HU226527B1 - Készítmények nátha kezelésére - Google Patents
Készítmények nátha kezelésére Download PDFInfo
- Publication number
- HU226527B1 HU226527B1 HU0402075A HUP0402075A HU226527B1 HU 226527 B1 HU226527 B1 HU 226527B1 HU 0402075 A HU0402075 A HU 0402075A HU P0402075 A HUP0402075 A HU P0402075A HU 226527 B1 HU226527 B1 HU 226527B1
- Authority
- HU
- Hungary
- Prior art keywords
- xylometazoline
- ipratropium
- salt
- composition
- acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 183
- 238000011282 treatment Methods 0.000 title claims description 65
- 201000009240 nasopharyngitis Diseases 0.000 title abstract description 14
- 150000003839 salts Chemical class 0.000 claims abstract description 138
- 229960001888 ipratropium Drugs 0.000 claims abstract description 86
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 claims abstract description 86
- YGWFCQYETHJKNX-UHFFFAOYSA-N 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1h-imidazol-3-ium;chloride Chemical compound [Cl-].CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCC[NH2+]1 YGWFCQYETHJKNX-UHFFFAOYSA-N 0.000 claims abstract description 59
- 208000024891 symptom Diseases 0.000 claims abstract description 58
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- 208000036071 Rhinorrhea Diseases 0.000 claims abstract description 18
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 claims description 174
- 229960000833 xylometazoline Drugs 0.000 claims description 93
- 229960001361 ipratropium bromide Drugs 0.000 claims description 79
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 26
- 239000003814 drug Substances 0.000 claims description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 23
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
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- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 2
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- 235000013773 glyceryl triacetate Nutrition 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 2
- MQIPRYDNKGFOGV-VVQPYUEFSA-M ipratropium chloride Chemical compound [Cl-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 MQIPRYDNKGFOGV-VVQPYUEFSA-M 0.000 claims description 2
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- 229940095064 tartrate Drugs 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Polyurethanes Or Polyureas (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101356 | 2001-09-18 | ||
| PCT/IB2002/003828 WO2003024433A2 (en) | 2001-09-18 | 2002-09-18 | Compositions for treatment of common cold, comprising ipratropium and xylometazoline |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0402075A2 HUP0402075A2 (hu) | 2005-02-28 |
| HUP0402075A3 HUP0402075A3 (en) | 2008-04-28 |
| HU226527B1 true HU226527B1 (hu) | 2009-03-30 |
Family
ID=8160714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0402075A HU226527B1 (hu) | 2001-09-18 | 2002-09-18 | Készítmények nátha kezelésére |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7652030B2 (https=) |
| EP (2) | EP1446119B1 (https=) |
| JP (1) | JP4500045B2 (https=) |
| KR (1) | KR100810872B1 (https=) |
| CN (1) | CN1290502C (https=) |
| AT (1) | ATE318601T1 (https=) |
| BR (1) | BRPI0212586B8 (https=) |
| CA (1) | CA2460140C (https=) |
| DE (1) | DE60209511T2 (https=) |
| DK (1) | DK1446119T3 (https=) |
| EA (1) | EA008165B1 (https=) |
| ES (1) | ES2259098T3 (https=) |
| HU (1) | HU226527B1 (https=) |
| MX (1) | MXPA04002500A (https=) |
| NO (1) | NO334441B1 (https=) |
| NZ (1) | NZ531792A (https=) |
| PL (1) | PL208686B1 (https=) |
| PT (1) | PT1446119E (https=) |
| SI (1) | SI1446119T1 (https=) |
| WO (1) | WO2003024433A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| DE60209511T2 (de) * | 2001-09-18 | 2006-10-05 | Nycomed Danmark Aps | Zusammensetzungen zur behandlung des schnupfens, welche ipratropium und xylometazolin enthalten |
| TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| RU2006132043A (ru) * | 2004-02-06 | 2008-03-20 | МЕДА Фарма ГмбХ унд Ко.КГ (DE) | Комбинация и фармацевтический препарат для лечения ринита |
| WO2005084330A2 (en) * | 2004-03-02 | 2005-09-15 | Synergia Pharma, Inc. | Compositions and methods for treating nasal congestion |
| DE102004049008A1 (de) * | 2004-10-05 | 2006-04-06 | Merck Patent Gmbh | Neue Verwendung für α-Sympathomimetika mit 2-Imidazolinstruktur |
| MX2007007836A (es) * | 2004-12-27 | 2007-08-20 | Eisai R&D Man Co Ltd | Metodo para estabilizar un farmaco anti-demencia. |
| DE102006023770A1 (de) * | 2006-05-20 | 2007-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Treibgasfreie Aerosolformulierung für die Inhalation |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| US20090270472A1 (en) * | 2008-04-25 | 2009-10-29 | Kenneth Gould | Method to use oxymetazoline to interrupt the development of the common cold syndrome |
| EP2414560B1 (de) | 2009-03-31 | 2013-10-23 | Boehringer Ingelheim International GmbH | Verfahren zur beschichtung einer oberfläche eines bauteils |
| JP5763053B2 (ja) | 2009-05-18 | 2015-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アダプタ、吸入器具及びアトマイザ |
| WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
| BR112012012475B1 (pt) | 2009-11-25 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Nebulizador |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2011160932A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
| EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| WO2014158119A1 (en) * | 2013-03-29 | 2014-10-02 | Santa Farma İlaç Sanayi̇ A.Ş | Aqueous solution composition containing ipratropium and oxymetazoline |
| WO2014158118A1 (en) * | 2013-03-29 | 2014-10-02 | Santa Farma İlaç Sanayi̇ A.Ş. | Suspension composition containing ipratropium and oxymetazoline |
| ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
| JP6643231B2 (ja) | 2013-08-09 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| WO2015054359A1 (en) * | 2013-10-08 | 2015-04-16 | Ebadi Mark A | Methods and compositions for symptomatic reflief of the common cold |
| WO2015169430A1 (en) | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Nebulizer |
| IL247927B (en) | 2014-05-07 | 2022-09-01 | Boehringer Ingelheim Int | Container, a device that turns a liquid into a fine spray and use |
| CN116036425A (zh) | 2014-05-07 | 2023-05-02 | 勃林格殷格翰国际有限公司 | 喷雾器、指示器装置及容器 |
| US20170348230A1 (en) * | 2014-12-24 | 2017-12-07 | Jadran-Galenski Laboratorij D.D | A nasal composition containing sea water as stability-improving excipient |
| MX383771B (es) * | 2015-12-02 | 2025-03-14 | Pablo Cortes Borrego | Combinación de oximetazolina e ipratropio en aplicación tópica nasal para el tratamiento de la tos. |
| US20220031739A1 (en) * | 2020-07-31 | 2022-02-03 | Eye Therapies Llc | Anti-viral compositions and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69229880T2 (de) * | 1991-11-19 | 2000-05-04 | The University Of Virginia Patent Foundation, Charlottesville | Kombinierte virustatikum-antimediator-behandlung (covam) von gewöhnlichen erkältungen |
| IL101056A (en) | 1992-02-24 | 1997-03-18 | Res & Dev Co Ltd | Composition for nasal treatment |
| GB9218834D0 (en) | 1992-09-05 | 1992-10-21 | Procter & Gamble | Nasal spray products |
| ATE177941T1 (de) * | 1992-12-09 | 1999-04-15 | Boehringer Ingelheim Pharma | Stabilisierte medizinische aerosollösungen |
| EP0780127A1 (en) | 1995-12-19 | 1997-06-25 | The Procter & Gamble Company | A nasal spray containing a steroid and a antihistamine |
| DE19653969A1 (de) | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| WO1998048839A1 (en) * | 1997-04-30 | 1998-11-05 | Warner-Lambert Company | Topical nasal antiinflammatory compositions |
| CA2311530C (en) * | 1998-01-30 | 2008-06-10 | Novartis Consumer Health S.A. | Nasal solutions |
| BR9911351A (pt) | 1998-06-18 | 2001-03-13 | Boehringer Ingelheim Pharma | Formulações farmacêuticas para aerossóis com duas ou mais substâncias ativas |
| AU765736B2 (en) | 1999-06-22 | 2003-09-25 | Boehringer Ingelheim International Gmbh | Stable xylometazoline and oxymetazoline solution |
| DE60209511T2 (de) * | 2001-09-18 | 2006-10-05 | Nycomed Danmark Aps | Zusammensetzungen zur behandlung des schnupfens, welche ipratropium und xylometazolin enthalten |
-
2002
- 2002-09-18 DE DE60209511T patent/DE60209511T2/de not_active Expired - Lifetime
- 2002-09-18 EP EP02765268A patent/EP1446119B1/en not_active Expired - Lifetime
- 2002-09-18 DK DK02765268T patent/DK1446119T3/da active
- 2002-09-18 ES ES02765268T patent/ES2259098T3/es not_active Expired - Lifetime
- 2002-09-18 PL PL370536A patent/PL208686B1/pl unknown
- 2002-09-18 WO PCT/IB2002/003828 patent/WO2003024433A2/en not_active Ceased
- 2002-09-18 SI SI200230311T patent/SI1446119T1/sl unknown
- 2002-09-18 HU HU0402075A patent/HU226527B1/hu unknown
- 2002-09-18 MX MXPA04002500A patent/MXPA04002500A/es active IP Right Grant
- 2002-09-18 EP EP06075452A patent/EP1661570A3/en not_active Withdrawn
- 2002-09-18 US US10/489,655 patent/US7652030B2/en not_active Expired - Lifetime
- 2002-09-18 CA CA002460140A patent/CA2460140C/en not_active Expired - Lifetime
- 2002-09-18 BR BRPI0212586A patent/BRPI0212586B8/pt not_active IP Right Cessation
- 2002-09-18 CN CNB028182871A patent/CN1290502C/zh not_active Expired - Lifetime
- 2002-09-18 AT AT02765268T patent/ATE318601T1/de active
- 2002-09-18 JP JP2003528530A patent/JP4500045B2/ja not_active Expired - Lifetime
- 2002-09-18 EA EA200400444A patent/EA008165B1/ru unknown
- 2002-09-18 PT PT02765268T patent/PT1446119E/pt unknown
- 2002-09-18 KR KR1020047003882A patent/KR100810872B1/ko not_active Expired - Lifetime
- 2002-09-18 NZ NZ531792A patent/NZ531792A/en not_active IP Right Cessation
-
2004
- 2004-03-12 NO NO20041070A patent/NO334441B1/no not_active IP Right Cessation
-
2009
- 2009-12-11 US US12/654,145 patent/US8450339B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: TAKEDA PHARMA A/S, DK Free format text: FORMER OWNER(S): NYCOMED DANMARK APS, DK |
|
| HC9A | Change of name, address |
Owner name: TAKEDA PHARMA A/S, DK Free format text: FORMER OWNER(S): NYCOMED DANMARK APS, DK; TAKEDA PHARMA A/S, DK |