GR3035936T3 - Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase - Google Patents

Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase

Info

Publication number
GR3035936T3
GR3035936T3 GR20010400790T GR20010400790T GR3035936T3 GR 3035936 T3 GR3035936 T3 GR 3035936T3 GR 20010400790 T GR20010400790 T GR 20010400790T GR 20010400790 T GR20010400790 T GR 20010400790T GR 3035936 T3 GR3035936 T3 GR 3035936T3
Authority
GR
Greece
Prior art keywords
inhibitors
homohistidine
histidine
derivatives
protein farnesyltransferase
Prior art date
Application number
GR20010400790T
Other languages
English (en)
Inventor
Gary Louis Bolton
John Cooke Hodges
Michael William Wilson
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of GR3035936T3 publication Critical patent/GR3035936T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR20010400790T 1994-06-30 2001-05-25 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase GR3035936T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/268,364 US5571792A (en) 1994-06-30 1994-06-30 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
PCT/US1995/006660 WO1996000736A1 (en) 1994-06-30 1995-05-30 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase

Publications (1)

Publication Number Publication Date
GR3035936T3 true GR3035936T3 (en) 2001-08-31

Family

ID=23022659

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010400790T GR3035936T3 (en) 1994-06-30 2001-05-25 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase

Country Status (17)

Country Link
US (1) US5571792A (el)
EP (1) EP0767800B1 (el)
JP (1) JPH10502078A (el)
AT (1) ATE200085T1 (el)
AU (1) AU699629B2 (el)
CA (1) CA2190977A1 (el)
DE (1) DE69520499T2 (el)
DK (1) DK0767800T3 (el)
ES (1) ES2158115T3 (el)
GR (1) GR3035936T3 (el)
HR (1) HRP950337B1 (el)
MX (1) MX9605945A (el)
NO (1) NO315427B1 (el)
NZ (1) NZ287696A (el)
PT (1) PT767800E (el)
WO (1) WO1996000736A1 (el)
ZA (1) ZA955411B (el)

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EP0840605A4 (en) * 1995-07-13 2000-05-10 Univ Cincinnati COMPOUNDS FOR USE IN THE TREATMENT OF NEUROFIBROMATOSE
AU1529997A (en) * 1996-01-16 1997-08-11 Warner-Lambert Company Substituted histidine inhibitors of protein farnesyltransferase
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US5968965A (en) * 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU703988B2 (en) * 1996-01-30 1999-04-01 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5922883A (en) * 1996-04-03 1999-07-13 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU706629B2 (en) * 1996-04-03 1999-06-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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US6300501B1 (en) * 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
US6093816A (en) * 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
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US6015817A (en) * 1996-12-05 2000-01-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5932590A (en) * 1996-12-05 1999-08-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5977134A (en) * 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5972966A (en) * 1996-12-05 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
ATE261987T1 (de) 1996-12-17 2004-04-15 Warner Lambert Co Cycloalkyl inhibitoren der protein- farnesyltransferase
US6737410B1 (en) 1997-04-11 2004-05-18 Warner-Lambert Company Inhibitors of protein farnesyl transferase
WO1998046625A1 (en) * 1997-04-11 1998-10-22 Warner-Lambert Company Dipeptide inhibitors of protein farnesyltransferase
US6060038A (en) * 1997-05-15 2000-05-09 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
US6389117B1 (en) * 1997-09-08 2002-05-14 Mci Worldcom, Inc. Single telephone number access to multiple communications services
ATE259826T1 (de) 1998-04-27 2004-03-15 Warner Lambert Co Glycinamidederivate mit funktionalisierter alkyl- und alkenylseitenkette als inhibitoren der farnesyltransferase
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Also Published As

Publication number Publication date
WO1996000736A1 (en) 1996-01-11
ZA955411B (en) 1996-02-05
ATE200085T1 (de) 2001-04-15
AU2650495A (en) 1996-01-25
CA2190977A1 (en) 1996-01-11
NO965604L (no) 1997-02-25
AU699629B2 (en) 1998-12-10
EP0767800A1 (en) 1997-04-16
NO965604D0 (no) 1996-12-27
DE69520499D1 (de) 2001-05-03
DE69520499T2 (de) 2001-07-26
ES2158115T3 (es) 2001-09-01
EP0767800B1 (en) 2001-03-28
NO315427B1 (no) 2003-09-01
MX9605945A (es) 1997-12-31
HRP950337B1 (en) 2001-12-31
NZ287696A (en) 1997-12-19
PT767800E (pt) 2001-08-30
HRP950337A2 (en) 1997-08-31
JPH10502078A (ja) 1998-02-24
US5571792A (en) 1996-11-05
DK0767800T3 (da) 2001-06-18

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