ATE261435T1 - Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen - Google Patents
Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungenInfo
- Publication number
- ATE261435T1 ATE261435T1 AT99973289T AT99973289T ATE261435T1 AT E261435 T1 ATE261435 T1 AT E261435T1 AT 99973289 T AT99973289 T AT 99973289T AT 99973289 T AT99973289 T AT 99973289T AT E261435 T1 ATE261435 T1 AT E261435T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- indicates
- chem
- formula
- hydrogen atom
- Prior art date
Links
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical class C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940043274 prophylactic drug Drugs 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34535598 | 1998-12-04 | ||
| JP34536598 | 1998-12-04 | ||
| PCT/JP1999/006764 WO2000034262A1 (en) | 1998-12-04 | 1999-12-02 | Benzofuran derivatives, process for the preparation of the same and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261435T1 true ATE261435T1 (de) | 2004-03-15 |
Family
ID=26578009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99973289T ATE261435T1 (de) | 1998-12-04 | 1999-12-02 | Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6479536B1 (de) |
| EP (1) | EP1136477B1 (de) |
| JP (1) | JP4778570B2 (de) |
| KR (1) | KR100660788B1 (de) |
| CN (1) | CN1297550C (de) |
| AT (1) | ATE261435T1 (de) |
| AU (1) | AU1414600A (de) |
| CA (1) | CA2352786C (de) |
| DE (1) | DE69915508T2 (de) |
| ES (1) | ES2213407T3 (de) |
| HU (1) | HU226652B1 (de) |
| NO (1) | NO327924B1 (de) |
| PT (1) | PT1136477E (de) |
| WO (1) | WO2000034262A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000034262A1 (en) * | 1998-12-04 | 2000-06-15 | Takeda Chemical Industries, Ltd. | Benzofuran derivatives, process for the preparation of the same and uses thereof |
| ES2317935T3 (es) * | 2000-10-05 | 2009-05-01 | Takeda Pharmaceutical Company Limited | Promotores de la proliferacion y diferenciacion de celulas pluripotenciales y/o celulas precursoras neuronales. |
| US6878831B2 (en) | 2000-12-28 | 2005-04-12 | Takeda Chemical Industries, Ltd. | Process for preparing optically active 2,3-dihydrobenzofuran compounds |
| US7208495B2 (en) | 2001-07-05 | 2007-04-24 | Takeda Pharmaceutical Company Limited | Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof |
| DE60228577D1 (de) | 2001-07-13 | 2008-10-09 | Takeda Pharmaceutical | Verfahren zur herstellung von benzofuranderivaten |
| AU2002366313A1 (en) * | 2001-12-19 | 2003-06-30 | Takeda Chemical Industries, Ltd. | Solid compositions containng compounds unstable to oxygen and method for stabilization thereof |
| US7078541B2 (en) * | 2002-02-07 | 2006-07-18 | Galileo Pharmaceuticals, Inc. | Benzofuran derivatives |
| US6653346B1 (en) * | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
| JP4537011B2 (ja) * | 2002-03-01 | 2010-09-01 | 武田薬品工業株式会社 | 抗うつ剤 |
| US20050148650A1 (en) * | 2002-03-01 | 2005-07-07 | Shigenori Ohkawa | Antidepressant |
| HRP20130638T1 (en) * | 2003-06-26 | 2013-08-31 | Takeda Pharmaceutical Company Limited | Cannabinoid receptor modulator |
| EP1589016A1 (de) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thiosubstituierte tricyclische und bicyclische aromatische Methansulfinylderivate |
| US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| CN100540546C (zh) * | 2004-05-05 | 2009-09-16 | 弗·哈夫曼-拉罗切有限公司 | 用于调节5-ht6受体、5-ht2a受体或两者的芳基磺酰基苯并二烷 |
| CA2576063A1 (en) * | 2004-08-27 | 2006-03-02 | Takeda Pharmaceutical Company Limited | Azo compounds and process for production thereof |
| US20060125084A1 (en) * | 2004-12-15 | 2006-06-15 | Fazzio Ronald S | Integration of micro-electro mechanical systems and active circuitry |
| JP4560551B2 (ja) * | 2004-12-21 | 2010-10-13 | エフ．ホフマン−ラ ロシュ アーゲー | テトラリン及びインダン誘導体及びその使用 |
| MX2007007482A (es) * | 2004-12-21 | 2007-07-20 | Hoffmann La Roche | Derivados de tetralina e indano y usos de los mismos como antagonistas de 5-ht. |
| DE602005017663D1 (de) * | 2004-12-21 | 2009-12-24 | Hoffmann La Roche | Tetralin- und indanderivate und anwendungen davon |
| BRPI0515830A (pt) | 2004-12-21 | 2008-08-05 | F Hoffmann La Roche | derivados de cromano e usos dos mesmos no tratamento de distúrbios do sistema nervoso central |
| MX2007007480A (es) * | 2004-12-21 | 2007-07-20 | Hoffmann La Roche | Derivados de cromano y su uso como ligandos del receptor 5-ht. |
| PE20070077A1 (es) * | 2005-06-10 | 2007-02-07 | Takeda Pharmaceutical | Comprimido con recubierta con azucar |
| CN101300246A (zh) * | 2005-11-03 | 2008-11-05 | 弗·哈夫曼-拉罗切有限公司 | 作为5－ht6抑制剂的芳基磺酰基色满类化合物作为蛋白激酶抑制剂的吲哚基马来酰亚胺衍生物 |
| WO2007069693A1 (ja) | 2005-12-15 | 2007-06-21 | Seikagaku Corporation | 長鎖コンドロイチン糖鎖及びその製造方法並びにコンドロイチン合成の促進方法 |
| CA2654822A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonyl naphthalene derivatives and uses thereof |
| MX2008015843A (es) * | 2006-06-20 | 2009-01-09 | Hoffmann La Roche | Derivados de tetralina e indano y usos de los mismos. |
| CA2655524A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffman-La Roche Ag | Arylsulfonamidyl tetralin derivatives and uses thereof |
| ATE456365T1 (de) * | 2006-11-09 | 2010-02-15 | Takeda Pharmaceutical | Pharmazeutische zusammensetzung mit einem dihydrobenzofuranyl-isoindolin und einer lipophilen komponente |
| US8288390B2 (en) * | 2009-03-10 | 2012-10-16 | Takeda Pharmaceutical Company Limited | Benzofuran derivatives |
| EP2502909A4 (de) | 2009-11-18 | 2013-04-03 | Takeda Pharmaceutical | Aminopyridinderivat |
| US9765264B2 (en) | 2009-12-24 | 2017-09-19 | Scg Chemicals Co., Ltd. | Process for reducing the bromine index of a hydrocarbon |
| CN105294662B (zh) * | 2015-09-11 | 2018-04-20 | 中山大学 | 苯并呋喃喹啉衍生物及其在制备治疗阿尔茨海默病症的药品中的应用 |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
| CN115260136B (zh) * | 2022-08-09 | 2023-08-15 | 嘉兴学院 | 一种苯酞类化合物及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU163046B (de) | 1970-08-25 | 1973-05-28 | ||
| US4212865A (en) | 1978-12-26 | 1980-07-15 | Riker Laboratories, Inc. | Amine derivatives of 2-nitro-3-phenylbenzofuran |
| US4881967A (en) | 1986-12-10 | 1989-11-21 | E. I. Du Pont De Nemours And Company | Heterocyclic 2,3-dihydrobenzofuran herbicides |
| IE68675B1 (en) * | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
| WO1992012144A1 (en) * | 1990-12-28 | 1992-07-23 | Teijin Limited | Condensed benzoxa ring compound, production thereof, and pharmaceutical composition containing the same |
| EP0539709A1 (de) * | 1991-09-18 | 1993-05-05 | FUJIREBIO Inc. | 3,5-Dihydroxyheptansäurederivate und deren Lactone als HMG-CoA-Reduktase-Inhibitoren |
| JP3168728B2 (ja) * | 1991-09-18 | 2001-05-21 | 富士レビオ株式会社 | ３，５−ジヒドロキシヘプタン酸誘導体 |
| GB9408577D0 (en) * | 1994-04-29 | 1994-06-22 | Fujisawa Pharmaceutical Co | New compound |
| DK0685475T3 (da) * | 1994-05-31 | 1999-08-30 | Bayer Ag | Amino-benzofuryl- og thienylderivater |
| GB9522007D0 (en) * | 1995-10-27 | 1996-01-03 | Fujisawa Pharmaceutical Co | New compound |
| ATE234298T1 (de) | 1996-08-29 | 2003-03-15 | Takeda Chemical Industries Ltd | Zyklische etherverbindungen als natriumkanal- modulatoren |
| US7008950B1 (en) | 1997-06-05 | 2006-03-07 | Takeda Chemical Industries, Ltd. | Benzofurans as suppressors of neurodegeneration |
| WO2000034262A1 (en) * | 1998-12-04 | 2000-06-15 | Takeda Chemical Industries, Ltd. | Benzofuran derivatives, process for the preparation of the same and uses thereof |
-
1999
- 1999-12-02 WO PCT/JP1999/006764 patent/WO2000034262A1/ja not_active Ceased
- 1999-12-02 US US09/857,293 patent/US6479536B1/en not_active Expired - Lifetime
- 1999-12-02 CA CA002352786A patent/CA2352786C/en not_active Expired - Fee Related
- 1999-12-02 AU AU14146/00A patent/AU1414600A/en not_active Abandoned
- 1999-12-02 HU HU0105480A patent/HU226652B1/hu not_active IP Right Cessation
- 1999-12-02 DE DE69915508T patent/DE69915508T2/de not_active Expired - Lifetime
- 1999-12-02 EP EP99973289A patent/EP1136477B1/de not_active Expired - Lifetime
- 1999-12-02 PT PT99973289T patent/PT1136477E/pt unknown
- 1999-12-02 ES ES99973289T patent/ES2213407T3/es not_active Expired - Lifetime
- 1999-12-02 KR KR1020017006999A patent/KR100660788B1/ko not_active Expired - Fee Related
- 1999-12-02 CN CNB998156825A patent/CN1297550C/zh not_active Expired - Fee Related
- 1999-12-02 AT AT99973289T patent/ATE261435T1/de active
-
2001
- 2001-06-01 NO NO20012726A patent/NO327924B1/no not_active IP Right Cessation
-
2002
- 2002-04-11 US US10/120,102 patent/US7101867B2/en not_active Expired - Fee Related
-
2005
- 2005-03-17 US US11/081,615 patent/US7456162B2/en not_active Expired - Fee Related
-
2009
- 2009-04-08 JP JP2009094172A patent/JP4778570B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69915508D1 (de) | 2004-04-15 |
| KR20010081113A (ko) | 2001-08-27 |
| US20020160996A1 (en) | 2002-10-31 |
| JP2009185049A (ja) | 2009-08-20 |
| JP4778570B2 (ja) | 2011-09-21 |
| ES2213407T3 (es) | 2004-08-16 |
| HU226652B1 (en) | 2009-05-28 |
| US20050187238A1 (en) | 2005-08-25 |
| KR100660788B1 (ko) | 2007-02-28 |
| US7456162B2 (en) | 2008-11-25 |
| US6479536B1 (en) | 2002-11-12 |
| EP1136477B1 (de) | 2004-03-10 |
| NO20012726D0 (no) | 2001-06-01 |
| EP1136477A1 (de) | 2001-09-26 |
| CN1297550C (zh) | 2007-01-31 |
| CA2352786A1 (en) | 2000-06-15 |
| HUP0105480A3 (en) | 2003-07-28 |
| NO327924B1 (no) | 2009-10-19 |
| DE69915508T2 (de) | 2005-01-27 |
| CN1333764A (zh) | 2002-01-30 |
| HUP0105480A2 (hu) | 2002-11-28 |
| PT1136477E (pt) | 2004-08-31 |
| US7101867B2 (en) | 2006-09-05 |
| AU1414600A (en) | 2000-06-26 |
| WO2000034262A1 (en) | 2000-06-15 |
| CA2352786C (en) | 2009-02-03 |
| EP1136477A4 (de) | 2002-04-10 |
| NO20012726L (no) | 2001-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE261435T1 (de) | Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen | |
| AU550774B2 (en) | 1-aryl-2-aminomethyl cyclopropane carboxylates | |
| BG104998A (en) | Isothiazole derivatives useful as anticancer agents | |
| CA2183655A1 (en) | 4-polycyclic amino-substituted quinazoline derivatives | |
| ATE175676T1 (de) | Propiophenon-derivate und verfahren zur ihrer herstellung | |
| CA2212326A1 (en) | O-carbamoyl-(d)-phenylalanilol compounds and process for preparing the same | |
| CA2240060A1 (en) | O-carbamoyl-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same | |
| ATE211474T1 (de) | Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente | |
| DE69119875D1 (de) | Verwendung von Dioxabicyclo [3.3.0]octane Derivaten zur Herstellung eines Arzneimittels zur Hemmung des Cholesterinmetabolismus. | |
| HUT63409A (en) | Process for producing 4-amino-2-ureidopyrimidine-5-carboxylic acid amide derivatives and pharmaceutical compositions comprising same | |
| DE3683822D1 (de) | Chartreusinderivate und salze, diese enthaltende antitumorzusammensetzungen und verfahren zu ihrer herstellung. | |
| ATE159029T1 (de) | Phosphonsäurederivate, verfahren zur herstellung und ihre verwendung | |
| ES8604960A1 (es) | Procedimiento para preparar derivados de 1,6-naftiridina | |
| ATE149165T1 (de) | Stickstoff enthaltende bizyklische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen | |
| ATE154359T1 (de) | 2'-methylidenpyrimidinnukleosidverbindungen, ihre verwendung und verfahren zu ihrer herstellung | |
| KR880013896A (ko) | 벤조푸로[3,2-c]퀴놀린 화합물 | |
| DE69818060D1 (de) | Polyhydroxyalkylpyrazine derivate, deren herstellung,diese enthaltende arzneimitteln | |
| DE69608030D1 (de) | Verfahren zur Herstellung von 2-Naphthamid-Derivate, und Zwischenprodukte zur Herstellung von 2-Naphthamid-Derivate | |
| RU97119859A (ru) | Производные азациклоалкана, их получение и применение в терапии |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1136477 Country of ref document: EP |