HUE032199T2 - Benzilaralkiléter vegyületek, eljárás ezek elõállítására, intermedier vegyületek, ezen vegyületek alkalmazása, eljárás kezelésre és/vagy megelõzésre, ezeket tartalmazó gyógyszerkészítmények és gyógyszerek - Google Patents

Benzilaralkiléter vegyületek, eljárás ezek elõállítására, intermedier vegyületek, ezen vegyületek alkalmazása, eljárás kezelésre és/vagy megelõzésre, ezeket tartalmazó gyógyszerkészítmények és gyógyszerek Download PDF

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Publication number
HUE032199T2
HUE032199T2 HUE10811042A HUE10811042A HUE032199T2 HU E032199 T2 HUE032199 T2 HU E032199T2 HU E10811042 A HUE10811042 A HU E10811042A HU E10811042 A HUE10811042 A HU E10811042A HU E032199 T2 HUE032199 T2 HU E032199T2
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HU
Hungary
Prior art keywords
ahol ahol
compounds
fungi
benzyl
ethyl
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HUE10811042A
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English (en)
Inventor
Artur Franz Keppler
Sergio Luiz Sacurai
Marcio Henrique Zaim
Carlos Eduardo Da Costa Touzarim
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Biolab Sanus Farmaceutica Ltda
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Application filed by Biolab Sanus Farmaceutica Ltda filed Critical Biolab Sanus Farmaceutica Ltda
Publication of HUE032199T2 publication Critical patent/HUE032199T2/hu

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C22/00Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
    • C07C22/02Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
    • C07C22/04Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
    • C07C22/08Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings containing fluorine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Claims (2)

  1. 'ίΛΑΪΗΗΛΙ ΜΙ ΗΑ'Μ ROMOK
    ^ mm ^V>kv' OStt » X ,WT~\ - xä X '^Í'O'W ! 'XÍ xíí ' Vi, * dí x-V kmnâi, ahol : A r jetemése inudazoliU Riv Rís Rí, sís R. jelenkor vavmavxd uggbe-nÜ! i'.ídíog^», R> jckmds« balogéi. Rs jelentése ittflucxmetii vagj< IrlÖnBstü; ti ofíeke o ,' egá.v \vam: m érték«
  2. !, 2. Λ ? L jgérívpi.sní szennn veg> ak:*eL. sho'í e/ek gjógysKíré^i-rtSeg a‘ka In »adható savakkal kspvíít add it sós sé fámájában vannak hiísuc.ü;o.\s j-etíli -1Ib;;mdaí.ot vagy ennek vgyógys;2ri'«S£oi:íeg askalmavhab yéga. - Γΐιακ^α/ί ' «^ν'ην,χ no, V-tv ' ske s-'tsnr vv§> χ\ χ χ' ' <óh, « , mw χ \ηκΑη ✓ ',A,t segg aktét dtl) képkstű vs;;ívüíeuetrerufättaiunt.
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    n's gibt kv t ν\·\·., io Lvx, \t -αν,'Η > n Ar jdesrtkse im-daaold; feds Rs.jVteïUlsti ««ymâ^ôi::S|gg«ttetÂàftoftn|; Rí jsdenfèse hatosén; lx üde* t.'so iji''ootííí>'iíí \ a ô snkksmseok « km-ksr o- 2 viiON?. sáísts; s» érsike s ; ahol X K^nUCse-O. Br. k meitottulffmat va?) toluols/uH'onât küzU? megválasztott. -*· ^ -) i&amp;èoyposss sstermo eljárás. aboi a svsskesó k-areg tars-dnw t&amp;) poláros szerves oklészoft. ^ oíssR« ok «ei omevraek U s o % o i '\ -. ► ' ->'> kmoaNV vv) 5>} vïervt's bswissM sók amelvssek kon«, erűm tója 0.00) - 0.1 taU'jnfcinvba '.sík a fs-skció k-veg ^äjss; skdogakssa vonatkodafya. Ás 5. igénypont szem!i ^átíbgahnl·; a) a poláros -szerves okios/.sf sscesotx msül-elll-keton. vagy szék elegyes csoportbeli megválasztott, )0 ar f ic\ 0 i? \ aus m"i it'viouj ν'- ka a a a .so cum v -cot -οοο- o« gwiasdctp v io' 1 \ Sii''^'OSiki "O'Oü {!« \ ·> O X ') s....ολposts ^vrois» o«« r»as s\o5 .o .. sdsses;:th».μ*ΙΠ) sstse* snobent s v\io. soportos hoidoersak äsloli »sbiinifitiyA^AOdismilsznlfooamld p~mmrdfenilszulfonamKL bsrnmlszulfonaraki 2.2,2-asx i c < iv.'biSi« 'sosli.i's« <\ V kaüi! am s S t m'epotnls s, i«)«s«\ ' sssîsokss? t'sss ΐ,-ν usrc N 2 sossahsoscpss mskmso esoportkd otcgvälßssityin •1 Az ) -.3. sgésss pontok tóssndyjke sxertmi vegyülhet: slkatetóisá-in&amp;s^rgtóíxíRíögoktó:Ssszoffig- _ t'ikp«*'» s s AîiW .Λ b x'i.'\ s ' so . Ci '-i' s aosssrstsss „ όθ'\'\ κο\ί1 ÆMiMàxêimi 9. Λ^ΐΙίΙϊ: ifi söpörnek bármelyike Sgcrinp v·:: gyb 1¾ I MsIxöbsikbJkÄ ösvsefííggó álopciók v''.'' N Cg-Og. k U*' 's'k ·. V.i i>‘ 'sCk' '« 'iKS:jfî<\. 4f> ICI Ä sl):s1|lnypi>stl ssegssiîi: aliyjmsgirv'sgv. a 3k ígápyposk ssrthis vegySI^. alsóit: a) a mikroorganizniua gosrsba. b) ;s snsksoorg&amp;m/smss haksedism. vag;. c) si tïsiki'aorgaisizsmis protonon,.. ! 1 G>ôgys.x iki)siitîBéî!y, arstçiy hsdoasnagkenv tartalmaz legalább ogy. a<? I > i#o>p<mt<i|.Í^§t#~'' kike dredníi vegybUne·. egy '.agy több gyôgys?«rész<;ÈHeg alkalmazható seg&amp;taoysg melletti. 12. Λ ; 1. igény pmst szerinti gy«Sg>sxefkészlíotény ahol az említett vegyíUes 1 -[2'C2^ikléffe«ilh2*· > (4 -OriOnormetil jbenzil joxi * etil j- I * t-l«»i<1axol vagy essssek gyógysaesesíc-ileg a lka lma/líf^§^ U. A il. íg#íSi;pn| ssgsább:pb®sz«:st;lszÍ|sábyo#Í0k8 p?ósygzeíkéssl^ issisSivéssás adagolásai alkalinssü forrnâbssss vas·.
HUE10811042A 2009-08-28 2010-08-27 Benzilaralkiléter vegyületek, eljárás ezek elõállítására, intermedier vegyületek, ezen vegyületek alkalmazása, eljárás kezelésre és/vagy megelõzésre, ezeket tartalmazó gyógyszerkészítmények és gyógyszerek HUE032199T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0904249-0A BRPI0904249B1 (pt) 2009-08-28 2009-08-28 Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica

Publications (1)

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HUE032199T2 true HUE032199T2 (hu) 2017-08-28

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HUE10811042A HUE032199T2 (hu) 2009-08-28 2010-08-27 Benzilaralkiléter vegyületek, eljárás ezek elõállítására, intermedier vegyületek, ezen vegyületek alkalmazása, eljárás kezelésre és/vagy megelõzésre, ezeket tartalmazó gyógyszerkészítmények és gyógyszerek

Country Status (24)

Country Link
US (1) US8975289B2 (hu)
EP (1) EP2471781B1 (hu)
JP (1) JP5718334B2 (hu)
KR (1) KR101765752B1 (hu)
CN (1) CN102625800A (hu)
AR (1) AR078115A1 (hu)
AU (1) AU2010286266B2 (hu)
BR (1) BRPI0904249B1 (hu)
CA (1) CA2771044C (hu)
CL (1) CL2012000463A1 (hu)
DK (1) DK2471781T3 (hu)
ES (1) ES2606168T3 (hu)
HU (1) HUE032199T2 (hu)
IL (1) IL218044A (hu)
IN (1) IN2012DN00611A (hu)
MX (1) MX2012002276A (hu)
PE (1) PE20120921A1 (hu)
PL (1) PL2471781T3 (hu)
PT (1) PT2471781T (hu)
RU (1) RU2548009C2 (hu)
SG (1) SG178298A1 (hu)
UA (1) UA108479C2 (hu)
WO (1) WO2011022798A1 (hu)
ZA (1) ZA201201442B (hu)

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CN104016837B (zh) * 2014-05-26 2016-08-24 武汉有机实业有限公司 4,4’-二甲基二苄基醚的制备方法
RU2603622C1 (ru) * 2015-06-25 2016-11-27 Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" Комплексный метод лечения тейлериоза мелкого рогатого скота
CN108047147A (zh) * 2017-12-08 2018-05-18 长江大学 一类三唑类化合物以及作为杀菌剂的用途
KR101983575B1 (ko) * 2017-12-21 2019-06-03 대한민국 신균주 세라토바시디움 속 js1289 및 이의 용도
EP4013405A4 (en) * 2019-08-16 2023-08-09 Purdue Research Foundation SMALL MOLECULE STIMULATORS OF THE PROTEASOME CORE PARTICLE

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EP2471781A4 (en) 2013-01-23
UA108479C2 (en) 2015-05-12
BRPI0904249A2 (pt) 2011-05-17
AR078115A1 (es) 2011-10-12
RU2012110925A (ru) 2013-10-10
US20120196908A1 (en) 2012-08-02
JP2013503111A (ja) 2013-01-31
BRPI0904249B1 (pt) 2018-03-06
IL218044A (en) 2017-02-28
EP2471781A1 (en) 2012-07-04
PT2471781T (pt) 2016-12-15
IL218044A0 (en) 2012-04-30
ZA201201442B (en) 2012-10-31
CL2012000463A1 (es) 2012-09-21
SG178298A1 (en) 2012-03-29
EP2471781B1 (en) 2016-09-07
KR101765752B1 (ko) 2017-08-07
KR20120050490A (ko) 2012-05-18
AU2010286266B2 (en) 2015-02-12
PL2471781T3 (pl) 2017-08-31
MX2012002276A (es) 2012-04-19
CA2771044A1 (en) 2011-03-03
RU2548009C2 (ru) 2015-04-10
DK2471781T3 (da) 2017-01-02
IN2012DN00611A (hu) 2015-06-12
AU2010286266A1 (en) 2012-04-05
CN102625800A (zh) 2012-08-01
ES2606168T3 (es) 2017-03-23
CA2771044C (en) 2017-07-04
JP5718334B2 (ja) 2015-05-13
WO2011022798A1 (pt) 2011-03-03
US8975289B2 (en) 2015-03-10
PE20120921A1 (es) 2012-08-01

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