NO965604L - Histidin- og homohistidin-derivater som inhibitorer for protein-farnesyltransferase - Google Patents
Histidin- og homohistidin-derivater som inhibitorer for protein-farnesyltransferaseInfo
- Publication number
- NO965604L NO965604L NO965604A NO965604A NO965604L NO 965604 L NO965604 L NO 965604L NO 965604 A NO965604 A NO 965604A NO 965604 A NO965604 A NO 965604A NO 965604 L NO965604 L NO 965604L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- homohistidine
- histidine
- derivatives
- farnesyl transferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/268,364 US5571792A (en) | 1994-06-30 | 1994-06-30 | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase |
PCT/US1995/006660 WO1996000736A1 (en) | 1994-06-30 | 1995-05-30 | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase |
Publications (3)
Publication Number | Publication Date |
---|---|
NO965604D0 NO965604D0 (no) | 1996-12-27 |
NO965604L true NO965604L (no) | 1997-02-25 |
NO315427B1 NO315427B1 (no) | 2003-09-01 |
Family
ID=23022659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19965604A NO315427B1 (no) | 1994-06-30 | 1996-12-27 | Histidin- og homohistidin-derivater som inhibitorer for protein-farnesyltransferase, anvendelse derav, farmasöytisk preparat, opplösnings-syntesemetode samt fastfase-syntesemetode |
Country Status (17)
Country | Link |
---|---|
US (1) | US5571792A (no) |
EP (1) | EP0767800B1 (no) |
JP (1) | JPH10502078A (no) |
AT (1) | ATE200085T1 (no) |
AU (1) | AU699629B2 (no) |
CA (1) | CA2190977A1 (no) |
DE (1) | DE69520499T2 (no) |
DK (1) | DK0767800T3 (no) |
ES (1) | ES2158115T3 (no) |
GR (1) | GR3035936T3 (no) |
HR (1) | HRP950337B1 (no) |
MX (1) | MX9605945A (no) |
NO (1) | NO315427B1 (no) |
NZ (1) | NZ287696A (no) |
PT (1) | PT767800E (no) |
WO (1) | WO1996000736A1 (no) |
ZA (1) | ZA955411B (no) |
Families Citing this family (85)
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US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5756528A (en) * | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2226623A1 (en) * | 1995-07-13 | 1997-01-30 | University Of Cincinnati | Compounds useful in the treatment of neurofibromatosis |
US6008372A (en) * | 1996-01-16 | 1999-12-28 | Warner-Lambert Company | Substituted dinaphthylmethyl and diheteroarylmethylacetyl histidine inhibitors of protein farnesyltransferase |
US5981562A (en) * | 1996-01-30 | 1999-11-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997027852A1 (en) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5968965A (en) * | 1996-01-30 | 1999-10-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AU704087B2 (en) * | 1996-01-30 | 1999-04-15 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
JP2000505797A (ja) * | 1996-01-30 | 2000-05-16 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質転移酵素の阻害剤 |
WO1997036584A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5922883A (en) * | 1996-04-03 | 1999-07-13 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6300501B1 (en) * | 1996-05-22 | 2001-10-09 | Warner-Lambert Company | Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase |
EA199801031A1 (ru) * | 1996-05-22 | 1999-06-24 | Варнер-Ламберт Компани | Ингибиторы протеинфарнезилтрансферазы |
US6093816A (en) * | 1996-06-27 | 2000-07-25 | Isis Pharmaceuticals, Inc. | Cationic lipids |
AU3513497A (en) * | 1996-07-01 | 1998-01-21 | Eli Lilly And Company | Hypoglycemic and hypolipidemic compounds |
US5972966A (en) * | 1996-12-05 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5932590A (en) * | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6015817A (en) * | 1996-12-05 | 2000-01-18 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CO4920227A1 (es) | 1996-12-17 | 2000-05-29 | Warner Lambert Co | Histidina-n-bencil glicinamida sustituida con cicloalquilos . |
US6737410B1 (en) | 1997-04-11 | 2004-05-18 | Warner-Lambert Company | Inhibitors of protein farnesyl transferase |
WO1998046625A1 (en) * | 1997-04-11 | 1998-10-22 | Warner-Lambert Company | Dipeptide inhibitors of protein farnesyltransferase |
US6060038A (en) * | 1997-05-15 | 2000-05-09 | Merck & Co., Inc. | Radiolabeled farnesyl-protein transferase inhibitors |
US6870909B2 (en) * | 1997-09-08 | 2005-03-22 | Mci, Inc. | Single telephone number access to multiple communications services |
DE69914893T2 (de) | 1998-04-27 | 2004-07-22 | Warner-Lambert Co. Llc | Glycinamidederivate mit funktionalisierter alkyl- und alkenylseitenkette als inhibitoren der farnesyltransferase |
ID27933A (id) | 1998-05-12 | 2001-05-03 | Warner Lambert Co | Gabungan protein farnesiltransferase dan inhibitor hmg-coa reduktase serta penggunaannya untuk mengobati kanker |
US6458935B1 (en) | 1999-06-23 | 2002-10-01 | Merck & Co., Inc. | Radiolabeled farnesyl-protein transferase inhibitors |
EP1090909A1 (en) * | 1999-09-28 | 2001-04-11 | Rijksuniversiteit Leiden | Novel inhibitors of prenylated pyrophosphate consuming enzymes |
US6624147B1 (en) | 1999-09-28 | 2003-09-23 | Rijksuniversiteit Leiden | Inhibitors of prenylated pyrophosphate consuming enzymes |
AU2003226051A1 (en) * | 2002-04-16 | 2003-11-03 | Banyu Pharmaceutical Co., Ltd. | Solid forms of salts with tyrosine kinase activity |
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US20070275956A1 (en) * | 2003-10-14 | 2007-11-29 | Lohray Braj B | Novel Heterocyclic Compounds |
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US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
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US10870651B2 (en) | 2014-12-23 | 2020-12-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
WO2016160617A2 (en) | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
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WO2018053222A1 (en) | 2016-09-16 | 2018-03-22 | Research Traingle Institute | Tetrahydroisoquinoline kappa opioid antagonists |
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WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
CA2044333A1 (en) * | 1990-06-12 | 1991-12-13 | Jackson B. Gibbs | Chemotherapeutic agents |
US5260276A (en) * | 1991-06-14 | 1993-11-09 | Warner-Lambert Company | Linear and monocyclic endothelin antagonists |
CA2072048A1 (en) * | 1991-06-28 | 1992-12-29 | Jackson B. Gibbs | Non-substrate inhibitors of farnesyl protein transferase |
CA2072033A1 (en) * | 1991-06-28 | 1992-12-29 | Jackson B. Gibbs | Non-substrate inhibitors of farnesyl protein transferase |
EP0528486A2 (en) * | 1991-08-16 | 1993-02-24 | Merck & Co. Inc. | Non-substrate inhibitors of farnesyl protein transferase |
US5340828A (en) * | 1991-09-30 | 1994-08-23 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
US5352705A (en) * | 1992-06-26 | 1994-10-04 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
US5464820A (en) * | 1993-06-22 | 1995-11-07 | The University Hospital | Specific inhibitors of tissue kallikrein |
WO1995009001A1 (en) * | 1993-09-30 | 1995-04-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
-
1994
- 1994-06-30 US US08/268,364 patent/US5571792A/en not_active Expired - Fee Related
-
1995
- 1995-05-30 MX MX9605945A patent/MX9605945A/es not_active IP Right Cessation
- 1995-05-30 DE DE69520499T patent/DE69520499T2/de not_active Expired - Fee Related
- 1995-05-30 DK DK95921421T patent/DK0767800T3/da active
- 1995-05-30 WO PCT/US1995/006660 patent/WO1996000736A1/en active IP Right Grant
- 1995-05-30 NZ NZ287696A patent/NZ287696A/en unknown
- 1995-05-30 AU AU26504/95A patent/AU699629B2/en not_active Ceased
- 1995-05-30 CA CA002190977A patent/CA2190977A1/en not_active Abandoned
- 1995-05-30 EP EP95921421A patent/EP0767800B1/en not_active Expired - Lifetime
- 1995-05-30 ES ES95921421T patent/ES2158115T3/es not_active Expired - Lifetime
- 1995-05-30 PT PT95921421T patent/PT767800E/pt unknown
- 1995-05-30 JP JP8503154A patent/JPH10502078A/ja active Pending
- 1995-05-30 AT AT95921421T patent/ATE200085T1/de not_active IP Right Cessation
- 1995-06-14 HR HR950337A patent/HRP950337B1/xx not_active IP Right Cessation
- 1995-06-29 ZA ZA955411A patent/ZA955411B/xx unknown
-
1996
- 1996-12-27 NO NO19965604A patent/NO315427B1/no not_active IP Right Cessation
-
2001
- 2001-05-25 GR GR20010400790T patent/GR3035936T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX9605945A (es) | 1997-12-31 |
PT767800E (pt) | 2001-08-30 |
EP0767800B1 (en) | 2001-03-28 |
AU699629B2 (en) | 1998-12-10 |
DE69520499T2 (de) | 2001-07-26 |
ZA955411B (en) | 1996-02-05 |
NZ287696A (en) | 1997-12-19 |
NO315427B1 (no) | 2003-09-01 |
GR3035936T3 (en) | 2001-08-31 |
ES2158115T3 (es) | 2001-09-01 |
JPH10502078A (ja) | 1998-02-24 |
CA2190977A1 (en) | 1996-01-11 |
AU2650495A (en) | 1996-01-25 |
DE69520499D1 (de) | 2001-05-03 |
US5571792A (en) | 1996-11-05 |
DK0767800T3 (da) | 2001-06-18 |
NO965604D0 (no) | 1996-12-27 |
EP0767800A1 (en) | 1997-04-16 |
HRP950337A2 (en) | 1997-08-31 |
HRP950337B1 (en) | 2001-12-31 |
ATE200085T1 (de) | 2001-04-15 |
WO1996000736A1 (en) | 1996-01-11 |
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