HU221499B - 27-hydroxyrapamycin and derivatives thereof, pharmaceutical compositions containing them and intermediates thereof - Google Patents
27-hydroxyrapamycin and derivatives thereof, pharmaceutical compositions containing them and intermediates thereof Download PDFInfo
- Publication number
- HU221499B HU221499B HU9500432A HU9500432A HU221499B HU 221499 B HU221499 B HU 221499B HU 9500432 A HU9500432 A HU 9500432A HU 9500432 A HU9500432 A HU 9500432A HU 221499 B HU221499 B HU 221499B
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- HU
- Hungary
- Prior art keywords
- rapamycin
- hydroxy
- comp
- pharmaceutically acceptable
- compound
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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- 150000005671 trienes Chemical class 0.000 description 1
- STMPXDBGVJZCEX-UHFFFAOYSA-N triethylsilyl trifluoromethanesulfonate Chemical compound CC[Si](CC)(CC)OS(=O)(=O)C(F)(F)F STMPXDBGVJZCEX-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93012492A | 1992-08-13 | 1992-08-13 | |
| US08/009,605 US5256790A (en) | 1992-08-13 | 1993-01-27 | 27-hydroxyrapamycin and derivatives thereof |
| PCT/US1993/007581 WO1994004540A1 (en) | 1992-08-13 | 1993-08-12 | 27-hydroxyrapamycin and derivatives thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9500432D0 HU9500432D0 (en) | 1995-04-28 |
| HUT71614A HUT71614A (en) | 1996-01-29 |
| HU221499B true HU221499B (en) | 2002-10-28 |
Family
ID=26679675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9500432A HU221499B (en) | 1992-08-13 | 1993-08-12 | 27-hydroxyrapamycin and derivatives thereof, pharmaceutical compositions containing them and intermediates thereof |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0655065B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH08501084A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE146179T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU5007193A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2142288A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69306585T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK0655065T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2096941T3 (cg-RX-API-DMAC10.html) |
| GR (1) | GR3022730T3 (cg-RX-API-DMAC10.html) |
| HU (1) | HU221499B (cg-RX-API-DMAC10.html) |
| MX (1) | MX9304868A (cg-RX-API-DMAC10.html) |
| WO (1) | WO1994004540A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| WO1995014023A1 (en) * | 1993-11-19 | 1995-05-26 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| AU712193B2 (en) * | 1995-06-09 | 1999-10-28 | Novartis Ag | Rapamycin derivatives |
| EP1212331B1 (en) | 1999-08-24 | 2004-04-21 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| PL216224B1 (pl) | 2002-02-01 | 2014-03-31 | Ariad Pharmaceuticals | Pochodne rapamycyny zawierające fosfor, kompozycja je zawierająca oraz ich zastosowanie |
| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| WO2008060546A2 (en) | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Oral formulations |
| US8921642B2 (en) | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
| CA2905229C (en) | 2013-06-11 | 2023-10-10 | Clontech Laboratories, Inc. | Protein enriched microvesicles and methods of making and using the same |
| EP3788050B1 (en) | 2018-05-01 | 2024-08-28 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
| CR20240382A (es) | 2018-05-01 | 2025-08-29 | Revolution Medicines Inc | ANÁLOGOS DE RAPAMICINA A C40, C28 Y C32 COMO INHIBIDORES DE MTOR (Divisional 2020-578) |
| EP4320101A2 (en) * | 2021-04-09 | 2024-02-14 | Revolution Medicines, Inc. | Synthesis of rapamycin analog compounds |
| AU2023275778A1 (en) | 2022-05-25 | 2024-12-12 | Revolution Medicines, Inc. | Methods of treating cancer with an mtor inhibitor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
-
1993
- 1993-08-11 MX MX9304868A patent/MX9304868A/es not_active IP Right Cessation
- 1993-08-12 DK DK93919994.9T patent/DK0655065T3/da active
- 1993-08-12 AU AU50071/93A patent/AU5007193A/en not_active Abandoned
- 1993-08-12 CA CA002142288A patent/CA2142288A1/en not_active Abandoned
- 1993-08-12 EP EP93919994A patent/EP0655065B1/en not_active Expired - Lifetime
- 1993-08-12 JP JP6506398A patent/JPH08501084A/ja active Pending
- 1993-08-12 HU HU9500432A patent/HU221499B/hu not_active IP Right Cessation
- 1993-08-12 DE DE69306585T patent/DE69306585T2/de not_active Expired - Fee Related
- 1993-08-12 WO PCT/US1993/007581 patent/WO1994004540A1/en not_active Ceased
- 1993-08-12 AT AT93919994T patent/ATE146179T1/de not_active IP Right Cessation
- 1993-08-12 ES ES93919994T patent/ES2096941T3/es not_active Expired - Lifetime
-
1997
- 1997-03-03 GR GR970400422T patent/GR3022730T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE146179T1 (de) | 1996-12-15 |
| DK0655065T3 (cg-RX-API-DMAC10.html) | 1997-02-24 |
| DE69306585T2 (de) | 1997-04-17 |
| MX9304868A (es) | 1994-05-31 |
| HUT71614A (en) | 1996-01-29 |
| JPH08501084A (ja) | 1996-02-06 |
| ES2096941T3 (es) | 1997-03-16 |
| CA2142288A1 (en) | 1994-03-03 |
| AU5007193A (en) | 1994-03-15 |
| HU9500432D0 (en) | 1995-04-28 |
| GR3022730T3 (en) | 1997-06-30 |
| DE69306585D1 (de) | 1997-01-23 |
| WO1994004540A1 (en) | 1994-03-03 |
| EP0655065A1 (en) | 1995-05-31 |
| EP0655065B1 (en) | 1996-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DGB9 | Succession in title of applicant |
Owner name: WYETH, US |
|
| HMM4 | Cancellation of final prot. due to non-payment of fee |