HUP0002459A2 - Optikailag aktív szulfoxidszármazékok sói, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Optikailag aktív szulfoxidszármazékok sói, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0002459A2 HUP0002459A2 HU0002459A HUP0002459A HUP0002459A2 HU P0002459 A2 HUP0002459 A2 HU P0002459A2 HU 0002459 A HU0002459 A HU 0002459A HU P0002459 A HUP0002459 A HU P0002459A HU P0002459 A2 HUP0002459 A2 HU P0002459A2
- Authority
- HU
- Hungary
- Prior art keywords
- prevent
- treat
- optically active
- salts
- sulfoxide derivative
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 150000003462 sulfoxides Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 2
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 2
- 108010040722 Neurokinin-2 Receptors Proteins 0.000 abstract 2
- 102100037342 Substance-K receptor Human genes 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 102000003141 Tachykinin Human genes 0.000 abstract 1
- 206010046555 Urinary retention Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 206010039083 rhinitis Diseases 0.000 abstract 1
- 108060008037 tachykinin Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány egy optikailag aktív (I) képletű szulfoxidszármazék újsóira és az ezeket tartalmazó gyógyszerkészítményekre és azokalkalmazására vonatkozik. Ezek a vegyületek kiváló antagonistaaktivitást mutatnak mind a P anyag receptorok, mint a neurokinin Areceptorok ellen. Közelebbről, a találmány szerinti új sók az 1-{2-[(2R)-(3,4-diklór-fenil)-4-(3,4,5-trimetoxi-benzoil)-morfolin--2-il]-etil}spiro[benzol(c)tiofén-1(3H),4'-piperidin]-(2S)-oxidhidrokloridsója és fumarátsója. A találmány szerinti új sókathatóanyagként tartalmazó gyógyászati készítmények felhasználhatóktöbbek között tachikinin által közvetített megbetegedések megelőzésérevagy kezelésére, NK1 receptor és/vagy NK2 receptor gátlására, asztmaés/vagy bronchitis megelőzésére vagy kezelésére, rhinitisz, azazszénanátha megelőzésére vagy kezelésére, allergia megelőzésére vagykezelésére, valamint vizeletvisszatartási rendellenességekmegelőzésére vagy kezelésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14180597 | 1997-05-30 | ||
| PCT/JP1998/002308 WO1998054191A1 (fr) | 1997-05-30 | 1998-05-27 | Sels de derive de sulfoxyde optiquement actif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002459A2 true HUP0002459A2 (hu) | 2001-06-28 |
| HUP0002459A3 HUP0002459A3 (en) | 2002-10-28 |
Family
ID=15300548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002459A HUP0002459A3 (en) | 1997-05-30 | 1998-05-27 | Salts of optically active sulfoxide derivative, pharmaceutical compositions containing them and use thereof |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6362179B1 (hu) |
| EP (1) | EP0987269B1 (hu) |
| KR (1) | KR100432210B1 (hu) |
| CN (1) | CN1153773C (hu) |
| AT (1) | ATE247122T1 (hu) |
| AU (1) | AU732384B2 (hu) |
| BR (1) | BR9809713A (hu) |
| CA (1) | CA2290392C (hu) |
| CZ (1) | CZ296599B6 (hu) |
| DE (1) | DE69817178T2 (hu) |
| DK (1) | DK0987269T3 (hu) |
| ES (1) | ES2202853T3 (hu) |
| HK (1) | HK1025321A1 (hu) |
| HU (1) | HUP0002459A3 (hu) |
| ID (1) | ID23697A (hu) |
| IL (2) | IL132962A0 (hu) |
| NO (1) | NO995847L (hu) |
| NZ (2) | NZ513904A (hu) |
| PL (1) | PL193115B1 (hu) |
| PT (1) | PT987269E (hu) |
| RU (1) | RU2190615C2 (hu) |
| TR (1) | TR199902943T2 (hu) |
| WO (1) | WO1998054191A1 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2203061T3 (es) * | 1998-01-23 | 2004-04-01 | Sankyo Company Limited | Derivados de espiropiperadina. |
| US20040058914A1 (en) * | 2000-12-22 | 2004-03-25 | Takayuki Doi | Combination drugs |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3742649B2 (ja) | 1993-01-22 | 2006-02-08 | アデザ・バイオメデイカル・コーポレイシヨン | 切迫分娩についての危険にある女性における膜の破裂を決定するための検定方法 |
| ATE158580T1 (de) | 1993-05-06 | 1997-10-15 | Merrell Pharma Inc | Substituierte pyrrolidin-3-alkyl-piperidine verwendbar als tachykinin-antagonisten |
| AU680020B2 (en) | 1993-06-07 | 1997-07-17 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| WO1995028389A1 (fr) * | 1994-04-15 | 1995-10-26 | Yamanouchi Pharmaceutical Co., Ltd. | Compose spiro et composition medicinale issue de ce compose |
| FR2729954B1 (fr) * | 1995-01-30 | 1997-08-01 | Sanofi Sa | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| JP3088672B2 (ja) * | 1995-12-01 | 2000-09-18 | 三共株式会社 | 飽和複素環化合物 |
| HU224225B1 (hu) | 1995-12-01 | 2005-06-28 | Sankyo Co. Ltd. | Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására |
-
1998
- 1998-05-27 AT AT98921817T patent/ATE247122T1/de not_active IP Right Cessation
- 1998-05-27 WO PCT/JP1998/002308 patent/WO1998054191A1/ja active IP Right Grant
- 1998-05-27 EP EP98921817A patent/EP0987269B1/en not_active Expired - Lifetime
- 1998-05-27 NZ NZ513904A patent/NZ513904A/xx not_active Application Discontinuation
- 1998-05-27 HU HU0002459A patent/HUP0002459A3/hu unknown
- 1998-05-27 CZ CZ0419599A patent/CZ296599B6/cs not_active IP Right Cessation
- 1998-05-27 NZ NZ501332A patent/NZ501332A/en unknown
- 1998-05-27 CA CA002290392A patent/CA2290392C/en not_active Expired - Fee Related
- 1998-05-27 PL PL336894A patent/PL193115B1/pl not_active IP Right Cessation
- 1998-05-27 DK DK98921817T patent/DK0987269T3/da active
- 1998-05-27 ID IDW991467A patent/ID23697A/id unknown
- 1998-05-27 PT PT98921817T patent/PT987269E/pt unknown
- 1998-05-27 AU AU74515/98A patent/AU732384B2/en not_active Ceased
- 1998-05-27 CN CNB988074117A patent/CN1153773C/zh not_active Expired - Fee Related
- 1998-05-27 ES ES98921817T patent/ES2202853T3/es not_active Expired - Lifetime
- 1998-05-27 DE DE69817178T patent/DE69817178T2/de not_active Expired - Lifetime
- 1998-05-27 TR TR1999/02943T patent/TR199902943T2/xx unknown
- 1998-05-27 BR BR9809713-0A patent/BR9809713A/pt not_active Application Discontinuation
- 1998-05-27 IL IL13296298A patent/IL132962A0/xx not_active IP Right Cessation
- 1998-05-27 RU RU99123631/04A patent/RU2190615C2/ru not_active IP Right Cessation
- 1998-05-27 KR KR10-1999-7010921A patent/KR100432210B1/ko not_active IP Right Cessation
-
1999
- 1999-11-16 IL IL132962A patent/IL132962A/en unknown
- 1999-11-23 US US09/447,401 patent/US6362179B1/en not_active Expired - Fee Related
- 1999-11-29 NO NO995847A patent/NO995847L/no not_active Application Discontinuation
-
2000
- 2000-07-20 HK HK00104485A patent/HK1025321A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |