HUP0001261A2 - Eljárás az in vivo bekövetkező sejthalál leképezésére - Google Patents

Eljárás az in vivo bekövetkező sejthalál leképezésére

Info

Publication number
HUP0001261A2
HUP0001261A2 HU0001261A HUP0001261A HUP0001261A2 HU P0001261 A2 HUP0001261 A2 HU P0001261A2 HU 0001261 A HU0001261 A HU 0001261A HU P0001261 A HUP0001261 A HU P0001261A HU P0001261 A2 HUP0001261 A2 HU P0001261A2
Authority
HU
Hungary
Prior art keywords
vivo
cell death
imaging cell
imaging
things
Prior art date
Application number
HU0001261A
Other languages
English (en)
Inventor
Francis G. Blankenberg
Peter D. Katsikis
H. W. Strauss
Jonathan F. Tait
Original Assignee
The Board Of Trustees Of The Leland Stanford Junior University
University Of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The Leland Stanford Junior University, University Of Washington filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Publication of HUP0001261A2 publication Critical patent/HUP0001261A2/hu
Publication of HUP0001261A3 publication Critical patent/HUP0001261A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4057—Arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/425—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using detectors specially adapted to be used in the interior of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydroponics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Atalálmány az in vivő bekövetkező apőptózis leképezésének eljárásátírja le, melyhez többek között radiőaktívan jelölt annexint használfel. ŕ
HU0001261A 1997-04-30 1998-04-28 Method of imaging cell death in vivo HUP0001261A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4539997P 1997-04-30 1997-04-30

Publications (2)

Publication Number Publication Date
HUP0001261A2 true HUP0001261A2 (hu) 2000-08-28
HUP0001261A3 HUP0001261A3 (en) 2001-11-28

Family

ID=21937648

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001261A HUP0001261A3 (en) 1997-04-30 1998-04-28 Method of imaging cell death in vivo

Country Status (16)

Country Link
US (3) US6197278B1 (hu)
EP (1) EP1017318B1 (hu)
JP (1) JP4963748B2 (hu)
KR (1) KR20010020443A (hu)
CN (1) CN1265572A (hu)
AT (1) ATE379990T1 (hu)
AU (1) AU754577B2 (hu)
CA (1) CA2288131A1 (hu)
DE (1) DE69838811T2 (hu)
ES (1) ES2398118T3 (hu)
HU (1) HUP0001261A3 (hu)
NZ (1) NZ500598A (hu)
PL (1) PL336571A1 (hu)
RU (1) RU2228765C2 (hu)
TW (1) TW541184B (hu)
WO (1) WO1998048699A1 (hu)

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HUP0001261A3 (en) * 1997-04-30 2001-11-28 Univ Washington Seattle Method of imaging cell death in vivo
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US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
WO2000002584A2 (en) * 1998-07-13 2000-01-20 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
US6692724B1 (en) 1999-10-25 2004-02-17 Board Of Regents, The University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
DK1286704T3 (da) 2000-06-02 2014-09-22 Univ Texas Ethylendicystein (EC)-glucose analoge konjugater
US7247501B2 (en) * 2000-06-22 2007-07-24 Henry Ford Health System Imaging and targeting tumors using sickle cells
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WO2002082044A2 (en) * 2001-04-03 2002-10-17 The Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
US20050013778A1 (en) * 2001-04-03 2005-01-20 Theseus Imaging Corporation Methods and compositions for predicting the response to a therapeutic regimen in a subject having a disease associated with cell death
CA2444383A1 (en) * 2001-04-26 2002-11-07 Board Of Regents, The University Of Texas System Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use
US20030202937A1 (en) * 2001-06-05 2003-10-30 Sabbadini Roger A. Minicell-based diagnostics
US20030152513A1 (en) * 2001-09-06 2003-08-14 Imetrix, Inc. Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector
US7261875B2 (en) 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
US20040042959A1 (en) * 2002-08-28 2004-03-04 Michael Montalto Imaging cell death in vivo using non-radionuclide contrast agents
JP2006515835A (ja) * 2002-11-07 2006-06-08 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 組織特異的疾患のイメージングのための、エチレンジシステイン（ｅｃ）−薬物結合体、組成物、および方法
US20070031333A1 (en) * 2003-01-02 2007-02-08 Mease Ronnie C Novel F-18 labeled annexin V, synthesis thereof, and use thereof
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US7511016B2 (en) * 2004-07-07 2009-03-31 Mosamedix B.V. Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof
US7874975B2 (en) * 2005-07-20 2011-01-25 Clear Vascular, Inc. Methods and compositions for treating luminal inflammatory disease
US9623129B2 (en) * 2005-09-26 2017-04-18 Snip Holdings, Inc. Methods and therapies for treating inflammatory conditions with exposed collagen
AU2006306592A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis
US7871623B2 (en) * 2005-12-21 2011-01-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for imaging pain and stress in vivo
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
MX2009007880A (es) * 2007-01-30 2009-08-18 Ge Healthcare Ltd Herramientas para ayudar en el diagnostico de enfermedades neurodegenerativas.
EP2162762B1 (en) * 2007-05-16 2016-06-08 Koninklijke Philips N.V. Virtual pet detector and quasi-pixelated readout scheme for pet
US8055039B2 (en) * 2008-02-21 2011-11-08 General Electric Company System and method to obtain noise mitigated monochromatic representation for varying energy level
ES2531828T3 (es) * 2008-03-31 2015-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Derivados de purina como agonistas selectivos de los receptores A3 de adenosina
US8916570B2 (en) 2008-03-31 2014-12-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor agonists and antagonists
EP2331542B1 (en) * 2008-08-01 2016-07-27 The United States of America, as Represented by The Secretary, Department of Health and Human Services A3 adenosine receptor antagonists and partial agonists
US9181253B2 (en) 2008-08-01 2015-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists, partial agonists, and antagonists
US8747808B2 (en) 2008-08-26 2014-06-10 Mosamedix B.V. Radiolabeled annexins
US8283167B2 (en) * 2009-02-11 2012-10-09 Clear Vascular Inc. Preparation of annexin derivatives
KR101945554B1 (ko) 2011-04-04 2019-02-07 이데 인터내셔널 알앤디 인코퍼레이션 무바늘 인젝터용 안전 주사기
JP2016522832A (ja) * 2013-05-23 2016-08-04 ニューロエスエヌ・インコーポレイテッド 放射性核種で標識したアネキシンを使用したアルツハイマー病の診断及び治療
CN105669855B (zh) * 2016-02-04 2020-02-11 江苏省原子医学研究所 一种18F快速标记Cys-Annexin V的方法及其应用
RU2622983C1 (ru) * 2016-07-25 2017-06-21 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ интраоперационной визуализации ишемически-реперфузионного повреждения миокарда
WO2019169241A1 (en) * 2018-03-02 2019-09-06 Serene, Llc Methods of treating and imaging ungulate laminitis
JP2024022034A (ja) * 2022-08-05 2024-02-16 浜松ホトニクス株式会社 プログラムされた細胞死を起こした細胞の領域を決定する方法、決定部を備える装置及び決定ステップを含む情報処理プログラム

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BR9912053A (pt) * 1998-07-13 2001-04-03 Univ Texas Processos de tratamento de câncer utilizando conjugados terapêuticos que se ligam a aminofosfolipìdios
US6406693B1 (en) * 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
WO2000002584A2 (en) 1998-07-13 2000-01-20 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids

Also Published As

Publication number Publication date
US7357915B2 (en) 2008-04-15
ES2398118T3 (es) 2013-03-13
KR20010020443A (ko) 2001-03-15
CA2288131A1 (en) 1998-11-05
DE69838811T2 (de) 2008-10-30
AU754577B2 (en) 2002-11-21
EP1017318B1 (en) 2007-12-05
EP1017318A1 (en) 2000-07-12
US6197278B1 (en) 2001-03-06
DE69838811D1 (de) 2008-01-17
US20070243133A1 (en) 2007-10-18
TW541184B (en) 2003-07-11
ATE379990T1 (de) 2007-12-15
NZ500598A (en) 2001-09-28
AU7271498A (en) 1998-11-24
RU2228765C2 (ru) 2004-05-20
CN1265572A (zh) 2000-09-06
WO1998048699A1 (en) 1998-11-05
HUP0001261A3 (en) 2001-11-28
JP4963748B2 (ja) 2012-06-27
US20080138279A1 (en) 2008-06-12
JP2002500757A (ja) 2002-01-08
EP1017318A4 (en) 2003-04-23
PL336571A1 (en) 2000-07-03
US7666389B2 (en) 2010-02-23

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Legal Events

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