HU202526B - Process for producing new 4-oh-quinolinecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds - Google Patents

Process for producing new 4-oh-quinolinecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds Download PDF

Info

Publication number
HU202526B
HU202526B HU862842A HU284286A HU202526B HU 202526 B HU202526 B HU 202526B HU 862842 A HU862842 A HU 862842A HU 284286 A HU284286 A HU 284286A HU 202526 B HU202526 B HU 202526B
Authority
HU
Hungary
Prior art keywords
formula
compound
alkyl
defined above
compounds
Prior art date
Application number
HU862842A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT43598A (en
Inventor
Francois Clemence
Francoise Delevallee
Martret Odile Le
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of HUT43598A publication Critical patent/HUT43598A/hu
Publication of HU202526B publication Critical patent/HU202526B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU862842A 1985-07-25 1986-07-08 Process for producing new 4-oh-quinolinecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds HU202526B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8511389A FR2585356B1 (fr) 1985-07-25 1985-07-25 Nouveaux derives de l'acide 4-oh quinoleine carboxylique substitues en 2 par deux fonctions hydroxyle eventuellement etherifiees ou esterifiees, leurs procedes de preparation, les nouveaux intermediaires obtenus, leur application comme medicaments et les compositions les renfermant

Publications (2)

Publication Number Publication Date
HUT43598A HUT43598A (en) 1987-11-30
HU202526B true HU202526B (en) 1991-03-28

Family

ID=9321642

Family Applications (1)

Application Number Title Priority Date Filing Date
HU862842A HU202526B (en) 1985-07-25 1986-07-08 Process for producing new 4-oh-quinolinecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds

Country Status (16)

Country Link
EP (1) EP0214004B1 (de)
JP (1) JPH0710863B2 (de)
KR (1) KR940003759B1 (de)
AT (1) ATE87625T1 (de)
AU (1) AU609377B2 (de)
CA (1) CA1262903A (de)
DE (1) DE3688161T2 (de)
DK (1) DK172034B1 (de)
ES (1) ES2000739A6 (de)
FI (1) FI86426C (de)
FR (1) FR2585356B1 (de)
GR (1) GR861924B (de)
HU (1) HU202526B (de)
PT (1) PT83064B (de)
SU (1) SU1584749A3 (de)
ZA (1) ZA865260B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845105A (en) * 1984-10-30 1989-07-04 Roussel Uclaf 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
US5438344A (en) * 1990-11-05 1995-08-01 Oliva; Anthony Portable video book
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
WO1997048707A1 (en) * 1996-06-20 1997-12-24 Smithkline Beecham Plc 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents
JP3337992B2 (ja) * 1997-11-04 2002-10-28 ファイザー製薬株式会社 ５−置換ピコリン酸化合物及びその製造方法
JP4804590B1 (ja) 2010-04-14 2011-11-02 帝人テクノプロダクツ株式会社 メタ型全芳香族ポリアミド繊維

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS593996B2 (ja) * 1975-11-25 1984-01-27 キツセイ薬品工業株式会社 ２−スチリル−３，１−ベンゾオキサジン−４−オン誘導体及びその製造方法
JPS593995B2 (ja) * 1975-12-31 1984-01-27 キツセイヤクヒンコウギヨウ カブシキガイシヤ ２− スチリル −３，１− ベンゾオキサジン −４− オンユウドウタイノセイゾウホウホウ
FR2509728A1 (fr) * 1981-07-17 1983-01-21 Roussel Uclaf Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2530633A1 (fr) * 1982-06-03 1984-01-27 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
ZA871658B (en) * 1986-03-27 1987-08-28 Warner-Lambert Company Chewing gum and confectionery compositions containing a soy flavor enhancer

Also Published As

Publication number Publication date
FI863040A0 (fi) 1986-07-24
EP0214004A3 (en) 1989-04-05
DK351886D0 (da) 1986-07-24
SU1584749A3 (ru) 1990-08-07
GR861924B (en) 1986-11-25
DK172034B1 (da) 1997-09-22
FR2585356B1 (fr) 1987-10-23
PT83064A (en) 1986-08-01
ATE87625T1 (de) 1993-04-15
JPS6229585A (ja) 1987-02-07
FI86426B (fi) 1992-05-15
CA1262903A (fr) 1989-11-14
EP0214004A2 (de) 1987-03-11
FI86426C (fi) 1992-08-25
FI863040A (fi) 1987-01-26
AU6050986A (en) 1987-01-29
DE3688161T2 (de) 1993-10-14
PT83064B (pt) 1989-02-28
AU609377B2 (en) 1991-05-02
FR2585356A1 (fr) 1987-01-30
DK351886A (da) 1987-01-26
EP0214004B1 (de) 1993-03-31
KR940003759B1 (ko) 1994-04-30
DE3688161D1 (de) 1993-05-06
JPH0710863B2 (ja) 1995-02-08
ES2000739A6 (es) 1988-03-16
HUT43598A (en) 1987-11-30
ZA865260B (en) 1987-09-30
KR870001206A (ko) 1987-03-12

Similar Documents

Publication Publication Date Title
US4107310A (en) Quinoline-3-carboxamides
US4233299A (en) 4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts thereof
US4299831A (en) 2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-inflammatory compositions and methods employing them
EP0003893B1 (de) Dibenzo (b,f) oxepin und Dibenzo (b,f) thiepinderivate, ihre pharmazeutisch akzeptablen Salze, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DK152212B (da) Analogifremgangsmaade til fremstilling af 2-substituerede 4-hydroxy-3-quinolincarboxylsyrederivater
US3933905A (en) (5-Oxo-10,11-dihydrodibenzo[a,d]-cyclohepten-2-yl)-alkanoic acids
US4845105A (en) 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
DE3131527A1 (de) 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
HU202526B (en) Process for producing new 4-oh-quinolinecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds
US4450275A (en) Cyclic iminocarboxylic acid derivatives
US3816443A (en) 4-(benzothiazol-2-yl)fluoro phenyl-acetic acids
Zinnes et al. 1, 2-Benzothiazines. 6. 3-Carbamoyl-4-hydroxy-2H-1, 2-benzothiazine 1, 1-dioxides as antiinflammatory agents
GB2061274A (en) 3-benzoyl-2-nitrophenylacetic acids metal salts amides and esters
EP0096890B1 (de) Oxazolessigsäure-Derivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Zusammensetzungen
US4736033A (en) Certain 1,3-dihydro-1-[heterocyclic)imino]-furo-[3,4-b]quinoline 9-ol compounds having analgesic and anti-inflammatory activity
US4486594A (en) Thiazolidine derivatives and production thereof
CZ590689A3 (en) 3-acyl-2-octindole-1-carboxamides, and process for preparing thereof
KR960012367B1 (ko) 2-알킬설피닐-4(3h)-퀴나졸리논 유도체, 이의 제조방법 및 약제학적 조성물
HU180209B (en) Process for producing substituted acyl-bracket-bicyclic aryl-bracket closed-amino alkanoic acids
US4735951A (en) Novel 4-hydroxy-3-quinoline-carboxylates having analgesic and anti-inflammatory activity
US4297369A (en) Certain muscle relaxant 3-methyl-2-benzofuran acetamides
GB2054593A (en) 6-Alkyl-7-phenyl-1,6-naphthyridine- 5(6H)-one derivatives
RU2090559C1 (ru) Рацемические или оптически активные производные изохинолина, способ их получения, фармацевтическая композиция на их основе и способ получения фармацевтической композиции
FI70574B (fi) Foerfarande foer framstaellning av nya farmaceutiskt anvaendbara derivat av 2-((4-kinolinyl)-amino)-5-fluor- bensoesyra
US3975437A (en) Dibenzo (a,d) cycloheptene derivatives

Legal Events

Date Code Title Description
HPC4 Succession in title of patentee

Owner name: HOECHST MARION ROUSSEL, FR

HPC4 Succession in title of patentee

Owner name: AVENTIS PHARMA S.A., FR

HMM4 Cancellation of final prot. due to non-payment of fee