SI2560951T1 - Proizvodnja atorvastanina z nizko vsebnostjo etrskih nečistoč - Google Patents
Proizvodnja atorvastanina z nizko vsebnostjo etrskih nečistočInfo
- Publication number
- SI2560951T1 SI2560951T1 SI201130926A SI201130926A SI2560951T1 SI 2560951 T1 SI2560951 T1 SI 2560951T1 SI 201130926 A SI201130926 A SI 201130926A SI 201130926 A SI201130926 A SI 201130926A SI 2560951 T1 SI2560951 T1 SI 2560951T1
- Authority
- SI
- Slovenia
- Prior art keywords
- atorvastatin
- production
- low
- ether impurities
- impurities
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10160279 | 2010-04-19 | ||
| EP10175420 | 2010-09-06 | ||
| EP11714776.9A EP2560951B1 (en) | 2010-04-19 | 2011-04-18 | Production of atorvastatin low in ether impurities |
| PCT/EP2011/056103 WO2011131605A1 (en) | 2010-04-19 | 2011-04-18 | Production of atorvastatin low in ether impurities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2560951T1 true SI2560951T1 (sl) | 2016-10-28 |
Family
ID=43902823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201130926A SI2560951T1 (sl) | 2010-04-19 | 2011-04-18 | Proizvodnja atorvastanina z nizko vsebnostjo etrskih nečistoč |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130041162A1 (sl) |
| EP (1) | EP2560951B1 (sl) |
| CN (1) | CN103108863B (sl) |
| HU (1) | HUE030160T2 (sl) |
| SI (1) | SI2560951T1 (sl) |
| WO (1) | WO2011131605A1 (sl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109232355A (zh) * | 2018-10-09 | 2019-01-18 | 河南师范大学 | 一种有效去除阿托伐他汀钙粗品中杂质阿托伐他汀缩合物的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL155890A0 (en) * | 2000-11-16 | 2003-12-23 | Teva Pharma | HYDROLYSIS OF [R(R*,R*)]-2-(4-FLUOROPHENYL)-beta,delta-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID ESTERS WITH CALCIUM HYDROXIDE |
| US6777552B2 (en) * | 2001-08-16 | 2004-08-17 | Teva Pharmaceutical Industries, Ltd. | Processes for preparing calcium salt forms of statins |
| SI20814A (sl) * | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Priprava amorfnega atorvastatina |
| CZ296967B6 (cs) * | 2002-02-01 | 2006-08-16 | Zentiva, A.S. | Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) |
| WO2005092852A1 (en) * | 2004-03-17 | 2005-10-06 | Ranbaxy Laboratories Limited | Process for the production of atorvastatin calcium in amorphous form |
| US20090209612A1 (en) * | 2004-05-31 | 2009-08-20 | Sattigeri Jitendra A | Process for the preparation of atorvastatin |
| WO2006011155A1 (en) * | 2004-07-26 | 2006-02-02 | Apollo International Limited | One pot process for amorphous atorvastain calcium |
| WO2006048893A2 (en) * | 2004-11-05 | 2006-05-11 | Morepen Laboratories Limited | A process for synthesis of large particle size statin compounds |
| WO2008075165A1 (en) * | 2006-12-19 | 2008-06-26 | Pfizer Products Inc. | Novel process for the synthesis of [r-(r*, r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid or a pharmaceutically acceptable salt thereof |
| WO2008129562A2 (en) | 2007-04-20 | 2008-10-30 | Morepen Laboratories Limited | An improved process for the preparation of stable amorphous atorvastatin hemi calcium and their salts thereof |
| EP2532660B1 (en) | 2007-08-03 | 2014-09-10 | Pfizer Products Inc. | Process for preparing chiral compounds |
-
2011
- 2011-04-18 WO PCT/EP2011/056103 patent/WO2011131605A1/en active Application Filing
- 2011-04-18 HU HUE11714776A patent/HUE030160T2/en unknown
- 2011-04-18 SI SI201130926A patent/SI2560951T1/sl unknown
- 2011-04-18 US US13/642,005 patent/US20130041162A1/en not_active Abandoned
- 2011-04-18 EP EP11714776.9A patent/EP2560951B1/en active Active
- 2011-04-18 CN CN201180020007.4A patent/CN103108863B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011131605A1 (en) | 2011-10-27 |
| CN103108863B (zh) | 2015-08-19 |
| EP2560951B1 (en) | 2016-05-25 |
| CN103108863A (zh) | 2013-05-15 |
| EP2560951A1 (en) | 2013-02-27 |
| US20130041162A1 (en) | 2013-02-14 |
| HUE030160T2 (en) | 2017-05-29 |
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