HU9500436D0 - Pharmaceutically active diketopiperazines - Google Patents

Pharmaceutically active diketopiperazines

Info

Publication number
HU9500436D0
HU9500436D0 HU9500436A HU9500436A HU9500436D0 HU 9500436 D0 HU9500436 D0 HU 9500436D0 HU 9500436 A HU9500436 A HU 9500436A HU 9500436 A HU9500436 A HU 9500436A HU 9500436 D0 HU9500436 D0 HU 9500436D0
Authority
HU
Hungary
Prior art keywords
pct
nco2r11
nhco
alkyl
sec
Prior art date
Application number
HU9500436A
Other languages
English (en)
Other versions
HUT71592A (en
Inventor
Mark Anthony Collins
Maria Chicarelli-Robinson
Justin Bryans
Stephen Brocchini
John Shaw
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Ltd filed Critical Xenova Ltd
Publication of HU9500436D0 publication Critical patent/HU9500436D0/hu
Publication of HUT71592A publication Critical patent/HUT71592A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
HU9500436A 1992-08-14 1993-08-16 Pharmaceutically active diketopiperazines HUT71592A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929217331A GB9217331D0 (en) 1992-08-14 1992-08-14 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
HU9500436D0 true HU9500436D0 (en) 1995-04-28
HUT71592A HUT71592A (en) 1996-01-29

Family

ID=10720385

Family Applications (2)

Application Number Title Priority Date Filing Date
HU9500437A HUT71593A (en) 1992-08-14 1993-08-16 Diketopiperazines, pharmaceutical compositions containing and process for producing the compounds
HU9500436A HUT71592A (en) 1992-08-14 1993-08-16 Pharmaceutically active diketopiperazines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU9500437A HUT71593A (en) 1992-08-14 1993-08-16 Diketopiperazines, pharmaceutical compositions containing and process for producing the compounds

Country Status (24)

Country Link
US (1) US5700804A (hu)
EP (2) EP0655060B1 (hu)
JP (2) JPH08504175A (hu)
KR (2) KR950702967A (hu)
AT (1) ATE162186T1 (hu)
AU (2) AU678172B2 (hu)
BG (2) BG99496A (hu)
BR (2) BR9306904A (hu)
CA (2) CA2141938A1 (hu)
CZ (2) CZ38395A3 (hu)
DE (1) DE69316370T2 (hu)
DK (1) DK0655060T3 (hu)
ES (1) ES2111169T3 (hu)
FI (2) FI950616A (hu)
GB (2) GB9217331D0 (hu)
GR (1) GR3026272T3 (hu)
HU (2) HUT71593A (hu)
IL (2) IL106696A0 (hu)
PL (2) PL307438A1 (hu)
RU (2) RU95108759A (hu)
SK (2) SK19595A3 (hu)
TW (1) TW334427B (hu)
WO (2) WO1994004512A1 (hu)
ZA (2) ZA935968B (hu)

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GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
DK85193D0 (da) 1993-07-16 1993-07-16 Cancerforskningsfondet Af 1989 Suppression of inhibitors
GB9402805D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
IL112627A0 (en) * 1994-02-14 1995-05-26 Xenova Ltd Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them
GB9402809D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9410387D0 (en) * 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds
GB9426090D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB2311781B (en) * 1994-12-23 1998-09-16 Xenova Ltd Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
GB2310854B (en) * 1994-12-23 1998-09-09 Xenova Ltd Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
GB9426224D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB9426071D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
US5891877A (en) * 1995-02-14 1999-04-06 Xenova Limited Pharmaceutical compounds
EP1242379A1 (en) * 1999-12-03 2002-09-25 Emory University Curcumin analogues for treating cancer
US7288545B2 (en) * 2000-05-09 2007-10-30 Angiorx Corporation Piperazinedione compounds
EP1282609B1 (en) 2000-05-09 2008-12-17 AngioRx Corporation Piperazinedione compounds
CA2774959C (en) 2000-08-04 2016-05-31 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
ES2294026T3 (es) 2000-09-06 2008-04-01 Ap Pharma, Inc. Polimeros degradables de poliacetal.
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
WO2002062797A2 (en) * 2000-12-29 2002-08-15 Celltech R & D, Inc. Pharmaceutical uses and synthesis of diketopiperazines
GB2372740A (en) * 2001-01-17 2002-09-04 Xenova Ltd Diketopiperazines
US20060229239A9 (en) * 2002-03-08 2006-10-12 Mamoru Shoji Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
US7935704B2 (en) 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
DE60316688T2 (de) 2002-08-02 2008-07-17 Nereus Pharmaceuticals, Inc., San Diego Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon
DE10238144A1 (de) * 2002-08-15 2004-02-26 Basf Ag Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
CA2500652A1 (en) 2002-10-02 2004-04-15 Dmi Biosciences, Inc. Diagnosis and monitoring of diseases
JP2007500747A (ja) 2003-05-15 2007-01-18 ディーエムアイ バイオサイエンシズ インコーポレイテッド Ｔ細胞媒介性疾患の処置
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
US7732605B2 (en) 2005-03-29 2010-06-08 Nereus Pharmaceuticals, Inc. Synthesis of diketopiperazines
US20070270464A1 (en) * 2006-02-24 2007-11-22 Emory University Prodrugs of curcumin analogs
US8129527B2 (en) 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
SG10201802008TA (en) * 2011-02-10 2018-04-27 Mannkind Corp Formation of n-protected bis-3,6-(4-aminoalkyl) -2,5,diketopiperazine
SG10201608087WA (en) 2011-10-10 2016-11-29 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP2766029B1 (en) 2011-10-10 2020-03-25 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
MX355446B (es) 2011-10-28 2018-04-18 Ampio Pharmaceuticals Inc Tratamiento de rinitis.
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
CN103396372B (zh) * 2013-08-09 2015-05-20 中国科学院南海海洋研究所 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
CN105272968B (zh) * 2014-06-10 2018-03-13 首都医科大学 (3s,6r)‑3,6二取代哌嗪‑2,5‑二酮,其制备及应用
KR20170045274A (ko) 2014-08-18 2017-04-26 앰피오 파마슈티컬스 인코퍼레이티드 관절 징후의 치료
CN104610170B (zh) * 2015-01-14 2017-02-01 中国科学院南海海洋研究所 2,5‑二酮哌嗪衍生物及其制备方法和应用
KR102626155B1 (ko) 2015-03-06 2024-01-17 비욘드스프링 파마수티컬스, 인코포레이티드. Ras 돌연변이와 관련된 암의 치료 방법
EP3265091A4 (en) 2015-03-06 2018-08-01 Beyondspring Pharmaceuticals Inc. Method of treating a brain tumor
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
KR20180027563A (ko) 2015-07-13 2018-03-14 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린 조성물
US10912748B2 (en) 2016-02-08 2021-02-09 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
SG11201810872UA (en) 2016-06-06 2019-01-30 Beyondspring Pharmaceuticals Inc Composition and method for reducing neutropenia
EP3565812B1 (en) 2017-01-06 2023-12-27 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
JP2020514412A (ja) 2017-02-01 2020-05-21 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 好中球減少症の低減方法
CN110054619A (zh) * 2018-01-18 2019-07-26 西北农林科技大学 新型二酮哌嗪类组蛋白去乙酰化酶抑制剂
WO2019147615A1 (en) 2018-01-24 2019-08-01 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing thrombocytopenia via the administration of plinabulin
WO2021195265A1 (en) 2020-03-24 2021-09-30 Ampio Pharmaceuticals, Inc. Methods for treating diseases associated with respiratory viruses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE621862C (de) * 1932-07-01 1935-11-14 Guenther Schiemann Dr Verfahren zur Darstellung von Kondensationsprodukten kernfluorierter Arylaldehyde
BE584914A (hu) * 1958-11-24
JPS5747357A (en) * 1980-09-04 1982-03-18 Ricoh Co Ltd Novel disazo compound and its preparation
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
CA2141939A1 (en) 1994-03-03
ATE162186T1 (de) 1998-01-15
EP0672036A1 (en) 1995-09-20
AU4726593A (en) 1994-03-15
BG99495A (en) 1995-12-29
AU678172B2 (en) 1997-05-22
WO1994004512A1 (en) 1994-03-03
ZA935969B (en) 1995-02-16
CZ38195A3 (en) 1995-09-13
WO1994004513A1 (en) 1994-03-03
PL307438A1 (en) 1995-05-29
ES2111169T3 (es) 1998-03-01
FI950616A (fi) 1995-04-13
FI950617A (fi) 1995-04-13
HUT71592A (en) 1996-01-29
BG99496A (en) 1995-12-29
GB2284420B (en) 1996-09-25
TW334427B (en) 1998-06-21
CZ38395A3 (en) 1995-10-18
CA2141938A1 (en) 1994-03-03
JPH08504176A (ja) 1996-05-07
DK0655060T3 (da) 1998-02-09
IL106695A0 (en) 1993-12-08
KR950702967A (ko) 1995-08-23
HUT71593A (en) 1996-01-29
GB2284420A (en) 1995-06-07
EP0655060A1 (en) 1995-05-31
DE69316370T2 (de) 1998-07-16
SK19495A3 (en) 1995-11-08
FI950616A0 (fi) 1995-02-13
SK19595A3 (en) 1995-09-13
AU693420B2 (en) 1998-07-02
HU9500437D0 (en) 1995-04-28
US5700804A (en) 1997-12-23
RU95108759A (ru) 1996-12-10
KR950702968A (ko) 1995-08-23
ZA935968B (en) 1995-02-16
EP0655060B1 (en) 1998-01-14
IL106696A0 (en) 1993-12-08
FI950617A0 (fi) 1995-02-13
AU4726493A (en) 1994-03-15
RU95108387A (ru) 1996-12-10
BR9306904A (pt) 1998-12-08
GB9502859D0 (en) 1995-04-05
DE69316370D1 (de) 1998-02-19
GB9217331D0 (en) 1992-09-30
PL307437A1 (en) 1995-05-29
GR3026272T3 (en) 1998-06-30
JPH08504175A (ja) 1996-05-07
BR9306905A (pt) 1998-12-08

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Legal Events

Date Code Title Description
DFD9 Temporary protection cancelled due to non-payment of fee