HUP0105480A2 - Benzofuránszármazékok, eljárás előállításukra, és alkalmazásuk - Google Patents

Benzofuránszármazékok, eljárás előállításukra, és alkalmazásuk

Info

Publication number
HUP0105480A2
HUP0105480A2 HU0105480A HUP0105480A HUP0105480A2 HU P0105480 A2 HUP0105480 A2 HU P0105480A2 HU 0105480 A HU0105480 A HU 0105480A HU P0105480 A HUP0105480 A HU P0105480A HU P0105480 A2 HUP0105480 A2 HU P0105480A2
Authority
HU
Hungary
Prior art keywords
group
general formula
hydrogen atom
heterocyclic
ring
Prior art date
Application number
HU0105480A
Other languages
English (en)
Inventor
Yasuyoshi Arikawa
Kouki Kato
Shigenori Ohkawa
Masahiro Okura
Masaki Setoh
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of HUP0105480A2 publication Critical patent/HUP0105480A2/hu
Publication of HUP0105480A3 publication Critical patent/HUP0105480A3/hu
Publication of HU226652B1 publication Critical patent/HU226652B1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)

Abstract

Az (I) általános képletű vegyületek - a képletben R1 és R2 jelentésehidrogénatom, szénhidrogéncsoport vagy heterociklusos csoport, vagy R1és R2 a kapcsolódó szénatommal együtt 3-8 tagú homociklusos vagyheterociklusos gyűrűt alkot, W jelentése (i) (Wa) általános képletűcsoport, amelyben a B-gyűrű 5-7 tagú gyűrűt jelent, vagy (ii) (Wb)általános képletű csoport, amelyben R4 jelentése (1) alifásszénhidrogéncsoport, amely aromás csoporttal lehet szubsztituálva,vagy (2) acilcsoport, amely aromás csoportot tartalmaz, R5 jelentésehidrogénatom, 1-6 szénatomos alkilcsoport vagy acilcsoport, azzal amegkötéssel, hogy ha W jelentése (Wa) általános képletű csoport, R3jelentése hidrogénatom, szénhidrogéncsoport vagy heterociklusoscsoport, és ha W jelentése (Wb) általános képletű csoport, akkor R3jelentése 6-14 szénatomos arilcsoport - valamint sóik vagy prodrogjaikneurodegenerációt gátló hatást mutatnak, valamint agyi penetrációsképességük kiváló, és toxicitásuk alacsony, ezért idegi degeneratívbetegségek megelőzésére vagy kezelésére alkalmazhatók. Ó
HU0105480A 1998-12-04 1999-12-02 Benzofuran derivatives, process for preparation of the same and uses thereof HU226652B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34535598 1998-12-04
JP34536598 1998-12-04
PCT/JP1999/006764 WO2000034262A1 (fr) 1998-12-04 1999-12-02 Derives de benzofuranne, leur procede de preparation et leurs utilisations

Publications (3)

Publication Number Publication Date
HUP0105480A2 true HUP0105480A2 (hu) 2002-11-28
HUP0105480A3 HUP0105480A3 (en) 2003-07-28
HU226652B1 HU226652B1 (en) 2009-05-28

Family

ID=26578009

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105480A HU226652B1 (en) 1998-12-04 1999-12-02 Benzofuran derivatives, process for preparation of the same and uses thereof

Country Status (14)

Country Link
US (3) US6479536B1 (hu)
EP (1) EP1136477B1 (hu)
JP (1) JP4778570B2 (hu)
KR (1) KR100660788B1 (hu)
CN (1) CN1297550C (hu)
AT (1) ATE261435T1 (hu)
AU (1) AU1414600A (hu)
CA (1) CA2352786C (hu)
DE (1) DE69915508T2 (hu)
ES (1) ES2213407T3 (hu)
HU (1) HU226652B1 (hu)
NO (1) NO327924B1 (hu)
PT (1) PT1136477E (hu)
WO (1) WO2000034262A1 (hu)

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US6878831B2 (en) 2000-12-28 2005-04-12 Takeda Chemical Industries, Ltd. Process for preparing optically active 2,3-dihydrobenzofuran compounds
CA2452596C (en) * 2001-07-05 2010-12-21 Takeda Chemical Industries, Ltd. Benzo-fused 5-membered heterocyclic compounds, their production and use
DE60228577D1 (de) 2001-07-13 2008-10-09 Takeda Pharmaceutical Verfahren zur herstellung von benzofuranderivaten
WO2003051355A1 (fr) * 2001-12-19 2003-06-26 Takeda Chemical Industries, Ltd. Compositions solides refermant des composes instables a l'oxygene et procede de stabilisation de ces composes
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
ATE478666T1 (de) 2002-03-01 2010-09-15 Takeda Pharmaceutical Antidepressivum
JP4537011B2 (ja) * 2002-03-01 2010-09-01 武田薬品工業株式会社 抗うつ剤
WO2005000829A1 (ja) 2003-06-26 2005-01-06 Takeda Pharmaceutical Company Limited カンナビノイド受容体調節剤
EP1589016A1 (en) * 2004-04-13 2005-10-26 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
JP2007536302A (ja) * 2004-05-05 2007-12-13 エフ．ホフマン−ラ　ロシュ　アーゲー ５−ｈｔ６受容体、５−ｈｔ２ａ受容体、又はその両方の調節に有用なアリールスルホニルベンゾジオキサン類
US7521545B2 (en) * 2004-08-27 2009-04-21 Takeda Pharmaceutical Company Limited Azo compounds and process for production thereof
US20060125084A1 (en) * 2004-12-15 2006-06-15 Fazzio Ronald S Integration of micro-electro mechanical systems and active circuitry
JP4560551B2 (ja) * 2004-12-21 2010-10-13 エフ．ホフマン−ラ ロシュ アーゲー テトラリン及びインダン誘導体及びその使用
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AU2005318595B2 (en) * 2004-12-21 2011-03-03 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
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JP5081629B2 (ja) 2005-12-15 2012-11-28 生化学工業株式会社 長鎖コンドロイチン糖鎖及びその製造方法並びにコンドロイチン合成の促進方法
WO2007147763A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonyl naphthalene derivatives and uses thereof
WO2007147762A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonamidyl tetralin derivatives and uses thereof
CA2653758A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
CA2668864A1 (en) * 2006-11-09 2008-05-15 Takeda Pharmaceutical Company Limited Pharmaceutical composition comprising a dihydrobenzofuranyl isoindoline and a lipophilic component
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Also Published As

Publication number Publication date
WO2000034262A1 (fr) 2000-06-15
NO20012726D0 (no) 2001-06-01
KR100660788B1 (ko) 2007-02-28
KR20010081113A (ko) 2001-08-27
CN1333764A (zh) 2002-01-30
US20050187238A1 (en) 2005-08-25
US6479536B1 (en) 2002-11-12
US7456162B2 (en) 2008-11-25
CN1297550C (zh) 2007-01-31
ATE261435T1 (de) 2004-03-15
HUP0105480A3 (en) 2003-07-28
EP1136477A1 (en) 2001-09-26
AU1414600A (en) 2000-06-26
ES2213407T3 (es) 2004-08-16
EP1136477B1 (en) 2004-03-10
HU226652B1 (en) 2009-05-28
DE69915508D1 (de) 2004-04-15
NO20012726L (no) 2001-07-31
NO327924B1 (no) 2009-10-19
PT1136477E (pt) 2004-08-31
CA2352786C (en) 2009-02-03
US20020160996A1 (en) 2002-10-31
US7101867B2 (en) 2006-09-05
EP1136477A4 (en) 2002-04-10
CA2352786A1 (en) 2000-06-15
JP2009185049A (ja) 2009-08-20
JP4778570B2 (ja) 2011-09-21
DE69915508T2 (de) 2005-01-27

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