HUE026953T2 - Immunglobulin konstans régió FC-receptort kötõ ágensek - Google Patents

Immunglobulin konstans régió FC-receptort kötõ ágensek Download PDF

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HUE026953T2
HUE026953T2 HUE08769936A HUE08769936A HUE026953T2 HU E026953 T2 HUE026953 T2 HU E026953T2 HU E08769936 A HUE08769936 A HU E08769936A HU E08769936 A HUE08769936 A HU E08769936A HU E026953 T2 HUE026953 T2 HU E026953T2
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Scott E Strome
Dan H Schulze
David S Block
Henrik Olsen
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Univ Maryland
Gliknik Inc
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Claims (2)

mmo mmmm ÍMHUN@ya8UUN kün§t&&s régió fc-reœptgrî koto ágensek Szabadalmi Igénypontok
1. Vegyidet amely két vagy több mu&amp;manzát egységet tartalmaz, ahol mindegyik ágyáéi tartalmaz muliimedzáló légiót, valamint olyan régsót, amely tartalmat legalább egy olyan Fc-domént, amely képes egy Foy-reeepiorhoz kbtédnl, ahol mindegyik egység tartalmaz két dimefizált monomert, ahol mindegyik monomer törtálmat multsmerizáió régié monomer valamint olyan régiét, amely tartalmat legalist) agy Fe-domén monomert, aboi a két monomer dimenzáolója muftimerizáló régiét képez, valamint olyan régiót, amely tartalmat legalább egy olyan fc-domént, amely képes egy Fo^reoeptortioz Itötődrb, ahol a két vagy több egység multtmerizáiö régiéi oieíiimartzálódva létrehozzák a vegyíMet, és ahol a vegyület képes egy első Fey-dornénen keresztül egy első Fcy-reoeptorhez, és egy második Fcy-doménen keresztül egy második Fcy-reeeptorhoz kötődni ahol a melmehzálé régió a következők által alkotott csoportból kerül kiválasztásra: Igó2~csukló, IgE CH2-domén, íeueíhöipzár, izoleuoinclpzár és <É?k~yj| és ahol mindegyik olyan régié, amely tartalmaz legalább egy olyan Fc-domént, amply képes egy Fcy-recepiorhcz kötődni tartalmaz !gG1-csuklói, tgGI CH2-domént és Ig0i ÓH^dornént
2, Készítmény, amely tartalmaz beöltethető vagy csatlakoztatható orvostechnikai eszközt és hozzákötve legalább egy 1. igénypont szerinti vegyötetet,
2, Gyógyászati készítmény, amely tartalmazza 1 igénypont szerinti vegyület terápiásán hatásos mennyiségét, gyógyszerként történő alkalmazásra olyan epiéÉhán, amelynek során megváltoztatunk egy immunválaszt egy alanyban, amely eljárás tartalmazza, hogy beadjuk a gyógyászati készítményt az arra szoruló alanynak. 4» Készítmény, amely tartalmaz olyan szubsztrétot amelyhez hozzá van kötődve 1 Igénypont szedni vegyület, gyulladásos állapot, autoimmun betegség, rákbetegség, esontsöröségs rendellenesség:, akté fertőzés vagy krónikus fertőzés olyan kezelésére szolgáié eljárásban történő alkalmazásra, amelyben gátoljuk egy monoelteerectetö sejt (IVIDC) aktivitását, amely eljárás tartalmazza, hogy in vivő érlntkeztetjük a sejtet a készítménnyel. S. Készítmény, amely tartalmaz olyan szubsztrétot, amelyhez hozzá van kötődve 1. Igénypont szerinti vegyilet, olyan kezelési eljárásban történő alkalmazásra, amelynek során beadjuk a készítmény egy állati alanynak, ahol az állatnál fennáll egy menooltaeredetű sejtek által közvetített állapot (MDMC) vagy annak kockázata, ahol az fvlöfvIC egy gyulladásos állapot, egy autoimmun betegség, egy rákbetegség, egy csontsűrűség! rendellenesség, egy akut 0< A készítmény alkalmazásra a 4, vagy ö. Igénypont szedni, ahol a gyulladásos állapot colitis ulcerosa vagy Âlzhelmer-kér, az autoimmun betegség gyulladásos derayeinlsstíöa polyradiculoneuropatlna, vagy a rákbetegség lymphoma.
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