HU167933B - - Google Patents

Info

Publication number
HU167933B
HU167933B HULI244A HULI000244A HU167933B HU 167933 B HU167933 B HU 167933B HU LI244 A HULI244 A HU LI244A HU LI000244 A HULI000244 A HU LI000244A HU 167933 B HU167933 B HU 167933B
Authority
HU
Hungary
Prior art keywords
cyclising
pyretic
aminophenol
inflammatory
derivatives
Prior art date
Application number
HULI244A
Other languages
English (en)
Hungarian (hu)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of HU167933B publication Critical patent/HU167933B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
HULI244A 1972-05-18 1973-05-16 HU167933B (th)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2340972A GB1435721A (en) 1972-05-18 1972-05-18 Benzoxazole derivatives

Publications (1)

Publication Number Publication Date
HU167933B true HU167933B (th) 1976-01-28

Family

ID=10195157

Family Applications (1)

Application Number Title Priority Date Filing Date
HULI244A HU167933B (th) 1972-05-18 1973-05-16

Country Status (31)

Country Link
US (1) US3912748A (th)
JP (6) JPS5912672B2 (th)
KR (1) KR780000234B1 (th)
AR (4) AR230991A1 (th)
AT (1) AT333752B (th)
BE (1) BE799790A (th)
BG (1) BG21408A3 (th)
CA (1) CA1029019A (th)
CH (5) CH587834A5 (th)
CS (1) CS200455B2 (th)
CY (1) CY1016A (th)
DD (1) DD105229A5 (th)
DE (1) DE2324443A1 (th)
DK (1) DK140340B (th)
ES (1) ES414863A1 (th)
FR (2) FR2184966B1 (th)
GB (1) GB1435721A (th)
HK (1) HK72579A (th)
HU (1) HU167933B (th)
IE (2) IE37564B1 (th)
IL (2) IL42102A (th)
KE (1) KE2975A (th)
MY (1) MY8000063A (th)
NL (1) NL170145C (th)
PH (3) PH9685A (th)
PL (3) PL92565B1 (th)
RO (2) RO66800A (th)
SE (3) SE386174B (th)
SU (3) SU574157A3 (th)
YU (3) YU130473A (th)
ZA (1) ZA732791B (th)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888864A (en) 1973-06-29 1975-06-10 Hoffmann La Roche Amino lower alkyl ether derivatives of opium alkaloids
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
US4087437A (en) * 1976-09-07 1978-05-02 Eli Lilly And Company 2-Phenyl-5-benzoxazolylalkanoic acid purification process
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen
IT1099589B (it) * 1978-08-04 1985-09-18 Ravizza Spa Processo per la preparazione di derivati dell'acido benzoxazolil propionico
CA1125768A (en) * 1978-10-31 1982-06-15 Hoffmann-La Roche Limited Benzoxazole derivatives
GB2058381B (en) 1979-07-18 1983-01-19 Fuji Photo Film Co Ltd Colour photographic light-sensitive material containing dye-releasing redox compound
GR75153B (th) * 1981-03-27 1984-07-13 Lilly Co Eli
IT1157295B (it) * 1982-07-19 1987-02-11 Ravizza Spa Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico
DE3413875A1 (de) * 1984-04-12 1985-10-17 Ludwig Heumann & Co GmbH, 8500 Nürnberg Benzothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
IT1233836B (it) * 1988-01-13 1992-04-21 Euroresearch Srl Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
WO2004046122A2 (en) * 2002-11-16 2004-06-03 Oxford Glycosciences (Uk) Ltd Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
WO2004076386A2 (en) 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
ZA200704824B (en) * 2004-12-15 2008-10-29 Dompe Pha R Ma Spa Res & Mfg 2-Arylpropionic acid derivatives and pharmaceutical compositions containing them
US7973025B2 (en) 2005-05-26 2011-07-05 Neuron Systems, Inc. Compositions and methods of treating retinal disease
JP5369854B2 (ja) 2008-04-21 2013-12-18 住友化学株式会社 有害節足動物防除組成物および縮合複素環化合物
MX2015009383A (es) 2013-01-23 2016-03-17 Aldeyra Therapeutics Inc Enfermedades relacionadas con aldehido toxico y tratamiento.
RU2015126015A (ru) 2013-01-25 2017-03-03 Альдейра Терапьютикс, Инк. Новые улавливатели в лечении макулодистрофии
US20170298081A1 (en) * 2014-08-08 2017-10-19 Kasuma Partners Inc. Condensed heterocyclic compound
WO2017035077A1 (en) 2015-08-21 2017-03-02 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
CA3022665A1 (en) 2016-05-09 2017-11-16 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
US10414732B2 (en) 2017-03-16 2019-09-17 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
AU2018348174A1 (en) 2017-10-10 2020-04-23 Aldeyra Therapeutics, Inc. Treatment of inflammatory disorders
JP2021533154A (ja) 2018-08-06 2021-12-02 アルデイラ セラピューティクス， インコーポレイテッド 多形化合物およびその使用
JP7505786B2 (ja) 2018-09-25 2024-06-25 アルデイラ セラピューティクス， インコーポレイテッド ドライアイ疾患を処置するための製剤
JP2022526917A (ja) 2019-03-26 2022-05-27 アルデイラ セラピューティクス， インコーポレイテッド 眼科用製剤およびその使用
JP2022530967A (ja) 2019-05-02 2022-07-05 アルデイラ セラピューティクス， インコーポレイテッド 多形化合物およびその使用
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70860A (th) *
NL285932A (th) * 1961-11-27
CH516339A (de) * 1969-03-03 1971-12-15 Ciba Geigy Ag Verwendung von Azolverbindungen als Antioxydantien
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IL37633A (en) * 1970-09-10 1975-08-31 Merck & Co Inc 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen

Also Published As

Publication number Publication date
SU580837A3 (ru) 1977-11-15
NL170145C (nl) 1982-10-01
JPS56167645A (en) 1981-12-23
PL92565B1 (th) 1977-04-30
YU117179A (en) 1981-08-31
SU582762A3 (ru) 1977-11-30
FR2284592A1 (fr) 1976-04-09
PH11718A (en) 1978-05-30
CA1029019A (en) 1978-04-04
PH9685A (en) 1976-02-10
CH595361A5 (th) 1978-02-15
AR207857A1 (es) 1976-11-08
ES414863A1 (es) 1976-02-01
CH592071A5 (th) 1977-10-14
RO66800A (ro) 1982-03-24
SE434399B (sv) 1984-07-23
MY8000063A (en) 1980-12-31
FR2184966A1 (th) 1973-12-28
RO66278A (ro) 1981-06-26
IE37563B1 (en) 1977-08-17
NL170145B (nl) 1982-05-03
IL42102A0 (en) 1973-06-29
JPS56167675A (en) 1981-12-23
AU5590773A (en) 1974-11-21
DK140340B (da) 1979-08-06
DK140340C (th) 1979-12-31
AR205021A1 (es) 1976-03-31
JPS56167674A (en) 1981-12-23
AT333752B (de) 1976-12-10
JPS59161346A (ja) 1984-09-12
CH587834A5 (th) 1977-05-13
SE435838B (sv) 1984-10-22
BG21408A3 (bg) 1976-05-20
JPS56167673A (en) 1981-12-23
KE2975A (en) 1979-07-20
DD105229A5 (th) 1974-04-12
GB1435721A (en) 1976-05-12
DE2324443A1 (de) 1973-11-29
IE37564B1 (en) 1977-08-17
JPS6021976B2 (ja) 1985-05-30
JPS5929185B2 (ja) 1984-07-18
SE7710602L (sv) 1977-09-21
JPS5912672B2 (ja) 1984-03-24
IL42102A (en) 1977-07-31
PL89247B1 (th) 1976-11-30
YU36298B (en) 1982-06-18
YU130473A (en) 1981-08-31
AR212010A1 (es) 1978-04-28
ATA432573A (de) 1976-04-15
CH594643A5 (th) 1978-01-13
AR230991A1 (es) 1984-08-31
HK72579A (en) 1979-10-19
FR2184966B1 (th) 1979-01-12
PL94208B1 (th) 1977-07-30
SE7509387L (sv) 1975-08-22
BE799790A (fr) 1973-11-19
NL7307018A (th) 1973-11-20
IE37564L (en) 1973-11-18
US3912748A (en) 1975-10-14
YU117079A (en) 1981-08-31
CY1016A (en) 1979-11-23
CH595362A5 (th) 1978-02-15
KR780000234B1 (en) 1978-07-01
SE386174B (sv) 1976-08-02
IE37563L (en) 1973-11-18
FR2284592B1 (th) 1979-01-05
CS200455B2 (en) 1980-09-15
PH10704A (en) 1977-08-24
IL48711A0 (en) 1976-02-29
JPS4954363A (th) 1974-05-27
SU574157A3 (ru) 1977-09-25
ZA732791B (en) 1974-12-24

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee