ES2096941T3 - 27-hidroxirrapamicina y derivados de la misma. - Google Patents
27-hidroxirrapamicina y derivados de la misma.Info
- Publication number
- ES2096941T3 ES2096941T3 ES93919994T ES93919994T ES2096941T3 ES 2096941 T3 ES2096941 T3 ES 2096941T3 ES 93919994 T ES93919994 T ES 93919994T ES 93919994 T ES93919994 T ES 93919994T ES 2096941 T3 ES2096941 T3 ES 2096941T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- hydroxirrapamicina
- same
- hydroxyrapamycin
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93012492A | 1992-08-13 | 1992-08-13 | |
| US08/009,605 US5256790A (en) | 1992-08-13 | 1993-01-27 | 27-hydroxyrapamycin and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2096941T3 true ES2096941T3 (es) | 1997-03-16 |
Family
ID=26679675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93919994T Expired - Lifetime ES2096941T3 (es) | 1992-08-13 | 1993-08-12 | 27-hidroxirrapamicina y derivados de la misma. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0655065B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH08501084A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE146179T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU5007193A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2142288A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69306585T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK0655065T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2096941T3 (cg-RX-API-DMAC10.html) |
| GR (1) | GR3022730T3 (cg-RX-API-DMAC10.html) |
| HU (1) | HU221499B (cg-RX-API-DMAC10.html) |
| MX (1) | MX9304868A (cg-RX-API-DMAC10.html) |
| WO (1) | WO1994004540A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| WO1995014023A1 (en) * | 1993-11-19 | 1995-05-26 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| AU712193B2 (en) * | 1995-06-09 | 1999-10-28 | Novartis Ag | Rapamycin derivatives |
| EP1212331B1 (en) | 1999-08-24 | 2004-04-21 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| PL216224B1 (pl) | 2002-02-01 | 2014-03-31 | Ariad Pharmaceuticals | Pochodne rapamycyny zawierające fosfor, kompozycja je zawierająca oraz ich zastosowanie |
| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| WO2008060546A2 (en) | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Oral formulations |
| US8921642B2 (en) | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
| CA2905229C (en) | 2013-06-11 | 2023-10-10 | Clontech Laboratories, Inc. | Protein enriched microvesicles and methods of making and using the same |
| EP3788050B1 (en) | 2018-05-01 | 2024-08-28 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
| CR20240382A (es) | 2018-05-01 | 2025-08-29 | Revolution Medicines Inc | ANÁLOGOS DE RAPAMICINA A C40, C28 Y C32 COMO INHIBIDORES DE MTOR (Divisional 2020-578) |
| EP4320101A2 (en) * | 2021-04-09 | 2024-02-14 | Revolution Medicines, Inc. | Synthesis of rapamycin analog compounds |
| AU2023275778A1 (en) | 2022-05-25 | 2024-12-12 | Revolution Medicines, Inc. | Methods of treating cancer with an mtor inhibitor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
-
1993
- 1993-08-11 MX MX9304868A patent/MX9304868A/es not_active IP Right Cessation
- 1993-08-12 DK DK93919994.9T patent/DK0655065T3/da active
- 1993-08-12 AU AU50071/93A patent/AU5007193A/en not_active Abandoned
- 1993-08-12 CA CA002142288A patent/CA2142288A1/en not_active Abandoned
- 1993-08-12 EP EP93919994A patent/EP0655065B1/en not_active Expired - Lifetime
- 1993-08-12 JP JP6506398A patent/JPH08501084A/ja active Pending
- 1993-08-12 HU HU9500432A patent/HU221499B/hu not_active IP Right Cessation
- 1993-08-12 DE DE69306585T patent/DE69306585T2/de not_active Expired - Fee Related
- 1993-08-12 WO PCT/US1993/007581 patent/WO1994004540A1/en not_active Ceased
- 1993-08-12 AT AT93919994T patent/ATE146179T1/de not_active IP Right Cessation
- 1993-08-12 ES ES93919994T patent/ES2096941T3/es not_active Expired - Lifetime
-
1997
- 1997-03-03 GR GR970400422T patent/GR3022730T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE146179T1 (de) | 1996-12-15 |
| DK0655065T3 (cg-RX-API-DMAC10.html) | 1997-02-24 |
| DE69306585T2 (de) | 1997-04-17 |
| MX9304868A (es) | 1994-05-31 |
| HUT71614A (en) | 1996-01-29 |
| JPH08501084A (ja) | 1996-02-06 |
| CA2142288A1 (en) | 1994-03-03 |
| AU5007193A (en) | 1994-03-15 |
| HU9500432D0 (en) | 1995-04-28 |
| HU221499B (en) | 2002-10-28 |
| GR3022730T3 (en) | 1997-06-30 |
| DE69306585D1 (de) | 1997-01-23 |
| WO1994004540A1 (en) | 1994-03-03 |
| EP0655065A1 (en) | 1995-05-31 |
| EP0655065B1 (en) | 1996-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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