HRP950337B1 - Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase - Google Patents
Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferaseInfo
- Publication number
- HRP950337B1 HRP950337B1 HR950337A HRP950337A HRP950337B1 HR P950337 B1 HRP950337 B1 HR P950337B1 HR 950337 A HR950337 A HR 950337A HR P950337 A HRP950337 A HR P950337A HR P950337 B1 HRP950337 B1 HR P950337B1
- Authority
- HR
- Croatia
- Prior art keywords
- inhibitors
- homohistidine
- histidine
- derivatives
- protein farnesyltransferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/268,364 US5571792A (en) | 1994-06-30 | 1994-06-30 | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP950337A2 HRP950337A2 (en) | 1997-08-31 |
HRP950337B1 true HRP950337B1 (en) | 2001-12-31 |
Family
ID=23022659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR950337A HRP950337B1 (en) | 1994-06-30 | 1995-06-14 | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase |
Country Status (17)
Country | Link |
---|---|
US (1) | US5571792A (xx) |
EP (1) | EP0767800B1 (xx) |
JP (1) | JPH10502078A (xx) |
AT (1) | ATE200085T1 (xx) |
AU (1) | AU699629B2 (xx) |
CA (1) | CA2190977A1 (xx) |
DE (1) | DE69520499T2 (xx) |
DK (1) | DK0767800T3 (xx) |
ES (1) | ES2158115T3 (xx) |
GR (1) | GR3035936T3 (xx) |
HR (1) | HRP950337B1 (xx) |
MX (1) | MX9605945A (xx) |
NO (1) | NO315427B1 (xx) |
NZ (1) | NZ287696A (xx) |
PT (1) | PT767800E (xx) |
WO (1) | WO1996000736A1 (xx) |
ZA (1) | ZA955411B (xx) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5756528A (en) * | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
JPH11509204A (ja) * | 1995-07-13 | 1999-08-17 | ユニバーシテイ・オブ・シンシナテイ | 神経線維腫症の治療に有用な化合物 |
US6008372A (en) * | 1996-01-16 | 1999-12-28 | Warner-Lambert Company | Substituted dinaphthylmethyl and diheteroarylmethylacetyl histidine inhibitors of protein farnesyltransferase |
WO1997027853A1 (en) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5968965A (en) * | 1996-01-30 | 1999-10-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
EP0944387A1 (en) * | 1996-01-30 | 1999-09-29 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6090948A (en) * | 1996-01-30 | 2000-07-18 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5981562A (en) * | 1996-01-30 | 1999-11-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
EP0935464A1 (en) * | 1996-04-03 | 1999-08-18 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5922883A (en) * | 1996-04-03 | 1999-07-13 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
EA199801031A1 (ru) * | 1996-05-22 | 1999-06-24 | Варнер-Ламберт Компани | Ингибиторы протеинфарнезилтрансферазы |
US6300501B1 (en) * | 1996-05-22 | 2001-10-09 | Warner-Lambert Company | Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase |
US6093816A (en) * | 1996-06-27 | 2000-07-25 | Isis Pharmaceuticals, Inc. | Cationic lipids |
ATE277907T1 (de) * | 1996-07-01 | 2004-10-15 | Lilly Co Eli | Blutzuckersenkende und lipidsenkende verbindungen |
US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5932590A (en) * | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5972966A (en) * | 1996-12-05 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6015817A (en) * | 1996-12-05 | 2000-01-18 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
BR9713744A (pt) | 1996-12-17 | 2000-03-21 | Warner Lambert Co | Inibidores de cicloalquia da proteìna farnesil transferase |
US6265382B1 (en) * | 1997-04-11 | 2001-07-24 | Warner-Lambert Company | Dipeptide inhibitors of protein farnesyltransferase |
US6737410B1 (en) | 1997-04-11 | 2004-05-18 | Warner-Lambert Company | Inhibitors of protein farnesyl transferase |
US6060038A (en) * | 1997-05-15 | 2000-05-09 | Merck & Co., Inc. | Radiolabeled farnesyl-protein transferase inhibitors |
US6792084B1 (en) * | 1997-09-08 | 2004-09-14 | Mci, Inc. | Single telephone number access to multiple communications services |
PT1076663E (pt) | 1998-04-27 | 2004-06-30 | Warner Lambert Co | Derivados funcionalizados de alquilo e alcenilo de cadeia lateral de glicinamidas como inibidores de farnesil transferase |
YU68900A (sh) * | 1998-05-12 | 2002-12-10 | Warner-Lambert Company | Kombinacije inhibitora protein farnesiltransferaze i hmg coa reduktaze i njihova upotreba u tretmanu raka |
US6458935B1 (en) | 1999-06-23 | 2002-10-01 | Merck & Co., Inc. | Radiolabeled farnesyl-protein transferase inhibitors |
JP2001158799A (ja) | 1999-09-28 | 2001-06-12 | Rijksuniv Leiden | プレニル化ピロリン酸消費酵素の新規な阻害剤 |
EP1090909A1 (en) * | 1999-09-28 | 2001-04-11 | Rijksuniversiteit Leiden | Novel inhibitors of prenylated pyrophosphate consuming enzymes |
CA2480325A1 (en) * | 2002-04-16 | 2003-10-30 | Merck & Co., Inc. | Solid forms of salts with tyrosine kinase activity |
CA2524222C (en) * | 2003-04-29 | 2012-02-07 | Roger Alberto | N.epsilon. and/or n.alpha. derivatized, metal and organic protected l-histidine for coupling to biomolecules for highly efficient labeling with [m(oh2)3(co)3]+ by fac coordination |
US20070275956A1 (en) * | 2003-10-14 | 2007-11-29 | Lohray Braj B | Novel Heterocyclic Compounds |
EP1888050B1 (en) | 2005-05-17 | 2012-03-21 | Merck Sharp & Dohme Ltd. | cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer |
PE20070335A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Benzimidazoles sustituidos y metodos para su preparacion |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
TW200806284A (en) * | 2006-03-31 | 2008-02-01 | Alcon Mfg Ltd | Prenyltransferase inhibitors for ocular hypertension control and the treatment of glaucoma |
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EP2698157B1 (en) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
KR101591656B1 (ko) | 2007-01-10 | 2016-02-19 | 엠에스디 이탈리아 에스.알.엘. | 폴리(adp-리보오스) 폴리머라아제(parp) 억제제로서의 아미드 치환된 인다졸 |
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US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
JP6073677B2 (ja) | 2009-06-12 | 2017-02-01 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 縮合複素環式化合物およびそれらの使用 |
MX2012004377A (es) | 2009-10-14 | 2012-06-01 | Merck Sharp & Dohme | Piperidinas sustituidas que aumentan la actividad de p53 y sus usos. |
CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
AU2011227643A1 (en) | 2010-03-16 | 2012-09-20 | Dana-Farber Cancer Institute, Inc. | Indazole compounds and their uses |
EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
US8518907B2 (en) | 2010-08-02 | 2013-08-27 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
EP3587574B1 (en) | 2010-08-17 | 2022-03-16 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
WO2012036997A1 (en) | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
US9351965B2 (en) | 2010-12-21 | 2016-05-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
AU2012245971A1 (en) | 2011-04-21 | 2013-10-17 | Piramal Enterprises Limited | A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
WO2013063214A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
EP2822935B1 (en) | 2011-11-17 | 2019-05-15 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
MX2015004041A (es) | 2012-09-28 | 2015-07-06 | Merck Sharp & Dohme | Compuestos novedosos que son inhibidores de erk. |
EP2909194A1 (en) | 2012-10-18 | 2015-08-26 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
WO2014063061A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
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CA2927917C (en) | 2013-10-18 | 2022-08-09 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of proliferative diseases |
CN105849099B (zh) | 2013-10-18 | 2020-01-17 | 达纳-法伯癌症研究所股份有限公司 | 周期蛋白依赖性激酶7(cdk7)的多环抑制剂 |
WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
WO2015164604A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
CA2972239A1 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
EP3273966B1 (en) | 2015-03-27 | 2023-05-03 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CA2996978A1 (en) | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
MX2019000735A (es) | 2016-09-16 | 2019-12-02 | Res Triangle Inst | Antagonistas opioides kappa de tetrahidroisoquinolina. |
JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
JP7160833B2 (ja) | 2017-04-13 | 2022-10-25 | サイロパ ビー.ブイ. | 抗sirpアルファ抗体 |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2019148412A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
CA2044333A1 (en) * | 1990-06-12 | 1991-12-13 | Jackson B. Gibbs | Chemotherapeutic agents |
US5260276A (en) * | 1991-06-14 | 1993-11-09 | Warner-Lambert Company | Linear and monocyclic endothelin antagonists |
CA2072048A1 (en) * | 1991-06-28 | 1992-12-29 | Jackson B. Gibbs | Non-substrate inhibitors of farnesyl protein transferase |
CA2072033A1 (en) * | 1991-06-28 | 1992-12-29 | Jackson B. Gibbs | Non-substrate inhibitors of farnesyl protein transferase |
EP0528486A2 (en) * | 1991-08-16 | 1993-02-24 | Merck & Co. Inc. | Non-substrate inhibitors of farnesyl protein transferase |
US5340828A (en) * | 1991-09-30 | 1994-08-23 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
US5352705A (en) * | 1992-06-26 | 1994-10-04 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
US5464820A (en) * | 1993-06-22 | 1995-11-07 | The University Hospital | Specific inhibitors of tissue kallikrein |
JPH09504277A (ja) * | 1993-09-30 | 1997-04-28 | メルク エンド カンパニー インコーポレーテッド | ファルネシル−タンパク質トランスフェラーゼの阻害剤 |
-
1994
- 1994-06-30 US US08/268,364 patent/US5571792A/en not_active Expired - Fee Related
-
1995
- 1995-05-30 JP JP8503154A patent/JPH10502078A/ja active Pending
- 1995-05-30 DE DE69520499T patent/DE69520499T2/de not_active Expired - Fee Related
- 1995-05-30 CA CA002190977A patent/CA2190977A1/en not_active Abandoned
- 1995-05-30 DK DK95921421T patent/DK0767800T3/da active
- 1995-05-30 PT PT95921421T patent/PT767800E/pt unknown
- 1995-05-30 NZ NZ287696A patent/NZ287696A/en unknown
- 1995-05-30 EP EP95921421A patent/EP0767800B1/en not_active Expired - Lifetime
- 1995-05-30 WO PCT/US1995/006660 patent/WO1996000736A1/en active IP Right Grant
- 1995-05-30 AT AT95921421T patent/ATE200085T1/de not_active IP Right Cessation
- 1995-05-30 MX MX9605945A patent/MX9605945A/es not_active IP Right Cessation
- 1995-05-30 ES ES95921421T patent/ES2158115T3/es not_active Expired - Lifetime
- 1995-05-30 AU AU26504/95A patent/AU699629B2/en not_active Ceased
- 1995-06-14 HR HR950337A patent/HRP950337B1/xx not_active IP Right Cessation
- 1995-06-29 ZA ZA955411A patent/ZA955411B/xx unknown
-
1996
- 1996-12-27 NO NO19965604A patent/NO315427B1/no not_active IP Right Cessation
-
2001
- 2001-05-25 GR GR20010400790T patent/GR3035936T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2158115T3 (es) | 2001-09-01 |
ATE200085T1 (de) | 2001-04-15 |
NO315427B1 (no) | 2003-09-01 |
CA2190977A1 (en) | 1996-01-11 |
EP0767800B1 (en) | 2001-03-28 |
DK0767800T3 (da) | 2001-06-18 |
PT767800E (pt) | 2001-08-30 |
NO965604L (no) | 1997-02-25 |
NZ287696A (en) | 1997-12-19 |
HRP950337A2 (en) | 1997-08-31 |
MX9605945A (es) | 1997-12-31 |
NO965604D0 (no) | 1996-12-27 |
ZA955411B (en) | 1996-02-05 |
AU2650495A (en) | 1996-01-25 |
DE69520499T2 (de) | 2001-07-26 |
JPH10502078A (ja) | 1998-02-24 |
WO1996000736A1 (en) | 1996-01-11 |
US5571792A (en) | 1996-11-05 |
GR3035936T3 (en) | 2001-08-31 |
EP0767800A1 (en) | 1997-04-16 |
AU699629B2 (en) | 1998-12-10 |
DE69520499D1 (de) | 2001-05-03 |
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ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20030423 Year of fee payment: 9 |
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