DE69941563D1 - Elektrochemisches System zur Bestimmung der Blutgerinnungszeit - Google Patents

Elektrochemisches System zur Bestimmung der Blutgerinnungszeit

Info

Publication number
DE69941563D1
DE69941563D1 DE69941563T DE69941563T DE69941563D1 DE 69941563 D1 DE69941563 D1 DE 69941563D1 DE 69941563 T DE69941563 T DE 69941563T DE 69941563 T DE69941563 T DE 69941563T DE 69941563 D1 DE69941563 D1 DE 69941563D1
Authority
DE
Germany
Prior art keywords
determination
blood clotting
clotting time
electrochemical system
electrochemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941563T
Other languages
English (en)
Inventor
Erik Jan Frenkel
Andre Haeberli
Anita Moresi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asulab AG
Original Assignee
Asulab AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asulab AG filed Critical Asulab AG
Application granted granted Critical
Publication of DE69941563D1 publication Critical patent/DE69941563D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Ecology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
DE69941563T 1999-02-23 1999-02-23 Elektrochemisches System zur Bestimmung der Blutgerinnungszeit Expired - Lifetime DE69941563D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99103418A EP1031830B8 (de) 1999-02-23 1999-02-23 Elektrochemisches System zur Bestimmung der Blutgerinnungszeit

Publications (1)

Publication Number Publication Date
DE69941563D1 true DE69941563D1 (de) 2009-12-03

Family

ID=8237613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69941563T Expired - Lifetime DE69941563D1 (de) 1999-02-23 1999-02-23 Elektrochemisches System zur Bestimmung der Blutgerinnungszeit

Country Status (7)

Country Link
US (1) US6352630B1 (de)
EP (2) EP2042610A1 (de)
JP (1) JP4662596B2 (de)
AU (1) AU760256B2 (de)
CA (1) CA2298994C (de)
DE (1) DE69941563D1 (de)
NO (1) NO330614B1 (de)

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US6620310B1 (en) * 2000-12-13 2003-09-16 Lifescan, Inc. Electrochemical coagulation assay and device
US20040048241A1 (en) * 2001-06-11 2004-03-11 Freeman Beverly Annette Methods for attaching molecules
US6824974B2 (en) * 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
US7166208B2 (en) * 2004-03-03 2007-01-23 Stephen Eliot Zweig Apoenzyme reactivation electrochemical detection method and assay
US8118991B2 (en) * 2001-09-04 2012-02-21 Stephen Eliot Zweig Apoenzyme reactivation electrochemical detection method and assay
US6866758B2 (en) * 2002-03-21 2005-03-15 Roche Diagnostics Corporation Biosensor
AU2003900285A0 (en) * 2003-01-20 2003-02-06 Universal Biosensors Pty Limited Electrochemical detection method
CA2479452C (en) * 2003-08-30 2008-11-04 F.Hoffmann-La Roche Ag Method and device for determining analytes in a liquid
FR2874385B1 (fr) * 2004-08-18 2006-12-08 Biopep Sa Procede et dispositif de mesure d'une activite enzymatique dans un fluide biologique
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GB0525997D0 (en) * 2005-12-21 2006-02-01 Oxford Biosensors Ltd Micro-fluidic structures
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TWI516601B (zh) * 2007-10-26 2016-01-11 環球生物醫療感測器私人有限公司 電化學檢測之裝置及方法
WO2009121089A1 (de) * 2008-04-04 2009-10-08 Nanoident Technologies Ag Modulares absorptionsmesssystem
EP2144061A1 (de) * 2008-07-11 2010-01-13 F. Hoffmann-Roche AG Kontinuierliches Verfahren zum Inline-Auftrag von Tensid auf beschichteter Sensorfolie
FR2943789B1 (fr) 2009-03-26 2013-07-26 Commissariat Energie Atomique Procede et dispositif pour la caracterisation de la dynamique de coagulation ou sedimentation d'un fluide tel que le sang ou le plasma sanguin
EP2524965A1 (de) * 2011-05-16 2012-11-21 The Swatch Group Research and Development Ltd. Steigerung der Lagerungszeit eines Thrombinsensors
JP5911345B2 (ja) * 2012-03-27 2016-04-27 シスメックス株式会社 凝固時間測定用試薬、凝固時間測定用試薬キットおよび凝固時間の測定方法
WO2014192196A1 (ja) * 2013-05-31 2014-12-04 京セラ株式会社 センサ、検出方法、検出システム、および検出装置
JP6567549B2 (ja) 2014-04-30 2019-08-28 インストゥルメンテーション ラボラトリー カンパニー 光学検出によるポイントオブケア凝固アッセイのための方法及びシステム
CN104182649A (zh) * 2014-09-10 2014-12-03 钟礼军 手持移动物联网体外快检仪及使用方法
WO2016049557A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Ellagic acid formulations for use in coagulation assays
WO2016049515A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples
EP3198280B1 (de) 2014-09-26 2021-05-26 Abbott Point Of Care, Inc. Sensoren zur prüfung von koagulation in flüssigen proben
WO2016049533A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device with fluidic junctions for coagulation assays in fluid samples
WO2016049552A1 (en) * 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device identification for coagulation assays in fluid samples
EP4043879A1 (de) * 2014-09-26 2022-08-17 Abbott Point Of Care Inc Einzelkanalkartuschenvorrichtung für blutgerinnungstests in fluidproben
CN106999930B (zh) 2014-09-26 2020-09-08 雅培医护站股份有限公司 用于测定流体样本中的凝结的具有分段射流的盒设备
CN104374765B (zh) * 2014-11-17 2015-08-19 济南大学 一种电化学发光适配体传感器、其制备方法及其用途
CN108614017B (zh) * 2016-12-09 2021-02-09 广州好芝生物科技有限公司 一种凝血酶原时间检测方法和装置
CN106680339A (zh) * 2016-12-28 2017-05-17 北京乐普医疗科技有限责任公司 一种基于电化学方法的凝血酶原时间测试卡及其制备方法
CN109100394B (zh) * 2018-07-18 2020-10-02 浙江大学 一种凝血时间检测仪及其检测方法
CN109507260A (zh) * 2018-12-29 2019-03-22 中国科学院苏州生物医学工程技术研究所 电化学检测芯片、电化学传感器及其制备方法和应用

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CH478410A (de) 1966-10-11 1969-09-15 Greiner Electronic Ag Verfahren zur Bestimmung der Blutgerinnung
US3967934A (en) 1969-06-13 1976-07-06 Baxter Laboratories, Inc. Prothrombin timer
US3674012A (en) 1970-04-17 1972-07-04 American Optical Corp Blood coagulation detection device
US3890098A (en) 1973-11-16 1975-06-17 Enrique Moreno Machine for the determination of protrombin time and p.t.t.
FR2455083A1 (fr) * 1979-04-24 1980-11-21 Jozefonvicz Marcel Nouveau procede de dosage des proteases et des antiproteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
DE3061860D1 (en) * 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
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JPH0820400B2 (ja) * 1989-03-17 1996-03-04 松下電器産業株式会社 バイオセンサ
DE4003194A1 (de) * 1990-02-03 1991-08-08 Boehringer Mannheim Gmbh Verfahren und sensorelektrodensystem zur elektrochemischen bestimmung eines analyts oder einer oxidoreduktase sowie verwendung hierfuer geeigneter verbindungen
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US5154082A (en) 1991-05-20 1992-10-13 International Technidyne Corporation Microprocessor-controlled apparatus and method for detecting the coagulation of blood
DK0565665T3 (da) 1991-10-04 1998-09-28 Dade Behring Inc Fremstilling af prothrombin-tidsreagenser ud fra rekombinant human faktor og syntetiske phospholipider
EP0560336B1 (de) * 1992-03-12 1998-05-06 Matsushita Electric Industrial Co., Ltd. Biosensor mit einem Katalysator aus Phosphat
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Also Published As

Publication number Publication date
EP1031830B8 (de) 2009-12-09
EP1031830B1 (de) 2009-10-21
NO330614B1 (no) 2011-05-30
US6352630B1 (en) 2002-03-05
NO20000862L (no) 2000-08-24
EP2042610A1 (de) 2009-04-01
JP4662596B2 (ja) 2011-03-30
EP1031830A1 (de) 2000-08-30
CA2298994A1 (en) 2000-08-23
AU760256B2 (en) 2003-05-08
NO20000862D0 (no) 2000-02-22
JP2000241384A (ja) 2000-09-08
CA2298994C (en) 2010-01-26
AU1849700A (en) 2000-08-24

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ASULAB S.A., MARIN, CH

8364 No opposition during term of opposition