DE69915508D1 - Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen - Google Patents

Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen

Info

Publication number
DE69915508D1
DE69915508D1 DE69915508T DE69915508T DE69915508D1 DE 69915508 D1 DE69915508 D1 DE 69915508D1 DE 69915508 T DE69915508 T DE 69915508T DE 69915508 T DE69915508 T DE 69915508T DE 69915508 D1 DE69915508 D1 DE 69915508D1
Authority
DE
Germany
Prior art keywords
group
indicates
chem
formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69915508T
Other languages
English (en)
Other versions
DE69915508T2 (de
Inventor
Shigenori Ohkawa
Yasuyoshi Arikawa
Kouki Kato
Masahiro Okura
Masaki Setoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69915508D1 publication Critical patent/DE69915508D1/de
Publication of DE69915508T2 publication Critical patent/DE69915508T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)
DE69915508T 1998-12-04 1999-12-02 Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen Expired - Lifetime DE69915508T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP34535598 1998-12-04
JP34535598 1998-12-04
JP34536598 1998-12-04
JP34536598 1998-12-04
PCT/JP1999/006764 WO2000034262A1 (fr) 1998-12-04 1999-12-02 Derives de benzofuranne, leur procede de preparation et leurs utilisations

Publications (2)

Publication Number Publication Date
DE69915508D1 true DE69915508D1 (de) 2004-04-15
DE69915508T2 DE69915508T2 (de) 2005-01-27

Family

ID=26578009

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69915508T Expired - Lifetime DE69915508T2 (de) 1998-12-04 1999-12-02 Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen

Country Status (14)

Country Link
US (3) US6479536B1 (de)
EP (1) EP1136477B1 (de)
JP (1) JP4778570B2 (de)
KR (1) KR100660788B1 (de)
CN (1) CN1297550C (de)
AT (1) ATE261435T1 (de)
AU (1) AU1414600A (de)
CA (1) CA2352786C (de)
DE (1) DE69915508T2 (de)
ES (1) ES2213407T3 (de)
HU (1) HU226652B1 (de)
NO (1) NO327924B1 (de)
PT (1) PT1136477E (de)
WO (1) WO2000034262A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1136477B1 (de) * 1998-12-04 2004-03-10 Takeda Chemical Industries, Ltd. Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen
US20040034049A1 (en) * 2000-10-05 2004-02-19 Shigenori Okawa Promoters for the proliferation and differentiation of stem cells and/or neuron precursor cells
ATE414070T1 (de) 2000-12-28 2008-11-15 Takeda Pharmaceutical Verfahren zur herstellung von optisch aktiven 2,4-dihydrobenzofuranverbindungen
CA2452596C (en) 2001-07-05 2010-12-21 Takeda Chemical Industries, Ltd. Benzo-fused 5-membered heterocyclic compounds, their production and use
WO2003006448A1 (fr) * 2001-07-13 2003-01-23 Takeda Chemical Industries, Ltd. Procede de production d'un derive de benzofuranne
US20050118202A1 (en) * 2001-12-19 2005-06-02 Akio Yamashita Solid compositions containing compounds unstable to oxygen and method for stabilization thereof
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
JP4537011B2 (ja) * 2002-03-01 2010-09-01 武田薬品工業株式会社 抗うつ剤
DE60333902D1 (de) * 2002-03-01 2010-10-07 Takeda Pharmaceutical Antidepressivum
CA2531020C (en) * 2003-06-26 2014-03-25 Takeda Pharmaceutical Company Limited Cannabinoid receptor modulator
EP1589016A1 (de) * 2004-04-13 2005-10-26 Cephalon France Thiosubstituierte tricyclische und bicyclische aromatische Methansulfinylderivate
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
WO2005105776A1 (en) * 2004-05-05 2005-11-10 F. Hoffmann-La Roche Ag Arylsulfonyl benzodioxanes useful for modulation the 5-ht6 receptor, the 5-ht2areceptor or both
EP1783121A4 (de) * 2004-08-27 2009-08-05 Takeda Pharmaceutical Azoverbindungen und verfahren zu deren herstellung
US20060125084A1 (en) * 2004-12-15 2006-06-15 Fazzio Ronald S Integration of micro-electro mechanical systems and active circuitry
DE602005019098D1 (de) * 2004-12-21 2010-03-11 Hoffmann La Roche Tetralin- und indanderivate und deren anwendungen
KR20070088798A (ko) * 2004-12-21 2007-08-29 에프. 호프만-라 로슈 아게 크로만 유도체 및 그의 5-ｈｔ 수용체 리간드로서의 용도
BRPI0515835A (pt) * 2004-12-21 2008-08-12 Hoffmann La Roche derivados de tetralina e de indano e seus usos
KR100965190B1 (ko) 2004-12-21 2010-06-24 에프. 호프만-라 로슈 아게 크로만 유도체 및 중추 신경계 장애의 치료에서 그의 용도
JP2008524277A (ja) * 2004-12-21 2008-07-10 エフ．ホフマン−ラ ロシュ アーゲー テトラリン及びインダン誘導体、並びにそれらの５−ｈｔ拮抗薬としての使用
PE20070077A1 (es) * 2005-06-10 2007-02-07 Takeda Pharmaceutical Comprimido con recubierta con azucar
CA2628173A1 (en) * 2005-11-03 2007-05-10 F. Hoffmann-La Roche Ag Arylsulfonylchromans as 5-ht6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors
EP1964924B1 (de) 2005-12-15 2015-09-30 Seikagaku Corporation Langkettige chondroitinzuckerkette und verfahren zur herstellung davon sowie verfahren zur förderung der chondroitinsynthese
JP2009541249A (ja) * 2006-06-20 2009-11-26 エフ．ホフマン−ラ ロシュ アーゲー アリールスルホニルナフタレン誘導体およびその使用
CA2653758A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
WO2007147762A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonamidyl tetralin derivatives and uses thereof
AR063618A1 (es) * 2006-11-09 2009-02-04 Takeda Pharmaceutical Composicion farmaceutica
TWI477497B (zh) * 2009-03-10 2015-03-21 Takeda Pharmaceutical 苯并呋喃衍生物
JPWO2011062194A1 (ja) 2009-11-18 2013-04-04 武田薬品工業株式会社 アミノピリジン誘導体
CN102712853B (zh) 2009-12-24 2014-12-24 Scg化学有限公司 用于减小烃的溴指数的方法
CN105294662B (zh) * 2015-09-11 2018-04-20 中山大学 苯并呋喃喹啉衍生物及其在制备治疗阿尔茨海默病症的药品中的应用
CN115260136B (zh) * 2022-08-09 2023-08-15 嘉兴学院 一种苯酞类化合物及其制备方法

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HU163046B (de) 1970-08-25 1973-05-28
US4212865A (en) 1978-12-26 1980-07-15 Riker Laboratories, Inc. Amine derivatives of 2-nitro-3-phenylbenzofuran
US4881967A (en) 1986-12-10 1989-11-21 E. I. Du Pont De Nemours And Company Heterocyclic 2,3-dihydrobenzofuran herbicides
TW199152B (de) 1990-11-01 1993-02-01 Takeda Pharm Industry Co Ltd
WO1992012144A1 (fr) * 1990-12-28 1992-07-23 Teijin Limited Compose cyclique condense de benzoxa, son procede de production, et composition pharmaceutique le contenant
JP3168728B2 (ja) * 1991-09-18 2001-05-21 富士レビオ株式会社 ３，５−ジヒドロキシヘプタン酸誘導体
EP0539709A1 (de) * 1991-09-18 1993-05-05 FUJIREBIO Inc. 3,5-Dihydroxyheptansäurederivate und deren Lactone als HMG-CoA-Reduktase-Inhibitoren
GB9408577D0 (en) * 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound
DK0685475T3 (da) 1994-05-31 1999-08-30 Bayer Ag Amino-benzofuryl- og thienylderivater
GB9522007D0 (en) * 1995-10-27 1996-01-03 Fujisawa Pharmaceutical Co New compound
WO1998008842A1 (en) 1996-08-29 1998-03-05 Takeda Chemical Industries, Ltd. Cyclic ether compounds as sodium channel modulators
AU7550398A (en) 1997-06-05 1998-12-21 Takeda Chemical Industries Ltd. Heterocyclic compounds, their production and use
EP1136477B1 (de) * 1998-12-04 2004-03-10 Takeda Chemical Industries, Ltd. Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen

Also Published As

Publication number Publication date
EP1136477A4 (de) 2002-04-10
WO2000034262A1 (fr) 2000-06-15
JP2009185049A (ja) 2009-08-20
US20050187238A1 (en) 2005-08-25
CA2352786A1 (en) 2000-06-15
NO20012726D0 (no) 2001-06-01
KR20010081113A (ko) 2001-08-27
NO20012726L (no) 2001-07-31
EP1136477B1 (de) 2004-03-10
DE69915508T2 (de) 2005-01-27
CN1333764A (zh) 2002-01-30
JP4778570B2 (ja) 2011-09-21
US6479536B1 (en) 2002-11-12
CA2352786C (en) 2009-02-03
AU1414600A (en) 2000-06-26
HUP0105480A2 (hu) 2002-11-28
HUP0105480A3 (en) 2003-07-28
US7101867B2 (en) 2006-09-05
ES2213407T3 (es) 2004-08-16
HU226652B1 (en) 2009-05-28
US7456162B2 (en) 2008-11-25
CN1297550C (zh) 2007-01-31
EP1136477A1 (de) 2001-09-26
KR100660788B1 (ko) 2007-02-28
NO327924B1 (no) 2009-10-19
US20020160996A1 (en) 2002-10-31
ATE261435T1 (de) 2004-03-15
PT1136477E (pt) 2004-08-31

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Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP