HUE030160T2 - Alacsony éterszennyezõdés tartalmú atorvasztatin elõállítása - Google Patents

Alacsony éterszennyezõdés tartalmú atorvasztatin elõállítása Download PDF

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Publication number
HUE030160T2
HUE030160T2 HUE11714776A HUE11714776A HUE030160T2 HU E030160 T2 HUE030160 T2 HU E030160T2 HU E11714776 A HUE11714776 A HU E11714776A HU E11714776 A HUE11714776 A HU E11714776A HU E030160 T2 HUE030160 T2 HU E030160T2
Authority
HU
Hungary
Prior art keywords
mixture
added
solvent
stirred
atorvastatin
Prior art date
Application number
HUE11714776A
Other languages
English (en)
Inventor
De Ben Lange
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Publication of HUE030160T2 publication Critical patent/HUE030160T2/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (3)

  1. I «.£p*âs » (2) képtetij aîorvÎis*t3im-hëmj-ksJ<îmms6 debâsèm <i 1 áltyps3S Repídö vegyide&amp;ôk shd R} telentese «CHfCH·»)? Os &amp;> es R;i jek&amp;tese egymástól fögpsíltíi-mí &amp; étik me»! «s ptvpti -,ag> «*N >1 B s v ooeisahd'M" >, s> v'Mohextkdeft gyirtii Äöt> amelyiëut^^^Î::I"kâ%^k^ Sépésektl.
    tat ss (O ákakinox képkiö vegyöleöíék egy eho okitkserbeo kèssiïlt okat-Sítak keaeiése egy savval; ih) aa (s) tépésbe« kapott keverékkesgièse egy aík|Ik%»'|íít|a>xky&amp;l; te) a tb) lépesbe« k^^:ikiv^^::ikp%e|#se.k^icmpi^vil wgg. kslelsamhidíomdásk assai JelUïttw^x, »ps At v*> 'ép, "est kapott keveseket > jseradl S étiigieîjedin#i| tb^éttyltjök 18 rtC > 38 fok híbttép^klgten,
  2. 2. Az l- Igén, pont s remit I eljárás, ahol Rjés R;. jelentése sttsttk:
  3. 3. As I. vagy 2. $gé«ypoflt bármelyike ssertrrät eljárás, aboi as első oldószer alkoi-pk: 4v As . I >3. igéttyíxmtok bámidy Ike szermti eljárás, aboi aa első oklôsser metsmok JsAs I -4, tgè«y|3ont»'N bamtcíyike ste-noti dt&amp;as, ahol a lépesben kopottkeveréket egy második oldószered mossuk a (e) Iâî>csî ïÿl^îÎ, &amp;. As 5, t gésypont'$aerl%ti^játÉk. àfesâ a második oldószer egy éteri
HUE11714776A 2010-04-19 2011-04-18 Alacsony éterszennyezõdés tartalmú atorvasztatin elõállítása HUE030160T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10160279 2010-04-19
EP10175420 2010-09-06

Publications (1)

Publication Number Publication Date
HUE030160T2 true HUE030160T2 (hu) 2017-05-29

Family

ID=43902823

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE11714776A HUE030160T2 (hu) 2010-04-19 2011-04-18 Alacsony éterszennyezõdés tartalmú atorvasztatin elõállítása

Country Status (6)

Country Link
US (1) US20130041162A1 (hu)
EP (1) EP2560951B1 (hu)
CN (1) CN103108863B (hu)
HU (1) HUE030160T2 (hu)
SI (1) SI2560951T1 (hu)
WO (1) WO2011131605A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109232355A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种有效去除阿托伐他汀钙粗品中杂质阿托伐他汀缩合物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777552B2 (en) * 2001-08-16 2004-08-17 Teva Pharmaceutical Industries, Ltd. Processes for preparing calcium salt forms of statins
PT1341785E (pt) * 2000-11-16 2009-01-16 Teva Pharma Hidrólise de ésteres de ácidos r(r*,r*)-2-(4-fluorofenil)-beta,delta-di-hidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1h-pirrole-1-heptanóico com hidróxido de cálcio
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
FI120344B (fi) * 2004-03-17 2009-09-30 Ranbaxy Lab Ltd Menetelmä amorfisessa muodossa olevan atorvastatiinikalsiumin valmistamiseksi
CN1980890A (zh) * 2004-05-31 2007-06-13 兰贝克赛实验室有限公司 阿托伐他汀的制备方法
WO2006011155A1 (en) * 2004-07-26 2006-02-02 Apollo International Limited One pot process for amorphous atorvastain calcium
WO2006048893A2 (en) * 2004-11-05 2006-05-11 Morepen Laboratories Limited A process for synthesis of large particle size statin compounds
WO2008075165A1 (en) * 2006-12-19 2008-06-26 Pfizer Products Inc. Novel process for the synthesis of [r-(r*, r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid or a pharmaceutically acceptable salt thereof
WO2008129562A2 (en) * 2007-04-20 2008-10-30 Morepen Laboratories Limited An improved process for the preparation of stable amorphous atorvastatin hemi calcium and their salts thereof
ES2523404T3 (es) * 2007-08-03 2014-11-25 Pfizer Products Inc. Procedimiento de preparación de compuestos quirales

Also Published As

Publication number Publication date
EP2560951A1 (en) 2013-02-27
EP2560951B1 (en) 2016-05-25
SI2560951T1 (sl) 2016-10-28
CN103108863B (zh) 2015-08-19
CN103108863A (zh) 2013-05-15
US20130041162A1 (en) 2013-02-14
WO2011131605A1 (en) 2011-10-27

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