HUE033746T2 - MIR-135 és ezt tartalmazó kompozíciók szerotoninhoz társult gyógyászati körülmények kezeléséhez - Google Patents
MIR-135 és ezt tartalmazó kompozíciók szerotoninhoz társult gyógyászati körülmények kezeléséhez Download PDFInfo
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- HUE033746T2 HUE033746T2 HUE12759827A HUE12759827A HUE033746T2 HU E033746 T2 HUE033746 T2 HU E033746T2 HU E12759827 A HUE12759827 A HU E12759827A HU E12759827 A HUE12759827 A HU E12759827A HU E033746 T2 HUE033746 T2 HU E033746T2
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/00—Structure or type of the nucleic acid
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Claims (1)
- :i*tlíR-13§ !!·ΡΪΤΜΙΙΜΑ£0 KOMPOZÍCIÓK SZEROTONSNHO^ÎÂR^IÎ KEZELÉSÉHEZ SZABADALMI IGÉNYPONTOK il %y nAK-ISík ennek pretezsta; vagy egy exegén pofíukieoiis| amely: kodofa M: emlíiétt a!kain-;szásrs elyan gyógyászati këmimèfpk condition). IÄI», arnetyekben $ szerotesin színi múlásé gyógyászeíiiag előnyös. 1 M. ! igénypont mM% ΛΜ33 iêaÊmâim· ábéiáz említett; ¢1-13¾ vágy említett ;preku«örá! ÄgÄ®i# polindkieotid agy nukieinssv ksssíafóéfean taÄkodl. Ä 4ΜΚ*ηΜ& fciMalforf szabàlyezè (regulatory) stem:'#iiisis2i|iiiptása (transcnpkonf ρρηΐρί) alatt ||. 3. »I» konstrukei. afeoí m festste tmesy kódolja; az miRA3S,at vagy gfekurssrát as äÄlkaukÄav szekvencia egy oipn sisz-müködö szabályozó feiern átírás« szabályozása alatt áll. amely aktív agy neuroglia sejtbe;:. 4 a il m\tm *μφ*φ**> S, Az 1:. igénypont szcmík m|R43f alkalmasásfa, a 3. tgégyportiíszefistretíkteínsasí konstrukció. ahol az emitted mpHAá be m mutatva a SEQ ID NO:58-B2 szekvenciákban. δ Az 1 igénypont, szerM mll-13$: ái»§Z^meáPoÍ az említett miE435 tartalmaz egy módosítási ^mety a következők köztit mmáhM KI: módosított gerinc {feafelc&ón&jy modositótt rmkieoaibokAöztí lioteomdeosíde) kötés (Imkage). ás egy móöositots bázis. 7. A 6. igénypont szecnti ?raR-r33i#àii5à2Ssr|ii. « dnÄmddosftöti gsrteóíyaB ti»«' íartálmpyfmeíy « köveikezók; tkMbyiesztiáfé Ki: IsÄiü lü joszibrotlsáí. tbs^adtöoát/Éssfefcteg «Hfl- mmm. mm mmm tosztinál, :»ei tionolosztöramidát tioboaikitfeszfeolL tit5nöaii<iiiös®föfíér. ttónösikiíf^^tn^sátigA bôrarÎ^ïjsgrfà^ fósáíöcttésietfer, ps^tid ;t1 {FNä)( és Aï-C>'meîoxAsttA δ AZ 1. l§^yp«!:::^risisiP4#alkim«2Äm:me0m WMM* a# eukote mind egy Aükiöiidpk-ká.ztl kötésben. :·1· $$. i.©§lftypÄÄNl lÄttöäfefc á Äö&ÄPöM választások: ki: :<mmÊk szorongás (anxiety), stressz. kimerúiíségifátlgOé), károsuk észlelési tunkoló (impaired cognitive function), pánikrobam, Aénysierbátogság (conceive fc#gyjp4 s»#i^iagsag *ÉM$*ttátfe lois, mm rendellenesség. átköss# ikapesPleios rendÂessèg (food; related disorder), növekedési ^ mwMàtà rendellenesség {t^reäu» disorder). to A-1 .igénypont szerint; miE~l35 alkalmazásra ahol az említett gyógyászati komimén* hangolás. Asetkéölsr reodellefiesséf (meed disorder). íi. Gyógyászati kompod, amely MIMA 3; ^pí«i:imK^ssv- ^r^fém.-èSr-Wtâfenâst.-^^ggtítóz^lias ellogadtmtőlördozól (prdsf) vagy hígítót (düsaru) 12. a 11 igénypont szenet; gyógyászod kMício. ahol az említeti míR-l 35 olyan, amely be van mutatva a SEQ ÎD 010:88-82 szekvenciákban; 13. A11. igénypont szenni! gyógyászat; kornpozicio. sno! az említett m;R-13S tartalmaz egy mcAosiiósi mind egy cukorban, mind egy nukíeozidck-kozíl Kötésben.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201161514954P | 2011-08-04 | 2011-08-04 |
Publications (1)
Publication Number | Publication Date |
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HUE033746T2 true HUE033746T2 (hu) | 2018-01-29 |
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ID=46875925
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE17163200A HUE044154T2 (hu) | 2011-08-04 | 2012-08-02 | MIR-15 mikro-RNS, valamint az ezt tartalmazó készítmények kortikotropin-felszabadító hormonhoz kapcsolódó orvosi állapotok kezelésére |
HUE12759827A HUE033746T2 (hu) | 2011-08-04 | 2012-08-02 | MIR-135 és ezt tartalmazó kompozíciók szerotoninhoz társult gyógyászati körülmények kezeléséhez |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE17163200A HUE044154T2 (hu) | 2011-08-04 | 2012-08-02 | MIR-15 mikro-RNS, valamint az ezt tartalmazó készítmények kortikotropin-felszabadító hormonhoz kapcsolódó orvosi állapotok kezelésére |
Country Status (10)
Country | Link |
---|---|
US (5) | US9150858B2 (hu) |
EP (3) | EP3524679B1 (hu) |
JP (2) | JP6309450B2 (hu) |
CN (3) | CN104039960B (hu) |
BR (1) | BR112014002737B1 (hu) |
CA (2) | CA3107434C (hu) |
ES (2) | ES2732427T3 (hu) |
HU (2) | HUE044154T2 (hu) |
IL (1) | IL230814A (hu) |
WO (1) | WO2013018060A2 (hu) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3524679B1 (en) | 2011-08-04 | 2021-10-06 | Yeda Research and Development Co., Ltd. | Micro-rna mir-19 and compositions comprising same for the treatment of medical conditions in which low adrenaline or noradrenaline level is therapeutically beneficial |
KR102181103B1 (ko) * | 2013-11-27 | 2020-11-23 | 시그마-알드리치 컴퍼니., 엘엘씨 | 생물학적 유체로부터 마이크로 rna 단리 |
CN111733231A (zh) * | 2014-02-05 | 2020-10-02 | 耶达研究及发展有限公司 | 用于治疗和诊断的微rna和包含所述微rna的组合物 |
WO2015164431A2 (en) * | 2014-04-22 | 2015-10-29 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods, processes, devices and kits for the measurement of post traumatic stress disorder microrna markers |
WO2016055892A1 (en) * | 2014-10-09 | 2016-04-14 | Consorzio Delta Ti Research | 3d integrated thermoelectric generator operating in an out-of-plane heat flux configuration with internal voids and heat conduction paths conditioning vias |
CN104826131B (zh) * | 2015-04-15 | 2018-12-18 | 涛康生物科技(上海)有限公司 | miR-17-92基因簇在制备治疗精神类疾病药物中的用途 |
CN105349643B (zh) * | 2015-11-05 | 2018-09-07 | 中国航天员科研训练中心 | 预测睡眠剥夺后5-羟色胺变化的方法与microRNAs标志物 |
EP3377074B1 (en) * | 2015-11-18 | 2024-01-03 | Dignity Health | Methods of diagnosing post traumatic epilepsy |
CN105709240B (zh) * | 2016-03-23 | 2020-07-07 | 中国人民解放军第四军医大学 | 一种miR-26a抑制剂及其应用 |
CN105748501B (zh) * | 2016-03-31 | 2017-07-28 | 成都仕康美生物科技有限公司 | 一种miRNA‑182抑制剂及其在制备防治心脏移植免疫排斥反应药物中的应用 |
CN111566212A (zh) | 2017-11-03 | 2020-08-21 | 因特尔纳技术有限公司 | miRNA分子,等同物,安塔够妙或其来源用于治疗和/或诊断与神经元缺陷相关的病症和/或疾病或用于神经元生成和/或再生 |
CN112852961B (zh) * | 2021-01-08 | 2022-09-13 | 上海市胸科医院 | 肺腺癌铁死亡敏感性标志物adcy10及其应用 |
CN113897435A (zh) * | 2021-11-22 | 2022-01-07 | 山西农业大学 | 一种用于评估黑色素瘤转移风险的miRNA及其应用 |
WO2023182507A1 (ja) * | 2022-03-24 | 2023-09-28 | 北海道公立大学法人 札幌医科大学 | 薬学的組成物、間葉系幹細胞の三次元培養物の製造方法、エクソソームの製造方法、および薬学的組成物の製造方法 |
WO2024020376A1 (en) * | 2022-07-22 | 2024-01-25 | University Of Massachusetts | Aav-mediated delivery of osteoblast/osteoclast-regulating mirnas for osteoporosis therapy |
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