HUP0004577A1 - Kationos nukleinsav transzfekciós ágensek új csoportja - Google Patents

Kationos nukleinsav transzfekciós ágensek új csoportja

Info

Publication number
HUP0004577A1
HUP0004577A1 HU0004577A HUP0004577A HUP0004577A1 HU P0004577 A1 HUP0004577 A1 HU P0004577A1 HU 0004577 A HU0004577 A HU 0004577A HU P0004577 A HUP0004577 A HU P0004577A HU P0004577 A1 HUP0004577 A1 HU P0004577A1
Authority
HU
Hungary
Prior art keywords
nucleic acid
novel class
acid cationic
transfecting agents
cationic
Prior art date
Application number
HU0004577A
Other languages
English (en)
Inventor
Michel Bessodes
Jean Herscovici
Daniel Scherman
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of HUP0004577A1 publication Critical patent/HUP0004577A1/hu
Publication of HUP0004577A3 publication Critical patent/HUP0004577A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgya nukleinsav kationos transzfekciós ágensek újcsoportja, azzal jellemezve, hogy a transzfekciós ágensek tartalmaznaklegalább egy lipofil részt egy kationos hidrofil részhez kapcsolva,ahol az említett hidrofil kationos rész egy 5 vagy 6 atomból álló,aminocsoportokkal szubsztituált heterociklusos gyűrűből áll. Atalálmány tárgyát képezi ezen túl az említett transzfekciós ágensekalkalmazása nukleinsavak in vivo, ex vivo és/vagy in vitrotranszfektálására, valamint az előállításukra szolgáló eljárás. Ó
HU0004577A 1997-06-06 1998-06-03 Novel class of nucleic acid cationic transfecting agents HUP0004577A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9707014A FR2764304B1 (fr) 1997-06-06 1997-06-06 Nouvelle classe d'agents transfectants cationiques des acides nucleiques
PCT/FR1998/001112 WO1998055490A1 (fr) 1997-06-06 1998-06-03 Nouvelle classe d'agents transfectants cationiques des acides nucleiques

Publications (2)

Publication Number Publication Date
HUP0004577A1 true HUP0004577A1 (hu) 2001-04-28
HUP0004577A3 HUP0004577A3 (en) 2003-03-28

Family

ID=9507684

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004577A HUP0004577A3 (en) 1997-06-06 1998-06-03 Novel class of nucleic acid cationic transfecting agents

Country Status (18)

Country Link
EP (1) EP0986568B1 (hu)
JP (1) JP2002504815A (hu)
KR (1) KR20010013312A (hu)
CN (1) CN1259134A (hu)
AT (1) ATE214708T1 (hu)
AU (1) AU737579B2 (hu)
BR (1) BR9809953A (hu)
CA (1) CA2292837A1 (hu)
DE (1) DE69804302T2 (hu)
DK (1) DK0986568T3 (hu)
ES (1) ES2174445T3 (hu)
FR (1) FR2764304B1 (hu)
HU (1) HUP0004577A3 (hu)
NO (1) NO314147B1 (hu)
PL (1) PL337177A1 (hu)
PT (1) PT986568E (hu)
WO (1) WO1998055490A1 (hu)
ZA (1) ZA984845B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012945A2 (en) * 1997-09-08 1999-03-18 Valentis,Inc. Hydrophobic glycosylamine derivatives, compositions, and methods for use
DE19942864A1 (de) * 1999-09-08 2001-03-15 Knoell Hans Forschung Ev Neue O-(Aminoalkyl)-Derivate von Monosacchariden, Verfahren zu ihrer Herstellung und ihre Verwendung als antibakterielle Mittel
JP4629333B2 (ja) * 2001-08-29 2011-02-09 アベンティス・ファーマ・ソシエテ・アノニム アミノグリコシドの脂質誘導体
FR2829136B1 (fr) * 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
DK2027137T3 (en) 2005-06-08 2015-05-18 Amicus Therapeutics Inc Imino and aminosugar PURIFICATION
WO2008081686A1 (ja) * 2006-12-28 2008-07-10 Konica Minolta Holdings, Inc. コレステロール誘導体、リポソーム、リポソームの形成方法およびｘ線用造影剤
WO2017151733A1 (en) * 2016-03-01 2017-09-08 Molecular Transfer, Inc. Plant virus movement proteins and methods of using the same
CN112384523A (zh) * 2018-05-16 2021-02-19 川斯勒佰尔公司 核糖阳离子脂质
JP2021534196A (ja) 2018-08-23 2021-12-09 シージェン インコーポレイテッド 抗ｔｉｇｉｔ抗体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2774417B2 (ja) * 1991-08-07 1998-07-09 株式会社ディ・ディ・エス研究所 ペプチド骨格を有する分枝鎖型糖複合体及び微粒子キャリヤー
DE4329093A1 (de) * 1993-08-30 1995-03-02 Bayer Ag Substituierte Aminoalkylglycoside
AU4923696A (en) * 1995-02-10 1996-08-27 Nexstar Pharmaceuticals, Inc. Lipid constructs for cytoplasmic delivery of agents

Also Published As

Publication number Publication date
AU737579B2 (en) 2001-08-23
EP0986568A1 (fr) 2000-03-22
AU8025098A (en) 1998-12-21
EP0986568B1 (fr) 2002-03-20
FR2764304B1 (fr) 1999-07-16
HUP0004577A3 (en) 2003-03-28
NO995858L (no) 1999-11-30
BR9809953A (pt) 2000-08-01
CN1259134A (zh) 2000-07-05
ES2174445T3 (es) 2002-11-01
WO1998055490A1 (fr) 1998-12-10
FR2764304A1 (fr) 1998-12-11
DK0986568T3 (da) 2002-06-10
ATE214708T1 (de) 2002-04-15
PT986568E (pt) 2002-08-30
JP2002504815A (ja) 2002-02-12
ZA984845B (en) 1998-12-29
NO995858D0 (no) 1999-11-30
KR20010013312A (ko) 2001-02-26
CA2292837A1 (fr) 1998-12-10
NO314147B1 (no) 2003-02-03
DE69804302D1 (de) 2002-04-25
DE69804302T2 (de) 2002-10-17
PL337177A1 (en) 2000-08-14

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees