HU200792B - Process for producing new fibrinolytic enzymes and pharmaceutical compositions comprising such enzymes as active ingredient - Google Patents

Process for producing new fibrinolytic enzymes and pharmaceutical compositions comprising such enzymes as active ingredient Download PDF

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Publication number
HU200792B
HU200792B HU831903A HU190383A HU200792B HU 200792 B HU200792 B HU 200792B HU 831903 A HU831903 A HU 831903A HU 190383 A HU190383 A HU 190383A HU 200792 B HU200792 B HU 200792B
Authority
HU
Hungary
Prior art keywords
enzyme
enzymes
gpk
cell
activity
Prior art date
Application number
HU831903A
Other languages
English (en)
Hungarian (hu)
Inventor
Anthony Atkinson
Asgar Electricwala
John Bryan Griffith
Peter Morgan Sutton
Patrick Anthony Riley
Amy Latter
Original Assignee
Health Lab Service Board
Univ London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Lab Service Board, Univ London filed Critical Health Lab Service Board
Publication of HU200792B publication Critical patent/HU200792B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
HU831903A 1982-03-05 1983-03-04 Process for producing new fibrinolytic enzymes and pharmaceutical compositions comprising such enzymes as active ingredient HU200792B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8206576 1982-03-05

Publications (1)

Publication Number Publication Date
HU200792B true HU200792B (en) 1990-08-28

Family

ID=10528816

Family Applications (1)

Application Number Title Priority Date Filing Date
HU831903A HU200792B (en) 1982-03-05 1983-03-04 Process for producing new fibrinolytic enzymes and pharmaceutical compositions comprising such enzymes as active ingredient

Country Status (18)

Country Link
US (1) US4780412A (no)
EP (1) EP0104194B1 (no)
JP (1) JPS59500351A (no)
AT (1) ATE32232T1 (no)
AU (2) AU567491B2 (no)
BR (1) BR8306108A (no)
CA (1) CA1213231A (no)
DE (1) DE3375491D1 (no)
DK (1) DK163134C (no)
FI (1) FI76375C (no)
HU (1) HU200792B (no)
IE (1) IE54593B1 (no)
IT (1) IT1194148B (no)
NO (1) NO161445C (no)
RO (1) RO88552A (no)
SU (1) SU1507204A3 (no)
WO (1) WO1983003101A1 (no)
ZA (1) ZA831399B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
JPS60158115A (ja) * 1984-01-30 1985-08-19 Meiji Milk Prod Co Ltd プラズミノーゲンアクチベーターの製造法
EP0151996B1 (en) * 1984-01-30 1991-04-03 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a double-chain plasminogen activator
US4661453A (en) * 1984-06-19 1987-04-28 American Biogenetic Sciences, Inc. Production of tissue plasminogen activator factor
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
AT391812B (de) * 1985-05-28 1990-12-10 Wellcome Found Verfahren zur herstellung einer parenteralen t-pa-loesung
DE3722522A1 (de) * 1987-07-08 1989-01-19 Boehringer Ingelheim Int Verwendung eines vehikels mit hoher affinitaet zu tumoren
GB8723082D0 (en) * 1987-10-01 1987-11-04 Porton Prod Ltd Enzyme production
DE3843126C3 (de) * 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
GB9000629D0 (en) * 1990-01-11 1990-03-14 Porton Prod Ltd Tissue plasminogen activator
IT1245485B (it) * 1991-05-03 1994-09-20 Butterfly Srl Membrane permselettive e loro impiego

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
IT1170913B (it) * 1981-04-23 1987-06-03 Manetti & Roberts Italo Brit Procedimento per la produzione di un principio attivo fibrinolitico vasale prodotto enzimatico specifico angiochinasi cosi' ottenuto e sue applicazioni farmaceutiche
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines

Also Published As

Publication number Publication date
CA1213231A (en) 1986-10-28
DK506683D0 (da) 1983-11-04
EP0104194A1 (en) 1984-04-04
SU1507204A3 (ru) 1989-09-07
AU567491B2 (en) 1987-11-26
EP0104194B1 (en) 1988-01-27
DK163134C (da) 1992-06-09
BR8306108A (pt) 1984-01-17
NO834024L (no) 1983-11-04
JPS59500351A (ja) 1984-03-08
ZA831399B (en) 1984-02-29
IE54593B1 (en) 1989-12-06
AU1214688A (en) 1988-09-08
DE3375491D1 (en) 1988-03-03
WO1983003101A1 (en) 1983-09-15
NO161445C (no) 1989-08-16
FI76375C (fi) 1988-10-10
DK506683A (da) 1983-11-04
AU1337783A (en) 1983-10-18
NO161445B (no) 1989-05-08
FI834042A0 (fi) 1983-11-03
IE830480L (en) 1983-09-05
AU625283B2 (en) 1992-07-09
IT1194148B (it) 1988-09-14
RO88552A (ro) 1986-02-28
DK163134B (da) 1992-01-20
FI834042A (fi) 1983-11-03
FI76375B (fi) 1988-06-30
IT8319914A1 (it) 1984-09-04
IT8319914A0 (it) 1983-03-04
US4780412A (en) 1988-10-25
ATE32232T1 (de) 1988-02-15

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee