HU211667A9 - Apolipoprotein - Google Patents
Apolipoprotein Download PDFInfo
- Publication number
- HU211667A9 HU211667A9 HU95P/P00630P HU9500630P HU211667A9 HU 211667 A9 HU211667 A9 HU 211667A9 HU 9500630 P HU9500630 P HU 9500630P HU 211667 A9 HU211667 A9 HU 211667A9
- Authority
- HU
- Hungary
- Prior art keywords
- dimer
- apo
- apolipoprotein
- milano
- plasma
- Prior art date
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Claims (17)
1. Apolipoprotein-Al-Milano dimer, lényegében tiszta formában.
2. Az 1. igénypont szerinti Apolipoprotein-Al-Milano dimer, amely vérplazmából származik.
3. Apolipoprotein-Al-Milano dimer, amely lényegében megegyezik az 1. vagy 2. példában leírt és bemutatott Apolipoprotein-Al-Milano dimerekkel.
4. Az 1, igénypont szerinti Apolipoprotein-Al-Milano dimer, amely rekombináns eljárással van előállítva.
5. Apolipoprotein-Al-Milano dimer, amely lényegében megegyezik a 3. példában leírt és bemutatott Apolipoprotein-Al-Milano dimerrel.
6. Gyógyászati készítmény, amely az 1. igénypont szerinti dimert hordozóval együtt tartalmazza.
7. Gyógyászati készítmény, amely az 1. igénypont szerinti dimert stabilizáló ágenssel és adott esetben hordozóval együtt tartalmazza.
8. Az 6. vagy 7. igénypont szerinti gyógyászati készítmény, amely lipid tartalom csökkentő anyagot és hordozót is tartalmaz.
9. Az 7. igénypont szerinti gyógyászati készítmény. amely a dimert egy stabilizáló lipid vegyülettel együtt tartalmazza, és adott esetben lipidtartalom csökkentő anyagot, valamint adott esetben hordozót is tartalmaz.
10. Az 6. igénypont szerinti gyógyászati készítmény, amely foszfolipidet is tartalmaz, adott esetben lipidtartalom csökkentő anyaggal és adott esetben hordozóval együtt.
11. Eljárás az 1. igénypont szerinti dimer előállítására, azzal jellemezve hogy
a) a dimert olyan rekombináns eljárással állítjuk elő, mely szerint E. coli intracelluláris fúziós fehérje rendszert, majd hangyasavas hasítást alkalmazunk,
b) a dimert vérplazmából állítjuk elő úgy, hogy Apolipoprotein-Al-Milano hordozó személyektől vérplazmát gyűjtünk, izoláljuk a HDL-apolipoproteineket és a dimert több lépésben végzett Sephacryl-kromatográfiával választjuk el,
c) a dimert vérplazmából állítjuk elő úgy, hogy először a monomert tisztítjuk, majd azt dimerré alakítjuk.
12. Az 1. igénypont szerinti dimer alkalmazása a dimert tartalmazó ateroszklerózis és más kardiovaszkuláris betegségek kezelésére alkalmas gyógyászati készítmény előállítására.
13. A 12. igénypont szerinti alkalmazás főbb szív- és érrendszeri betegségek, mint például szívizom infarktus, kiegyensúlyozatlan angina és akut perifériális érrendszeri elzáródások megelőzésére és kezelésére.
14. A 12. igénypont szerinti alkalmazás a krónikus artériás állapotok kezelésére.
15. A 12. igénypont szerinti alkalmazás trombózis megelőzésére és kezelésére.
16. A 12. igénypont szerinti alkalmazás, amelynél a gyógyászati készítmény lipidtartalom csökkentő hatóanyagot is tartalmaz.
17. Az 1. igénypont szerinti dimer alkalmazása a dimert tartalmazó, ateroszklerózis és más kardiovaszkuláris betegségek kezelésére alkalmas gyógyászati készítmény előállítására, amelynél a dimer a monomer „prodrug”-jaként hat.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9103701A SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Apolipoprotein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU211667A9 true HU211667A9 (en) | 1995-12-28 |
Family
ID=20384608
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9302344A HU217203B (hu) | 1991-12-13 | 1992-12-11 | Apolipoprotein molekuláris variánsának dimerje, és az előállítására szolgáló eljárás |
| HU95P/P00630P HU211667A9 (en) | 1991-12-13 | 1995-06-30 | Apolipoprotein |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9302344A HU217203B (hu) | 1991-12-13 | 1992-12-11 | Apolipoprotein molekuláris variánsának dimerje, és az előállítására szolgáló eljárás |
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Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
| IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
| SE9103701D0 (sv) * | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
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1991
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1992
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Owner name: ESPERION THERAPEUTICS INC.,, US |