (en) | 2000-07-24 |
NO20013383L (no) | 2001-09-07 |
NO20013383D0 (no) | 2001-07-06 |
CN1161336C (zh) | 2004-08-11 |
CA2353636A1 (en) | 2000-07-13 |
TR200101906T2 (tr) | 2001-12-21 |
JP2002534416A (ja) | 2002-10-15 |
ID29550A (id) | 2001-09-06 |
EA200100757A1 (ru) | 2001-12-24 |
EA003945B1 (ru) | 2003-10-30 |
HUP0200308A2 (en) | 2002-06-29 |
CN1333753A (zh) | 2002-01-30 |
WO2000040561A1 (en) | 2000-07-13 |
KR20010101421A (ko) | 2001-11-14 |
EP1140850A1 (en) | 2001-10-10 |
CZ20012454A3 (cs) | 2002-03-13 |
BR9916772A (pt) | 2004-06-15 |
HK1041699A1 (zh) | 2002-07-19 |
US6248739B1 (en) | 2001-06-19 |
IL144171A0 (en) | 2002-05-23 |
NZ512824A (en) | 2003-09-26 |
SK8302001A3 (en) | 2002-04-04 |
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