HUP0003396A1 - Szomatosztatin antagonista peptidek - Google Patents

Szomatosztatin antagonista peptidek

Info

Publication number
HUP0003396A1
HUP0003396A1 HU0003396A HUP0003396A HUP0003396A1 HU P0003396 A1 HUP0003396 A1 HU P0003396A1 HU 0003396 A HU0003396 A HU 0003396A HU P0003396 A HUP0003396 A HU P0003396A HU P0003396 A1 HUP0003396 A1 HU P0003396A1
Authority
HU
Hungary
Prior art keywords
somatostatin
amino acid
antagonist peptides
somatostatin antagonist
somatostatin receptors
Prior art date
Application number
HU0003396A
Other languages
English (en)
Inventor
David H. Coy
Barry Morgan
William Murphy
Original Assignee
Societe De Conseils De Recherches Et D'applications Scientifiques S.A.
The Administration Of The Tulane Educational Fund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/855,204 external-priority patent/US6262229B1/en
Application filed by Societe De Conseils De Recherches Et D'applications Scientifiques S.A., The Administration Of The Tulane Educational Fund filed Critical Societe De Conseils De Recherches Et D'applications Scientifiques S.A.
Publication of HUP0003396A1 publication Critical patent/HUP0003396A1/hu
Publication of HUP0003396A3 publication Critical patent/HUP0003396A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány olyan szomatosztatinanalógokra vonatkozik, amelyekaminosavszekvenciájában a második helyen D-aminosav szerepel, ésamelyek a szomatosztatinreceptorokra antagonista hatást fejtenek ki,így a növekedési hormon és az inzulin felszabadulásának elősegítésére,valamint a sebgyógyulás és az angiogenezis fokozására, ezenkívül a Tyrcsoporton jódizotóppal jelzett formában a szomatosztatinreceptorokdetektálására alkalmazhatók. Ó
HU0003396A 1996-12-04 1997-12-04 Somatostatin antagonist peptides HUP0003396A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3235896P 1996-12-04 1996-12-04
US76067296A 1996-12-04 1996-12-04
US08/855,204 US6262229B1 (en) 1996-12-04 1997-05-13 Somatostatin antagonists

Publications (2)

Publication Number Publication Date
HUP0003396A1 true HUP0003396A1 (hu) 2001-02-28
HUP0003396A3 HUP0003396A3 (en) 2001-03-28

Family

ID=27364103

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003396A HUP0003396A3 (en) 1996-12-04 1997-12-04 Somatostatin antagonist peptides

Country Status (17)

Country Link
EP (1) EP0956296B1 (hu)
JP (2) JP4124820B2 (hu)
KR (1) KR100479149B1 (hu)
AT (1) ATE330966T1 (hu)
AU (1) AU728224B2 (hu)
BR (1) BR9714376A (hu)
CA (1) CA2274144C (hu)
DE (1) DE69736193T2 (hu)
ES (1) ES2264174T3 (hu)
HU (1) HUP0003396A3 (hu)
IL (1) IL130166A0 (hu)
MX (1) MXPA99004944A (hu)
NZ (1) NZ335879A (hu)
PL (1) PL334089A1 (hu)
RU (1) RU2179172C2 (hu)
TW (1) TW575582B (hu)
WO (1) WO1998024807A2 (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864234B1 (en) 1999-06-25 2005-03-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin agonists
WO2001000676A1 (en) * 1999-06-25 2001-01-04 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin agonists
DE60226419D1 (de) * 2001-03-08 2008-06-19 Univ Tulane Somatostatin-antagonisten
MXPA03009048A (es) * 2001-04-09 2004-02-12 Univ Tulane Agonistas de la somatostatina.
US8691761B2 (en) 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
US7960342B2 (en) * 2006-10-16 2011-06-14 The Salk Institute For Biological Studies Receptor(SSTR2)-selective somatostatin antagonists
ES2351569B8 (es) * 2009-05-07 2012-06-20 Bcn Peptides S.A. Ligandos peptídicos de receptores de somatostatina.
WO2011151782A1 (en) 2010-06-02 2011-12-08 Preglem Sa A role for somatostatin to modulate initiation of follicular growth in the human ovary
EP2399931A1 (fr) * 2010-06-22 2011-12-28 Ipsen Pharma S.A.S. Nouveaux composés octapeptidiques et leur utilisation thérapeutique

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
JP2882679B2 (ja) * 1989-04-26 1999-04-12 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 線状ソマトスタチン類似体
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin

Also Published As

Publication number Publication date
EP0956296B1 (en) 2006-06-21
IL130166A0 (en) 2000-06-01
DE69736193T2 (de) 2007-05-03
EP0956296A2 (en) 1999-11-17
MXPA99004944A (es) 2004-09-10
NZ335879A (en) 2000-11-24
JP4264762B2 (ja) 2009-05-20
WO1998024807A2 (en) 1998-06-11
WO1998024807A3 (en) 1998-10-15
KR100479149B1 (ko) 2005-03-25
JP4124820B2 (ja) 2008-07-23
AU7624898A (en) 1998-06-29
CA2274144A1 (en) 1998-06-11
ATE330966T1 (de) 2006-07-15
PL334089A1 (en) 2000-01-31
HUP0003396A3 (en) 2001-03-28
ES2264174T3 (es) 2006-12-16
TW575582B (en) 2004-02-11
DE69736193D1 (de) 2006-08-03
CA2274144C (en) 2004-03-30
KR20000069243A (ko) 2000-11-25
BR9714376A (pt) 2000-03-21
JP2008120818A (ja) 2008-05-29
RU2179172C2 (ru) 2002-02-10
AU728224B2 (en) 2001-01-04
JP2001505580A (ja) 2001-04-24

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees