EP1109931A4 - Verfahren zum studium von proteinwechselwirkungen in vivo - Google Patents

Verfahren zum studium von proteinwechselwirkungen in vivo

Info

Publication number
EP1109931A4
EP1109931A4 EP99945460A EP99945460A EP1109931A4 EP 1109931 A4 EP1109931 A4 EP 1109931A4 EP 99945460 A EP99945460 A EP 99945460A EP 99945460 A EP99945460 A EP 99945460A EP 1109931 A4 EP1109931 A4 EP 1109931A4
Authority
EP
European Patent Office
Prior art keywords
vivo
protein interactions
studying protein
studying
interactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99945460A
Other languages
English (en)
French (fr)
Other versions
EP1109931A1 (de
Inventor
Aladar A Szalay
Yubao Wang
Gefu Wang-Pruski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Loma Linda University
Original Assignee
Loma Linda University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loma Linda University filed Critical Loma Linda University
Publication of EP1109931A1 publication Critical patent/EP1109931A1/de
Publication of EP1109931A4 publication Critical patent/EP1109931A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
EP99945460A 1998-09-03 1999-09-02 Verfahren zum studium von proteinwechselwirkungen in vivo Withdrawn EP1109931A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9906898P 1998-09-03 1998-09-03
US99068P 1998-09-03
US13583599P 1999-05-24 1999-05-24
US135835P 1999-05-24
PCT/US1999/020207 WO2000014271A1 (en) 1998-09-03 1999-09-02 METHOD FOR STUDYING PROTEIN INTERACTIONS $i(IN VIVO)

Publications (2)

Publication Number Publication Date
EP1109931A1 EP1109931A1 (de) 2001-06-27
EP1109931A4 true EP1109931A4 (de) 2004-12-15

Family

ID=26795497

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99945460A Withdrawn EP1109931A4 (de) 1998-09-03 1999-09-02 Verfahren zum studium von proteinwechselwirkungen in vivo

Country Status (6)

Country Link
EP (1) EP1109931A4 (de)
JP (1) JP2002524087A (de)
CN (1) CN1160470C (de)
AU (1) AU752675B2 (de)
CA (1) CA2341314A1 (de)
WO (1) WO2000014271A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7771952B2 (en) 2002-06-26 2010-08-10 Abott Laboratories Modulators and modulation of the interaction between RGM and Neogenin
EP1533619B1 (de) 2003-11-20 2009-04-29 F. Hoffmann-Roche AG Spezifische Marker für Stoffwechselssyndrome
CN1920021B (zh) * 2005-08-24 2010-05-05 中国医学科学院基础医学研究所 胰岛素样生长因子结合蛋白-6介导的有活性胰岛素样生长因子-ⅱ的制备方法
EP1928905B1 (de) 2005-09-30 2015-04-15 AbbVie Deutschland GmbH & Co KG Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
NZ593294A (en) 2009-01-29 2013-04-26 Commw Scient Ind Res Org Measuring g protein coupled receptor activation
CN101620233B (zh) * 2009-05-27 2012-10-31 华中科技大学 一种蛋白质相互作用的检测方法
CA2780069C (en) 2009-12-08 2018-07-17 Abbott Gmbh & Co. Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
WO2011083147A1 (en) 2010-01-08 2011-07-14 Cemm-Forschungsinstitut Für Molekulare Medizin Gmbh Wave1 inhibition in the medical intervention of inflammatory diseases and/or infections caused by a pathogen
US20130116304A1 (en) 2010-04-19 2013-05-09 Ernst R. Werner Tmem195 encodes for tetrahydrobiopterin-dependent alkylglycerol monooxygenase activity
CN107880124B (zh) 2012-01-27 2021-08-13 艾伯维德国有限责任两合公司 用于诊断和治疗与神经突变性相关的疾病的组合物和方法
CN102798717B (zh) * 2012-06-15 2014-11-26 杭州师范大学 一种o6-甲基鸟嘌呤-dna甲基转移酶活性检测方法
CN103616502B (zh) * 2013-09-12 2016-05-25 西北农林科技大学 基于细菌荧光素酶bret技术检测蛋白质相互作用的方法
US10415960B2 (en) 2015-04-06 2019-09-17 Worldvu Satellites Limited Elevation angle estimating system and method for user terminal placement
CA3022981A1 (en) 2017-11-01 2019-05-01 Queen's University At Kingston Hippo pathway bioluminescent biosensor
CN110794129B (zh) * 2018-08-01 2020-12-01 清华大学 细胞内检测生物分子间相互作用及其调控因子的方法与所用试剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137515A2 (de) * 1983-10-13 1985-04-17 The University Of Georgia Research Foundation, Inc. Biolumineszierende Immunoteste
WO1999066324A2 (en) * 1998-06-16 1999-12-23 Biosignal Packard Inc. A bioluminescence resonance energy transfer (bret) system and its use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604364A (en) * 1974-01-04 1986-08-05 Kosak Kenneth M Bioluminescent tracer composition and method of use in immunoassays
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US5683888A (en) * 1989-07-22 1997-11-04 University Of Wales College Of Medicine Modified bioluminescent proteins and their use
US5292658A (en) * 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
AT401526B (de) * 1993-02-10 1996-09-25 Scheirer Winfried Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung
US5491084A (en) * 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5976796A (en) * 1996-10-04 1999-11-02 Loma Linda University Construction and expression of renilla luciferase and green fluorescent protein fusion genes
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137515A2 (de) * 1983-10-13 1985-04-17 The University Of Georgia Research Foundation, Inc. Biolumineszierende Immunoteste
WO1999066324A2 (en) * 1998-06-16 1999-12-23 Biosignal Packard Inc. A bioluminescence resonance energy transfer (bret) system and its use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MAHAJAN N P ET AL: "BCL-2 AND BAX INTERACTIONS IN MITOCHONDRIA PROBED WITH GREEN FLUORESCENT PROTEIN AND FLUORESCENCE RESONANCE ENERGY TRANSFER", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 16, June 1998 (1998-06-01), pages 547 - 552, XP000876894, ISSN: 1087-0156 *
See also references of WO0014271A1 *
WANG Y ET AL: "Chemiluminescence energy transfer to study protein-protein interaction in living cells", BIOLUMINESCENCE AND CHEMILUMINESCENCE FOR THE 21ST CENTRUY - PROCEEDINGS OF THE 10TH INTERNATIONAL SYMPOSIUM ON BIOLUMINESCENCE AND CHEMILUMINESCENCE, 1999, pages 475 - 478, XP008036438 *

Also Published As

Publication number Publication date
AU752675B2 (en) 2002-09-26
CA2341314A1 (en) 2000-03-16
CN1323353A (zh) 2001-11-21
CN1160470C (zh) 2004-08-04
WO2000014271A1 (en) 2000-03-16
EP1109931A1 (de) 2001-06-27
AU5805699A (en) 2000-03-27
JP2002524087A (ja) 2002-08-06

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