HUE046565T2 - Tumorszelektív adenovírus E1A és E1B mutánsok - Google Patents

Tumorszelektív adenovírus E1A és E1B mutánsok

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Publication number
HUE046565T2
HUE046565T2 HUE15182086A HUE15182086A HUE046565T2 HU E046565 T2 HUE046565 T2 HU E046565T2 HU E15182086 A HUE15182086 A HU E15182086A HU E15182086 A HUE15182086 A HU E15182086A HU E046565 T2 HUE046565 T2 HU E046565T2
Authority
HU
Hungary
Prior art keywords
mutants
tumor
selective adenovirus
adenovirus
selective
Prior art date
Application number
HUE15182086A
Other languages
English (en)
Hungarian (hu)
Inventor
Tony Reid
Farah Hedjran
Shantanu Kumar
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of HUE046565T2 publication Critical patent/HUE046565T2/hu

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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HUE15182086A 2009-03-02 2010-03-02 Tumorszelektív adenovírus E1A és E1B mutánsok HUE046565T2 (hu)

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US15682209P 2009-03-02 2009-03-02

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HUE046565T2 true HUE046565T2 (hu) 2020-03-30

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HUE10749205A HUE026386T2 (en) 2009-03-02 2010-03-02 Tumor-selective adenovirus e1a and e1b mutants
HUE15182086A HUE046565T2 (hu) 2009-03-02 2010-03-02 Tumorszelektív adenovírus E1A és E1B mutánsok

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US (6) US9073980B2 (OSRAM)
EP (4) EP3029144B1 (OSRAM)
JP (5) JP6072414B2 (OSRAM)
KR (4) KR102150027B1 (OSRAM)
CY (1) CY1122385T1 (OSRAM)
DK (2) DK3029144T3 (OSRAM)
ES (2) ES2750305T3 (OSRAM)
HR (2) HRP20151396T1 (OSRAM)
HU (2) HUE026386T2 (OSRAM)
LT (1) LT3029144T (OSRAM)
PL (2) PL2403951T3 (OSRAM)
PT (2) PT3029144T (OSRAM)
SI (2) SI2403951T1 (OSRAM)
SM (2) SMT201900565T1 (OSRAM)
WO (1) WO2010101921A2 (OSRAM)

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EP4114449A2 (en) 2020-03-05 2023-01-11 Neotx Therapeutics Ltd. Methods and compositions for treating cancer with immune cells
CN114262691A (zh) * 2020-09-16 2022-04-01 杭州康万达医药科技有限公司 分离的能够用于表达外源基因的溶瘤腺病毒、载体、治疗剂及其用途
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SI2403951T1 (sl) 2009-03-02 2016-04-29 The Regents Of The University Of California Tumorsko selektivni mutanti adenovirusa e1a in e1b

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US20210171917A1 (en) 2021-06-10
SI2403951T1 (sl) 2016-04-29
US20190136204A1 (en) 2019-05-09
JP2016028035A (ja) 2016-02-25
EP4123030A1 (en) 2023-01-25
KR20110122866A (ko) 2011-11-11
EP3029144B1 (en) 2019-07-10
KR102020018B1 (ko) 2019-09-09
US11618888B2 (en) 2023-04-04
JP6375273B2 (ja) 2018-08-15
WO2010101921A3 (en) 2011-01-06
EP2403951A4 (en) 2012-08-22
JP2020078326A (ja) 2020-05-28
KR20190104643A (ko) 2019-09-10
SMT201500329B (it) 2016-02-25
US20230272349A1 (en) 2023-08-31
PL2403951T3 (pl) 2016-04-29
PT3029144T (pt) 2019-10-28
DK2403951T3 (en) 2016-01-11
KR20170077278A (ko) 2017-07-05
EP3591059B1 (en) 2022-07-20
HRP20151396T1 (hr) 2016-03-25
KR20180049188A (ko) 2018-05-10
JP2018113971A (ja) 2018-07-26
EP3591059A1 (en) 2020-01-08
KR101752910B1 (ko) 2017-06-30
ES2750305T3 (es) 2020-03-25
JP2012519014A (ja) 2012-08-23
PT2403951E (pt) 2016-01-29
ES2557812T3 (es) 2016-01-28
SI3029144T1 (sl) 2019-11-29
US20160017294A1 (en) 2016-01-21
JP6817979B2 (ja) 2021-01-20
EP3029144A1 (en) 2016-06-08
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US20250327037A1 (en) 2025-10-23
LT3029144T (lt) 2019-10-25
SMT201900565T1 (it) 2019-11-13
HUE026386T2 (en) 2016-06-28
HRP20191808T1 (hr) 2019-12-27
CY1122385T1 (el) 2021-01-27
WO2010101921A2 (en) 2010-09-10
JP6072414B2 (ja) 2017-02-01
KR102150027B1 (ko) 2020-10-26
US20110318311A1 (en) 2011-12-29
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DK3029144T3 (da) 2019-10-21
US9073980B2 (en) 2015-07-07
JP7326396B2 (ja) 2023-08-15
US10876097B2 (en) 2020-12-29
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EP2403951B1 (en) 2015-09-30

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