ATE379990T1 - Verfahren zur darstellung von abgestorbenen zellen in-vivo - Google Patents

Verfahren zur darstellung von abgestorbenen zellen in-vivo

Info

Publication number
ATE379990T1
ATE379990T1 AT98920065T AT98920065T ATE379990T1 AT E379990 T1 ATE379990 T1 AT E379990T1 AT 98920065 T AT98920065 T AT 98920065T AT 98920065 T AT98920065 T AT 98920065T AT E379990 T1 ATE379990 T1 AT E379990T1
Authority
AT
Austria
Prior art keywords
vivo
dead cells
displaying
displaying dead
cells
Prior art date
Application number
AT98920065T
Other languages
English (en)
Inventor
Francis Blankenberg
H Strauss
Jonathan Tait
Peter Katsikis
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE379990T1 publication Critical patent/ATE379990T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4057—Arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/425—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using detectors specially adapted to be used in the interior of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Hydroponics (AREA)
AT98920065T 1997-04-30 1998-04-28 Verfahren zur darstellung von abgestorbenen zellen in-vivo ATE379990T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4539997P 1997-04-30 1997-04-30

Publications (1)

Publication Number Publication Date
ATE379990T1 true ATE379990T1 (de) 2007-12-15

Family

ID=21937648

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98920065T ATE379990T1 (de) 1997-04-30 1998-04-28 Verfahren zur darstellung von abgestorbenen zellen in-vivo

Country Status (16)

Country Link
US (3) US6197278B1 (de)
EP (1) EP1017318B1 (de)
JP (1) JP4963748B2 (de)
KR (1) KR20010020443A (de)
CN (1) CN1265572A (de)
AT (1) ATE379990T1 (de)
AU (1) AU754577B2 (de)
CA (1) CA2288131A1 (de)
DE (1) DE69838811T2 (de)
ES (1) ES2398118T3 (de)
HU (1) HUP0001261A3 (de)
NZ (1) NZ500598A (de)
PL (1) PL336571A1 (de)
RU (1) RU2228765C2 (de)
TW (1) TW541184B (de)
WO (1) WO1998048699A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048699A1 (en) * 1997-04-30 1998-11-05 The Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
US7736651B1 (en) * 2000-11-24 2010-06-15 Sloan-Kettering Institute For Cancer Research Alpha emitting constructs and uses thereof
EP2311490A3 (de) * 1998-07-13 2011-05-04 Board of Regents, The University of Texas System Verwendung von Antikörper gegen Aminophospholipide zur Krebsbehandlung
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
IL140700A0 (en) * 1998-07-13 2002-02-10 Univ Texas Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
US6818213B1 (en) * 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US6692724B1 (en) 1999-10-25 2004-02-17 Board Of Regents, The University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
DK1286704T3 (da) 2000-06-02 2014-09-22 Univ Texas Ethylendicystein (EC)-glucose analoge konjugater
US7247501B2 (en) * 2000-06-22 2007-07-24 Henry Ford Health System Imaging and targeting tumors using sickle cells
US20050013778A1 (en) * 2001-04-03 2005-01-20 Theseus Imaging Corporation Methods and compositions for predicting the response to a therapeutic regimen in a subject having a disease associated with cell death
WO2002080754A2 (en) * 2001-04-03 2002-10-17 Theseus Imaging Corporation Methods for using annexin for detecting cell death in vivo and treating associated conditions
WO2002082044A2 (en) * 2001-04-03 2002-10-17 The Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
EP1389090A2 (de) * 2001-04-26 2004-02-18 Board of Regents, The University of Texas System Diagnostische bildgebende zusammensetzungen, ihre syntheseverfahren und ihre verwendung
US20030202937A1 (en) * 2001-06-05 2003-10-30 Sabbadini Roger A. Minicell-based diagnostics
US20030152513A1 (en) * 2001-09-06 2003-08-14 Imetrix, Inc. Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector
US7261875B2 (en) 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
US20040042959A1 (en) * 2002-08-28 2004-03-04 Michael Montalto Imaging cell death in vivo using non-radionuclide contrast agents
EP1562641A4 (de) * 2002-11-07 2008-12-03 Univ Texas Ethylendicystein(ec)-arzneimittelkonjugate, zusammensetzungen und verfahren für die gewebsspezifische darstellung von krankheiten
US20070031333A1 (en) * 2003-01-02 2007-02-08 Mease Ronnie C Novel F-18 labeled annexin V, synthesis thereof, and use thereof
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US7511016B2 (en) * 2004-07-07 2009-03-31 Mosamedix B.V. Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof
US7874975B2 (en) * 2005-07-20 2011-01-25 Clear Vascular, Inc. Methods and compositions for treating luminal inflammatory disease
US9623129B2 (en) * 2005-09-26 2017-04-18 Snip Holdings, Inc. Methods and therapies for treating inflammatory conditions with exposed collagen
EP1946101A4 (de) * 2005-10-21 2011-08-10 Immunochemistry Technologies Llc In-vivo-apoptosenachweis
US7871623B2 (en) * 2005-12-21 2011-01-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for imaging pain and stress in vivo
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
WO2008093057A1 (en) * 2007-01-30 2008-08-07 Ge Healthcare Limited Tools for aiding in the diagnosis of neurodegenerative diseases
CN101680953B (zh) * 2007-05-16 2014-08-13 皇家飞利浦电子股份有限公司 虚拟pet探测器和用于pet的准像素化读出方案
US8055039B2 (en) * 2008-02-21 2011-11-08 General Electric Company System and method to obtain noise mitigated monochromatic representation for varying energy level
US8735407B2 (en) * 2008-03-31 2014-05-27 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Purine derivatives as A3 adenosine receptor-selective agonists
US8916570B2 (en) 2008-03-31 2014-12-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor agonists and antagonists
US9181253B2 (en) 2008-08-01 2015-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists, partial agonists, and antagonists
EP2331542B1 (de) * 2008-08-01 2016-07-27 The United States of America, as Represented by The Secretary, Department of Health and Human Services Antagonisten und partielle agonisten des a3-adenosinrezeptors
US8747808B2 (en) 2008-08-26 2014-06-10 Mosamedix B.V. Radiolabeled annexins
US8283167B2 (en) * 2009-02-11 2012-10-09 Clear Vascular Inc. Preparation of annexin derivatives
RU2595504C2 (ru) 2011-04-04 2016-08-27 Айди Интернешнл Научно-Исследовательская И Опытно-Конструкторская Корпорация Одноразовый шприц для безыгольного инъектора
JP2016522832A (ja) * 2013-05-23 2016-08-04 ニューロエスエヌ・インコーポレイテッド 放射性核種で標識したアネキシンを使用したアルツハイマー病の診断及び治療
CN105669855B (zh) * 2016-02-04 2020-02-11 江苏省原子医学研究所 一种18F快速标记Cys-Annexin V的方法及其应用
RU2622983C1 (ru) * 2016-07-25 2017-06-21 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ интраоперационной визуализации ишемически-реперфузионного повреждения миокарда
WO2019169241A1 (en) * 2018-03-02 2019-09-06 Serene, Llc Methods of treating and imaging ungulate laminitis
JP2024022034A (ja) * 2022-08-05 2024-02-16 浜松ホトニクス株式会社 プログラムされた細胞死を起こした細胞の領域を決定する方法、決定部を備える装置及び決定ステップを含む情報処理プログラム

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671256A (en) * 1984-05-25 1987-06-09 Lemelson Jerome H Medical scanning, monitoring and treatment system and method
US5627036A (en) 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
US5552525A (en) 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
US5632986A (en) * 1991-05-09 1997-05-27 The University Of Washington Phospholipid-targeted thrombolytic agents
WO1992019279A1 (en) 1991-05-09 1992-11-12 Board Of Regents Of The University Of Washington Phospholipid-targeted thrombolytic agents
US5519221A (en) 1992-01-22 1996-05-21 Ansel M. Schwartz Dedicated apparatus and method for emission mammography
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
PT627940E (pt) 1992-03-05 2003-07-31 Univ Texas Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados
GB9223168D0 (en) 1992-11-05 1992-12-16 Johnson Matthey Plc Improvements in molecule labelling
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
AU689248B2 (en) 1994-04-11 1998-03-26 Nexins Research B.V. A method for detecting and/or optionally quantifying and/or separating apoptotic cells in or from a sample
EP0765166B1 (de) 1994-06-16 2003-05-21 Neorx Corporation Radioaktivmarkierte annexin-galaktose konjugate
DE69533366T2 (de) 1994-12-07 2005-08-04 Neorx Corp., Seattle Radioaktivmarkierte annexin-galaktose-cluster konjugate
WO1998048699A1 (en) * 1997-04-30 1998-11-05 The Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
EP2311490A3 (de) 1998-07-13 2011-05-04 Board of Regents, The University of Texas System Verwendung von Antikörper gegen Aminophospholipide zur Krebsbehandlung
IL140700A0 (en) 1998-07-13 2002-02-10 Univ Texas Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids

Also Published As

Publication number Publication date
JP4963748B2 (ja) 2012-06-27
NZ500598A (en) 2001-09-28
EP1017318A4 (de) 2003-04-23
DE69838811D1 (de) 2008-01-17
KR20010020443A (ko) 2001-03-15
TW541184B (en) 2003-07-11
CA2288131A1 (en) 1998-11-05
US20070243133A1 (en) 2007-10-18
US7357915B2 (en) 2008-04-15
HUP0001261A3 (en) 2001-11-28
US7666389B2 (en) 2010-02-23
JP2002500757A (ja) 2002-01-08
EP1017318A1 (de) 2000-07-12
WO1998048699A1 (en) 1998-11-05
DE69838811T2 (de) 2008-10-30
HUP0001261A2 (hu) 2000-08-28
US20080138279A1 (en) 2008-06-12
ES2398118T3 (es) 2013-03-13
PL336571A1 (en) 2000-07-03
US6197278B1 (en) 2001-03-06
AU7271498A (en) 1998-11-24
RU2228765C2 (ru) 2004-05-20
AU754577B2 (en) 2002-11-21
EP1017318B1 (de) 2007-12-05
CN1265572A (zh) 2000-09-06

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